Myoc (myocilin) - Rat Genome Database

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Gene: Myoc (myocilin) Rattus norvegicus
Analyze
Symbol: Myoc
Name: myocilin
RGD ID: 620430
Description: Predicted to enable fibronectin binding activity; myosin light chain binding activity; and signaling receptor binding activity. Involved in cellular response to nerve growth factor stimulus and nerve development. Located in Schmidt-Lanterman incisure; mesaxon; and myelin sheath abaxonal region. Biomarker of membranoproliferative glomerulonephritis and ocular hypertension. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Orthologous to human MYOC (myocilin); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: myocilin, trabecular meshwork inducible glucocorticoid response; Tigr; trabecular meshwork-induced glucocorticoid response protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,509,963 - 77,520,361 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1377,509,963 - 77,520,361 (+)EnsemblGRCr8
mRatBN7.21374,976,730 - 74,987,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,976,730 - 74,987,127 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1377,554,373 - 77,564,765 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,858,850 - 78,869,297 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,118,721 - 76,129,168 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,517,531 - 80,527,928 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,517,536 - 80,527,928 (+)Ensemblrn6Rnor6.0
Rnor_5.01385,409,611 - 85,420,008 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41378,303,830 - 78,314,228 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1374,726,592 - 74,736,986 (+)NCBICelera
RGSC_v3.11378,318,017 - 78,328,415 (+)NCBI
Cytogenetic Map13q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Variations in the myocilin gene in patients with open-angle glaucoma. Alward WL, etal., Arch Ophthalmol. 2002 Sep;120(9):1189-97.
2. Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A) Alward WL, etal., N Engl J Med. 1998 Apr 9;338(15):1022-7.
3. A molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein response. Anholt RR and Carbone MA, Trends Mol Med. 2013 Oct;19(10):586-93. doi: 10.1016/j.molmed.2013.06.005. Epub 2013 Jul 19.
4. The novel Y371D myocilin mutation causes an aggressive form of juvenile open-angle glaucoma in a Caucasian family from the Middle-East. Avisar I, etal., Mol Vis. 2009 Sep 24;15:1945-50.
5. Comprehensive analysis of myocilin variants in east Indian POAG patients. Banerjee D, etal., Mol Vis. 2012;18:1548-57. Epub 2012 Jun 13.
6. New mutation in the myocilin gene segregates with juvenile-onset open-angle glaucoma in a Brazilian family. Braghini CA, etal., Gene. 2013 Jul 1;523(1):50-7. doi: 10.1016/j.gene.2013.02.054. Epub 2013 Apr 5.
7. Mutations in the myocilin gene in families with primary open-angle glaucoma and juvenile open-angle glaucoma. Bruttini M, etal., Arch Ophthalmol. 2003 Jul;121(7):1034-8.
8. MYOC gene mutations in Spanish patients with autosomal dominant primary open-angle glaucoma: a founder effect in southeast Spain. Campos-Mollo E, etal., Mol Vis. 2007 Sep 13;13:1666-73.
9. Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of primary open-angle glaucoma. Chen J, etal., Mol Vis. 2011;17:1431-5. Epub 2011 May 31.
10. Association of a single nucleotide polymorphism in the TIGR/MYOCILIN gene promoter with the severity of primary open-angle glaucoma. Colomb E, etal., Clin Genet. 2001 Sep;60(3):220-5.
11. Novel myocilin mutation in a Chinese family with juvenile-onset open-angle glaucoma. Fan BJ, etal., Arch Ophthalmol. 2006 Jan;124(1):102-6.
12. SNPs and interaction analyses of myocilin, optineurin, and apolipoprotein E in primary open angle glaucoma patients. Fan BJ, etal., Mol Vis. 2005 Aug 29;11:625-31.
13. Founder TIGR/myocilin mutations for glaucoma in the Quebec population. Faucher M, etal., Hum Mol Genet. 2002 Sep 1;11(18):2077-90.
14. Analysis of myocilin mutations in 1703 glaucoma patients from five different populations. Fingert JH, etal., Hum Mol Genet. 1999 May;8(5):899-905.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Myocilin is expressed in the glomerulus of the kidney and induced in mesangioproliferative glomerulonephritis. Goldwich A, etal., Kidney Int. 2005 Jan;67(1):140-51.
