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RGD Obesity & Metabolic Syndrome Disease Portal – Rat Strain Models
The following tables list strains which have been annotated as models for the Obesity & Metabolic Syndrome Disease Portal. For mutant strains, the mutated gene is listed after the strain symbol. Control strains are listed for the respective strain, for given references. The strains listed below are curated with a set of special qualifiers indicating a MODEL of disease, whether induced or spontaneously exhibited. The MODEL qualifier indicates that the curated strain is a rat model developed and used to study human disease. This requires multiple references or a detailed description of disease phenotypes to support the classification.

A more extensive search for strains that exhibit specific diseases, including those not specifically defined as MODELs, can be completed using the Find Models by Disease or Phenotype tool.

Obesity
Strain Affected Gene Control(s) Reference(s)
WI-Mc4rm1Hubr (MODEL: spontaneous) Mc4r Crl:WI 6478803
Slc:ZUC-Leprfa (MODEL: spontaneous) Lepr ZUCfa+/-; SHRSP/Izm 12859276; 2300017
SDDIO/Rrrc (MODEL: spontaneous) SDDR/Rrrc 1302371; 21408576
ZUC-LeprfaSte-/- (MODEL: spontaneous) Lepr ZUC-Lepr+Ste 628910; 628581
FDIO/Rrrc (MODEL: spontaneous) F344 24922212
FDIO/Rrrc (MODEL: induced) F344 24922212; 6482246
LA-cp/NJcr MODEL: spontaneous) cp+/+ 1642391; 21408584; 21408581
OLETF (MODEL:treatment) LETO 21406435
SDT.ZDF-Leprfa/Jtt (MODEL: spontaneous) Lepr 2314024; 2314022; 2314025
ZUC-LeprfaSteJrpz-/- (MODEL:spontaneous) Lepr 628436; 24922198

Metabolic Syndrome
Strain Affected Gene Control(s) Reference(s)
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcr (MODEL) SHRSP/Izm 2300017
PD/Cub (MODEL:spontaneous) SHR; BN 1580750; 728088
SHR-Tg(PEPCK-SREBF1)2Ipcv (MODEL: induced) SREBF1 SHR/Ola 2313691
SHR.PD-(D8Rat42-D8Arb23)/Cub (MODEL:spontaneous) 1580747

Didn’t find what you are looking for? Try the Find Models by Disease or Phenotype tool


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.