Fzd2 (frizzled class receptor 2) - Rat Genome Database

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Gene: Fzd2 (frizzled class receptor 2) Rattus norvegicus
Analyze
Symbol: Fzd2
Name: frizzled class receptor 2
RGD ID: 71012
Description: Enables Wnt receptor activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; Wnt signaling pathway; and cellular response to vitamin D. Located in plasma membrane. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, non-canonical pathway; basal cell carcinoma pathway; INTERACTS WITH (R)-lipoic acid; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 2; frizzled family receptor 2; frizzled homolog 2; frizzled homolog 2 (Drosophila); frizzled-2; Fz-10; fz-2; Fzd10; rFz2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,061,988 - 88,063,898 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1088,061,667 - 88,065,396 (+)EnsemblGRCr8
mRatBN7.21087,561,866 - 87,563,776 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,561,326 - 87,565,334 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1092,598,641 - 92,600,551 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,064,095 - 92,066,005 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,457,426 - 87,459,336 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,550,147 - 90,552,057 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,550,147 - 90,552,057 (+)Ensemblrn6Rnor6.0
Rnor_5.01090,343,133 - 90,345,043 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41091,709,222 - 91,711,132 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1086,269,032 - 86,270,942 (+)NCBICelera
RGSC_v3.11091,723,591 - 91,725,502 (+)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
2-nitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromochloroacetic acid  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
graphite  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
picrotoxin  (EXP)
potassium bromate  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanillin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA,ISO,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP. Ahumada A, etal., Science 2002 Dec 6;298(5600):2006-10.
2. Increased expression of a homologue of drosophila tissue polarity gene "frizzled" in left ventricular hypertrophy in the rat, as identified by subtractive hybridization. Blankesteijn WM, etal., J Mol Cell Cardiol. 1996 May;28(5):1187-91.
3. A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart. Blankesteijn WM, etal., Nat Med. 1997 May;3(5):541-4.
4. Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology. Catherino WH, etal., Fertil Steril. 2003 Aug;80(2):282-90.
5. Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues. Chan SD, etal., J Biol Chem 1992 Dec 15;267(35):25202-7.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. Jiang F, etal., J Hepatol. 2006 Sep;45(3):401-9. Epub 2006 May 3.
9. Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization. Kaykas A, etal., Nat Cell Biol. 2004 Jan;6(1):52-8. Epub 2003 Dec 14.
10. Gene Data Set MGD Curation, June 12, 2002
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma. Milovanovic T, etal., Int J Oncol. 2004 Nov;25(5):1337-42.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Analysis of Fz10 expression in mouse embryos. Nunnally AP and Parr BA, Dev Genes Evol 2004 Mar;214(3):144-8. Epub 2004 Jan 31.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
21. Up-regulation of Frizzled-10 (FZD10) by beta-estradiol in MCF-7 cells and by retinoic acid in NT2 cells. Saitoh T, etal., Int J Oncol 2002 Jan;20(1):117-20.
22. Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling. Xavier CP, etal., Cell Signal. 2014 Jan;26(1):94-101. doi: 10.1016/j.cellsig.2013.09.016. Epub 2013 Sep 28.
Additional References at PubMed
PMID:10395542   PMID:10893270   PMID:12839624   PMID:15809042   PMID:18215320   PMID:18929644   PMID:19038973   PMID:19388021   PMID:20802536   PMID:20940229   PMID:21423176   PMID:22510436  
PMID:22521824   PMID:25120137   PMID:27878554   PMID:28733458   PMID:29276006  