18. The optic nerve head in myocilin glaucoma. Hewitt AW, etal., Invest Ophthalmol Vis Sci. 2007 Jan;48(1):238-43.
19. Myocilin levels in primary open-angle glaucoma and pseudoexfoliation glaucoma human aqueous humor. Howell KG, etal., J Glaucoma. 2010 Dec;19(9):569-75. doi: 10.1097/IJG.0b013e3181d13020.
20. Correction of the disease phenotype of myocilin-causing glaucoma by a natural osmolyte. Jia LY, etal., Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3743-9. doi: 10.1167/iovs.08-3151. Epub 2009 Feb 21.
21. Multiple gene polymorphisms analysis revealed a different profile of genetic polymorphisms of primary open-angle glaucoma in northern Chinese. Jia LY, etal., Mol Vis. 2009;15:89-98. Epub 2009 Jan 16.
22. TIGR is upregulated in the chronic glial scar in response to central nervous system injury and inhibits neurite outgrowth. Jurynec MJ, etal., Mol Cell Neurosci. 2003 May;23(1):69-80.
23. A de novo MYOC mutation detected in juvenile open angle glaucoma associated with reduced myocilin protein in aqueous humor. Kuchtey J, etal., Eur J Med Genet. 2013 Jun;56(6):292-6. doi: 10.1016/j.ejmg.2013.03.002. Epub 2013 Mar 19.
24. Triamcinolone acetonide decreases outflow facility in C57BL/6 mouse eyes. Kumar S, etal., Invest Ophthalmol Vis Sci. 2013 Feb 1;54(2):1280-7. doi: 10.1167/iovs.12-11223.
25. Low prevalence of myocilin mutations in an African American population with primary open-angle glaucoma. Liu W, etal., Mol Vis. 2012;18:2241-6. Epub 2012 Aug 10.
26. Novel and known MYOC exon 3 mutations in an admixed Peruvian primary open-angle glaucoma population. Mendoza-Reinoso V, etal., Mol Vis. 2012;18:2067-75. Epub 2012 Aug 8.
27. Presence of myocilin sequence variants in Japanese patients with open-angle glaucoma. Mengkegale M, etal., Mol Vis. 2008 Mar 4;14:413-7.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. Novel mutations in the MYOC/GLC1A gene in a large group of glaucoma patients. Michels-Rautenstrauss K, etal., Hum Mutat. 2002 Dec;20(6):479-80.
30. Mutations in MYOC gene of Indian primary open angle glaucoma patients. Mukhopadhyay A, etal., Mol Vis. 2002 Nov 15;8:442-8.
31. Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure. Naskar R and Thanos S, Mol Vis. 2006 Oct 18;12:1199-210.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Secreted glycoprotein myocilin is a component of the myelin sheath in peripheral nerves. Ohlmann A, etal., Glia. 2003 Aug;43(2):128-40.
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. Interaction between two glaucoma genes, optineurin and myocilin. Park BC, etal., Genes Cells. 2007 Aug;12(8):969-79.
36. A large GLC1C Greek family with a myocilin T377M mutation: inheritance and phenotypic variability. Petersen MB, etal., Invest Ophthalmol Vis Sci. 2006 Feb;47(2):620-5.
37. New mutation in the MYOC gene and its association with primary open-angle glaucoma in a Chinese family. Qu X, etal., Mol Biol Rep. 2010 Jan;37(1):255-61. doi: 10.1007/s11033-009-9667-3. Epub 2009 Aug 18.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Comprehensive gene review and curation RGD comprehensive gene curation
42. Mutations including the promoter region of myocilin/TIGR gene. Saura M, etal., Eur J Hum Genet. 2005 Mar;13(3):384-7.
43. Higher prevalence of myocilin mutations in advanced glaucoma in comparison with less advanced disease in an Australasian disease registry. Souzeau E, etal., Ophthalmology. 2013 Jun;120(6):1135-43. doi: 10.1016/j.ophtha.2012.11.029. Epub 2013 Feb 28.
44. Identification of a gene that causes primary open angle glaucoma. Stone EM, etal., Science. 1997 Jan 31;275(5300):668-70.
45. Molecular cloning and expression profile of rat myocilin. Taguchi M, etal., Mol Genet Metab 2000 May;70(1):75-80.
46. The novel heterozygous Thr377Arg MYOC mutation causes severe Juvenile Open Angle Glaucoma in a large Pakistani family. Waryah AM, etal., Gene. 2013 Oct 10;528(2):356-9. doi: 10.1016/j.gene.2013.07.016. Epub 2013 Jul 23.
47. Prevalence of mutations in TIGR/Myocilin in patients with adult and juvenile primary open-angle glaucoma. Wiggs JL, etal., Am J Hum Genet. 1998 Nov;63(5):1549-52.
