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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,8-cineole
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Accession:CHEBI:27961 term browser browse the term
Definition:A cineole that has formula C10H18O.
Synonyms:related_synonym: 1,3,3-TRIMETHYL-2-OXABICYCLO[2.2.2]OCTANE;   1,8-Cineol;   1,8-epoxy-p-menthane;   1,8-oxido-p-menthane;   Formula=C10H18O;   InChI=1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3/t8-,10+;   InChIKey=WEEGYLXZBRQIMU-WAAGHKOSSA-N;   SMILES=C[C@@]12CC[C@@H](CC1)C(C)(C)O2;   Zineol;   cajeputol;   cineole;   eucalyptol
 alt_id: CHEBI:18956;   CHEBI:23242;   CHEBI:35814;   CHEBI:41535;   CHEBI:561
 xref: Beilstein:105109;   Beilstein:5239941;   CAS:470-82-6;   DrugBank:DB03852;   Gmelin:131076;   KEGG:C09844;   KEGG:D04115;   KNApSAcK:C00000136
 xref_mesh: MESH:D000077591
 xref: PDBeChem:CNL;   Wikipedia:Eucalyptol


show annotations for term's descendants           Sort by:
1,8-cineole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of ACTR2 protein] CTD PMID:31483951 NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524 		JBrowse link
G Ankrd17 ankyrin repeat domain 17 decreases expression ISO Eucalyptol results in decreased expression of ANKRD17 mRNA CTD PMID:36331666 NCBI chr14:17,723,239...17,861,841
Ensembl chr14:17,721,932...17,862,617 		JBrowse link
G Apc APC regulator of WNT signaling pathway increases expression ISO Eucalyptol results in increased expression of APC mRNA CTD PMID:36331666 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression ISO Eucalyptol results in decreased expression of ASCL1 mRNA CTD PMID:36331666 NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Eucalyptol results in increased expression of BAD mRNA CTD PMID:36331666 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in increased expression of CDC42 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of CDC42 protein] CTD PMID:31483951 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO Eucalyptol results in decreased expression of CITED2 mRNA CTD PMID:36331666 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [Eucalyptol results in increased expression of CTSD mRNA] CTD PMID:31393563 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Cttn cortactin multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of CTTN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of CTTN protein] CTD PMID:31483951 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Eucalyptol inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion] CTD PMID:18611395 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation
multiple interactions		 ISO CYP3A4 protein results in increased hydroxylation of Eucalyptol
Eucalyptol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]		 CTD PMID:15715982 PMID:18385293 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Eucalyptol CTD PMID:15715982 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Ezr ezrin multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of EZR protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of EZR protein] CTD PMID:31483951 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [Eucalyptol results in increased expression of GREB1 mRNA] CTD PMID:31393563 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in increased expression of GSK3B protein]; RHOA protein inhibits the reaction [Eucalyptol inhibits the reaction [Glucose results in increased expression of GSK3B protein]] CTD PMID:31483951 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO Eucalyptol results in decreased expression of HMGCR protein CTD PMID:24613879 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ICAM1 mRNA]; Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ICAM1 protein] CTD PMID:29789401 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA] CTD PMID:36346500 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 protein] CTD PMID:29789401 PMID:36346500 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Eucalyptol results in decreased expression of LEF1 mRNA CTD PMID:36331666 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lep leptin multiple interactions ISO Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of CTTN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of EZR protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PTK2 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PXN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SRC protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SYNPO protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of TLN1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of VCL protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased abundance of Blood Glucose]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of CDC42 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of PXN protein modified form]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RAC1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RHOA protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of ROCK1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of VCL protein modified form] CTD PMID:31483951 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Eucalyptol inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased phosphorylation of MAPK8 protein] CTD PMID:23872422 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Eucalyptol inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased phosphorylation of MAPK9 protein] CTD PMID:23872422 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Muc19 mucin 19, oligomeric decreases expression ISO Eucalyptol results in decreased expression of MUC19 mRNA CTD PMID:26207629 NCBI chr 7:123,017,896...123,139,053
