Pold1 (DNA polymerase delta 1, catalytic subunit) - Rat Genome Database

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Gene: Pold1 (DNA polymerase delta 1, catalytic subunit) Rattus norvegicus
Analyze
Symbol: Pold1
Name: DNA polymerase delta 1, catalytic subunit
RGD ID: 621839
Description: Enables DNA-directed DNA polymerase activity. Involved in DNA biosynthetic process and DNA-templated DNA replication. Part of delta DNA polymerase complex. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; base excision repair pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3'-5' exodeoxyribonuclease; DAN polymerase delta 1, catalytic subunit; DNA polymerase delta catalytic subunit; DNA polymerase delta, catalytic subunit; DNA-directed DNA polymerase delta 1; polymerase (DNA directed), delta 1, catalytic subunit; polymerase (DNA) delta 1, catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,161,984 - 104,178,074 (-)NCBIGRCr8
mRatBN7.2195,025,462 - 95,041,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,025,499 - 95,036,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,410,903 - 100,421,871 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,883,547 - 108,894,515 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,173,968 - 102,184,936 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,538,066 - 100,554,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,537,900 - 100,554,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,603,453 - 101,619,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,010,719 - 95,021,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,088,829 - 95,099,797 (-)NCBI
Celera189,287,965 - 89,298,931 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
Aflatoxin B2 alpha  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
furan  (EXP)
guanine  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
miconazole  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
progesterone  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*. Birkus G, etal., Antimicrob Agents Chemother. 2002 May;46(5):1610-3.
2. Evidence for reduced copying fidelity of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells. Fox G, etal., J Cancer Res Clin Oncol. 1997;123(11-12):659-68.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading. Goldsby RE, etal., Proc Natl Acad Sci U S A 2002 Nov 26;99(24):15560-5. Epub 2002 Nov 12.
6. DNA polymerases and repair synthesis in NER in human cells. Lehmann AR DNA Repair (Amst). 2011 Jul 15;10(7):730-3. doi: 10.1016/j.dnarep.2011.04.023. Epub 2011 May 20.
7. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
8. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. Lopez-Girona A, etal., Biochem Biophys Res Commun. 1995 Dec 14;217(2):566-74.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. A mutation detected in DNA polymerase delta cDNA from Novikoff hepatoma cells correlates with abnormal catalytic properties of the enzyme. Popanda O, etal., J Cancer Res Clin Oncol 1999 Nov;125(11):598-608.
14. DNA polymerases delta and epsilon in developing and aging rat brain. Prapurna DR and Rao KS, Int J Dev Neurosci. 1997 Feb;15(1):67-73.
15. Reactome: A Knowledgebase of Biological Processes Reactome
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. POLD1 and POLE Gene Mutations in Jewish Cohorts of Early-Onset Colorectal Cancer and of Multiple Colorectal Adenomas. Rosner G, etal., Dis Colon Rectum. 2018 Sep;61(9):1073-1079. doi: 10.1097/DCR.0000000000001150.
21. POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East. Siraj AK, etal., Mol Genet Genomic Med. 2020 Aug;8(8):e1368. doi: 10.1002/mgg3.1368. Epub 2020 Jun 22.
22. Single nucleotide polymorphisms of nucleotide excision repair pathway are significantly associated with outcomes of platinum-based chemotherapy in lung cancer. Song X, etal., Sci Rep. 2017 Sep 18;7(1):11785. doi: 10.1038/s41598-017-08257-7.
Additional References at PubMed
PMID:1730053   PMID:3335506   PMID:10559260   PMID:10559261   PMID:11595739   PMID:15177179   PMID:16762037   PMID:19946888   PMID:20070946   PMID:20227374   PMID:20713449   PMID:22465957  
PMID:23770608   PMID:24115439   PMID:24191025   PMID:24270157   PMID:24939902  


Genomics

Comparative Map Data
Pold1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,161,984 - 104,178,074 (-)NCBIGRCr8
mRatBN7.2195,025,462 - 95,041,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,025,499 - 95,036,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,410,903 - 100,421,871 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,883,547 - 108,894,515 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,173,968 - 102,184,936 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,538,066 - 100,554,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,537,900 - 100,554,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,603,453 - 101,619,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,010,719 - 95,021,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,088,829 - 95,099,797 (-)NCBI
Celera189,287,965 - 89,298,931 (-)NCBICelera
Cytogenetic Map1q22NCBI
POLD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,384,323 - 50,418,018 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,384,204 - 50,418,018 (+)EnsemblGRCh38hg38GRCh38
GRCh371950,887,580 - 50,921,275 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,579,405 - 55,613,083 (+)NCBINCBI36Build 36hg18NCBI36
Build 341955,579,407 - 55,613,082NCBI
Celera1947,937,836 - 47,971,517 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1947,225,718 - 47,259,759 (+)NCBIHuRef
CHM1_11950,889,357 - 50,923,058 (+)NCBICHM1_1
T2T-CHM13v2.01953,471,875 - 53,505,574 (+)NCBIT2T-CHM13v2.0
Pold1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,182,168 - 44,198,239 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,182,170 - 44,198,273 (-)EnsemblGRCm39 Ensembl
GRCm38744,532,744 - 44,548,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,532,746 - 44,548,849 (-)EnsemblGRCm38mm10GRCm38
MGSCv37751,788,114 - 51,804,185 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,400,791 - 44,416,858 (-)NCBIMGSCv36mm8
Celera739,982,884 - 39,998,944 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.83NCBI
Pold1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955559712,321 - 725,661 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955559712,375 - 730,551 (-)NCBIChiLan1.0ChiLan1.0
POLD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22056,449,766 - 56,483,752 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11958,371,169 - 58,405,169 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,347,919 - 47,381,772 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,251,356 - 56,284,263 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,251,356 - 56,297,611 (+)Ensemblpanpan1.1panPan2
POLD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,302,583 - 106,331,353 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,302,574 - 106,331,385 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,875,694 - 105,904,437 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,813,663 - 106,842,434 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11106,485,820 - 106,514,537 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,127,322 - 106,156,071 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,967,996 - 106,996,721 (-)NCBIUU_Cfam_GSD_1.0
Pold1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,355,338 - 22,382,953 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889251,874 - 258,201 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_004936889231,373 - 250,987 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889231,373 - 250,985 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,247,880 - 55,272,085 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,247,799 - 55,272,087 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,096,669 - 51,120,965 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pold1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,117,341 - 4,135,035 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,117,597 - 4,135,092 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pold1
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:140
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000026797
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat

