Prkci (protein kinase C, iota) - Rat Genome Database

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Gene: Prkci (protein kinase C, iota) Rattus norvegicus
Analyze
Symbol: Prkci
Name: protein kinase C, iota
RGD ID: 620961
Description: Predicted to enable diacylglycerol-dependent, calcium-independent serine/threonine kinase activity and phospholipid binding activity. Involved in several processes, including Golgi vesicle budding; cellular response to insulin stimulus; and response to interleukin-1. Located in bicellular tight junction and cell leading edge. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Orthologous to human PRKCI (protein kinase C iota); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; interleukin-1 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aPKC-lambda/iota; atypical protein kinase C-lambda/iota; nPKC-iota; Pkcl; protein kinase C iota type; protein kinase C, lambda
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,250,398 - 114,310,784 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2114,250,398 - 114,310,784 (-)EnsemblGRCr8
mRatBN7.22112,321,919 - 112,382,305 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,321,929 - 112,382,352 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2118,969,610 - 119,036,697 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02117,082,171 - 117,149,259 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02111,791,942 - 111,852,081 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02115,941,998 - 116,002,550 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2115,941,993 - 116,002,561 (-)Ensemblrn6Rnor6.0
Rnor_5.02135,636,956 - 135,697,732 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42116,739,625 - 116,801,084 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2107,508,914 - 107,569,241 (-)NCBICelera
RGSC_v3.12116,686,636 - 116,699,453 (-)NCBI
Cytogenetic Map2q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
decabromodiphenyl ether  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicyclanil  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
fenvalerate  (EXP)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
glafenine  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
methidathion  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nefazodone  (EXP)
oxybenzone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
Ro 31-8220  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulforaphane  (EXP)
sulindac  (EXP)
tamibarotene  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
wogonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Albert CJ and Ford DA, Am J Physiol. 1999 Feb;276(2 Pt 2):H642-50.
2. Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Corsini E, etal., Br J Dermatol. 2009 Jan;160(1):16-25. Epub 2008 Oct 11.
3. Corticotropin-releasing hormone activates protein kinase C in an isoenzyme-specific manner. Dermitzaki E, etal., Biochem Biophys Res Commun. 2005 Feb 18;327(3):828-36.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. Izumi Y, etal., J Cell Biol 1998 Oct 5;143(1):95-106.
7. Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3. Kim YB, etal., J Biol Chem 2002 Sep 6;277(36):32915-22.
8. The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. Kojima Y, etal., Hum Pathol. 2008 Jun;39(6):824-31.
9. PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. Matsumoto M, etal., J Clin Invest. 2003 Sep;112(6):935-44.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. PKC¿ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP. Ren SQ, etal., EMBO J. 2013 May 15;32(10):1365-80. doi: 10.1038/emboj.2013.60. Epub 2013 Mar 19.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. Rosse C, etal., PLoS Biol. 2009 Nov;7(11):e1000235. Epub 2009 Nov 3.
20. Differential contributions of protein kinase C isoforms in the regulation of group IIA secreted phospholipase A(2) expression in cytokine-stimulated rat fibroblasts. Sugita M, etal., Biochim Biophys Acta. 2010 Jan;1801(1):70-6. Epub 2009 Sep 24.
21. The PAR-aPKC system: lessons in polarity. Suzuki A and Ohno S, J Cell Sci. 2006 Mar 15;119(Pt 6):979-87.
22. Atypical protein kinase C plays a critical role in protein transport from pre-Golgi intermediates. Tisdale EJ, etal., J Biol Chem 2003 Sep 26;278(39):38015-21.
23. Protein kinase C modulation of the regulation of sarcoplasmic reticular function by protein kinase A-mediated phospholamban phosphorylation in diabetic rats. Watanuki S, etal., Br J Pharmacol. 2004 Jan;141(2):347-59. Epub 2003 Dec 22.
24. Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis. Weichert W, etal., Int J Oncol. 2003 Sep;23(3):633-9.
