RGD Reference Report - Dynamic genetic architecture of metabolic syndrome attributes in the rat. - Rat Genome Database

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Dynamic genetic architecture of metabolic syndrome attributes in the rat.

Authors: Seda, O  Liska, F  Krenova, D  Kazdova, L  Sedova, L  Zima, T  Peng, J  Pelinkova, K  Tremblay, J  Hamet, P  Kren, V 
Citation: Seda O, etal., Physiol Genomics. 2005 Apr 14;21(2):243-52. Epub 2005 Feb 22.
RGD ID: 1580752
Pubmed: PMID:15728334   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00230.2004   (Journal Full-text)

The polydactylous rat strain (PD/Cub) is a highly inbred (F > 90) genetic model of metabolic syndrome. The aim of this study was to analyze the genetic architecture of the metabolic derangements found in the PD/Cub strain and to assess its dynamics in time and in response to diet and medication. We derived a PD/Cub x BN/Cub (Brown Norway) F2 intercross population of 149 male rats and performed metabolic profiling and genotyping and multiple levels of genetic linkage and statistical analyses at five different stages of ontogenesis and after high-sucrose diet feeding and dexamethasone administration challenges. The interval mapping analysis of 83 metabolic and morphometric traits revealed over 50 regions genomewide with significant or suggestive linkage to one or more of the traits in the segregating PD/Cub x BN/Cub population. The multiple interval mapping showed that, in addition to "single" quantitative train loci, there are more than 30 pairs of loci across the whole genome significantly influencing the variation of particular traits in an epistatic fashion. This study represents the first whole genome analysis of metabolic syndrome in the PD/Cub model and reveals several new loci previously not connected to the genetics of insulin resistance and dyslipidemia. In addition, it attempts to present the concept of "dynamic genetic architecture" of metabolic syndrome attributes, evidenced by shifts in the genetic determination of syndrome features during ontogenesis and during adaptation to the dietary and pharmacological influences.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cm60RatCardiomegaly  IAGP  RGD 
Gluco18Rathyperglycemia  TAS  RGD 
Gluco19Rathyperglycemia  TAS  RGD 
Gluco20Rathyperglycemia  TAS  RGD 
Gluco21Rathyperglycemia  TAS  RGD 
Gluco22Rathyperglycemia  TAS  RGD 
Gluco23Rathyperglycemia  TAS  RGD 
Gluco24Rathyperglycemia  TAS  RGD 
Gluco25Rathyperglycemia  TAS  RGD 
Gluco26Rathyperglycemia  TAS  RGD 
Gluco27Rathyperglycemia  TAS  RGD 
Gluco28Rathyperglycemia  TAS  RGD 
Gluco29Rathyperglycemia  TAS  RGD 
Gluco30Rathyperglycemia  TAS  RGD 
Insul10Rathyperinsulinism  TAS  RGD 
Insul5Rathyperinsulinism  TAS  RGD 
Insul6Rathyperinsulinism  TAS  RGD 
Insul7Rathyperinsulinism  TAS  RGD 
Insul8Rathyperinsulinism  TAS  RGD 
Insul9Rathyperinsulinism  TAS  RGD 
Bw63RatMetabolic Syndrome  TAS  RGD 
Bw64RatMetabolic Syndrome  TAS  RGD 
Bw65RatMetabolic Syndrome  TAS  RGD 
Bw66RatMetabolic Syndrome  TAS  RGD 
Bw67RatMetabolic Syndrome  TAS  RGD 
Bw68RatMetabolic Syndrome  TAS  RGD 
Bw69RatMetabolic Syndrome  TAS  RGD 
Bw70RatMetabolic Syndrome  TAS  RGD 
Bw71RatMetabolic Syndrome  TAS  RGD 
Bw72RatMetabolic Syndrome  TAS  RGD 
Bw73RatMetabolic Syndrome  TAS  RGD 
Bw74RatMetabolic Syndrome  TAS  RGD 
Bw75RatMetabolic Syndrome  TAS  RGD 
Bw76RatMetabolic Syndrome  TAS  RGD 
Bw77RatMetabolic Syndrome  TAS  RGD 
Bw78RatMetabolic Syndrome  TAS  RGD 
Bw79RatMetabolic Syndrome  TAS  RGD 
Cm60RatMetabolic Syndrome  IDA  RGD 
Epfw1RatMetabolic Syndrome  IDA  RGD 
Epfw2RatMetabolic Syndrome  IDA  RGD 
Epfw3RatMetabolic Syndrome  IDA  RGD 
Epfw4RatMetabolic Syndrome  IDA  RGD 
Gluco18RatMetabolic Syndrome  IDA  RGD 
Gluco19RatMetabolic Syndrome  IDA  RGD 
Gluco20RatMetabolic Syndrome  IDA  RGD 
Gluco21RatMetabolic Syndrome  IDA  RGD 
Gluco22RatMetabolic Syndrome  IDA  RGD 
Gluco23RatMetabolic Syndrome  IDA  RGD 
Gluco24RatMetabolic Syndrome  IDA  RGD 
Gluco25RatMetabolic Syndrome  IDA  RGD 
Gluco26RatMetabolic Syndrome  IDA  RGD 
Gluco27RatMetabolic Syndrome  IDA  RGD 
Gluco28RatMetabolic Syndrome  IDA  RGD 
Gluco29RatMetabolic Syndrome  IDA  RGD 
Gluco30RatMetabolic Syndrome  IDA  RGD 
Insul10RatMetabolic Syndrome  IDA  RGD 
Insul5RatMetabolic Syndrome  IDA  RGD 
Insul6RatMetabolic Syndrome  IDA  RGD 
Insul7RatMetabolic Syndrome  IDA  RGD 
Insul8RatMetabolic Syndrome  IDA  RGD 
Insul9RatMetabolic Syndrome  IDA  RGD 
Kidm30RatMetabolic Syndrome  IDA  RGD 
Kidm31RatMetabolic Syndrome  IDA  RGD 
Kidm32RatMetabolic Syndrome  IDA  RGD 
Kidm33RatMetabolic Syndrome  IDA  RGD 
Kidm34RatMetabolic Syndrome  IDA  RGD 
Livw1RatMetabolic Syndrome  TAS  RGD 
Livw2RatMetabolic Syndrome  TAS  RGD 
Sffal1RatMetabolic Syndrome  IDA  RGD 
Sffal2RatMetabolic Syndrome  IDA  RGD 
Stl20RatMetabolic Syndrome  IDA  RGD 
Stl21RatMetabolic Syndrome  IDA  RGD 
Sual1RatMetabolic Syndrome  IDA  RGD 
Bw63Ratobesity  IAGP  RGD 
Bw64Ratobesity  IAGP  RGD 
Bw65Ratobesity  IAGP  RGD 
Bw66Ratobesity  IAGP  RGD 
Bw67Ratobesity  IAGP  RGD 
Bw68Ratobesity  IAGP  RGD 
Bw69Ratobesity  IAGP  RGD 
Bw70Ratobesity  IAGP  RGD 
Bw71Ratobesity  IAGP  RGD 
Bw72Ratobesity  IAGP  RGD 
Bw73Ratobesity  IAGP  RGD 
Bw74Ratobesity  IAGP  RGD 
Bw75Ratobesity  IAGP  RGD 
Bw76Ratobesity  IAGP  RGD 
Bw77Ratobesity  IAGP  RGD 
Bw78Ratobesity  IAGP  RGD 
Bw79Ratobesity  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Epfw1Ratabnormal abdominal fat pad morphology  IAGP  RGD 
Epfw2Ratabnormal abdominal fat pad morphology  IAGP  RGD 
Epfw3Ratabnormal abdominal fat pad morphology  IAGP  RGD 
Epfw4Ratabnormal abdominal fat pad morphology  IAGP  RGD 
Bw63Ratincreased body weight  IAGP  RGD 
Bw64Ratincreased body weight  IAGP  RGD 
Bw65Ratincreased body weight  IAGP  RGD 
Bw66Ratincreased body weight  IAGP  RGD 
Bw67Ratincreased body weight  IAGP  RGD 
Bw68Ratincreased body weight  IAGP  RGD 
Bw69Ratincreased body weight  IAGP  RGD 
Bw70Ratincreased body weight  IAGP  RGD 
Bw71Ratincreased body weight  IAGP  RGD 
Bw72Ratincreased body weight  IAGP  RGD 
Bw73Ratincreased body weight  IAGP  RGD 
Bw74Ratincreased body weight  IAGP  RGD 
Bw75Ratincreased body weight  IAGP  RGD 
Bw76Ratincreased body weight  IAGP  RGD 
Gluco18Ratincreased circulating glucose level  IAGP  RGD 
Gluco19Ratincreased circulating glucose level  IAGP  RGD 
Gluco20Ratincreased circulating glucose level  IAGP  RGD 
Gluco21Ratincreased circulating glucose level  IAGP  RGD 
Gluco22Ratincreased circulating glucose level  IAGP  RGD 
Gluco23Ratincreased circulating glucose level  IAGP  RGD 
Gluco24Ratincreased circulating glucose level  IAGP  RGD 
Gluco25Ratincreased circulating glucose level  IAGP  RGD 
Gluco26Ratincreased circulating glucose level  IAGP  RGD 
Gluco27Ratincreased circulating glucose level  IAGP  RGD 
Gluco28Ratincreased circulating glucose level  IAGP  RGD 
Gluco29Ratincreased circulating glucose level  IAGP  RGD 
Gluco30Ratincreased circulating glucose level  IAGP  RGD 
Insul10Ratincreased circulating insulin level  IAGP  RGD 
Insul5Ratincreased circulating insulin level  IAGP  RGD 
Insul6Ratincreased circulating insulin level  IAGP  RGD 
Insul7Ratincreased circulating insulin level  IAGP  RGD 
Insul8Ratincreased circulating insulin level  IAGP  RGD 
Insul9Ratincreased circulating insulin level  IAGP  RGD 
Stl20Ratincreased circulating triglyceride level  IAGP  RGD 
Stl21Ratincreased circulating triglyceride level  IAGP  RGD 
Cm60Ratincreased heart weight  IAGP  RGD 
Kidm30Ratincreased kidney weight  IAGP  RGD 
Kidm31Ratincreased kidney weight  IAGP  RGD 
Kidm32Ratincreased kidney weight  IAGP  RGD 
Kidm33Ratincreased kidney weight  IAGP  RGD 
Kidm34Ratincreased kidney weight  IAGP  RGD 
Livw1Ratincreased liver weight  IAGP  RGD 
Livw2Ratincreased liver weight  IAGP  RGD 
Bw77Ratincreased total body fat amount  IDA  RGD 
Bw78Ratincreased total body fat amount  IDA  RGD 
Bw79Ratincreased total body fat amount  IDA  RGD 

