Pold1 (DNA polymerase delta 1, catalytic subunit) - Rat Genome Database

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Gene: Pold1 (DNA polymerase delta 1, catalytic subunit) Rattus norvegicus
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Symbol: Pold1
Name: DNA polymerase delta 1, catalytic subunit
RGD ID: 621839
Description: Enables DNA-directed DNA polymerase activity. Involved in DNA biosynthetic process and DNA-templated DNA replication. Part of delta DNA polymerase complex. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; base excision repair pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3'-5' exodeoxyribonuclease; DAN polymerase delta 1, catalytic subunit; DNA polymerase delta catalytic subunit; DNA polymerase delta, catalytic subunit; DNA-directed DNA polymerase delta 1; polymerase (DNA directed), delta 1, catalytic subunit; polymerase (DNA) delta 1, catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,161,984 - 104,178,074 (-)NCBIGRCr8
mRatBN7.2195,025,462 - 95,041,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,025,499 - 95,036,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,410,903 - 100,421,871 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,883,547 - 108,894,515 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,173,968 - 102,184,936 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,538,066 - 100,554,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,537,900 - 100,554,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,603,453 - 101,619,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,010,719 - 95,021,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,088,829 - 95,099,797 (-)NCBI
Celera189,287,965 - 89,298,931 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Pold1Ratcolorectal carcinoma exacerbatesISOPOLD1 (Homo sapiens)151347643protein:decreased expression:colorectum (human)RGD 
Pold1RatColorectal Neoplasms  ISOPOLD1 (Homo sapiens)151347647DNA:nonsense mutation and missense mutation:CDS:p.195*, p.V759I (human)RGD 
Pold1RatDrug-induced Neutropenia treatmentISOPOLD1 (Homo sapiens)153323316associated with lung non-small cell carcinoma more ...RGD 
Pold1Ratlung adenocarcinoma exacerbatesISOPOLD1 (Homo sapiens)9068941protein:increased expression:lung (human)RGDPMID:33442399 and REF_RGD_ID:153323317
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Pold1Ratbile duct cancer  ISOPOLD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Bile duct cancerClinVarPMID:25741868 more ...
Pold1Ratbreast cancer  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23376243 more ...
Pold1Ratcolon cancer  ISOPOLD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of colonClinVarPMID:25741868 more ...
Pold1Ratcolon carcinoma  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15322521 more ...
Pold1Ratcolorectal cancer  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24033266 more ...
Pold1Ratcolorectal cancer  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:21157497 more ...
Pold1Ratcolorectal cancer  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:21157497 more ...
Pold1Ratcolorectal cancer  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:21157497 more ...
Pold1RatColorectal Cancer 10  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10074927 more ...
Pold1Ratcombined immunodeficiency  ISOPOLD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Combined immunodeficiencyClinVarPMID:23770608 more ...
Pold1Ratendometrial carcinoma  ISOPOLD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Endometrial carcinomaClinVarPMID:12376507 more ...
Pold1Ratextrahepatic bile duct carcinoma  ISOPOLD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Extrahepatic bile duct cancerClinVarPMID:25741868 more ...
Pold1Ratfamilial adenomatous polyposis  ISOPOLD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Polymerase proofreading-related adenomatous polyposisClinVarPMID:25741868 more ...
Pold1RatHereditary Neoplastic Syndromes  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10074927 more ...
Pold1RatHereditary Neoplastic Syndromes  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10074927 more ...
Pold1RatHereditary Neoplastic Syndromes  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10074927 more ...
Pold1RatHereditary Neoplastic Syndromes  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10074927 more ...
Pold1RatHereditary Neoplastic Syndromes  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10074927 more ...
Pold1RatHereditary Neoplastic Syndromes  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10074927 more ...
Pold1RatHereditary Neoplastic Syndromes  ISOPOLD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10074927 more ...
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Original Reference(s)
Pold1RatColorectal Neoplasms  ISOPOLD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23263490
Pold1RatDeafness  ISOPOLD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23770608
Pold1RatEndometrial Neoplasms  ISOPOLD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23263490
Pold1Rathypogonadism  ISOPOLD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23770608
Pold1RatJaw Abnormalities  ISOPOLD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23770608
Pold1Ratlipodystrophy  ISOPOLD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23770608
Pold1RatMultiple Abnormalities  ISOPOLD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23770608

