Shisa5 (shisa family member 5) - Rat Genome Database

Name: Shisa5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Shisa5 (shisa family member 5) Rattus norvegicus

Analyze

Symbol:

Shisa5

Name:

shisa family member 5

RGD ID:

1359661

Description:

Predicted to enable WW domain binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in endoplasmic reticulum and nuclear envelope. Orthologous to human SHISA5 (shisa family member 5); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC94600; protein shisa-5; scotin; shisa homolog 5; shisa homolog 5 (Xenopus laevis)

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SHISA5 (shisa family member 5)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Shisa5 (shisa family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Shisa5 (shisa family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SHISA5 (shisa family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SHISA5 (shisa family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Shisa5 (shisa family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SHISA5 (shisa family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SHISA5 (shisa family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Shisa5 (shisa family member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	UBTD1 (ubiquitin domain containing 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SHISA5 (shisa family member 5)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Shisa5 (shisa family member 5)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	118,569,975 - 118,584,880 (+)	NCBI		GRCr8
mRatBN7.2	8	109,691,504 - 109,706,411 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,691,522 - 109,706,408 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	115,306,376 - 115,321,300 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	113,505,552 - 113,520,474 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	111,348,354 - 111,363,281 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,780,992 - 117,795,923 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,780,891 - 117,795,919 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	117,132,759 - 117,147,668 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	114,068,670 - 114,071,301 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	114,088,124 - 114,090,755 (+)	NCBI
Celera	8	108,995,220 - 108,997,851 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 1 (ISO)

genetic disease (ISO)

Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-butoxyethanol (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

all-trans-retinoic acid (ISO)

aluminium atom (ISO)

aluminium(0) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

cholesterol (ISO)

cisplatin (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diazinon (ISO)

dibutyl phthalate (EXP)

diethylstilbestrol (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

genistein (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pinostrobin (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thimerosal (ISO)

topotecan (EXP)

triptonide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intrinsic apoptotic signaling pathway by p53 class mediator (ISO)

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ISO)

positive regulation of canonical NF-kappaB signal transduction (IEA)

Cellular Component

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

nuclear envelope (ISO)

nuclear membrane (IEA)

nucleus (IEA)

Molecular Function

protein binding (ISO)

WW domain binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

p53 signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:12135983	PMID:12761501	PMID:15064722	PMID:23376485

Genomics

Comparative Map Data

Shisa5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	118,569,975 - 118,584,880 (+)	NCBI		GRCr8
mRatBN7.2	8	109,691,504 - 109,706,411 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,691,522 - 109,706,408 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	115,306,376 - 115,321,300 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	113,505,552 - 113,520,474 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	111,348,354 - 111,363,281 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,780,992 - 117,795,923 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,780,891 - 117,795,919 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	117,132,759 - 117,147,668 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	114,068,670 - 114,071,301 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	114,088,124 - 114,090,755 (+)	NCBI
Celera	8	108,995,220 - 108,997,851 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

SHISA5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	48,467,876 - 48,504,810 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	48,467,798 - 48,504,826 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	48,509,275 - 48,542,243 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	48,484,201 - 48,516,665 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	48,460,056 - 48,497,388 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	48,563,227 - 48,600,722 (-)	NCBI		HuRef
CHM1_1	3	48,461,497 - 48,494,529 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	48,495,881 - 48,533,775 (-)	NCBI		T2T-CHM13v2.0

Shisa5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	108,867,635 - 108,886,860 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	108,867,633 - 108,886,845 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	109,038,567 - 109,057,792 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	109,038,565 - 109,057,777 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	108,941,141 - 108,960,280 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	108,896,033 - 108,915,172 (+)	NCBI		MGSCv36	mm8
Celera	9	108,597,405 - 108,616,548 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	59.63	NCBI

Shisa5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955532	535,992 - 544,542 (-)	NCBI	ChiLan1.0	ChiLan1.0

SHISA5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	48,442,785 - 48,478,928 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	48,447,553 - 48,483,676 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	48,389,924 - 48,426,064 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	49,471,604 - 49,508,840 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	49,471,604 - 49,508,840 (-)	Ensembl	panpan1.1		panPan2

