Aia13 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Aia13 (Adjuvant induced arthritis QTL 13) Rattus norvegicus

Symbol: Aia13
Name: Adjuvant induced arthritis QTL 13
RGD ID: 2317058
Trait: joint integrity trait   (VT:0010548)    
Measurement Type: left rear ankle joint diameter   (CMO:0002149)    
LOD Score: 2.9
P Value: Not Available
Variance: 8.1
Inheritance Type: recessive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2276,539,322 - 77,991,361RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0278,321,410 - 79,969,856RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0298,037,122 - 99,636,963RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4277,630,629 - 79,118,861RGDRGSC3.4
Cross Type: intercross
Strains Crossed: F344/NCrl LEW/Crl 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
F344/NCrl  (IEA)
LEW/Crl  (IEA)

References

References - curated
1. Bleich A, etal., Inflamm Bowel Dis. 2009 Jun 12;15(12):1794-1802.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1593219LOC365713similar to 60S ribosomal protein L927660246676603113Rat
40928086LOC120101219U7 small nuclear RNA27664811376648175Rat
40992083LOC120100750uncharacterized LOC12010075027678800976854838Rat
1559945Marchf11membrane associated ring-CH-type finger 1127689833076999690Rat
1305813Fbxl7F-box and leucine-rich repeat protein 727713977577509223Rat
41235934LOC120100751uncharacterized LOC12010075127724835477260551Rat
41196546LOC120100753uncharacterized LOC12010075327726176677268562Rat
41093744LOC120100752uncharacterized LOC12010075227726901677284684Rat
1595140LOC685308similar to Heat shock protein HSP 90-beta (HSP 84) (Tumor-specific transplantation 84 kDa antigen) (TSTA)27763955877641665Rat
41056389LOC120101320small nucleolar RNA SNORA1727767562177675749Rat
41137062LOC120101105U2 spliceosomal RNA27770271777702836Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
33620D2Mit618927653932276539510Ratregion
37132D2Rat14412527689708576897216Ratregion
37664D2Rat16721527799114877991361Ratregion
41758D2Rat27220027668044076680636Ratregion
43502D2Got3624427750311977503363Ratregion
43503D2Got3812727734517377345300Ratregion
43505D2Got3712927772448077724609Ratregion
5049834RH13370819527713995477140148Ratregion
7191218D2Mit618927653932276539510Ratregion
5068358AU04719414227798317077983314Ratregion
5062060BF39734724427730501277305256Ratregion
5062904AW52886115027699947576999625Ratregion
5081635BE11772118527728315677283341Ratregion
Position Markers

Flank 1: (D2Mit6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2276,539,322 - 76,539,510 (+)MAPPER
Rnor_6.0278,321,410 - 78,321,595RGD
Rnor_6.0278,466,075 - 78,466,260RGD
Rnor_5.0298,153,283 - 98,153,468RGD
Rnor_5.0298,037,122 - 98,037,307RGD
RGSC_v3.4277,630,629 - 77,630,814UniSTS
RGSC_v3.1277,561,812 - 77,562,125RGD
Celera272,243,967 - 72,244,152UniSTS
RH 3.4 Map2500.7UniSTS
RH 3.4 Map2500.7RGD
RH 2.0 Map2406.8RGD
SHRSP x BN Map229.4498RGD
Cytogenetic Map2 RGD
Flank 2: (D2Rat167)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2277,991,148 - 77,991,361 (+)MAPPER
Rnor_6.0279,969,644 - 79,969,856NCBI
Rnor_5.0299,636,751 - 99,636,963UniSTS
RGSC_v3.4279,118,648 - 79,118,861RGD
RGSC_v3.4279,118,649 - 79,118,861UniSTS
RGSC_v3.1279,063,611 - 79,063,823RGD
Celera273,649,269 - 73,649,483UniSTS
RH 3.4 Map2390.6UniSTS
RH 3.4 Map2390.6RGD
RH 2.0 Map2401.5RGD
SHRSP x BN Map230.8598RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)25760561276539510Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)27478666494359546Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)27478666494359546Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)27653932277991361Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)276539322102785628Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_general number of animals used: 168 F2 females 2316974
qtl_general measurement method: animals were anesthetized, intestines exposed and 0.05 mL PG-PS suspension was injected; after 24 days these animals were exsanguinated and joint diameter of the left rear ankle measured on 21st day of the treatment 2316974
qtl_general inducing agent: peptidoglycan-polysaccharide (PG-PS) polymers 2316974
qtl_general software used: MapQTL software, Student's t-tests, median tests 2316974