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Original Reference(s)
Pold1Rat1,2-dichloroethane increases expressionISOPold1 (Mus musculus)6480464ethylene dichloride results in increased expression of POLD1 mRNACTDPMID:28960355
Pold1Rat1,2-dimethylhydrazine increases expressionISOPold1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of POLD1 mRNACTDPMID:22206623
Pold1Rat17alpha-ethynylestradiol affects expressionISOPold1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of POLD1 mRNACTDPMID:17555576
Pold1Rat17alpha-ethynylestradiol multiple interactionsISOPold1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLD1 mRNACTDPMID:17942748
Pold1Rat17alpha-ethynylestradiol increases expressionISOPold1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of POLD1 mRNACTDPMID:17942748
Pold1Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of POLD1 mRNACTDPMID:32145629
Pold1Rat17beta-estradiol decreases expressionISOPold1 (Mus musculus)6480464Estradiol results in decreased expression of POLD1 mRNACTDPMID:39298647
Pold1Rat2,2',5,5'-tetrachlorobiphenyl decreases expressionISOPOLD1 (Homo sapiens)64804642 more ...CTDPMID:36804509
Pold1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPold1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLD1 mRNACTDPMID:17942748
Pold1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of POLD1 mRNACTDPMID:33387578
Pold1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPOLD1 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of POLD1 mRNACTDPMID:22574217
Pold1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPold1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of POLD1 mRNACTDPMID:21570461
Pold1Rat3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643 more ...CTDPMID:23196670
Pold1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOPOLD1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of POLD1 mRNACTDPMID:28628672
Pold1Rat4,4'-sulfonyldiphenol multiple interactionsISOPOLD1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of POLD1 mRNACTDPMID:28628672
Pold1Rat4,4'-sulfonyldiphenol decreases expressionISOPold1 (Mus musculus)6480464bisphenol S results in decreased expression of POLD1 mRNACTDPMID:39298647
Pold1Rat4-hydroperoxycyclophosphamide decreases expressionISOPold1 (Mus musculus)6480464perfosfamide results in decreased expression of POLD1 mRNACTDPMID:19429390
Pold1Rat4-hydroxynon-2-enal decreases expressionISOPOLD1 (Homo sapiens)64804644-hydroxy-2-nonenal results in decreased expression of POLD1 mRNACTDPMID:12419474
Pold1Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of POLD1 mRNACTDPMID:30047161
Pold1Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of POLD1 mRNACTDPMID:31881176