SHISA5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	40,604,183 - 40,624,607 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	40,601,626 - 40,623,601 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	40,519,080 - 40,542,090 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	41,086,985 - 41,110,000 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	41,087,007 - 41,109,997 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	40,324,425 - 40,347,434 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	40,728,984 - 40,752,019 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	41,009,711 - 41,032,715 (+)	NCBI		UU_Cfam_GSD_1.0

Shisa5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	63,506,174 - 63,531,640 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	266,456 - 269,732 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	266,671 - 292,103 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SHISA5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	31,180,846 - 31,205,731 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	31,180,844 - 31,205,724 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	34,877,003 - 34,885,569 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SHISA5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	9,871,882 - 9,905,733 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	9,873,019 - 9,905,308 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	157,184,124 - 157,219,325 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Shisa5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	2,413,014 - 2,449,065 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	2,416,486 - 2,448,836 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Shisa5
38 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	179
Count of miRNA genes:	118
Interacting mature miRNAs:	144
Transcripts:	ENSRNOT00000056199
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat

Markers in Region

RH132489

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	109,705,209 - 109,705,574 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	117,794,724 - 117,795,088	NCBI	Rnor6.0
Rnor_5.0	8	117,146,469 - 117,146,833	UniSTS	Rnor5.0
RGSC_v3.4	8	114,070,105 - 114,070,469	UniSTS	RGSC3.4
Celera	8	108,996,655 - 108,997,019	UniSTS
RH 3.4 Map	8	1115.1	UniSTS
Cytogenetic Map	8	q32	UniSTS

AU041952

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	109,706,669 - 109,706,780 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	117,796,184 - 117,796,294	NCBI	Rnor6.0
Rnor_5.0	8	117,147,929 - 117,148,039	UniSTS	Rnor5.0
RGSC_v3.4	8	114,071,565 - 114,071,675	UniSTS	RGSC3.4
Celera	8	108,998,115 - 108,998,225	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH129942

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	109,706,643 - 109,706,834 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	117,796,158 - 117,796,348	NCBI	Rnor6.0
Rnor_5.0	8	117,147,903 - 117,148,093	UniSTS	Rnor5.0
RGSC_v3.4	8	114,071,539 - 114,071,729	UniSTS	RGSC3.4
Celera	8	108,998,089 - 108,998,279	UniSTS
RH 3.4 Map	8	1115.59	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH131155

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	109,706,148 - 109,706,328 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	117,795,663 - 117,795,842	NCBI	Rnor6.0
Rnor_5.0	8	117,147,408 - 117,147,587	UniSTS	Rnor5.0
RGSC_v3.4	8	114,071,044 - 114,071,223	UniSTS	RGSC3.4
Celera	8	108,997,594 - 108,997,773	UniSTS
RH 3.4 Map	8	1114.9	UniSTS
RH 3.4 Map	8	1114.2	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	36	50	34	19	34	1	2	74	35	35	11	1
Low		7	7	7		7	7	9			6		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001006989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001395736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001395737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001395738	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008766511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000056199 ⟹ ENSRNOP00000053045

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	109,703,740 - 109,706,406 (+)	Ensembl
Rnor_6.0 Ensembl	8	117,793,289 - 117,795,919 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000077236 ⟹ ENSRNOP00000072905

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	109,691,522 - 109,706,408 (+)	Ensembl
Rnor_6.0 Ensembl	8	117,780,891 - 117,795,144 (+)	Ensembl

RefSeq Acc Id:

NM_001006989 ⟹ NP_001006990

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	118,582,244 - 118,584,875 (+)	NCBI
mRatBN7.2	8	109,703,775 - 109,706,406 (+)	NCBI
Rnor_6.0	8	117,793,289 - 117,795,920 (+)	NCBI
Rnor_5.0	8	117,132,759 - 117,147,668 (+)	NCBI
RGSC_v3.4	8	114,068,670 - 114,071,301 (+)	RGD
Celera	8	108,995,220 - 108,997,851 (+)	RGD

Sequence:

show sequence

GTTTGAAACTGAGTGGCCCCCCTTCCCCCGATGAAAAGAGGGGAAGTCCTGGGCTGCAGGAGCC
CCTTGAGTGAAGGCGGAGGCTAACATGGGGTTCGGAGCGACCGTGGCCATCGGCCTGACCGTCT
TCGTGGTGTTTATCGCTACCATCATTGTGTGCTTTACCTGCTCCTGCTGCTGTCTATATAAGAT
GTGCTGCCGCCCACGACCTGTCGTGTCCAACACCACAACTACTACCGTGGTTCACACCGCTTAC
CCTCAGCCTCAACCTGTGGCCCCCAGCTATCCTGGACCAACATACCAGGGCTACCATCCCATGC
CCCCCCAGCCAGGAATGCCAGCAGCACCCTACCCAACGCAGTACCCTCCACCCTACCTGGCCCA
GTCCACAGGGCCACCAGCCTATCATGAGACGTTGGCTGGAGCCAGCCAGCCTCCATACAACCCG
GCCTACATGGATCCCCCAAAGGCAGTTCCCTGAGCCTGCCCCCAGCCTCTTTGGCTAACATTTG
ATTATGTCATGTGTGTGTGAGTGCTATGCAGAGTTCTTTACTGCTGTCTGTGGTGCGTGTGCCT
TGTCTAGACATGTGGCTTCCTCTGCTGATGACCAGGTAGGCACAAATCTTACCAGTGCTGGTTG
GGACCAATCTGTTTTCTTCCTCACTTGAAATTGTAATTTCTGAAATTTCAAGTAAATTAAAAAC
AATAGGGTAGGAGGTATTTCCCGCTTCACCCCAAGGTGACCAGCCATAGCCTGCCACACATAGG
AGAGCAAGCTTTTTGTGGGTCCATGTCCTGCTTTGGGGAGTAGCCAGCTAGCTGCTGCTATGGG
TTTATTCCCAGGGCTTGGCTGCATTTAGCTGGACAGAGAACAAGGGGCCTCAGTGGCAGTGGGT
CAGTGACTGATGTCAGAGCACACTAGGCAGAGAGCCCCGTCCGTCTCCATCAGCTGTCTGTCTG
GACGGTCCCACTGTCTTTCCTGGGACTATGTAGAGGGCCACATGTATTCACTATTCAGGCTCCA
GTGGCTTCCAGGCCAGGGGCCTCTGTCTACTACACACTCTGGTTTCTCCCTACAGTGTCTTTTT
ACGATTAGCCAAACATATTGCCTGTTTTTTGTATCCAGATGTGTGATAATTGGTGAGGTTGAAA
TCCTTGGTTCCTGGAGAACAGGAAACCTGACCTCTGACAGTCCATTTCCCTTGACACCAGCTTC
ATAGAATACCTGACTCCTGTACTACAGTCCAGTTTGTTCCAGTAGCAGGGACACCAGGGCCAGG
GGTTATCTGGACCAAGGGTGGGGGTGGAGAGCCTGGATGGTAGCTCTGGACCAGATGTGAATGC
CTCCATATTCCCTGTTGGTTCCTGTTTCACTGGCTGTTTTAGTTTTGTGTTAATTGGTGTTTCT
GAGCATTCAAACTCCGCACCCTCGTTTATAATAAATGAATATTTGGAAAAAAAAAAAAAAAAAA
AAAAAAA

hide sequence

RefSeq Acc Id:

NM_001395736 ⟹ NP_001382665

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	118,569,975 - 118,584,880 (+)	NCBI
mRatBN7.2	8	109,691,504 - 109,706,411 (+)	NCBI

RefSeq Acc Id:

NM_001395737 ⟹ NP_001382666

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	118,569,975 - 118,584,880 (+)	NCBI
mRatBN7.2	8	109,691,504 - 109,706,411 (+)	NCBI

RefSeq Acc Id:

NM_001395738 ⟹ NP_001382667

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	118,569,975 - 118,584,880 (+)	NCBI
mRatBN7.2	8	109,691,504 - 109,706,411 (+)	NCBI

RefSeq Acc Id:

XM_006243762 ⟹ XP_006243824

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	118,578,948 - 118,584,878 (+)	NCBI
mRatBN7.2	8	109,700,475 - 109,706,409 (+)	NCBI
Rnor_6.0	8	117,790,946 - 117,795,923 (+)	NCBI
Rnor_5.0	8	117,132,759 - 117,147,668 (+)	NCBI