Objects Annotated

QTLs
Bw63  (Body weight QTL 63)
Bw64  (Body weight QTL 64)
Bw65  (Body weight QTL 65)
Bw66  (Body weight QTL 66)
Bw67  (Body weight QTL 67)
Bw68  (Body weight QTL 68)
Bw69  (Body weight QTL 69)
Bw70  (Body weight QTL 70)
Bw71  (Body weight QTL 71)
Bw72  (Body weight QTL 72)
Bw73  (Body weight QTL 73)
Bw74  (Body weight QTL 74)
Bw75  (Body weight QTL 75)
Bw76  (Body weight QTL 76)
Bw77  (Body weight QTL 77)
Bw78  (Body weight QTL 78)
Bw79  (Body weight QTL 79)
Cm60  (Cardiac mass QTL 60)
Epfw1  (Epididymal fat weight QTL 1)
Epfw2  (Epididymal fat weight QTL 2)
Epfw3  (Epididymal fat weight QTL 3)
Epfw4  (Epididymal fat weight QTL 4)
Gluco18  (Glucose level QTL 18)
Gluco19  (Glucose level QTL 19)
Gluco20  (Glucose level QTL 20)
Gluco21  (Glucose level QTL 21)
Gluco22  (Glucose level QTL 22)
Gluco23  (Glucose level QTL 23)
Gluco24  (Glucose level QTL 24)
Gluco25  (Glucose level QTL 25)
Gluco26  (Glucose level QTL 26)
Gluco27  (Glucose level QTL 27)
Gluco28  (Glucose level QTL 28)
Gluco29  (Glucose level QTL 29)
Gluco30  (Glucose level QTL 30)
Insul10  (Insulin level QTL 10)
Insul5  (Insulin level QTL 5)
Insul6  (Insulin level QTL 6)
Insul7  (Insulin level QTL 7)
Insul8  (Insulin level QTL 8)
Insul9  (Insulin level QTL 9)
Kidm30  (Kidney mass QTL 30)
Kidm31  (Kidney mass QTL 31)
Kidm32  (Kidney mass QTL 32)
Kidm33  (Kidney mass QTL 33)
Kidm34  (Kidney mass QTL 34)
Livw1  (Liver weight QTL 1)
Livw2  (Liver weight QTL 2)
Sffal1  (Serum free fatty acids level QTL 1)
Sffal2  (Serum free fatty acids level QTL 2)
Stl20  (Serum triglyceride level QTL 20)
Stl21  (Serum triglyceride level QTL 21)
Sual1  (Serum uric acid level QTL 1)

Strains
BN/Cub  (NA)
PD/Cub  (polydactylous)


Additional Information