Additional References at PubMed
PMID:8226978   PMID:9819385   PMID:10467349   PMID:10882525   PMID:11257119   PMID:11260256   PMID:11463795   PMID:11500922   PMID:11724794   PMID:14570876   PMID:14685273   PMID:14758363  
PMID:15322187   PMID:15723051   PMID:15802290   PMID:16267237   PMID:16892058   PMID:18815554   PMID:19056867   PMID:19090727   PMID:19327373   PMID:19819945   PMID:20237282   PMID:20817751  
PMID:21419810   PMID:21983565   PMID:23152633   PMID:23305840   PMID:26199377   PMID:27498875   PMID:28073831   PMID:28432079  


Genomics

Comparative Map Data
Prkci
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,250,398 - 114,310,784 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2114,250,398 - 114,310,784 (-)EnsemblGRCr8
mRatBN7.22112,321,919 - 112,382,305 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,321,929 - 112,382,352 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2118,969,610 - 119,036,697 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02117,082,171 - 117,149,259 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02111,791,942 - 111,852,081 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02115,941,998 - 116,002,550 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2115,941,993 - 116,002,561 (-)Ensemblrn6Rnor6.0
Rnor_5.02135,636,956 - 135,697,732 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42116,739,625 - 116,801,084 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2107,508,914 - 107,569,241 (-)NCBICelera
RGSC_v3.12116,686,636 - 116,699,453 (-)NCBI
Cytogenetic Map2q24NCBI
PRKCI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383170,222,424 - 170,305,977 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3170,222,124 - 170,305,978 (+)Ensemblhg38GRCh38
GRCh373169,940,212 - 170,023,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363171,422,914 - 171,506,464 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343171,422,926 - 171,506,466NCBI
Celera3168,339,909 - 168,423,454 (+)NCBICelera
Cytogenetic Map3q26.2NCBI
HuRef3167,310,436 - 167,393,660 (+)NCBIHuRef
CHM1_13169,903,696 - 169,987,264 (+)NCBICHM1_1
T2T-CHM13v2.03173,007,078 - 173,090,623 (+)NCBIT2T-CHM13v2.0
Prkci
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39331,049,893 - 31,106,889 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl331,049,896 - 31,107,108 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38330,995,742 - 31,052,740 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl330,995,747 - 31,052,959 (+)Ensemblmm10GRCm38
MGSCv37330,894,693 - 30,951,662 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36331,186,790 - 31,243,616 (+)NCBIMGSCv36mm8
Celera330,907,826 - 30,963,884 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map314.65NCBI
Prkci
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955420423,140 - 489,592 (+)Ensembl
ChiLan1.0NW_004955420423,406 - 486,676 (+)NCBIChiLan1.0ChiLan1.0
PRKCI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22168,117,174 - 168,201,113 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13168,122,382 - 168,205,837 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03167,237,093 - 167,320,522 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13175,426,774 - 175,510,072 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3175,426,774 - 175,510,072 (+)EnsemblpanPan2panpan1.1
PRKCI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13434,767,066 - 34,839,823 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3434,766,801 - 34,837,605 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3443,779,787 - 43,851,893 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03434,847,084 - 34,921,270 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3434,846,775 - 34,923,810 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13434,792,870 - 34,864,800 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03434,760,842 - 34,834,497 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03435,025,008 - 35,098,029 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prkci
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602101,385,061 - 101,451,426 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365932,170,808 - 2,236,673 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365932,170,539 - 2,236,904 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13108,913,173 - 108,997,931 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113108,913,018 - 108,997,934 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213117,694,977 - 117,742,789 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11519,103,682 - 19,180,689 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606327,884,831 - 27,966,994 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkci
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473048,258,524 - 48,340,217 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Prkci