Sequence:

show sequence

TCAAATCCAAGCAACCACATGGTTGTTTCGAAACAGGCTCTTGCTCTGTAGCCCAGACTAGCTG
GGATGTTCTTTGGGCTGGCTCAGAATTTGTTGTCCTCTTGCCTCTGCTTCCTGATTGCTGGAAT
TACAGACGTGAGCCCCCATGTTACCTTCCTACACTGGCGTCTTGTTTCCATCCACGGCCACAGA
GCAAGCTGCAGAGGAAAGGAACACATGCAGGCAGTCATTGGGCATGACCGTGACTTCCTGACCA
GAGATGTTGGGAGGGTAGAGTGGAGGTGGGTTGATGATGTTCAGACTGTGACTTCCTGACCAGA
GGTATTGGGAGGGTAGAGTGGAGGCATTGGTGGTGTTCAGCAGCTGCCTGCCAGTAAGGAACAA
AGGAGAGAATGGACGGACAAACAGATCCGGCCCTGCACGGAGATGCCAGGTTCGGAGCGACCGT
GGCCATCGGCCTGACCGTCTTCGTGGTGTTTATCGCTACCATCATTGTGTGCTTTACCTGCTCC
TGCTGCTGTCTATATAAGATGTGCTGCCGCCCACGACCTGTCGTGTCCAACACCACAACTACTA
CCGTGGTTCACACCGCTTACCCTCAGCCTCAACCTGTGGCCCCCAGCTATCCTGGACCAACATA
CCAGGGCTACCATCCCATGCCCCCCCAGCCAGGAATGCCAGCAGCACCCTACCCAACGCAGTAC
CCTCCACCCTACCTGGCCCAGTCCACAGGGCCACCAGCCTATCATGAGACGTTGGCTGGAGCCA
GCCAGCCTCCATACAACCCGGCCTACATGGATCCCCCAAAGGCAGTTCCCTGAGCCTGCCCCCA
GCCTCTTTGGCTAACATTTGATTATGTCATGTGTGTGTGAGTGCTATGCAGAGTTCTTTACTGC
TGTCTGTGGTGCGTGTGCCTTGTCTAGACATGTGGCTTCCTCTGCTGATGACCAGGTAGGCACA
AATCTTACCAGTGCTGGTTGGGACCAATCTGTTTTCTTCCTCACTTGAAATTGTAATTTCTGAA
ATTTCAAGTAAATTAAAAACAATAGGGTAGGAGGTATTTCCCGCTTCACCCCAAGGTGACCAGC
CATAGCCTGCCACACATAGGAGAGCAAGCTTTTTGTGGGTCCATGTCCTGCTTTGGGGAGTAGC
CAGCTAGCTGCTGCTATGGGTTTATTCCCAGGGCTTGGCTGCATTTAGCTGGACAGAGAACAAG
GGGCCTCAGTGGCAGTGGGTCAGTGACTGATGTCAGAGCACACTAGGCAGAGAGCCCCGTCCGT
CTCCATCAGCTGTCTGTCTGGACGGTCCCACTGTCTTTCCTGGGACTATGTAGAGGGCCACATG
TATTCACTATTCAGGCTCCAGTGGCTTCCAGGCCAGGGGCCTCTGTCTACTACACACTCTGGTT
TCTCCCTACAGTGTCTTTTTACGATTAGCCAAACATATTGCCTGTTTTTTGTATCCAGATGTGT
GATAATTGGTGAGGTTGAAATCCTTGGTTCCTGGAGAACAGGAAACCTGACCTCTGACAGTCCA
TTTCCCTTGACACCAGCTTCATAGAATACCTGACTCCTGTACTACAGTCCAGTTTGTTCCAGTA
GCAGGGACACCAGGGCCAGGGGTTATCTGGACCAAGGGTGGGGGTGGAGAGCCTGGATGGTAGC
TCTGGACCAGATGTGAATGCCTCCATATTCCCTGTTGGTTCCTGTTTCACTGGCTGTTTTAGTT
TTGTGTTAATTGGTGTTTCTGAGCATTCAAACTCCGCACCCTCGTTTATAATAAATGAATATTT
GGACCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001006990	(Get FASTA)	NCBI Sequence Viewer
	NP_001382665	(Get FASTA)	NCBI Sequence Viewer
	NP_001382666	(Get FASTA)	NCBI Sequence Viewer
	NP_001382667	(Get FASTA)	NCBI Sequence Viewer
	XP_006243824	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83710	(Get FASTA)	NCBI Sequence Viewer
	EDL77116	(Get FASTA)	NCBI Sequence Viewer
	EDL77117	(Get FASTA)	NCBI Sequence Viewer
	EDL77118	(Get FASTA)	NCBI Sequence Viewer
	EDL77119	(Get FASTA)	NCBI Sequence Viewer
	EDL77120	(Get FASTA)	NCBI Sequence Viewer
	EDL77121	(Get FASTA)	NCBI Sequence Viewer
	EDL77122	(Get FASTA)	NCBI Sequence Viewer
	EDL77123	(Get FASTA)	NCBI Sequence Viewer
	EDL77124	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000053045
	ENSRNOP00000053045.2
	ENSRNOP00000072905
	ENSRNOP00000072905.2
GenBank Protein	Q5XIH2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001006990 ⟸ NM_001006989
- Peptide Label:	isoform 4
- UniProtKB:	Q5XIH2 (UniProtKB/Swiss-Prot), A6I3A9 (UniProtKB/TrEMBL), A6I3A7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGFGATVAIGLTVFVVFIATIIVCFTCSCCCLYKMCCRPRPVVSNTTTTTVVHTAYPQPQPVAP SYPGPTYQGYHPMPPQPGMPAAPYPTQYPPPYLAQSTGPPAYHETLAGASQPPYNPAYMDPPKA VP hide sequence

