NOTCH2 (notch receptor 2) - Rat Genome Database

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Gene: NOTCH2 (notch receptor 2) Pan paniscus
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Symbol: NOTCH2
Name: notch receptor 2
RGD ID: 11843710
Description: ENCODES a protein that exhibits enzyme binding (ortholog); NF-kappaB binding (ortholog); INVOLVED IN cell fate determination (ortholog); cholangiocyte proliferation (ortholog); ciliary body morphogenesis (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Alagille syndrome (ortholog); Breast Neoplasms (ortholog); CAKUT (ortholog); FOUND IN cilium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: neurogenic locus notch homolog protein 2; notch 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11117,537,162 - 117,612,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,538,243 - 117,612,840 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0182,457,829 - 82,615,142 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IEA)
atrial septum morphogenesis  (IEA)
bone remodeling  (IEA)
cell differentiation  (IEA)
cell fate determination  (ISO)
cellular response to tumor cell  (IEA)
cholangiocyte proliferation  (ISO)
ciliary body morphogenesis  (ISO)
defense response to bacterium  (ISO)
determination of left/right symmetry  (ISO)
embryonic limb morphogenesis  (ISO)
glomerular capillary formation  (ISO)
glomerular visceral epithelial cell development  (ISO)
heart looping  (ISO)
hepatocyte proliferation  (ISO)
humoral immune response  (ISO)
in utero embryonic development  (ISO)
inflammatory response to antigenic stimulus  (ISO)
intrahepatic bile duct development  (ISO)
left/right axis specification  (ISO)
liver development  (ISO)
liver morphogenesis  (ISO)
marginal zone B cell differentiation  (ISO)
morphogenesis of an epithelial sheet  (ISO)
multicellular organism growth  (ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of gene expression  (IEA)
negative regulation of transcription by RNA polymerase II  (ISO)
Notch signaling pathway  (IEA)
placenta blood vessel development  (ISO)
placenta development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of keratinocyte proliferation  (IEA)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of Ras protein signal transduction  (IEA)
proximal tubule development  (ISO)
pulmonary valve morphogenesis  (IEA)
regulation of actin cytoskeleton reorganization  (IEA)
regulation of developmental process  (IEA)
regulation of osteoclast development  (IEA)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (IEA)
tissue regeneration  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
NOTCH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11117,537,162 - 117,612,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,538,243 - 117,612,840 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0182,457,829 - 82,615,142 (+)NCBIMhudiblu_PPA_v0panPan3
NOTCH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1119,911,553 - 120,100,779 (-)EnsemblGRCh38hg38GRCh38
GRCh381119,911,553 - 120,069,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371120,454,176 - 120,612,276 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361120,255,699 - 120,413,799 (-)NCBINCBI36hg18NCBI36
Build 341120,166,219 - 120,324,318NCBI
Celera1118,684,898 - 118,760,431 (-)NCBI
Cytogenetic Map1p12NCBI
HuRef1118,312,713 - 118,398,477 (-)NCBIHuRef
CHM1_11120,569,670 - 120,727,793 (-)NCBICHM1_1
Notch2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39397,920,854 - 98,057,683 (+)NCBIGRCm39mm39
GRCm39 Ensembl397,920,843 - 98,057,677 (+)Ensembl
GRCm38398,013,538 - 98,150,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,013,527 - 98,150,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv37397,817,461 - 97,954,290 (+)NCBIGRCm37mm9NCBIm37
MGSCv36398,098,943 - 98,232,854 (+)NCBImm8
Celera399,412,506 - 99,549,473 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.42NCBI
Notch2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22185,610,594 - 185,744,088 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2185,610,589 - 185,744,088 (+)Ensembl
Rnor_6.02200,187,184 - 200,320,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,187,179 - 200,320,215 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02219,662,511 - 219,793,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02207,597,473 - 207,599,560 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42192,839,350 - 192,986,589 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2178,101,416 - 178,234,556 (+)NCBICelera
Cytogenetic Map2q34NCBI
Notch2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555681,660,731 - 1,809,173 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555681,660,357 - 1,812,285 (+)NCBIChiLan1.0ChiLan1.0
NOTCH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,854,825 - 57,020,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,860,429 - 57,020,857 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1756,476,088 - 56,659,161 (-)NCBI
ROS_Cfam_1.01757,717,260 - 57,900,443 (-)NCBI
ROS_Cfam_1.0 Ensembl1757,739,989 - 57,996,124 (-)Ensembl
UMICH_Zoey_3.11756,764,520 - 56,924,479 (-)NCBI
UNSW_CanFamBas_1.01756,800,478 - 56,960,572 (-)NCBI
UU_Cfam_GSD_1.01757,426,245 - 57,608,931 (-)NCBI
LOC101965998
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050582,620,590 - 2,684,163 (-)NCBI
SpeTri2.0NW_004936872454,273 - 539,544 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4100,951,507 - 101,150,198 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14100,951,522 - 101,152,348 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24110,927,023 - 110,985,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOTCH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12013,712,140 - 13,871,777 (+)NCBIChlSab1.1chlSab2
ChlSab1.12013,712,140 - 13,871,777 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2013,712,292 - 13,871,784 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603816,342,675 - 16,501,918 (+)NCBIVero_WHO_p1.0
Notch2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477215,572,350 - 15,726,312 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000036636   ⟹   ENSPPAP00000013961
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1117,538,243 - 117,612,840 (+)Ensembl
RefSeq Acc Id: XM_034954795   ⟹   XP_034810686
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0182,457,829 - 82,615,142 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034810686 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034810686   ⟸   XM_034954795
RefSeq Acc Id: ENSPPAP00000013961   ⟸   ENSPPAT00000036636
Protein Domains
EGF-like   LNR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030139 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000013961 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036636 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  DUF3454_notch UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
  Notch-like_dom_sf UniProtKB/TrEMBL
  Notch_2 UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/TrEMBL
KEGG Report pps:100992229 UniProtKB/TrEMBL
NCBI Gene NOTCH2 ENTREZGENE
Pfam Ank_2 UniProtKB/TrEMBL
  DUF3454 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
PIRSF Notch UniProtKB/TrEMBL
PRINTS LNOTCHREPEAT UniProtKB/TrEMBL
  NOTCH2 UniProtKB/TrEMBL
PROSITE ANK_REPEAT UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LNR UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  DUF3454 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF90193 UniProtKB/TrEMBL
UniProt A0A2R9AAN4_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-08 NOTCH2  notch receptor 2    notch 2  Symbol and/or name change 5135510 APPROVED