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13125,230,654 - 125,288,515 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prkci
323 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:380
Count of miRNA genes:203
Interacting mature miRNAs:261
Transcripts:ENSRNOT00000012924
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat

Markers in Region
RH143812  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,322,042 - 112,322,150 (+)MAPPERmRatBN7.2
Rnor_6.02115,942,122 - 115,942,229NCBIRnor6.0
Rnor_5.02135,637,080 - 135,637,187UniSTSRnor5.0
RGSC_v3.42116,739,749 - 116,739,856UniSTSRGSC3.4
Celera2107,509,038 - 107,509,145UniSTS
RH 3.4 Map2719.4UniSTS
Cytogenetic Map2q24UniSTS
AI406627  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,322,077 - 112,322,223 (+)MAPPERmRatBN7.2
Rnor_6.02115,942,157 - 115,942,302NCBIRnor6.0
Rnor_5.02135,637,115 - 135,637,260UniSTSRnor5.0
RGSC_v3.42116,739,784 - 116,739,929UniSTSRGSC3.4
Celera2107,509,073 - 107,509,218UniSTS
RH 3.4 Map2721.5UniSTS
Cytogenetic Map2q24UniSTS
AI007955  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,377,692 - 112,377,852 (+)MAPPERmRatBN7.2
Rnor_6.02115,997,940 - 115,998,099NCBIRnor6.0
Rnor_5.02135,693,122 - 135,693,281UniSTSRnor5.0
RGSC_v3.42116,796,473 - 116,796,632UniSTSRGSC3.4
Celera2107,564,634 - 107,564,793UniSTS
RH 3.4 Map2722.3UniSTS
Cytogenetic Map2q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 91 59 6 355 191 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012924   ⟹   ENSRNOP00000012924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2114,250,398 - 114,310,784 (-)Ensembl
mRatBN7.2 Ensembl2112,321,929 - 112,382,352 (-)Ensembl
Rnor_6.0 Ensembl2115,941,993 - 116,002,561 (-)Ensembl
RefSeq Acc Id: NM_032059   ⟹   NP_114448
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,250,398 - 114,310,784 (-)NCBI
mRatBN7.22112,321,919 - 112,382,305 (-)NCBI
Rnor_6.02115,941,998 - 116,002,550 (-)NCBI
Rnor_5.02135,636,956 - 135,697,732 (-)NCBI
RGSC_v3.42116,739,625 - 116,801,084 (-)RGD
Celera2107,508,914 - 107,569,241 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114448 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB41799 (Get FASTA)   NCBI Sequence Viewer  
  ACA66272 (Get FASTA)   NCBI Sequence Viewer  
  BAA78372 (Get FASTA)   NCBI Sequence Viewer  
  EDM01152 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012924
  ENSRNOP00000012924.4
GenBank Protein F1M7Y5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114448   ⟸   NM_032059
- UniProtKB: B1PZT8 (UniProtKB/Swiss-Prot),   F1M7Y5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012924   ⟸   ENSRNOT00000012924
Protein Domains
AGC-kinase C-terminal   PB1   Phorbol-ester/DAG-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7Y5-F1-model_v2 AlphaFold F1M7Y5 1-596 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691273
Promoter ID:EPDNEW_R1798
Type:initiation region
Name:Prkci_1
Description:protein kinase C, iota
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02116,002,588 - 116,002,648EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620961 AgrOrtholog
BioCyc Gene G2FUF-53470 BioCyc
Ensembl Genes ENSRNOG00000009652 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012924 ENTREZGENE
  ENSRNOT00000012924.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.20 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  aPKC_iota UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  DAG/PE-bd UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PB1-like UniProtKB/Swiss-Prot
  PB1_aPKC UniProtKB/Swiss-Prot
  PB1_dom UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  PKC UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:84006 UniProtKB/Swiss-Prot
NCBI Gene 84006 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  PB1 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PhenoGen Prkci PhenoGen
PIRSF PKC_zeta UniProtKB/Swiss-Prot
PRINTS DAGPEDOMAIN UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PB1 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009652 RatGTEx
SMART PB1 UniProtKB/Swiss-Prot
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
Superfamily-SCOP CAD & PB1 domains UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
  SSF57889 UniProtKB/Swiss-Prot
UniProt A6IHK4_RAT UniProtKB/TrEMBL
  B1PZT8 ENTREZGENE
  F1M7Y5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B1PZT8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Prkci  protein kinase C, iota  Pkcl  protein kinase C, lambda  Symbol and Name updated 1299863 APPROVED
2002-08-07 Pkcl  protein kinase C, lambda      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process mediates protein transport in the early secretory pathway 724652
gene_regulation activated by phosphatidylinositol 3,4,5-triphosphate and phosphatidic acid 724652