RefSeq Acc Id:	XP_006243824 ⟸ XM_006243762
- Peptide Label:	isoform X1
- UniProtKB:	A6I3A8 (UniProtKB/TrEMBL), A6I3B0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDGQTDPALHGDARFGATVAIGLTVFVVFIATIIVCFTCSCCCLYKMCCRPRPVVSNTTTTTVV HTAYPQPQPVAPSYPGPTYQGYHPMPPQPGMPAAPYPTQYPPPYLAQSTGPPAYHETLAGASQP PYNPAYMDPPKAVP hide sequence

RefSeq Acc Id:

ENSRNOP00000072905 ⟸ ENSRNOT00000077236

RefSeq Acc Id:

ENSRNOP00000053045 ⟸ ENSRNOT00000056199

RefSeq Acc Id:	NP_001382665 ⟸ NM_001395736
- Peptide Label:	isoform 1 precursor
- UniProtKB:	A0A0G2K447 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001382666 ⟸ NM_001395737
- Peptide Label:	isoform 2 precursor
- UniProtKB:	A6I3A3 (UniProtKB/TrEMBL), A0A0G2K447 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001382667 ⟸ NM_001395738
- Peptide Label:	isoform 3 precursor
- UniProtKB:	A0A0G2K447 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5XIH2-F1-model_v2	AlphaFold	Q5XIH2	1-130	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696319

Promoter ID:

EPDNEW_R6844

Type:

initiation region

Name:

Shisa5_1

Description:

shisa family member 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	117,793,230 - 117,793,290	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359661	AgrOrtholog
BioCyc Gene	G2FUF-29096	BioCyc
Ensembl Genes	ENSRNOG00000020667	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000056199	ENTREZGENE
	ENSRNOT00000056199.3	UniProtKB/Swiss-Prot
	ENSRNOT00000077236	ENTREZGENE
	ENSRNOT00000077236.2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7190608	IMAGE-MGC_LOAD
InterPro	Shisa	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:301013	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:94600	IMAGE-MGC_LOAD
NCBI Gene	301013	ENTREZGENE
PANTHER	PROTEIN SHISA-5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR31395	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Shisa	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Shisa5	PhenoGen
RatGTEx	ENSRNOG00000020667	RatGTEx
UniProt	A0A0G2K447	ENTREZGENE, UniProtKB/TrEMBL
	A6I3A3	ENTREZGENE, UniProtKB/TrEMBL
	A6I3A7	ENTREZGENE, UniProtKB/TrEMBL
	A6I3A8	ENTREZGENE, UniProtKB/TrEMBL
	A6I3A9	ENTREZGENE, UniProtKB/TrEMBL
	A6I3B0	ENTREZGENE, UniProtKB/TrEMBL
	Q5XIH2	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-07	Shisa5	shisa family member 5	Shisa5	shisa homolog 5 (Xenopus laevis)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-04-23	Shisa5	shisa homolog 5 (Xenopus laevis)	MGC94600	scotin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-29	MGC94600	scotin			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)