Markers in Region
RH144354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,028,872 - 95,029,168 (+)MAPPERmRatBN7.2
Rnor_6.01100,541,472 - 100,541,767NCBIRnor6.0
Rnor_5.01101,606,859 - 101,607,154UniSTSRnor5.0
RGSC_v3.4195,014,093 - 95,014,388UniSTSRGSC3.4
Celera189,291,339 - 89,291,634UniSTS
RH 3.4 Map1903.69UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026797   ⟹   ENSRNOP00000026797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,025,499 - 95,036,465 (-)Ensembl
Rnor_6.0 Ensembl1100,537,900 - 100,554,488 (-)Ensembl
RefSeq Acc Id: NM_021662   ⟹   NP_067694
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,162,016 - 104,172,982 (-)NCBI
mRatBN7.2195,025,499 - 95,036,465 (-)NCBI
Rnor_6.01100,538,098 - 100,549,064 (-)NCBI
Rnor_5.01101,603,453 - 101,619,471 (-)NCBI
RGSC_v3.4195,010,719 - 95,021,686 (-)RGD
Celera189,287,965 - 89,298,931 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229142   ⟹   XP_006229204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,161,984 - 104,178,074 (-)NCBI
mRatBN7.2195,025,462 - 95,041,559 (-)NCBI
Rnor_6.01100,538,066 - 100,554,105 (-)NCBI
Rnor_5.01101,603,453 - 101,619,471 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272283   ⟹   XP_063128353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,161,984 - 104,177,938 (-)NCBI
RefSeq Acc Id: NP_067694   ⟸   NM_021662
- UniProtKB: O54747 (UniProtKB/Swiss-Prot),   A6JAQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229204   ⟸   XM_006229142
- Peptide Label: isoform X1
- UniProtKB: G3V8M1 (UniProtKB/TrEMBL),   A6JAQ6 (UniProtKB/TrEMBL),   A6JAQ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026797   ⟸   ENSRNOT00000026797
RefSeq Acc Id: XP_063128353   ⟸   XM_063272283
- Peptide Label: isoform X1
- UniProtKB: A6JAQ6 (UniProtKB/TrEMBL),   G3V8M1 (UniProtKB/TrEMBL)
Protein Domains
C4-type zinc-finger of DNA polymerase delta   DNA-directed DNA polymerase family B   DNA-directed DNA polymerase family B exonuclease

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54747-F1-model_v2 AlphaFold O54747 1-1103 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621839 AgrOrtholog
BioCyc Gene G2FUF-59763 BioCyc
Ensembl Genes ENSRNOG00000019681 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026797.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.132.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1600.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.1540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA Polymerase, chain B, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA-dir_DNA_pol_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_DNA_pol_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_DNA_pol_B_exonuc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_DNA_pol_B_multi_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA/RNA_pol_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_pol_B_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_pol_palm_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_pol_type-B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf-C4pol UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59294 UniProtKB/Swiss-Prot
NCBI Gene 59294 ENTREZGENE
PANTHER DNA POLYMERASE CATALYTIC SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA POLYMERASE DELTA CATALYTIC SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DNA_pol_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_pol_B_exo1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4pol UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pold1 PhenoGen
PRINTS DNAPOLB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DNA_POLYMERASE_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019681 RatGTEx
SMART POLBc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56672 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JAQ5 ENTREZGENE, UniProtKB/TrEMBL
  A6JAQ6 ENTREZGENE, UniProtKB/TrEMBL
  A6JAQ9_RAT UniProtKB/TrEMBL
  A6JAR0_RAT UniProtKB/TrEMBL
  DPOD1_RAT UniProtKB/Swiss-Prot
  G3V8M1 ENTREZGENE, UniProtKB/TrEMBL
  O54747 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-29 Pold1  DNA polymerase delta 1, catalytic subunit  Pold1  DAN polymerase delta 1, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-21 Pold1  DAN polymerase delta 1, catalytic subunit  Pold1  polymerase (DNA) delta 1, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Pold1  polymerase (DNA) delta 1, catalytic subunit  Pold1  polymerase (DNA directed), delta 1, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pold1  polymerase (DNA directed), delta 1, catalytic subunit    DNA polymerase delta, catalytic subunit  Name updated 1299863 APPROVED
2002-08-07 Pold1  DNA polymerase delta, catalytic subunit      Symbol and Name status set to provisional 70820 PROVISIONAL