RGD Reference Report - Dynamic genetic architecture of metabolic syndrome attributes in the rat. - Rat Genome Database

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Dynamic genetic architecture of metabolic syndrome attributes in the rat.

Authors: Seda, O  Liska, F  Krenova, D  Kazdova, L  Sedova, L  Zima, T  Peng, J  Pelinkova, K  Tremblay, J  Hamet, P  Kren, V 
Citation: Seda O, etal., Physiol Genomics. 2005 Apr 14;21(2):243-52. Epub 2005 Feb 22.
RGD ID: 1580752
Pubmed: PMID:15728334   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00230.2004   (Journal Full-text)

The polydactylous rat strain (PD/Cub) is a highly inbred (F > 90) genetic model of metabolic syndrome. The aim of this study was to analyze the genetic architecture of the metabolic derangements found in the PD/Cub strain and to assess its dynamics in time and in response to diet and medication. We derived a PD/Cub x BN/Cub (Brown Norway) F2 intercross population of 149 male rats and performed metabolic profiling and genotyping and multiple levels of genetic linkage and statistical analyses at five different stages of ontogenesis and after high-sucrose diet feeding and dexamethasone administration challenges. The interval mapping analysis of 83 metabolic and morphometric traits revealed over 50 regions genomewide with significant or suggestive linkage to one or more of the traits in the segregating PD/Cub x BN/Cub population. The multiple interval mapping showed that, in addition to "single" quantitative train loci, there are more than 30 pairs of loci across the whole genome significantly influencing the variation of particular traits in an epistatic fashion. This study represents the first whole genome analysis of metabolic syndrome in the PD/Cub model and reveals several new loci previously not connected to the genetics of insulin resistance and dyslipidemia. In addition, it attempts to present the concept of "dynamic genetic architecture" of metabolic syndrome attributes, evidenced by shifts in the genetic determination of syndrome features during ontogenesis and during adaptation to the dietary and pharmacological influences.

Objects Annotated

Bw63  (Body weight QTL 63)
Bw64  (Body weight QTL 64)
Bw65  (Body weight QTL 65)
Bw66  (Body weight QTL 66)
Bw67  (Body weight QTL 67)
Bw68  (Body weight QTL 68)
Bw69  (Body weight QTL 69)
Bw70  (Body weight QTL 70)
Bw71  (Body weight QTL 71)
Bw72  (Body weight QTL 72)
Bw73  (Body weight QTL 73)
Bw74  (Body weight QTL 74)
Bw75  (Body weight QTL 75)
Bw76  (Body weight QTL 76)
Bw77  (Body weight QTL 77)
Bw78  (Body weight QTL 78)
Bw79  (Body weight QTL 79)
Cm60  (Cardiac mass QTL 60)
Epfw1  (Epididymal fat weight QTL 1)
Epfw2  (Epididymal fat weight QTL 2)
Epfw3  (Epididymal fat weight QTL 3)
Epfw4  (Epididymal fat weight QTL 4)
Gluco18  (Glucose level QTL 18)
Gluco19  (Glucose level QTL 19)
Gluco20  (Glucose level QTL 20)
Gluco21  (Glucose level QTL 21)
Gluco22  (Glucose level QTL 22)
Gluco23  (Glucose level QTL 23)
Gluco24  (Glucose level QTL 24)
Gluco25  (Glucose level QTL 25)
Gluco26  (Glucose level QTL 26)
Gluco27  (Glucose level QTL 27)
Gluco28  (Glucose level QTL 28)
Gluco29  (Glucose level QTL 29)
Gluco30  (Glucose level QTL 30)
Insul10  (Insulin level QTL 10)
Insul5  (Insulin level QTL 5)
Insul6  (Insulin level QTL 6)
Insul7  (Insulin level QTL 7)
Insul8  (Insulin level QTL 8)
Insul9  (Insulin level QTL 9)
Kidm30  (Kidney mass QTL 30)
Kidm31  (Kidney mass QTL 31)
Kidm32  (Kidney mass QTL 32)
Kidm33  (Kidney mass QTL 33)
Kidm34  (Kidney mass QTL 34)
Livw1  (Liver weight QTL 1)
Livw2  (Liver weight QTL 2)
Sffal1  (Serum free fatty acids level QTL 1)
Sffal2  (Serum free fatty acids level QTL 2)
Stl20  (Serum triglyceride level QTL 20)
Stl21  (Serum triglyceride level QTL 21)
Sual1  (Serum uric acid level QTL 1)

BN/Cub  (NA)
PD/Cub  (polydactylous)

Additional Information