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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Magnolol
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Accession:CHEBI:6643 term browser browse the term
Definition:A biphenyl that has formula C18H18O2.
Synonyms:related_synonym: Formula=C18H18O2;   InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2;   InChIKey=VVOAZFWZEDHOOU-UHFFFAOYSA-N;   SMILES=Oc1ccc(CC=C)cc1-c1cc(CC=C)ccc1O
 xref: CAS:528-43-8;   KEGG:C10651;   KNApSAcK:C00000591
 xref_mesh: MESH:C005498


show annotations for term's descendants           Sort by:
Magnolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased expression of ACE protein] CTD PMID:30466619 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in decreased expression of ACE2 protein] CTD PMID:30466619 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agt angiotensinogen multiple interactions EXP magnolol inhibits the reaction [AGT protein binds to AGTR1A protein]; magnolol inhibits the reaction [Monocrotaline results in increased expression of AGT protein] CTD PMID:30466619 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP magnolol inhibits the reaction [AGT protein binds to AGTR1A protein]; magnolol inhibits the reaction [Monocrotaline results in increased expression of AGTR1A protein] CTD PMID:30466619 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased expression of AIF1 protein] CTD PMID:26756313 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of AKT1 protein] CTD PMID:30466619 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased expression of BAX protein] CTD PMID:26756313 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein] CTD PMID:26756313 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO magnolol inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]
magnolol results in increased activity of CASP3 protein		 CTD PMID:26756313 PMID:31714653 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO magnolol results in increased activity of CASP9 protein CTD PMID:31714653 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases activity EXP magnolol results in increased activity of CAT protein CTD PMID:31708532 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO magnolol results in decreased expression of CCND1 protein CTD PMID:31714653 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO magnolol binds to and results in decreased activity of CES1 protein CTD PMID:31170387 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H multiple interactions ISO magnolol binds to and results in decreased activity of CES2 protein CTD PMID:31170387 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased expression of CTNNB1 protein] CTD PMID:30466619 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO magnolol results in decreased activity of CYP1A2 protein CTD PMID:19140158 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein] CTD PMID:30466619 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased expression of EDNRA protein] CTD PMID:30466619 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased expression of GFAP protein] CTD PMID:26756313 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions EXP magnolol inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:28919305 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP magnolol promotes the reaction [Pyruvaldehyde results in increased expression of GPX1 mRNA] CTD PMID:28919305 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of GSK3B protein] CTD PMID:30466619 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased expression of HMOX1 protein] CTD PMID:26756313 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP magnolol inhibits the reaction [Pyruvaldehyde results in decreased expression of IL1B protein] CTD PMID:28919305 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ins2 insulin 2 multiple interactions EXP magnolol inhibits the reaction [Pyruvaldehyde results in decreased expression of INS2 mRNA] CTD PMID:28919305 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 EXP
ISO		 magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of MAPK1 protein]
magnolol results in decreased phosphorylation of MAPK1 protein		 CTD PMID:30466619 PMID:31714653 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 EXP
ISO		 magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of MAPK3 protein]
magnolol results in decreased phosphorylation of MAPK3 protein		 CTD PMID:30466619 PMID:31714653 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK8 protein] CTD PMID:26756313 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of MAPK9 protein] CTD PMID:26756313 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO magnolol results in decreased expression of MMP9 protein CTD PMID:31714653 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased phosphorylation of NFKBIA protein] CTD PMID:26756313 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 magnolol inhibits the reaction [trimethyltin results in increased expression of NOS2 protein]
magnolol inhibits the reaction [Monocrotaline results in increased expression of NOS2 protein]		 CTD PMID:26756313 PMID:30466619 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP magnolol inhibits the reaction [Monocrotaline results in decreased expression of NOS3 protein] CTD PMID:30466619 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP magnolol results in increased activity of NQO1 protein CTD PMID:31708532 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of PDX1 mRNA CTD PMID:28919305 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [magnolol binds to and results in increased activity of PPARG protein]; magnolol binds to and results in increased activity of PPARG protein CTD PMID:20064974 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein CTD PMID:28919305 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO magnolol results in decreased expression of RELA protein CTD PMID:31714653 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [magnolol co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein CTD PMID:28919305 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 affects localization EXP magnolol affects the localization of SREBF1 protein CTD PMID:19371623 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO magnolol inhibits the reaction [trimethyltin results in increased secretion of TNF protein] CTD PMID:26756313 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases activity ISO magnolol results in decreased activity of UGT1A9 protein CTD PMID:26875642 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO magnolol results in decreased expression of VEGFA protein CTD PMID:31714653 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO magnolol results in decreased expression of XIAP protein CTD PMID:31714653 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      molecular entity 19842
        polyatomic entity 19799
          molecule 19702
            cyclic compound 19516
              ring assembly 9212
                biphenyls 6251
                  Magnolol 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19687
                              organic cyclic compound 19498
                                carbocyclic compound 18584
                                  benzenoid aromatic compound 18002
                                    biphenyls 6251
                                      Magnolol 44
paths to the root