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Strain: PD/Cub

Symbol: PD/Cub
Strain: PD
Substrain: Cub
Full Name: polydactylous
RGD ID: 728161
Citation ID: RRID:RGD_728161
Ontology ID: RS:0000126
Type: inbred
Source: Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Origin: Strain a highly inbred strain kept since 1969 at the Institute of Biology Medical Genetics, Charles University, Prague. Strain originated from Wistar rats exhibiting a spontaneous mutation which gave rise to the dolydactyly-luxate syndrome.
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View


References

References - curated
# Reference Title Reference Citation
1. Chromosomal mapping of a major quantitative trait locus regulating compensatory renal growth in the rat. Pravenec M, etal., J Am Soc Nephrol 2000 Jul;11(7):1261-5
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Metabolic characterization of insulin resistance syndrome feature loci in three brown Norway-derived congenic strains. Seda O, etal., Folia Biol (Praha) 2002;48(3):81-8.
4. Rosiglitazone improves insulin resistance, lipid profile and promotes adiposity in a genetic model of metabolic syndrome X. Seda O, etal., Folia Biol (Praha) 2002;48(6):237-41.
5. Differential linkage of triglyceride and glucose levels on rat chromosome 4 in two segregating rat populations. Seda O, etal., Folia Biol (Praha). 2003;49(6):223-6.
6. A 14-gene region of rat chromosome 8 in SHR-derived polydactylous congenic substrain affects muscle-specific insulin resistance, dyslipidaemia and visceral adiposity. Seda O, etal., Folia Biol (Praha). 2005;51(3):53-61.
7. Dynamic genetic architecture of metabolic syndrome attributes in the rat. Seda O, etal., Physiol Genomics. 2005 Apr 14;21(2):243-52. Epub 2005 Feb 22.
8. Novel double-congenic strain reveals effects of spontaneously hypertensive rat chromosome 2 on specific lipoprotein subfractions and adiposity. Seda O, etal., Physiol Genomics. 2006 Jul 5;.
9. Rat inbred PD/cub strain as a model of dyslipidemia and insulin resistance. Sedova L, etal., Folia Biol (Praha) 2000;46(3):99-106.
10. Isotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome. Sedova L, etal., Int J Obes Relat Metab Disord. 2004 May;28(5):719-25.

Region

Strain QTL Data
Symbol Name Trait
Bw63 Body weight QTL 63 body mass   (VT:0001259)    
Bw64 Body weight QTL 64 body mass   (VT:0001259)    
Bw65 Body weight QTL 65 body mass   (VT:0001259)    
Bw66 Body weight QTL 66 body mass   (VT:0001259)    
Bw67 Body weight QTL 67 body mass   (VT:0001259)    
Bw68 Body weight QTL 68 body mass   (VT:0001259)    
Bw69 Body weight QTL 69 body mass   (VT:0001259)    
Bw70 Body weight QTL 70 body mass   (VT:0001259)    
Bw71 Body weight QTL 71 body mass   (VT:0001259)    
Bw72 Body weight QTL 72 body mass   (VT:0001259)    
Bw73 Body weight QTL 73 body mass   (VT:0001259)    
Bw74 Body weight QTL 74 body mass   (VT:0001259)    
Bw75 Body weight QTL 75 body mass   (VT:0001259)    
Bw76 Body weight QTL 76 body mass   (VT:0001259)    
Bw77 Body weight QTL 77 epididymal fat pad mass   (VT:0010421)    
Bw78 Body weight QTL 78 epididymal fat pad mass   (VT:0010421)    
Bw79 Body weight QTL 79 epididymal fat pad mass   (VT:0010421)    
Cm60 Cardiac mass QTL 60 heart mass   (VT:0007028)    
Epfw1 Epididymal fat weight QTL 1 epididymal fat pad mass   (VT:0010421)    
Epfw2 Epididymal fat weight QTL 2 epididymal fat pad mass   (VT:0010421)    
Epfw3 Epididymal fat weight QTL 3 epididymal fat pad mass   (VT:0010421)    
Epfw4 Epididymal fat weight QTL 4 epididymal fat pad mass   (VT:0010421)    
Gluco18 Glucose level QTL 18 blood glucose amount   (VT:0000188)    
Gluco19 Glucose level QTL 19 blood glucose amount   (VT:0000188)    
Gluco20 Glucose level QTL 20 blood glucose amount   (VT:0000188)    
Gluco21 Glucose level QTL 21 blood glucose amount   (VT:0000188)    
Gluco22 Glucose level QTL 22 blood glucose amount   (VT:0000188)    
Gluco23 Glucose level QTL 23 blood glucose amount   (VT:0000188)    
Gluco24 Glucose level QTL 24 blood glucose amount   (VT:0000188)    
Gluco25 Glucose level QTL 25 blood glucose amount   (VT:0000188)    
Gluco26 Glucose level QTL 26 blood glucose amount   (VT:0000188)    
Gluco27 Glucose level QTL 27 blood glucose amount   (VT:0000188)    
Gluco28 Glucose level QTL 28 blood glucose amount   (VT:0000188)    
Gluco29 Glucose level QTL 29 blood glucose amount   (VT:0000188)    
Gluco30 Glucose level QTL 30 blood glucose amount   (VT:0000188)    
Insul10 Insulin level QTL 10 blood insulin amount   (VT:0001560)    
Insul5 Insulin level QTL 5 blood insulin amount   (VT:0001560)    
Insul6 Insulin level QTL 6 blood insulin amount   (VT:0001560)    
Insul7 Insulin level QTL 7 blood insulin amount   (VT:0001560)    
Insul8 Insulin level QTL 8 blood insulin amount   (VT:0001560)    
Insul9 Insulin level QTL 9 blood insulin amount   (VT:0001560)    
Kidm30 Kidney mass QTL 30 kidney mass   (VT:0002707)    
Kidm31 Kidney mass QTL 31 kidney mass   (VT:0002707)    
Kidm32 Kidney mass QTL 32 kidney mass   (VT:0002707)    
Kidm33 Kidney mass QTL 33 kidney mass   (VT:0002707)    
Kidm34 Kidney mass QTL 34 kidney mass   (VT:0002707)    
Livw1 Liver weight QTL 1 liver mass   (VT:0003402)    
Livw2 Liver weight QTL 2 liver mass   (VT:0003402)    
Sffal1 Serum free fatty acids level QTL 1 blood free fatty acid amount   (VT:0001553)    
Sffal2 Serum free fatty acids level QTL 2 blood free fatty acid amount   (VT:0001553)    
Stl20 Serum triglyceride level QTL 20 blood triglyceride amount   (VT:0002644)    
Stl21 Serum triglyceride level QTL 21 blood triglyceride amount   (VT:0002644)    
Sual1 Serum uric acid level QTL 1 blood uric acid amount   (VT:0010302)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Fenofibrate (100mg/kg/day) displayed an increase in adiposity and lowered the triglycerides 1580750
strain_drgs_chems Isotretinoin (30mg/kg/day) displayed increase in adiposity and triglycerides. 1580750
strain_phys_biochem Carries genes involved in lipid and carbohydrate metabolism. 632347