NOTCH2 (notch receptor 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: NOTCH2 (notch receptor 2) Canis lupus familiaris
Analyze
Symbol: NOTCH2
Name: notch receptor 2
RGD ID: 12093797
Description: ENCODES a protein that exhibits enzyme binding (ortholog); NF-kappaB binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); atrial septum morphogenesis (ortholog); bone remodeling (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Alagille syndrome (ortholog); Breast Neoplasms (ortholog); CAKUT (ortholog); FOUND IN cell surface (ortholog); cilium (ortholog); integral component of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC111090698; neurogenic locus notch homolog protein 2; notch 2; Notch homolog 2; uncharacterized LOC111090698
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,854,825 - 57,020,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,860,429 - 57,020,857 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1756,476,088 - 56,659,161 (-)NCBI
ROS_Cfam_1.01757,717,260 - 57,900,443 (-)NCBI
ROS_Cfam_1.0 Ensembl1757,739,989 - 57,996,124 (-)Ensembl
UMICH_Zoey_3.11756,764,520 - 56,924,479 (-)NCBI
UNSW_CanFamBas_1.01756,800,478 - 56,960,572 (-)NCBI
UU_Cfam_GSD_1.01757,426,245 - 57,608,931 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
bone remodeling  (ISO)
cell differentiation  (IEA)
cell fate determination  (ISO)
cellular response to tumor cell  (ISO)
central nervous system development  (IBA)
cholangiocyte proliferation  (ISO)
ciliary body morphogenesis  (ISO)
defense response to bacterium  (ISO)
determination of left/right symmetry  (ISO)
embryonic limb morphogenesis  (ISO)
glomerular capillary formation  (ISO)
glomerular visceral epithelial cell development  (ISO)
heart looping  (ISO)
hepatocyte proliferation  (ISO)
humoral immune response  (ISO)
in utero embryonic development  (ISO)
inflammatory response to antigenic stimulus  (ISO)
intrahepatic bile duct development  (ISO)
left/right axis specification  (ISO)
liver development  (ISO)
liver morphogenesis  (ISO)
marginal zone B cell differentiation  (ISO)
morphogenesis of an epithelial sheet  (ISO)
multicellular organism growth  (ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
Notch signaling pathway  (IEA)
placenta blood vessel development  (ISO)
placenta development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of keratinocyte proliferation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
proximal tubule development  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of actin cytoskeleton reorganization  (ISO)
regulation of developmental process  (IEA)
regulation of osteoclast development  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (IEA)
skeletal system development  (IBA)
tissue regeneration  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
NOTCH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,854,825 - 57,020,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,860,429 - 57,020,857 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1756,476,088 - 56,659,161 (-)NCBI
ROS_Cfam_1.01757,717,260 - 57,900,443 (-)NCBI
ROS_Cfam_1.0 Ensembl1757,739,989 - 57,996,124 (-)Ensembl
UMICH_Zoey_3.11756,764,520 - 56,924,479 (-)NCBI
UNSW_CanFamBas_1.01756,800,478 - 56,960,572 (-)NCBI
UU_Cfam_GSD_1.01757,426,245 - 57,608,931 (-)NCBI
NOTCH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1119,911,553 - 120,100,779 (-)EnsemblGRCh38hg38GRCh38
GRCh381119,911,553 - 120,069,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371120,454,176 - 120,612,276 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361120,255,699 - 120,413,799 (-)NCBINCBI36hg18NCBI36
Build 341120,166,219 - 120,324,318NCBI
Celera1118,684,898 - 118,760,431 (-)NCBI
Cytogenetic Map1p12NCBI
HuRef1118,312,713 - 118,398,477 (-)NCBIHuRef
CHM1_11120,569,670 - 120,727,793 (-)NCBICHM1_1
Notch2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39397,920,854 - 98,057,683 (+)NCBIGRCm39mm39
GRCm39 Ensembl397,920,843 - 98,057,677 (+)Ensembl
GRCm38398,013,538 - 98,150,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,013,527 - 98,150,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv37397,817,461 - 97,954,290 (+)NCBIGRCm37mm9NCBIm37
MGSCv36398,098,943 - 98,232,854 (+)NCBImm8
Celera399,412,506 - 99,549,473 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.42NCBI
Notch2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22185,610,594 - 185,744,088 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2185,610,589 - 185,744,088 (+)Ensembl
Rnor_6.02200,187,184 - 200,320,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,187,179 - 200,320,215 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02219,662,511 - 219,793,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02207,597,473 - 207,599,560 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42192,839,350 - 192,986,589 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2178,101,416 - 178,234,556 (+)NCBICelera