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Biological Process
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Original Reference(s)
Pold1Ratbase-excision repair, gap-filling involved_inISOPOLD1 (Homo sapiens)1624291 PMID:10559260 and PMID:10559261RGDPMID:10559260 and PMID:10559261
Pold1Ratbase-excision repair, gap-filling acts_upstream_of_or_withinIEAUniProtKB:P52431 and ensembl:ENSMUSP000000397761600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Ratbase-excision repair, gap-filling acts_upstream_of_or_withinISOPold1 (Mus musculus)1624291 PMID:15177179RGDPMID:15177179
Pold1Ratbase-excision repair, gap-filling involved_inIBAMGI:97741 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pold1Ratbase-excision repair, gap-filling involved_inIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Ratcellular response to UV involved_inISSUniProtKB:P283401600115GO_REF:0000024UniProtGO_REF:0000024
Pold1Ratcellular response to UV involved_inIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Ratcellular response to UV involved_inISOPOLD1 (Homo sapiens)1624291 PMID:24939902RGDPMID:24939902
Pold1RatDNA biosynthetic process  IMP 7247274 RGD 
Pold1RatDNA biosynthetic process involved_inIEAARBA:ARBA000285151600115GO_REF:0000117UniProtGO_REF:0000117
Pold1RatDNA biosynthetic process involved_inIEAUniProtKB:P52431 and ensembl:ENSMUSP000000397761600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1RatDNA biosynthetic process involved_inISOPold1 (Mus musculus)1624291 PMID:11595739RGDPMID:11595739
Pold1RatDNA biosynthetic process involved_inIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1RatDNA biosynthetic process involved_inISOPOLD1 (Homo sapiens)1624291 PMID:11595739RGDPMID:11595739
Pold1RatDNA damage response involved_inIEAUniProtKB-KW:KW-02271600115GO_REF:0000043UniProtGO_REF:0000043
Pold1RatDNA repair involved_inIEAUniProtKB-KW:KW-0228 and UniProtKB-KW:KW-02341600115GO_REF:0000043UniProtGO_REF:0000043
Pold1RatDNA repair involved_inIEAUniProtKB-KW:KW-02281600115GO_REF:0000043UniProtGO_REF:0000043
Pold1RatDNA replication  IDA 729526 RGD 
Pold1RatDNA replication involved_inIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1RatDNA replication involved_inIEAUniProtKB-KW:KW-02351600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component
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Pold1Rataggresome located_inIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Rataggresome located_inISOPOLD1 (Homo sapiens)1624291 RGDGO_REF:0000052
Pold1Ratchromosome, telomeric region located_inIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Ratchromosome, telomeric region located_inISOPOLD1 (Homo sapiens)1624291 PMID:24270157RGDPMID:24270157
Pold1Ratcytosol located_inISOPOLD1 (Homo sapiens)1624291 RGDGO_REF:0000052
Pold1Ratcytosol located_inIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Ratdelta DNA polymerase complex  ICGO:00038872307013 RGD 
Pold1Ratdelta DNA polymerase complex part_ofIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Ratdelta DNA polymerase complex part_ofIEAUniProtKB:P52431 and ensembl:ENSMUSP000000397761600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Ratdelta DNA polymerase complex part_ofISOPold1 (Mus musculus)1624291 PMID:11595739RGDPMID:11595739
Pold1Ratdelta DNA polymerase complex part_ofIBAFB:FBgn0263600 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pold1Ratdelta DNA polymerase complex part_ofIEAARBA:ARBA000288851600115GO_REF:0000117UniProtGO_REF:0000117
Pold1Ratdelta DNA polymerase complex part_ofISOPOLD1 (Homo sapiens)1624291 PMID:11595739 more ...RGDPMID:11595739 more ...
Pold1Ratdelta DNA polymerase complex part_ofISOComplexPortal:CPX-20971600115GO_REF:0000114ComplexPortalGO_REF:0000114
Pold1Ratdelta DNA polymerase complex  IDA 729526 RGD 
Pold1Ratnucleoplasm located_inIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Ratnucleoplasm located_inISOPOLD1 (Homo sapiens)1624291 RGDGO_REF:0000052
Pold1Ratnucleotide-excision repair complex part_ofIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Ratnucleotide-excision repair complex part_ofISOPOLD1 (Homo sapiens)1624291 PMID:20713449RGDPMID:20713449
Pold1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Pold1Rat3'-5' exonuclease activity enablesIEAUniProtKB:P52431 and ensembl:ENSMUSP000000397761600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Rat3'-5' exonuclease activity enablesISOPold1 (Mus musculus)1624291MGI:2447628 PMID:12429860RGDPMID:12429860
Pold1Rat3'-5'-DNA exonuclease activity enablesIBAFB:FBgn0263600 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pold1Rat4 iron, 4 sulfur cluster binding enablesIEAUniProtKB-KW:KW-00041600115GO_REF:0000043UniProtGO_REF:0000043
Pold1Ratchromatin binding enablesISSUniProtKB:P283401600115GO_REF:0000024UniProtGO_REF:0000024
Pold1Ratchromatin binding enablesISOPOLD1 (Homo sapiens)1624291 PMID:16762037 and PMID:24939902RGDPMID:16762037 and PMID:24939902
Pold1Ratchromatin binding enablesIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Ratdamaged DNA binding enablesIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1Ratdamaged DNA binding enablesISOPOLD1 (Homo sapiens)1624291 PMID:24939902RGDPMID:24939902
Pold1Ratdamaged DNA binding enablesISSUniProtKB:P283401600115GO_REF:0000024UniProtGO_REF:0000024
Pold1RatDNA binding enablesISOPOLD1 (Homo sapiens)1624291 PMID:16762037RGDPMID:16762037
Pold1RatDNA binding enablesIEAInterPro:IPR0061341600115GO_REF:0000002InterProGO_REF:0000002
Pold1RatDNA binding enablesIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Pold1RatDNA polymerase activity enablesIEARHEA:225081600115GO_REF:0000116RHEAGO_REF:0000116
Pold1RatDNA-directed DNA polymerase activity  IDA 2299945 RGD 
Pold1RatDNA-directed DNA polymerase activity  IMP 2307013 RGD 
Pold1RatDNA-directed DNA polymerase activity enablesIEAInterPro:IPR0061721600115GO_REF:0000002InterProGO_REF:0000002
Pold1RatDNA-directed DNA polymerase activity enablesIEAUniProtKB:P28340 and ensembl:ENSP000004060461600115GO_REF:0000107EnsemblGO_REF:0000107
Pold1RatDNA-directed DNA polymerase activity enablesIBAFB:FBgn0263600 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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RGD Manual Annotations