Ensembl chr 7:123,017,896...123,139,053 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming multiple interactions ISO Eucalyptol inhibits the reaction [Lipopolysaccharides results in increased expression of MUC2 mRNA] CTD PMID:26207629 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA]; Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein] CTD PMID:29215731 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Eucalyptol results in decreased expression of MYC mRNA CTD PMID:36331666 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Eucalyptol inhibits the reaction [Lipopolysaccharides affects the expression of NFKBIA protein]; Eucalyptol inhibits the reaction [Lipopolysaccharides inhibits the reaction [RELA protein binds to NFKBIA protein]] CTD PMID:23872422 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Eucalyptol results in decreased expression of NR4A3 mRNA CTD PMID:36331666 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO Eucalyptol results in decreased expression of PDGFRB mRNA CTD PMID:36331666 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of PTK2 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PTK2 protein] CTD PMID:31483951 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptk6 protein tyrosine kinase 6 decreases expression ISO Eucalyptol results in decreased expression of PTK6 mRNA CTD PMID:36331666 NCBI chr 3:168,307,073...168,315,664
Ensembl chr 3:168,307,073...168,315,664 		JBrowse link
G Pxn paxillin multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of PXN protein]; Eucalyptol inhibits the reaction [Glucose results in increased expression of PXN protein modified form]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of PXN protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of PXN protein modified form]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of PXN protein]] CTD PMID:31483951 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in increased expression of RAC1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RAC1 protein] CTD PMID:31483951 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Eucalyptol inhibits the reaction [Lipopolysaccharides inhibits the reaction [RELA protein binds to NFKBIA protein]] CTD PMID:23872422 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in increased expression of RHOA protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RHOA protein]; RHOA protein inhibits the reaction [Eucalyptol inhibits the reaction [Glucose results in increased expression of GSK3B protein]]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of PXN protein]]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of VCL protein]] CTD PMID:31483951 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in increased expression of ROCK1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of ROCK1 protein] CTD PMID:31483951 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO Eucalyptol inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of SRC protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SRC protein] CTD PMID:31483951 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Synpo synaptopodin multiple interactions ISO Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SYNPO protein] CTD PMID:31483951 NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126 		JBrowse link
G Tbx3 T-box transcription factor 3 affects expression ISO Eucalyptol affects the expression of TBX3 mRNA CTD PMID:36331666 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708 		JBrowse link
G Tgm1 transglutaminase 1 decreases expression ISO Eucalyptol results in decreased expression of TGM1 mRNA CTD PMID:36331666 NCBI chr15:29,191,039...29,206,000
Ensembl chr15:29,191,041...29,204,523 		JBrowse link
G Tln1 talin 1 multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of TLN1 protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of TLN1 protein] CTD PMID:31483951 NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Eucalyptol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF protein]
Eucalyptol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]		 CTD PMID:23872422 PMID:26207629 PMID:29789401 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trim21 tripartite motif-containing 21 decreases expression ISO Eucalyptol results in decreased expression of TRIM21 mRNA CTD PMID:36331666 NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440 		JBrowse link
G Vcl vinculin multiple interactions ISO Eucalyptol inhibits the reaction [Glucose results in decreased expression of VCL protein]; Eucalyptol inhibits the reaction [Glucose results in increased expression of VCL protein modified form]; Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of VCL protein]; Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of VCL protein modified form]; RHOA protein promotes the reaction [Eucalyptol inhibits the reaction [Glucose results in decreased expression of VCL protein]] CTD PMID:31483951 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606 		JBrowse link
tea tree oil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased activity of AR protein] CTD PMID:31393563 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of CTSD mRNA] CTD PMID:31393563 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA] CTD PMID:31393563 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Tea Tree Oil results in increased activity of ESR1 protein CTD PMID:31393563 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of GREB1 mRNA] CTD PMID:31393563 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions		 ISO Tea Tree Oil results in increased expression of PGR mRNA
Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of PGR mRNA]		 CTD PMID:31393563 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Sec14l2 SEC14-like lipid binding 2 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA] CTD PMID:31393563 NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788 		JBrowse link
G Ugt2b34l1 UDP glucuronosyltransferase 2 family, polypeptide B34 like 1 multiple interactions ISO Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA] CTD PMID:31393563 NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        food additive 16109
          flavouring agent 4529
            1,8-cineole 51
              tea tree oil 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            organic hydride 18669
                              organic fundamental parent 18669
                                hydrocarbon 18415
                                  terpene 14057
                                    terpenoid 13755
                                      monoterpenoid 2028
                                        p-menthane monoterpenoid 464
                                          cineole 51
                                            1,8-cineole 51
                                              tea tree oil 8
paths to the root