48. Association of POAG risk factors and the Thr377Met MYOC mutation in an isolated Greek population. Wirtz MK, etal., Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3055-60. doi: 10.1167/iovs.09-4652. Epub 2010 Jan 27.
49. Identification of mutations in the myocilin (MYOC) gene in Taiwanese patients with juvenile-onset open-angle glaucoma. Yen YC, etal., Mol Vis. 2007 Sep 10;13:1627-34.
50. Identification a novel MYOC gene mutation in a Chinese family with juvenile-onset open angle glaucoma. Zhao X, etal., Mol Vis. 2010 Aug 25;16:1728-35.
51. Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice. Zillig M, etal., Invest Ophthalmol Vis Sci. 2005 Jan;46(1):223-34.
52. Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma. Zode GS, etal., Invest Ophthalmol Vis Sci. 2012 Mar 21;53(3):1557-65. doi: 10.1167/iovs.11-8837. Print 2012 Mar.
Additional References at PubMed
PMID:11053284   PMID:11431441   PMID:11726618   PMID:11773026   PMID:11773029   PMID:12019210   PMID:16020952   PMID:16392033   PMID:17317787   PMID:17516541   PMID:17984096   PMID:18855004  
PMID:19188438   PMID:19959812   PMID:21362503   PMID:21656515   PMID:22206666   PMID:22371502   PMID:23533145   PMID:23629661   PMID:23897819   PMID:30945300  


Genomics

Comparative Map Data
Myoc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,509,963 - 77,520,361 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1377,509,963 - 77,520,361 (+)EnsemblGRCr8
mRatBN7.21374,976,730 - 74,987,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,976,730 - 74,987,127 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1377,554,373 - 77,564,765 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,858,850 - 78,869,297 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,118,721 - 76,129,168 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,517,531 - 80,527,928 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,517,536 - 80,527,928 (+)Ensemblrn6Rnor6.0
Rnor_5.01385,409,611 - 85,420,008 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41378,303,830 - 78,314,228 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1374,726,592 - 74,736,986 (+)NCBICelera
RGSC_v3.11378,318,017 - 78,328,415 (+)NCBI
Cytogenetic Map13q22NCBI
MYOC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,635,417 - 171,652,688 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,635,417 - 171,652,688 (-)Ensemblhg38GRCh38
GRCh371171,604,557 - 171,621,828 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,871,180 - 169,888,396 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341168,336,215 - 168,353,430NCBI
Celera1144,713,951 - 144,731,166 (-)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,827,834 - 142,845,046 (-)NCBIHuRef
CHM1_11173,026,640 - 173,043,840 (-)NCBICHM1_1
T2T-CHM13v2.01170,991,882 - 171,009,153 (-)NCBIT2T-CHM13v2.0
Myoc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,466,719 - 162,477,263 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,466,724 - 162,477,262 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381162,639,150 - 162,649,694 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,639,155 - 162,649,693 (+)Ensemblmm10GRCm38
MGSCv371164,569,281 - 164,579,825 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361164,475,844 - 164,486,368 (+)NCBIMGSCv36mm8
Celera1165,085,895 - 165,096,434 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.29NCBI
Myoc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540612,182,046 - 12,199,669 (-)Ensembl
ChiLan1.0NW_00495540612,182,115 - 12,194,683 (-)NCBIChiLan1.0ChiLan1.0
MYOC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,104,233 - 78,121,545 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1177,778,772 - 77,797,111 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,128,541 - 147,146,227 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,841,630 - 150,858,628 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,841,630 - 150,858,628 (-)EnsemblpanPan2panpan1.1
MYOC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,335,314 - 27,346,821 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,335,314 - 27,346,820 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha726,857,046 - 26,868,545 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0727,136,587 - 27,148,065 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,136,391 - 27,148,079 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1726,988,106 - 26,999,596 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,022,462 - 27,033,986 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,264,790 - 27,276,291 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Myoc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934497,697,971 - 97,710,064 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648115,544,660 - 15,556,857 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648115,544,733 - 15,556,813 