RGD Reference Report - Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. - Rat Genome Database

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Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats.

Authors: Levin, BE  Dunn-Meynell, AA  Balkan, B  Keesey, RE 
Citation: Levin BE, etal., Am J Physiol 1997 Aug;273(2 Pt 2):R725-30.
RGD ID: 1302371
Pubmed: PMID:9277561   (View Abstract at PubMed)

In outbred Sprague-Dawley rats, about one-half develop diet-induced obesity (DIO) on a diet relatively high in fat and energy (HE diet). The rest are diet resistant (DR), gaining weight and fat at the same rate as chow-fed controls. Here we selectively bred for high (DIO) and low (DR) weight gainers after 2 wk on HE diet. By the F5 generation, both male and female inbred DIO rats gained > 90% more weight than inbred DR rats on HE diets. Even on low-fat chow diet, DIO males were 31% and females were 22% heavier than their respective DR rats. Full metabolic characterization in male rats showed that weight-matched, chow-fed DIO-prone rats had similar energy intakes and feed efficiency [body weight (kg0.75)/energy intake (kcal)] but 44% more carcass fat than comparable DR-prone rats. Their basal plasma insulin and glucose levels in the fed state were 70 and 14% higher, respectively. But, when fasted, DIO-prone oral glucose tolerance results were comparable to DR-prone rats. Chow-fed DIO-prone males also had 42% greater 24-h urine norepinephrine levels than DR-prone males. During 2 wk on HE diet, DIO rats ate 25% more, gained 115% more weight, had 36% more carcass fat, and were 42% more feed efficient than comparable DR rats. Fasted HE diet-fed DIO rats developed frank glucose intolerance during a glucose tolerance test with 55 and 158% greater insulin and glucose areas under the curve, respectively. Thus the DIO and DR traits in the outbred Sprague-Dawley population appear to be due to a polygenic pattern of inheritance.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
obesity MODEL: spontaneousIAGP 1302371compared to SDDR/Rrrc strainRGD 
obesity MODEL: controlIAGP 1302371compared to SDDIO/Rrrc strainRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased body weight  IAGP 1302371compared to SDDIO/Rrrc strainRGD 
decreased susceptibility to diet-induced obesity  IAGP 1302371compared to SDDIO/Rrrc strainRGD 
increased body fat mass  IAGP 1302371compared to SDDR/Rrrc strainRGD 
increased body weight  IAGP 1302371compared to SDDR/Rrrc strainRGD 
increased circulating glucose level  IAGPstandard diet1302371compared to SDDR/Rrrc strainRGD 
increased circulating insulin level  IAGP 1302371compared to SDDR/Rrrc strainRGD 
increased liver weight  IAGP 1302371compared to SDDR/Rrrc strainRGD 
increased retroperitoneal fat pad weight  IAGP 1302371compared to SDDR/Rrrc strainRGD 
increased susceptibility to diet-induced obesity  IAGP 1302371compared to SDDR/Rrrc strainRGD 
increased urine noradrenaline level sexual_dimorphismIAGP 1302371compared to SDDR/Rrrc strain and males onlyRGD 
Objects Annotated

Strains
SDDIO/Rrrc  (NA)
SDDR/Rrrc  (NA)


Additional Information