Notch2 (notch receptor 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Notch2 (notch receptor 2) Rattus norvegicus
Analyze
Symbol: Notch2
Name: notch receptor 2
RGD ID: 3188
Description: Predicted to enable NF-kappaB binding activity; enzyme binding activity; and transcription coactivator activity. Involved in brain development; tissue regeneration; and wound healing. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neurogenic locus notch homolog protein 2; notch 2; notch gene homolog 2; notch gene homolog 2 (Drosophila); Notch homolog 2; Notch homolog 2 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,299,336 - 188,432,823 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2188,299,336 - 188,432,823 (+)EnsemblGRCr8
mRatBN7.22185,610,594 - 185,744,088 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2185,610,589 - 185,744,088 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2193,258,974 - 193,392,488 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,067,260 - 191,200,638 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02185,891,558 - 186,025,066 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,187,184 - 200,320,403 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,187,179 - 200,320,215 (+)Ensemblrn6Rnor6.0
Rnor_5.02219,662,511 - 219,793,306 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02207,597,473 - 207,599,560 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42192,839,350 - 192,986,589 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2178,101,416 - 178,234,556 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-methylfuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
carbamazepine  (ISO)
chlorpyrifos  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cypermethrin  (EXP,ISO)
DAPT  (EXP,ISO)
DDE  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP,ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
enzalutamide  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
folic acid  (ISO)
genistein  (EXP)
gentamycin  (EXP)
indometacin  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
leflunomide  (EXP)
linuron  (EXP)
melatonin  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
ochratoxin A  (ISO)
omacetaxine mepesuccinate  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
pirinixic acid  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
sarin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (EXP)
trovafloxacin  (EXP)
tungsten  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
animal organ development  (IEA)
animal organ morphogenesis  (IEA,ISO,ISS)
apoptotic process  (IEA)
atrial septum morphogenesis  (IEA,ISO)
bone remodeling  (IEA,ISO)
brain development  (IEP)
cell differentiation  (IEA)
cell fate determination  (IEA)
cellular response to tumor cell  (IEA,ISO,ISS)
cholangiocyte proliferation  (ISO)
ciliary body morphogenesis  (ISO)
defense response to bacterium  (ISO)
determination of left/right symmetry  (ISO)
embryonic limb morphogenesis  (ISO)
glomerular capillary formation  (IEA,ISO)
heart looping  (IEA,ISO)
heart morphogenesis  (IEA)
hemopoiesis  (IEA)
hepatocyte proliferation  (ISO)
humoral immune response  (ISO)
in utero embryonic development  (ISO)
inflammatory response to antigenic stimulus  (ISO)
intracellular signal transduction  (IEA,ISO,ISS)
intrahepatic bile duct development  (ISO)
kidney development  (IEA)
left/right axis specification  (IEA,ISO)
liver development  (ISO)
liver morphogenesis  (ISO)
marginal zone B cell differentiation  (IEA,ISO,ISS)
morphogenesis of an epithelial sheet  (ISO)
multicellular organism growth  (ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
Notch signaling pathway  (IEA,ISO,ISS)
placenta blood vessel development  (ISO)
placenta development  (ISO)
podocyte development  (IEA,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cell differentiation  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of keratinocyte proliferation  (IEA,ISO,ISS)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of osteoclast differentiation  (IEA,ISO)
positive regulation of Ras protein signal transduction  (IEA,ISO,ISS)
positive regulation of signal transduction  (IEA)
positive regulation of smooth muscle cell differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
proximal tubule development  (IEA,ISO)
pulmonary valve morphogenesis  (IEA,ISO)
regulation of apoptotic process  (IEA)
regulation of developmental process  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of hemopoiesis  (IEA)
regulation of osteoclast development  (IEA,ISO,ISS)
regulation of transcription by RNA polymerase II  (IEA,ISO)
system development  (IEA)
tissue regeneration  (IEA,IEP)
wound healing  (IEA,IEP,ISO)

Cellular Component
cell surface  (IEA,ISO,ISS,TAS)
cilium  (IEA,ISO)
cytoplasm  (IEA)
cytosol  (IEA,TAS)
endomembrane system  (IEA)
extracellular region  (IEA,TAS)
glutamatergic synapse  (EXP,IDA,IEP)
membrane  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO,ISS)
organelle  (IEA)
plasma membrane  (IEA,ISO,ISS,TAS)
postsynaptic density membrane  (EXP,IDA,IEP)
receptor complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Jundt F, etal., Blood. 2004 May 1;103(9):3511-5. Epub 2004 Jan 15.
5. Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Lindner V, etal., Am J Pathol. 2001 Sep;159(3):875-83. doi: 10.1016/S0002-9440(10)61763-4.
6. Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Loh KH, etal., Cell. 2016 Aug 25;166(5):1295-1307.e21. doi: 10.1016/j.cell.2016.07.041.
7. NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. McDaniell R, etal., Am J Hum Genet. 2006 Jul;79(1):169-73. Epub 2006 May 10.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Amyloid precursor protein interacts with notch receptors. Oh SY, etal., J Neurosci Res. 2005 Oct 1;82(1):32-42.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. Wang W, etal., J Biol Chem 2002 Jun 28;277(26):23165-71.
19. Notch2: a second mammalian Notch gene. Weinmaster G, etal., Development 1992 Dec;116(4):931-41.
Additional References at PubMed
PMID:1303260   PMID:9244302   PMID:11306509   PMID:11438922   PMID:11577080   PMID:11861489   PMID:12477932   PMID:12496659   PMID:12531696   PMID:12730124   PMID:15821257   PMID:16169548  
PMID:16641100   PMID:17219215   PMID:17359302   PMID:17573339   PMID:17658279   PMID:18311147   PMID:18469519   PMID:18710934   PMID:18801907   PMID:18838555   PMID:19217325   PMID:19828677  
PMID:19946888   PMID:20643108   PMID:21332343   PMID:21378985   PMID:21378989   PMID:21703454   PMID:23232913   PMID:23382219   PMID:23589286   PMID:23676271   PMID:23913046   PMID:25446530  
PMID:25985737   PMID:27942853   PMID:28495268   PMID:29063319   PMID:29149593   PMID:29329397   PMID:31217737   PMID:32866557   PMID:34581980   PMID:36348269   PMID:38148075  


Genomics

Comparative Map Data
Notch2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,299,336 - 188,432,823 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2188,299,336 - 188,432,823 (+)EnsemblGRCr8
mRatBN7.22185,610,594 - 185,744,088 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2185,610,589 - 185,744,088 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2193,258,974 - 193,392,488 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,067,260 - 191,200,638 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02185,891,558 - 186,025,066 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,187,184 - 200,320,403 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,187,179 - 200,320,215 (+)Ensemblrn6Rnor6.0
Rnor_5.02219,662,511 - 219,793,306 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02207,597,473 - 207,599,560 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42192,839,350 - 192,986,589 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2178,101,416 - 178,234,556 (+)NCBICelera
Cytogenetic Map2q34NCBI
NOTCH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,911,553 - 120,069,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,911,553 - 120,100,779 (-)Ensemblhg38GRCh38
GRCh371120,454,176 - 120,612,276 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361120,255,699 - 120,413,799 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341120,166,219 - 120,324,318NCBI
Celera1118,684,898 - 118,760,431 (-)NCBICelera
Cytogenetic Map1p12NCBI
HuRef1118,312,713 - 118,398,477 (-)NCBIHuRef
CHM1_11120,569,670 - 120,727,793 (-)NCBICHM1_1
T2T-CHM13v2.01119,924,810 - 120,082,923 (-)NCBIT2T-CHM13v2.0
Notch2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39397,920,854 - 98,057,683 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl397,920,843 - 98,057,677 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38398,013,538 - 98,150,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,013,527 - 98,150,361 (+)Ensemblmm10GRCm38
MGSCv37397,817,461 - 97,954,290 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36398,098,943 - 98,232,854 (+)NCBIMGSCv36mm8
Celera399,412,506 - 99,549,473 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.42NCBI
Notch2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555681,660,731 - 1,809,173 (+)Ensembl
ChiLan1.0NW_0049555681,660,357 - 1,812,285 (+)NCBIChiLan1.0ChiLan1.0
NOTCH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21112,490,679 - 112,716,322 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11112,158,059 - 112,315,530 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0182,457,829 - 82,615,142 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,537,162 - 117,612,840 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,538,243 - 117,612,840 (+)EnsemblpanPan2panpan1.1
NOTCH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,854,825 - 57,020,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,860,429 - 57,020,857 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1756,476,088 - 56,659,161 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01757,717,260 - 57,900,443 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1757,739,989 - 57,996,124 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11756,764,520 - 56,924,479 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01756,800,478 - 56,960,572 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01757,426,245 - 57,608,931 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101965998
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050582,620,590 - 2,684,163 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936872390,852 - 536,321 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936872454,273 - 539,544 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4100,981,636 - 101,150,195 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14100,951,522 - 101,152,348 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24110,927,023 - 110,985,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOTCH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12013,712,140 - 13,871,777 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2013,712,292 - 13,871,784 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603816,342,675 - 16,501,918 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Notch2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477215,571,998 - 15,726,426 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477215,572,350 - 15,726,312 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Notch2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1359,166,637 - 59,301,042 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Notch2