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9114,087,378 - 114,098,745 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19114,087,370 - 114,098,765 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,551,261 - 125,562,662 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYOC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,458,615 - 57,475,329 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,459,374 - 57,475,322 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605559,088,230 - 59,104,345 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myoc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477110,065,788 - 10,080,680 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477110,066,170 - 10,080,257 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Myoc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11041,900,497 - 41,911,292 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Myoc
90 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:292
Count of miRNA genes:186
Interacting mature miRNAs:214
Transcripts:ENSRNOT00000004386
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
PMC48141P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21374,985,700 - 74,986,475 (+)MAPPERmRatBN7.2
Rnor_6.01380,526,501 - 80,527,275NCBIRnor6.0
Rnor_5.01385,418,581 - 85,419,355UniSTSRnor5.0
RGSC_v3.41378,312,801 - 78,313,575UniSTSRGSC3.4
Celera1374,735,559 - 74,736,333UniSTS
Cytogenetic Map13q22UniSTS
PMC48141P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21374,986,275 - 74,986,475 (+)MAPPERmRatBN7.2
Rnor_6.01380,527,076 - 80,527,275NCBIRnor6.0
Rnor_5.01385,425,978 - 85,426,177UniSTSRnor5.0
Rnor_5.01385,419,156 - 85,419,355UniSTSRnor5.0
RGSC_v3.41378,313,376 - 78,313,575UniSTSRGSC3.4
Celera1374,736,134 - 74,736,333UniSTS
Cytogenetic Map13q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 12 46 124 50 48 18 39 18 6 186 118 11 99 30 69 30 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000004386   ⟹   ENSRNOP00000004386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1377,509,963 - 77,520,361 (+)Ensembl
mRatBN7.2 Ensembl1374,976,730 - 74,987,127 (+)Ensembl
Rnor_6.0 Ensembl1380,517,536 - 80,527,928 (+)Ensembl
RefSeq Acc Id: NM_030865   ⟹   NP_110492
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,509,963 - 77,520,361 (+)NCBI
mRatBN7.21374,976,730 - 74,987,128 (+)NCBI
Rnor_6.01380,517,531 - 80,527,928 (+)NCBI
Rnor_5.01385,409,611 - 85,420,008 (+)NCBI
RGSC_v3.41378,303,830 - 78,314,228 (+)RGD
Celera1374,726,592 - 74,736,986 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_110492 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD46401 (Get FASTA)   NCBI Sequence Viewer  
  AAK83081 (Get FASTA)   NCBI Sequence Viewer  
  BAA34199 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004386
GenBank Protein Q9R1J4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_110492   ⟸   NM_030865
- Peptide Label: precursor
- UniProtKB: Q9Z2Y4 (UniProtKB/Swiss-Prot),   Q9R1J4 (UniProtKB/Swiss-Prot),   G3V6E8 (UniProtKB/TrEMBL),   A6ID98 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004386   ⟸   ENSRNOT00000004386
Protein Domains
Olfactomedin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1J4-F1-model_v2 AlphaFold Q9R1J4 1-502 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698941
Promoter ID:EPDNEW_R9466
Type:single initiation site
Name:Myoc_1
Description:myocilin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01380,517,532 - 80,517,592EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620430 AgrOrtholog
BioCyc Gene G2FUF-17644 BioCyc
Ensembl Genes ENSRNOG00000003221 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000004386 ENTREZGENE
InterPro Olfac-like_dom UniProtKB/Swiss-Prot
  Olfactomedin-like_domain UniProtKB/Swiss-Prot
KEGG Report rno:81523 UniProtKB/Swiss-Prot
NCBI Gene 81523 ENTREZGENE
PANTHER OLFACTOMEDIN-RELATED UniProtKB/Swiss-Prot
  PTHR23192:SF33 UniProtKB/Swiss-Prot
Pfam OLF UniProtKB/Swiss-Prot
PhenoGen Myoc PhenoGen
PROSITE OLF UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003221 RatGTEx
SMART OLF UniProtKB/Swiss-Prot
UniProt A6ID98 ENTREZGENE, UniProtKB/TrEMBL
  G3V6E8 ENTREZGENE, UniProtKB/TrEMBL
  MYOC_RAT UniProtKB/Swiss-Prot
  Q924K5_RAT UniProtKB/TrEMBL
  Q9R1J4 ENTREZGENE
  Q9Z2Y4 ENTREZGENE
UniProt Secondary Q9Z2Y4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-17 Myoc  myocilin  Myoc  myocilin, trabecular meshwork inducible glucocorticoid response  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-22 Myoc  myocilin, trabecular meshwork inducible glucocorticoid response  Myoc  myocilin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Myoc  myocilin      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Myoc  myocilin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a myosin-like domain and an olfactmedin-like domain 633384
gene_expression expressed in retina, thyroid gland and skeletal muscle 633384