  
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Original Reference(s)
Pold1Ratmismatch repair pathway   ISOPOLD1 (Homo sapiens)2306716 RGD 
Pold1Ratnucleotide excision repair pathway   ISOPOLD1 (Homo sapiens)7246935 RGD 
Pold1Ratnucleotide excision repair pathway   IEA 1358139 RGD 

Imported Annotations - KEGG (archival)

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Pold1Ratbase excision repair pathway  IEA 6907045 KEGGrno:03410
Pold1RatDNA replication pathway  IEA 6907045 KEGGrno:03030
Pold1Rathomologous recombination pathway of double-strand break repair   IEA 6907045 KEGGrno:03440
Pold1Ratmismatch repair pathway   IEA 6907045 KEGGrno:03430
Pold1Ratnucleotide excision repair pathway   IEA 6907045 KEGGrno:03420
Pold1Ratpurine metabolic pathway  IEA 6907045 KEGGrno:00230
Pold1Ratpyrimidine metabolic pathway  IEA 6907045 KEGGrno:00240

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#
Reference Title
Reference Citation
1. Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*. Birkus G, etal., Antimicrob Agents Chemother. 2002 May;46(5):1610-3.
2. Evidence for reduced copying fidelity of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells. Fox G, etal., J Cancer Res Clin Oncol. 1997;123(11-12):659-68.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading. Goldsby RE, etal., Proc Natl Acad Sci U S A 2002 Nov 26;99(24):15560-5. Epub 2002 Nov 12.
6. DNA polymerases and repair synthesis in NER in human cells. Lehmann AR DNA Repair (Amst). 2011 Jul 15;10(7):730-3. doi: 10.1016/j.dnarep.2011.04.023. Epub 2011 May 20.
7. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
8. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. Lopez-Girona A, etal., Biochem Biophys Res Commun. 1995 Dec 14;217(2):566-74.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. A mutation detected in DNA polymerase delta cDNA from Novikoff hepatoma cells correlates with abnormal catalytic properties of the enzyme. Popanda O, etal., J Cancer Res Clin Oncol 1999 Nov;125(11):598-608.
14. DNA polymerases delta and epsilon in developing and aging rat brain. Prapurna DR and Rao KS, Int J Dev Neurosci. 1997 Feb;15(1):67-73.
15. Reactome: A Knowledgebase of Biological Processes Reactome
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. POLD1 and POLE Gene Mutations in Jewish Cohorts of Early-Onset Colorectal Cancer and of Multiple Colorectal Adenomas. Rosner G, etal., Dis Colon Rectum. 2018 Sep;61(9):1073-1079. doi: 10.1097/DCR.0000000000001150.
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PMID:1730053   PMID:3335506   PMID:10559260   PMID:10559261   PMID:11595739   PMID:15177179   PMID:16762037   PMID:19946888   PMID:20070946   PMID:20227374   PMID:20713449   PMID:22465957  
PMID:23770608   PMID:24115439   PMID:24191025   PMID:24270157   PMID:24939902  