Genomics

Comparative Map Data
Fzd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81088,061,988 - 88,063,898 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1088,061,667 - 88,065,396 (+)EnsemblGRCr8
mRatBN7.21087,561,866 - 87,563,776 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,561,326 - 87,565,334 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1092,598,641 - 92,600,551 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01092,064,095 - 92,066,005 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01087,457,426 - 87,459,336 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01090,550,147 - 90,552,057 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,550,147 - 90,552,057 (+)Ensemblrn6Rnor6.0
Rnor_5.01090,343,133 - 90,345,043 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41091,709,222 - 91,711,132 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1086,269,032 - 86,270,942 (+)NCBICelera
RGSC_v3.11091,723,591 - 91,725,502 (+)NCBI
Cytogenetic Map10q32.1NCBI
FZD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,557,484 - 44,561,262 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1744,557,484 - 44,561,262 (+)Ensemblhg38GRCh38
GRCh371742,634,852 - 42,638,630 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,990,451 - 39,992,433 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341739,990,450 - 39,992,433NCBI
Celera1739,345,439 - 39,347,421 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1738,399,310 - 38,404,081 (+)NCBIHuRef
CHM1_11742,870,888 - 42,874,706 (+)NCBICHM1_1
T2T-CHM13v2.01745,411,390 - 45,415,168 (+)NCBIT2T-CHM13v2.0
Fzd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,495,257 - 102,498,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11102,495,222 - 102,498,884 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811102,604,431 - 102,608,058 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,604,396 - 102,608,058 (+)Ensemblmm10GRCm38
MGSCv3711102,465,745 - 102,469,372 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611102,420,625 - 102,422,672 (+)NCBIMGSCv36mm8
Celera11114,314,619 - 114,318,312 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1166.45NCBI
Fzd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545117,501,410 - 17,503,726 (+)NCBIChiLan1.0ChiLan1.0
FZD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,351,899 - 20,354,575 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,313,946 - 22,318,336 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01712,839,362 - 12,843,803 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,007,752 - 13,013,346 (-)NCBIPanPan1.1PanPan1.1panPan2
FZD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1918,888,711 - 18,890,549 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl918,888,696 - 18,890,525 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha918,275,000 - 18,278,038 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0919,578,886 - 19,581,949 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl919,580,230 - 19,581,927 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,433,221 - 18,436,253 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0918,616,401 - 18,619,457 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0918,760,592 - 18,763,652 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fzd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,226,127 - 18,229,463 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541965,131 - 966,798 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936541965,135 - 967,018 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FZD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,740,653 - 18,742,420 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11218,740,417 - 18,742,301 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,086,025 - 19,087,228 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FZD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11661,837,202 - 61,839,126 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1661,837,304 - 61,839,013 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607732,597,814 - 32,601,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fzd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795578,571 - 580,235 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624795577,350 - 584,110 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fzd2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1961,900,270 - 61,902,432 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fzd2
5 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:50
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000032944
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
PMC16008P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,563,205 - 87,563,592 (+)MAPPERmRatBN7.2
Rnor_6.01090,551,487 - 90,551,873NCBIRnor6.0
Rnor_5.01090,344,473 - 90,344,859UniSTSRnor5.0
RGSC_v3.41091,710,562 - 91,710,948UniSTSRGSC3.4
Celera1086,270,372 - 86,270,758UniSTS
Cytogenetic Map10q32.1UniSTS
Fzd2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,562,741 - 87,563,398 (+)MAPPERmRatBN7.2
Rnor_6.01090,551,023 - 90,551,679NCBIRnor6.0
Rnor_5.01090,344,009 - 90,344,665UniSTSRnor5.0
RGSC_v3.41091,710,098 - 91,710,754UniSTSRGSC3.4
Celera1086,269,908 - 86,270,564UniSTS
Cytogenetic Map10q32.1UniSTS
Fzd2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,562,910 - 87,563,251 (+)MAPPERmRatBN7.2
Rnor_6.01090,551,192 - 90,551,532NCBIRnor6.0
Rnor_5.01090,344,178 - 90,344,518UniSTSRnor5.0
RGSC_v3.41091,710,267 - 91,710,607UniSTSRGSC3.4
Celera1086,270,077 - 86,270,417UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 160 91 90 59 57 59 6 319 156 10 139 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032944   ⟹   ENSRNOP00000036154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1088,061,689 - 88,065,396 (+)Ensembl
mRatBN7.2 Ensembl1087,561,326 - 87,565,334 (+)Ensembl
Rnor_6.0 Ensembl1090,550,147 - 90,552,057 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000145471   ⟹   ENSRNOP00000112818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1088,061,667 - 88,064,781 (+)Ensembl
RefSeq Acc Id: NM_172035   ⟹   NP_742032
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81088,061,988 - 88,063,898 (+)NCBI
mRatBN7.21087,561,866 - 87,563,776 (+)NCBI
Rnor_6.01090,550,147 - 90,552,057 (+)NCBI
Rnor_5.01090,343,133 - 90,345,043 (+)NCBI
RGSC_v3.41091,709,222 - 91,711,132 (+)RGD
Celera1086,269,032 - 86,270,942 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_742032 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41172 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000112818
GenBank Protein Q08464 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_742032   ⟸   NM_172035
- Peptide Label: precursor
- UniProtKB: Q08464 (UniProtKB/Swiss-Prot),   G3V954 (UniProtKB/TrEMBL),   A6HJL6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036154   ⟸   ENSRNOT00000032944
Ensembl Acc Id: ENSRNOP00000112818   ⟸   ENSRNOT00000145471
Protein Domains
FZ   G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08464-F1-model_v2 AlphaFold Q08464 1-570 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697792
Promoter ID:EPDNEW_R8316
Type:initiation region
Name:Fzd2_1
Description:frizzled class receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01090,550,240 - 90,550,300EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71012 AgrOrtholog
BioCyc Gene G2FUF-23095 BioCyc
Ensembl Genes ENSRNOG00000021962 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000145471 ENTREZGENE
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Frizzled/SFRP UniProtKB/Swiss-Prot
  Frizzled/Smoothened_TM UniProtKB/Swiss-Prot
  Frizzled_dom UniProtKB/Swiss-Prot
  Frizzled_dom_sf UniProtKB/Swiss-Prot
  FZ2_CRD UniProtKB/Swiss-Prot
  GPCR_2-like UniProtKB/Swiss-Prot
KEGG Report rno:64512 UniProtKB/Swiss-Prot
NCBI Gene 64512 ENTREZGENE
PANTHER PTHR11309 UniProtKB/Swiss-Prot
  PTHR11309:SF34 UniProtKB/Swiss-Prot
Pfam Frizzled UniProtKB/Swiss-Prot
  PF01392 UniProtKB/Swiss-Prot
PharmGKB FZD2 RGD
PhenoGen Fzd2 PhenoGen
PRINTS FRIZZLED UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot
  PS50038 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021962 RatGTEx
SMART FRI UniProtKB/Swiss-Prot
  Frizzled UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63501 UniProtKB/Swiss-Prot
UniProt A6HJL6 ENTREZGENE, UniProtKB/TrEMBL
  FZD2_RAT UniProtKB/Swiss-Prot
  G3V954 ENTREZGENE, UniProtKB/TrEMBL
  Q08464 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-06 Fzd2  frizzled class receptor 2  Fzd2  frizzled family receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Fzd2  frizzled family receptor 2  Fzd2  frizzled homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-08-15 Fzd2  frizzled homolog 2 (Drosophila)  Fzd10  Drosophila polarity gene (frizzled) homologue  Data merged from RGD:620345 737654 APPROVED
2003-04-28 Fzd10  Drosophila polarity gene (frizzled) homologue      Symbol withdrawn 625702 WITHDRAWN
2002-08-07 Fzd10  Drosophila polarity gene (frizzled) homologue      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-07-09 Fzd2  frizzled homolog 2 (Drosophila)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference