Predicted to enable several functions, including histone H3K9me/H3K9me2 demethylase activity; iron ion binding activity; and nuclear androgen receptor binding activity. Involved in male gonad development; positive regulation of gene expression; and response to hypoxia. Predicted to be located in chromatin; cytoplasm; and nucleus. Predicted to be part of histone deacetylase complex. Human ortholog(s) of this gene implicated in cervical cancer and colon cancer. Orthologous to human KDM3A (lysine demethylase 3A); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Metribolone promotes the reaction [KDM3A protein binds to KLK3 enhancer] and Metribolone promotes the reaction [KDM3A protein binds to NKX3-1 enhancer]
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of KDM3A protein
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of KDM3A protein
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of KDM3A protein
Oxygen deficiency promotes the reaction [HIF3A protein binds to KDM3A promoter] and Oxygen deficiency promotes the reaction [KDM3A protein binds to SPRY2 promoter]
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of KDM3A protein
Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A mRNA] and Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A protein]
Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A mRNA] and Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A protein]
[Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased oxidation of KDM3A mRNA and [Air Pollutants results in increased abundance of Ozone] which affects the expression of KDM3A mRNA
Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion.
