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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3188
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Notch2
Name: notch receptor 2
Acc ID: CHEBI:76995
Term: alpha-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).
Chemical ID: MESH:C011512
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch2decreases acetylationEXP 6480464CTDalpha-naphthoflavone results in decreased acetylation of NOTCH2 promoterPMID:29094188
Notch2increases methylationEXP 6480464CTDalpha-naphthoflavone results in increased methylation of NOTCH2 promoterPMID:29094188
Notch2multiple interactionsEXP 6480464CTDalpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of NOTCH2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of NOTCH2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of NOTCH2 promoter]PMID:29094188
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