Pold1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,161,984 - 104,178,074 (-)NCBIGRCr8
mRatBN7.2195,025,462 - 95,041,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,025,499 - 95,036,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,410,903 - 100,421,871 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,883,547 - 108,894,515 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,173,968 - 102,184,936 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,538,066 - 100,554,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,537,900 - 100,554,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,603,453 - 101,619,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,010,719 - 95,021,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,088,829 - 95,099,797 (-)NCBI
Celera189,287,965 - 89,298,931 (-)NCBICelera
Cytogenetic Map1q22NCBI
POLD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,384,323 - 50,418,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,384,204 - 50,418,018 (+)EnsemblGRCh38hg38GRCh38
GRCh371950,887,580 - 50,921,275 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,579,405 - 55,613,083 (+)NCBINCBI36Build 36hg18NCBI36
Build 341955,579,407 - 55,613,082NCBI
Celera1947,937,836 - 47,971,517 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1947,225,718 - 47,259,759 (+)NCBIHuRef
CHM1_11950,889,357 - 50,923,058 (+)NCBICHM1_1
T2T-CHM13v2.01953,471,875 - 53,505,574 (+)NCBIT2T-CHM13v2.0
Pold1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,182,168 - 44,198,239 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,182,170 - 44,198,273 (-)EnsemblGRCm39 Ensembl
GRCm38744,532,744 - 44,548,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,532,746 - 44,548,849 (-)EnsemblGRCm38mm10GRCm38
MGSCv37751,788,114 - 51,804,185 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,400,791 - 44,416,858 (-)NCBIMGSCv36mm8
Celera739,982,884 - 39,998,944 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.83NCBI
Pold1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955559712,321 - 725,661 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955559712,375 - 730,551 (-)NCBIChiLan1.0ChiLan1.0
POLD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22056,449,766 - 56,483,752 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,371,169 - 58,405,169 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,347,919 - 47,381,772 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,251,356 - 56,284,263 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,251,356 - 56,297,611 (+)Ensemblpanpan1.1panPan2
POLD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,302,583 - 106,331,353 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,302,574 - 106,331,385 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,875,694 - 105,904,437 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,813,663 - 106,842,434 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11106,485,820 - 106,514,537 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,127,322 - 106,156,071 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,967,996 - 106,996,721 (-)NCBIUU_Cfam_GSD_1.0
Pold1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,355,338 - 22,382,953 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889251,874 - 258,201 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936889231,373 - 250,987 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889231,373 - 250,985 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,247,880 - 55,272,085 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,247,799 - 55,272,087 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,096,669 - 51,120,965 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pold1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,117,341 - 4,135,035 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,117,597 - 4,135,092 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pold1
18 total Variants


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 95030903 95030904 C T snv SS/JrHsdMcwi (2019), SS/HsdMcwiCrl (2021), SS/JrHsdMcwi (2019NG), RCS/LavRrrcMcwi (2021), European Variation Archive Release 3, European Variation Archive Release 4, MR/NRrrc (2022), M520/NRrrcMcwi (2019), M520/N (2020), MR/N (2020), PVG/Seac (2019), M520/NRrrcMcwi (2019NG), European Variation Archive Release 6 View more Information


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 101608889 101608890 C T snv SS/JrHsdMcwi (MCW), MR/N (KNAW), SS/JrHsdMcwi (KNAW), KFRS3B/Kyo (KyushuU), RCS/Kyo (KyushuU), LEC/Tj (KyushuU), DOB/Oda (KyushuU), M520/N (KNAW) View more Information


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 100543502 100543503 C T snv CDS, SS/JrHsdMcwi (MCW), M520/N (MCW), MR/N (MCW), SS/JrHsdMcwi (2019), M520/NRrrcMcwi (2019), M520/N (2020), MR/N (2020), PVG/Seac (2019), SS/JrHsdMcwi (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:140
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000026797
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 45 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat

1 to 10 of 45 rows
RH144354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,028,872 - 95,029,168 (+)MAPPERmRatBN7.2
Rnor_6.01100,541,472 - 100,541,767NCBIRnor6.0
Rnor_5.01101,606,859 - 101,607,154UniSTSRnor5.0
RGSC_v3.4195,014,093 - 95,014,388UniSTSRGSC3.4
Celera189,291,339 - 89,291,634UniSTS
RH 3.4 Map1903.69UniSTS
Cytogenetic Map1q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000026797   ⟹   ENSRNOP00000026797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,025,499 - 95,036,465 (-)Ensembl
Rnor_6.0 Ensembl1100,537,900 - 100,554,488 (-)Ensembl
RefSeq Acc Id: NM_021662   ⟹   NP_067694
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,162,016 - 104,172,982 (-)NCBI
mRatBN7.2195,025,499 - 95,036,465 (-)NCBI
Rnor_6.01100,538,098 - 100,549,064 (-)NCBI
Rnor_5.01101,603,453 - 101,619,471 (-)NCBI
RGSC_v3.4195,010,719 - 95,021,686 (-)RGD
Celera189,287,965 - 89,298,931 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229142   ⟹   XP_006229204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,161,984 - 104,178,074 (-)NCBI
mRatBN7.2195,025,462 - 95,041,559 (-)NCBI
Rnor_6.01100,538,066 - 100,554,105 (-)NCBI
Rnor_5.01101,603,453 - 101,619,471 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272283   ⟹   XP_063128353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,161,984 - 104,177,938 (-)NCBI
RefSeq Acc Id: NP_067694   ⟸   NM_021662
- UniProtKB: O54747 (UniProtKB/Swiss-Prot),   A6JAQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229204   ⟸   XM_006229142
- Peptide Label: isoform X1
- UniProtKB: G3V8M1 (UniProtKB/TrEMBL),   A6JAQ6 (UniProtKB/TrEMBL),   A6JAQ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026797   ⟸   ENSRNOT00000026797
RefSeq Acc Id: XP_063128353   ⟸   XM_063272283
- Peptide Label: isoform X1
- UniProtKB: A6JAQ6 (UniProtKB/TrEMBL),   G3V8M1 (UniProtKB/TrEMBL),   A6JAQ5 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-O54747-F1-model_v2 AlphaFold O54747 1-1103 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-59763 BioCyc
Ensembl Genes ENSRNOG00000019681 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026797 ENTREZGENE
Gene3D-CATH 1.10.132.60 UniProtKB/Swiss-Prot
  3.30.420.10 UniProtKB/Swiss-Prot
  3.90.1600.10 UniProtKB/Swiss-Prot
  6.10.140.1540 UniProtKB/Swiss-Prot
  DNA Polymerase, chain B, domain 1 UniProtKB/Swiss-Prot
  Helix hairpin bin UniProtKB/Swiss-Prot
InterPro DNA-dir_DNA_pol_B UniProtKB/Swiss-Prot
  DNA-dir_DNA_pol_B_CS UniProtKB/Swiss-Prot
  DNA-dir_DNA_pol_B_exonuc UniProtKB/Swiss-Prot
  DNA-dir_DNA_pol_B_multi_dom UniProtKB/Swiss-Prot
  DNA/RNA_pol_sf UniProtKB/Swiss-Prot
  DNA_pol_B_C UniProtKB/Swiss-Prot
  DNA_pol_palm_dom_sf UniProtKB/Swiss-Prot
  DNA_pol_type-B UniProtKB/Swiss-Prot
  RNaseH-like_sf UniProtKB/Swiss-Prot
  RNaseH_sf UniProtKB/Swiss-Prot
  Znf-C4pol UniProtKB/Swiss-Prot
KEGG Report rno:59294 UniProtKB/Swiss-Prot
NCBI Gene 59294 ENTREZGENE
PANTHER DNA POLYMERASE CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
  DNA POLYMERASE DELTA CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
Pfam DNA_pol_B UniProtKB/Swiss-Prot
  DNA_pol_B_exo1 UniProtKB/Swiss-Prot
  zf-C4pol UniProtKB/Swiss-Prot
PhenoGen Pold1 PhenoGen
PRINTS DNAPOLB UniProtKB/Swiss-Prot
PROSITE DNA_POLYMERASE_B UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019681 RatGTEx
SMART POLBc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53098 UniProtKB/Swiss-Prot
  SSF56672 UniProtKB/Swiss-Prot
UniProt A6JAQ5 ENTREZGENE, UniProtKB/TrEMBL
  A6JAQ6 ENTREZGENE, UniProtKB/TrEMBL
  A6JAQ9_RAT UniProtKB/TrEMBL
  A6JAR0_RAT UniProtKB/TrEMBL
  DPOD1_RAT UniProtKB/Swiss-Prot
  G3V8M1 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-29 Pold1  DNA polymerase delta 1, catalytic subunit  Pold1  DAN polymerase delta 1, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-21 Pold1  DAN polymerase delta 1, catalytic subunit  Pold1  polymerase (DNA) delta 1, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Pold1  polymerase (DNA) delta 1, catalytic subunit  Pold1  polymerase (DNA directed), delta 1, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pold1  polymerase (DNA directed), delta 1, catalytic subunit    DNA polymerase delta, catalytic subunit  Name updated 1299863 APPROVED
2002-08-07 Pold1  DNA polymerase delta, catalytic subunit      Symbol and Name status set to provisional 70820 PROVISIONAL