761 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:57
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000025718
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
RH138723  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22185,609,809 - 185,609,964 (+)MAPPERmRatBN7.2
Rnor_6.02200,186,400 - 200,186,554NCBIRnor6.0
Rnor_5.02219,661,727 - 219,661,881UniSTSRnor5.0
RGSC_v3.42192,854,503 - 192,854,657UniSTSRGSC3.4
Celera2178,100,632 - 178,100,786UniSTS
RH 3.4 Map21255.2UniSTS
Cytogenetic Map2q34UniSTS
Notch2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22185,739,686 - 185,739,973 (+)MAPPERmRatBN7.2
Rnor_6.02200,316,002 - 200,316,288NCBIRnor6.0
Rnor_5.02219,791,687 - 219,791,973UniSTSRnor5.0
RGSC_v3.42192,984,970 - 192,985,256UniSTSRGSC3.4
Celera2178,230,155 - 178,230,441UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025718   ⟹   ENSRNOP00000025718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2188,299,336 - 188,432,823 (+)Ensembl
mRatBN7.2 Ensembl2185,610,594 - 185,744,088 (+)Ensembl
Rnor_6.0 Ensembl2200,187,184 - 200,320,215 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093564   ⟹   ENSRNOP00000076101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2185,610,589 - 185,612,201 (+)Ensembl
Rnor_6.0 Ensembl2200,187,179 - 200,188,792 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095490   ⟹   ENSRNOP00000095918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2188,332,966 - 188,432,823 (+)Ensembl
mRatBN7.2 Ensembl2185,644,226 - 185,744,088 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105572   ⟹   ENSRNOP00000097589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2188,299,336 - 188,432,823 (+)Ensembl
mRatBN7.2 Ensembl2185,644,226 - 185,744,088 (+)Ensembl
RefSeq Acc Id: NM_024358   ⟹   NP_077334
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,299,336 - 188,432,823 (+)NCBI
mRatBN7.22185,610,594 - 185,744,088 (+)NCBI
Rnor_6.02200,187,184 - 200,320,403 (+)NCBI
Rnor_5.02207,597,473 - 207,599,560 (-)NCBI
Rnor_5.02219,662,511 - 219,793,306 (+)NCBI
RGSC_v3.42192,839,350 - 192,986,589 (+)RGD
Celera2178,101,416 - 178,234,556 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_077334 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85571 (Get FASTA)   NCBI Sequence Viewer  
  EDL85572 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025718
GenBank Protein Q9QW30 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077334   ⟸   NM_024358
- Peptide Label: precursor
- UniProtKB: Q9QW30 (UniProtKB/Swiss-Prot),   G3V8G9 (UniProtKB/TrEMBL),   A6K3C8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000076101   ⟸   ENSRNOT00000093564
Ensembl Acc Id: ENSRNOP00000025718   ⟸   ENSRNOT00000025718
Ensembl Acc Id: ENSRNOP00000097589   ⟸   ENSRNOT00000105572
Ensembl Acc Id: ENSRNOP00000095918   ⟸   ENSRNOT00000095490
Protein Domains
EGF-like   LNR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QW30-F1-model_v2 AlphaFold Q9QW30 1-2471 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691600
Promoter ID:EPDNEW_R2125
Type:initiation region
Name:Notch2_1
Description:notch 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02200,187,188 - 200,187,248EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3188 AgrOrtholog
BioCyc Gene G2FUF-51921 BioCyc
Ensembl Genes ENSRNOG00000018835 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025718 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  3.30.300.320 UniProtKB/Swiss-Prot
  3.30.70.3310 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  DUF3454_notch UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Notch UniProtKB/Swiss-Prot
  Notch-like_dom_sf UniProtKB/Swiss-Prot
  Notch/Slit_guidance UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
  Notch_2 UniProtKB/Swiss-Prot
  Notch_dom UniProtKB/Swiss-Prot
  Notch_NOD_dom UniProtKB/Swiss-Prot
  Notch_NODP_dom UniProtKB/Swiss-Prot
NCBI Gene 29492 ENTREZGENE
PANTHER NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2 UniProtKB/Swiss-Prot
  SLIT HOMOLOG UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  NOD UniProtKB/Swiss-Prot
  NODP UniProtKB/Swiss-Prot
  Notch UniProtKB/Swiss-Prot
PhenoGen Notch2 PhenoGen
PIRSF Notch UniProtKB/Swiss-Prot
PRINTS LNOTCHREPEAT UniProtKB/Swiss-Prot
  NOTCH UniProtKB/Swiss-Prot
  NOTCH2 UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LNR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018835 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
  DUF3454 UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  NOD UniProtKB/Swiss-Prot
  NODP UniProtKB/Swiss-Prot
  SM00004 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
  SSF90193 UniProtKB/Swiss-Prot
TIGR TC203288
UniProt A0A8I6B3I0_RAT UniProtKB/TrEMBL
  A0A8I6GM47_RAT UniProtKB/TrEMBL
  A6K3C8 ENTREZGENE, UniProtKB/TrEMBL
  A6K3C9_RAT UniProtKB/TrEMBL
  G3V8G9 ENTREZGENE, UniProtKB/TrEMBL
  NOTC2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Notch2  notch receptor 2  Notch2  notch 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Notch2  notch 2  Notch2  Notch homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Notch2  Notch homolog 2 (Drosophila)  Notch2  notch gene homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Notch2  notch gene homolog 2, (Drosophila)      Name updated 70584 APPROVED
2001-10-23 Notch2  Notch gene homolog 2, (Drosophila)      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in spleen, kidney and liver 69906
gene_process Drosophila homolog controls ectodermal and neural cell fate 69906