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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of FLCN mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1615711 | 6480464 | Tetrachlorodibenzodioxin affects the expression of FLCN mRNA | CTD | PMID:21570461 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of FLCN mRNA | CTD | PMID:21346803 | amiodarone | increases expression | ISO | RGD:1604509 | 6480464 | Amiodarone results in increased expression of FLCN mRNA | CTD | PMID:19774075 | benzo[a]pyrene | multiple interactions | ISO | RGD:1615711 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of FLCN mRNA | CTD | PMID:21715664 | bisphenol A | decreases expression | ISO | RGD:1615711 | 6480464 | bisphenol A results in decreased expression of FLCN mRNA | CTD | PMID:21932408 | clofibrate | decreases expression | ISO | RGD:1615711 | 6480464 | Clofibrate results in decreased expression of FLCN mRNA | CTD | PMID:17585979 | copper(2+) sulfate | increases expression | ISO | RGD:1604509 | 6480464 | Copper Sulfate results in increased expression of FLCN mRNA | CTD | PMID:19549813 | coumestrol | decreases expression | ISO | RGD:1604509 | 6480464 | Coumestrol results in decreased expression of FLCN mRNA | CTD | PMID:19167446 | coumestrol | multiple interactions | ISO | RGD:1604509 | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FLCN mRNA | CTD | PMID:19167446 | crocidolite asbestos | increases expression | ISO | RGD:1604509 | 6480464 | Asbestos, Crocidolite results in increased expression of FLCN mRNA | CTD | PMID:18687144 | dioxygen | increases expression | ISO | RGD:1604509 | 6480464 | Oxygen deficiency results in increased expression of FLCN mRNA | CTD | PMID:17175027 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of FLCN mRNA | CTD | PMID:21551480 | formaldehyde | increases expression | ISO | RGD:1604509 | 6480464 | Formaldehyde results in increased expression of FLCN mRNA | CTD | PMID:20655997 | hydrogen peroxide | affects expression | ISO | RGD:1604509 | 6480464 | Hydrogen Peroxide affects the expression of FLCN mRNA | CTD | PMID:20044591 | manganese atom | increases expression | ISO | RGD:1604509 | 6480464 | Manganese results in increased expression of FLCN mRNA | CTD | PMID:17175027 | manganese(0) | increases expression | ISO | RGD:1604509 | 6480464 | Manganese results in increased expression of FLCN mRNA | CTD | PMID:17175027 | manganese(II) chloride | increases expression | ISO | RGD:1604509 | 6480464 | manganese chloride results in increased expression of FLCN mRNA | CTD | PMID:17175027 | menadione | affects expression | ISO | RGD:1604509 | 6480464 | Vitamin K 3 affects the expression of FLCN mRNA | CTD | PMID:20044591 | N-methyl-4-phenylpyridinium | increases expression | ISO | RGD:1615711 | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of FLCN mRNA | CTD | PMID:22776087 | paracetamol | affects expression | ISO | RGD:1615711 | 6480464 | Acetaminophen affects the expression of FLCN mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:1604509 | 6480464 | Acetaminophen results in increased expression of FLCN mRNA | CTD | PMID:22230336 | phenobarbital | affects methylation | ISO | RGD:1615711 | 6480464 | Phenobarbital affects the methylation of FLCN gene | CTD | PMID:19233941 | phenobarbital | affects expression | ISO | RGD:1615711 | 6480464 | Phenobarbital affects the expression of FLCN mRNA | CTD | PMID:23091169 | phenobarbital | affects expression | ISO | RGD:1604509 | 6480464 | Phenobarbital affects the expression of FLCN mRNA | CTD | PMID:19159669 | phorone | affects expression | EXP | | 6480464 | phorone affects the expression of FLCN mRNA | CTD | PMID:18198479 | pirinixic acid | multiple interactions | ISO | RGD:1604509 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FLCN mRNA | CTD | PMID:19710929 | pirinixic acid | decreases expression | ISO | RGD:1615711 | 6480464 | pirinixic acid results in decreased expression of FLCN mRNA | CTD | PMID:18445702 | quercetin | increases expression | ISO | RGD:1604509 | 6480464 | Quercetin results in increased expression of FLCN mRNA | CTD | PMID:21632981 | zinc atom | multiple interactions | ISO | RGD:1604509 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of FLCN mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | RGD:1604509 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of FLCN mRNA | CTD | PMID:18593933 | | 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Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Renal cell carcinoma |
Phenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway AnnotationsPhenotype Annotations
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References - curated| 1. |
Nickerson ML, etal., Cancer Cell. 2002 Aug;2(2):157-64. |
| 2. |
Okimoto K, etal., Proc Natl Acad Sci U S A 2004 Feb 17;101(7):2023-7. Epub 2004 Feb 09. |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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RGD automated data pipeline |
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RGD automated import pipeline for gene-chemical interactions |
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RGD Automated Pipelines |
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RGD comprehensive gene curation |
References - uncuratedRGD Disease Portals| Flcn has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Flcn (Rattus norvegicus) |
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| FLCN (Homo sapiens) |
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| Flcn (Mus musculus) |
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Position Markers| PMC357045P1 |
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| PMC357045P6 |
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| RH130087 |
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| PMC357045P10 |
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| PMC357045P11 |
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| PMC357045P12 |
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| PMC357045P2 |
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| PMC357045P3 |
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| PMC357045P4 |
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| PMC357045P5 |
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| PMC357045P7 |
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| PMC357045P8 |
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| PMC357045P9 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Related Rat StrainsNucleotide Sequences| Nucleotide RefSeqs | NM_199390 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06064078 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01064213 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01064214 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01064215 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB096213 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC085848 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ212214 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_199390 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_955422 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_955422 | (Get FASTA) |
| GenBank Protein | AAH85848 | (Get FASTA) |
| BAD01656 | (Get FASTA) | |
| EDM04621 | (Get FASTA) | |
| Q76JQ2 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000003302 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000004412 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000004412 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 303185 | ENTREZGENE |
| Germonline | ENSRNOG00000003302 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 14583 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7189414 | IMAGE-MGC_LOAD |
| InterPro | Folliculin | UniProtKB/Swiss-Prot |
| IPI | IPI00200751 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:303185 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:94558 | IMAGE-MGC_LOAD |
| Pfam | Folliculin | UniProtKB/Swiss-Prot |
| UniGene | Rn.12799 | ENTREZGENE |
| UniProt | FLCN_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2005-07-08 | Flcn | folliculin | Bhd | Symbol updated | 10779 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
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| gene_disease | in heterozygotes, a germline insertion of one nucleotide resulting in a nonsense mutation gives rise to renal adenocarcinomas by the age of 6 months; homozygosity is lethal at an early stage of embryogenesis | 1302869 |
| gene_homology | amino acid sequence is 93% and 97% homologous to human and mouse folliculin, respectively | 1302869 |
| gene_mutations_overexpression | 10 of 11 renal carcinomas showed a loss of heterozygosity at the Bhd locus and the one LOH-negative case displayed a spontaneous nonsense point mutation at the second Bhd locus | 1302869 |
| More on Flcn | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 735088 |
| Created: | 2004-02-05 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.