Muc19 (mucin 19, oligomeric) - Rat Genome Database

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Gene: Muc19 (mucin 19, oligomeric) Rattus norvegicus
Analyze
Symbol: Muc19 (Ensembl: AC096792.1)
Name: mucin 19, oligomeric
RGD ID: 1624205
Description: Predicted to be involved in cellular response to interleukin-1 and cellular response to tumor necrosis factor. Predicted to act upstream of or within cell differentiation involved in salivary gland development; hematopoietic progenitor cell differentiation; and negative regulation of inflammatory response. Orthologous to human MUC19 (mucin 19, oligomeric); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; indole-3-methanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Muc19l1; mucin 19; mucin 19-like 1; mucin apoprotein; mucin-19; RGD1624205; SMGC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87124,897,424 - 125,018,582 (+)NCBIGRCr8
mRatBN7.27123,017,896 - 123,139,053 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7123,017,896 - 123,139,053 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7124,796,332 - 124,919,313 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07127,022,195 - 127,145,177 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07126,950,304 - 127,075,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07133,048,727 - 133,166,551 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07132,769,775 - 132,845,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47130,338,439 - 130,417,203 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7119,454,490 - 119,555,901 (+)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
4. MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjogren syndrome patients. Yu DF, etal., Exp Eye Res. 2008 Feb;86(2):403-11. doi: 10.1016/j.exer.2007.11.013. Epub 2007 Nov 28.
Additional References at PubMed
PMID:8077681   PMID:8806790   PMID:9110981   PMID:10393849   PMID:10793067   PMID:12163455   PMID:12847143   PMID:15340121   PMID:23376485   PMID:23580649   PMID:24029230  


Genomics

Comparative Map Data
Muc19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87124,897,424 - 125,018,582 (+)NCBIGRCr8
mRatBN7.27123,017,896 - 123,139,053 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7123,017,896 - 123,139,053 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7124,796,332 - 124,919,313 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07127,022,195 - 127,145,177 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07126,950,304 - 127,075,782 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07133,048,727 - 133,166,551 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07132,769,775 - 132,845,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47130,338,439 - 130,417,203 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7119,454,490 - 119,555,901 (+)NCBICelera
Cytogenetic Map7q35NCBI
MUC19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381240,393,394 - 40,570,757 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1240,393,395 - 40,570,832 (+)EnsemblGRCh38hg38GRCh38
GRCh371240,787,196 - 40,964,559 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361239,099,241 - 39,159,173 (+)NCBINCBI36Build 36hg18NCBI36
Celera1239,730,155 - 39,736,719 (+)NCBICelera
Cytogenetic Map12q12NCBI
HuRef1237,819,296 - 37,991,533 (+)NCBIHuRef
CHM1_11240,756,791 - 40,928,894 (+)NCBICHM1_1
T2T-CHM13v2.01240,345,593 - 40,530,490 (+)NCBIT2T-CHM13v2.0
Muc19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391591,722,531 - 91,832,440 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1591,722,531 - 91,832,447 (+)EnsemblGRCm39 Ensembl
GRCm381591,838,326 - 91,934,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1591,838,326 - 91,934,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv371591,668,757 - 91,764,986 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361591,668,757 - 91,764,986 (+)NCBIMGSCv36mm8
Celera1593,953,946 - 94,069,110 (+)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1546.14NCBI
Muc19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955505729 - 64,653 (-)NCBIChiLan1.0ChiLan1.0
MUC19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21053,578,444 - 53,771,545 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11253,575,206 - 53,768,305 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01248,135,613 - 48,319,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11248,998,606 - 49,181,747 (-)NCBIpanpan1.1PanPan1.1panPan2
MUC19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12713,109,208 - 13,253,506 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2733,200,314 - 33,269,665 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02713,345,553 - 13,425,631 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12713,157,824 - 13,212,150 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02713,158,057 - 13,273,101 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02733,326,451 - 33,375,462 (+)NCBIUU_Cfam_GSD_1.0
LOC101958024
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494573,584,893 - 73,723,415 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936607418,290 - 443,988 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1571,964,131 - 72,069,073 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2574,792,758 - 74,839,816 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MUC19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11136,679,954 - 36,829,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037209,936,670 - 210,115,404 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Muc19
848 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:134
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000055708, ENSRNOT00000073062, ENSRNOT00000073633
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
AU047209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27123,063,478 - 123,063,702 (+)MAPPERmRatBN7.2
Rnor_6.07133,093,426 - 133,093,649NCBIRnor6.0
Rnor_5.07132,775,409 - 132,775,632UniSTSRnor5.0
RGSC_v3.47130,344,077 - 130,344,300UniSTSRGSC3.4
Celera7119,489,513 - 119,489,724UniSTS
BQ195594  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27123,050,902 - 123,051,054 (+)MAPPERmRatBN7.2
Rnor_6.07133,080,846 - 133,080,997NCBIRnor6.0
Rnor_5.07132,762,832 - 132,762,984NCBIRnor5.0
RGSC_v3.47130,331,497 - 130,331,648UniSTSRGSC3.4
Celera7119,477,139 - 119,477,290UniSTS
RH 3.4 Map71007.3UniSTS
Cytogenetic Map7q35UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001309489   ⟹   NP_001296418
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87124,897,424 - 125,018,582 (+)NCBI
mRatBN7.27123,017,896 - 123,139,053 (+)NCBI
Rnor_6.07133,048,727 - 133,166,551 (+)NCBI
Celera7119,454,490 - 119,555,901 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001296418 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA05595 (Get FASTA)   NCBI Sequence Viewer  
  DAA80473 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070320.2
Reference Protein Sequences
RefSeq Acc Id: NP_001296418   ⟸   NM_001309489
- Peptide Label: precursor
- Sequence:
Protein Domains
CTCK   VWFC   VWFD

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1624205 AgrOrtholog
BioCyc Gene G2FUF-32374 BioCyc
Ensembl Genes ENSRNOG00000054624 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085280.2 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/TrEMBL
  TIL_dom UniProtKB/TrEMBL
  Unchr_dom_Cys-rich UniProtKB/TrEMBL
  VWF_dom UniProtKB/TrEMBL
  VWF_type-D UniProtKB/TrEMBL
NCBI Gene 497227 ENTREZGENE
PANTHER MUCIN-19 UniProtKB/TrEMBL
  MUCIN-19 UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/TrEMBL
  PF08742 UniProtKB/TrEMBL
  TIL UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
PhenoGen Muc19 PhenoGen
PROSITE CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
  VWFD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054624 RatGTEx
SMART SM00041 UniProtKB/TrEMBL
  SM00832 UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
Superfamily-SCOP SSF57567 UniProtKB/TrEMBL
UniProt A0A0G2JXL5_RAT UniProtKB/TrEMBL
  A0A1Y1FJE1_RAT UniProtKB/TrEMBL
  I7KJR8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-17 Muc19  mucin 19, oligomeric  Muc19  mucin 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-06-01 Muc19  mucin 19  Muc19  mucin 19, oligomeric  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-06-01 Muc19  mucin 19, oligomeric  Muc19l1  mucin 19-like 1  Data merged from RGD:1310187 737654 PROVISIONAL
2016-12-06 Muc19  mucin 19, oligomeric  Muc19  mucin 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-15 Muc19  mucin 19  RGD1624205  mucin apoprotein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-15 Muc19l1  mucin 19-like 1  Muc19  mucin 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Muc19  mucin 19   Muc19_predicted  mucin 19 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Muc19_predicted  mucin 19 (predicted)      Symbol and Name status set to approved 70820 APPROVED