Notch2 (notch receptor 2) - Rat Genome Database

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Gene: Notch2 (notch receptor 2) Chinchilla lanigera
Analyze
Symbol: Notch2
Name: notch receptor 2
RGD ID: 8948357
Description: ENCODES a protein that exhibits enzyme binding (ortholog); NF-kappaB binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); atrial septum morphogenesis (ortholog); bone remodeling (ortholog); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; ASSOCIATED WITH Alagille syndrome (ortholog); Breast Neoplasms (ortholog); CAKUT (ortholog); FOUND IN cell surface (ortholog); cilium (ortholog); integral component of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: neurogenic locus notch homolog protein 2; notch 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555681,660,731 - 1,809,173 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555681,660,357 - 1,812,285 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
bone remodeling  (ISO)
cell fate determination  (ISO)
cellular response to tumor cell  (ISO)
cholangiocyte proliferation  (ISO)
ciliary body morphogenesis  (ISO)
defense response to bacterium  (ISO)
determination of left/right symmetry  (ISO)
embryonic limb morphogenesis  (ISO)
glomerular capillary formation  (ISO)
glomerular visceral epithelial cell development  (ISO)
heart looping  (ISO)
hepatocyte proliferation  (ISO)
humoral immune response  (ISO)
in utero embryonic development  (ISO)
inflammatory response to antigenic stimulus  (ISO)
intrahepatic bile duct development  (ISO)
left/right axis specification  (ISO)
liver development  (ISO)
liver morphogenesis  (ISO)
marginal zone B cell differentiation  (ISO)
morphogenesis of an epithelial sheet  (ISO)
multicellular organism growth  (ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
Notch signaling pathway  (ISO)
placenta blood vessel development  (ISO)
placenta development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of keratinocyte proliferation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
proximal tubule development  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of actin cytoskeleton reorganization  (ISO)
regulation of osteoclast development  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
tissue regeneration  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Notch2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555681,660,731 - 1,809,173 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555681,660,357 - 1,812,285 (+)NCBIChiLan1.0ChiLan1.0
NOTCH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1119,911,553 - 120,100,779 (-)EnsemblGRCh38hg38GRCh38
GRCh381119,911,553 - 120,069,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371120,454,176 - 120,612,276 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361120,255,699 - 120,413,799 (-)NCBINCBI36hg18NCBI36
Build 341120,166,219 - 120,324,318NCBI
Celera1118,684,898 - 118,760,431 (-)NCBI
Cytogenetic Map1p12NCBI
HuRef1118,312,713 - 118,398,477 (-)NCBIHuRef
CHM1_11120,569,670 - 120,727,793 (-)NCBICHM1_1
Notch2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39397,920,854 - 98,057,683 (+)NCBIGRCm39mm39
GRCm39 Ensembl397,920,843 - 98,057,677 (+)Ensembl
GRCm38398,013,538 - 98,150,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,013,527 - 98,150,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv37397,817,461 - 97,954,290 (+)NCBIGRCm37mm9NCBIm37
MGSCv36398,098,943 - 98,232,854 (+)NCBImm8
Celera399,412,506 - 99,549,473 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.42NCBI
Notch2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22185,610,594 - 185,744,088 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2185,610,589 - 185,744,088 (+)Ensembl
Rnor_6.02200,187,184 - 200,320,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,187,179 - 200,320,215 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,597,473 - 207,599,560 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02219,662,511 - 219,793,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42192,839,350 - 192,986,589 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2178,101,416 - 178,234,556 (+)NCBICelera
Cytogenetic Map2q34NCBI
NOTCH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11117,537,162 - 117,612,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,538,243 - 117,612,840 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0182,457,829 - 82,615,142 (+)NCBIMhudiblu_PPA_v0panPan3
NOTCH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,854,825 - 57,020,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,860,429 - 57,020,857 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1756,476,088 - 56,659,161 (-)NCBI
ROS_Cfam_1.01757,717,260 - 57,900,443 (-)NCBI
UMICH_Zoey_3.11756,764,520 - 56,924,479 (-)NCBI
UNSW_CanFamBas_1.01756,800,478 - 56,960,572 (-)NCBI
UU_Cfam_GSD_1.01757,426,245 - 57,608,931 (-)NCBI
LOC101965998
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050582,620,590 - 2,684,163 (-)NCBI
SpeTri2.0NW_004936872454,273 - 539,544 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4100,951,507 - 101,150,198 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14100,951,522 - 101,152,348 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24110,927,023 - 110,985,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOTCH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12013,712,140 - 13,871,777 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2013,712,292 - 13,871,784 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603816,342,675 - 16,501,918 (+)NCBIVero_WHO_p1.0
Notch2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477215,572,350 - 15,726,312 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000000811   ⟹   ENSCLAP00000000774
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555681,660,731 - 1,809,173 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000000812   ⟹   ENSCLAP00000000775
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555681,660,731 - 1,809,170 (+)Ensembl
RefSeq Acc Id: XM_005413481   ⟹   XP_005413538
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555681,660,481 - 1,812,285 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509349   ⟹   XP_013364803
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555681,690,662 - 1,812,285 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509350   ⟹   XP_013364804
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555681,660,357 - 1,812,285 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005413538 (Get FASTA)   NCBI Sequence Viewer  
  XP_013364803 (Get FASTA)   NCBI Sequence Viewer  
  XP_013364804 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005413538   ⟸   XM_005413481
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013364804   ⟸   XM_013509350
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013364803   ⟸   XM_013509349
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000000774   ⟸   ENSCLAT00000000811
RefSeq Acc Id: ENSCLAP00000000775   ⟸   ENSCLAT00000000812


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000000609 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000000774 ENTREZGENE
Ensembl Transcript ENSCLAT00000000811 ENTREZGENE
NCBI Gene Notch2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-08 Notch2  notch receptor 2    notch 2  Symbol and/or name change 5135510 APPROVED