Cytogenetic Map2q34NCBI
Notch2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555681,660,731 - 1,809,173 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555681,660,357 - 1,812,285 (+)NCBIChiLan1.0ChiLan1.0
NOTCH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11117,537,162 - 117,612,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,538,243 - 117,612,840 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0182,457,829 - 82,615,142 (+)NCBIMhudiblu_PPA_v0panPan3
LOC101965998
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050582,620,590 - 2,684,163 (-)NCBI
SpeTri2.0NW_004936872454,273 - 539,544 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4100,951,507 - 101,150,198 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14100,951,522 - 101,152,348 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24110,927,023 - 110,985,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOTCH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12013,712,140 - 13,871,777 (+)NCBIChlSab1.1chlSab2
ChlSab1.12013,712,140 - 13,871,777 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2013,712,292 - 13,871,784 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603816,342,675 - 16,501,918 (+)NCBIVero_WHO_p1.0
Notch2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477215,572,350 - 15,726,312 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 14 6 6 11 10 6
Low 1 5 8 6 6 6 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000016889   ⟹   ENSCAFP00000015629
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1756,860,429 - 57,020,857 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845012979   ⟹   ENSCAFP00845010116
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1757,739,989 - 57,996,124 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013210   ⟹   ENSCAFP00845010265
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1757,739,989 - 57,901,056 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845013400   ⟹   ENSCAFP00845010396
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1757,739,989 - 57,833,884 (-)Ensembl
RefSeq Acc Id: XM_005630688   ⟹   XP_005630745
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11756,859,738 - 57,020,157 (-)NCBI
Dog10K_Boxer_Tasha1756,476,088 - 56,659,161 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038422869   ⟹   XP_038278797
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01757,717,260 - 57,900,443 (-)NCBI
RefSeq Acc Id: XM_038499365   ⟹   XP_038355293
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11756,764,520 - 56,924,479 (-)NCBI
RefSeq Acc Id: XM_038561934   ⟹   XP_038417862
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01757,426,245 - 57,608,931 (-)NCBI
RefSeq Acc Id: XM_038626003   ⟹   XP_038481931
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01756,800,478 - 56,960,572 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005630745   ⟸   XM_005630688
- Peptide Label: isoform X1
- UniProtKB: F1PS94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000015629   ⟸   ENSCAFT00000016889
RefSeq Acc Id: XP_038355293   ⟸   XM_038499365
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038481931   ⟸   XM_038626003
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038278797   ⟸   XM_038422869
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038417862   ⟸   XM_038561934
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845010265   ⟸   ENSCAFT00845013210
RefSeq Acc Id: ENSCAFP00845010396   ⟸   ENSCAFT00845013400
RefSeq Acc Id: ENSCAFP00845010116   ⟸   ENSCAFT00845012979
Protein Domains
EGF-like   LNR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010476 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845007331 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000015629 UniProtKB/TrEMBL
  ENSCAFP00845010265 ENTREZGENE
Ensembl Transcript ENSCAFT00000016889 UniProtKB/TrEMBL
  ENSCAFT00845013210 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  DUF3454_notch UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
  Notch-like_dom_sf UniProtKB/TrEMBL
  Notch_2 UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/TrEMBL
NCBI Gene NOTCH2 ENTREZGENE
Pfam Ank_2 UniProtKB/TrEMBL
  DUF3454 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
PIRSF Notch UniProtKB/TrEMBL
PRINTS LNOTCHREPEAT UniProtKB/TrEMBL
  NOTCH2 UniProtKB/TrEMBL
PROSITE ANK_REPEAT UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LNR UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  DUF3454 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF90193 UniProtKB/TrEMBL
UniProt F1PS94 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 NOTCH2  notch receptor 2  LOC111090698  uncharacterized LOC111090698  Data Merged 737654 PROVISIONAL
2019-01-08 NOTCH2  notch receptor 2    notch 2  Symbol and/or name change 5135510 APPROVED