MYOC (myocilin) - Rat Genome Database

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Gene: MYOC (myocilin) Canis lupus familiaris
Analyze
Symbol: MYOC
Name: myocilin
RGD ID: 12340413
Description: ENCODES a protein that exhibits fibronectin binding (inferred); frizzled binding (inferred); metal ion binding (inferred); INVOLVED IN bone development (ortholog); cellular response to nerve growth factor stimulus (ortholog); clustering of voltage-gated sodium channels (ortholog); ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); autoimmune lymphoproliferative syndrome (ortholog); Brain Injuries (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); cytoplasmic vesicle (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,335,314 - 27,346,821 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,335,314 - 27,346,820 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha726,857,046 - 26,868,545 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,136,587 - 27,148,065 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,136,391 - 27,148,079 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1726,988,106 - 26,999,596 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,022,462 - 27,033,986 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,264,790 - 27,276,291 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:17149370   PMID:17973835   PMID:18435660   PMID:18638349   PMID:30032202  


Genomics

Comparative Map Data
MYOC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,335,314 - 27,346,821 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,335,314 - 27,346,820 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha726,857,046 - 26,868,545 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,136,587 - 27,148,065 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,136,391 - 27,148,079 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1726,988,106 - 26,999,596 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,022,462 - 27,033,986 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,264,790 - 27,276,291 (+)NCBIUU_Cfam_GSD_1.0
MYOC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,635,417 - 171,652,688 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,635,417 - 171,652,688 (-)EnsemblGRCh38hg38GRCh38
GRCh371171,604,557 - 171,621,828 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,871,180 - 169,888,396 (-)NCBINCBI36Build 36hg18NCBI36
Build 341168,336,215 - 168,353,430NCBI
Celera1144,713,951 - 144,731,166 (-)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,827,834 - 142,845,046 (-)NCBIHuRef
CHM1_11173,026,640 - 173,043,840 (-)NCBICHM1_1
T2T-CHM13v2.01170,991,882 - 171,009,153 (-)NCBIT2T-CHM13v2.0
Myoc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,466,719 - 162,477,263 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,466,724 - 162,477,262 (+)EnsemblGRCm39 Ensembl
GRCm381162,639,150 - 162,649,694 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,639,155 - 162,649,693 (+)EnsemblGRCm38mm10GRCm38
MGSCv371164,569,281 - 164,579,825 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,475,844 - 164,486,368 (+)NCBIMGSCv36mm8
Celera1165,085,895 - 165,096,434 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.29NCBI
Myoc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,509,963 - 77,520,361 (+)NCBIGRCr8
mRatBN7.21374,976,730 - 74,987,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,976,730 - 74,987,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,554,373 - 77,564,765 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,858,850 - 78,869,297 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,118,721 - 76,129,168 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,517,531 - 80,527,928 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,517,536 - 80,527,928 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,409,611 - 85,420,008 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,303,830 - 78,314,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11378,318,017 - 78,328,415 (+)NCBI
Celera1374,726,592 - 74,736,986 (+)NCBICelera
Cytogenetic Map13q22NCBI
Myoc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540612,182,046 - 12,199,669 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540612,182,115 - 12,194,683 (-)NCBIChiLan1.0ChiLan1.0
MYOC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,104,233 - 78,121,545 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1177,778,772 - 77,797,111 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,128,541 - 147,146,227 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,841,630 - 150,858,628 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,841,630 - 150,858,628 (-)Ensemblpanpan1.1panPan2
Myoc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934497,697,971 - 97,710,064 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648115,544,660 - 15,556,857 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648115,544,733 - 15,556,813 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9114,087,378 - 114,098,745 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19114,087,370 - 114,098,765 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,551,261 - 125,562,662 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYOC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,458,615 - 57,475,329 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,459,374 - 57,475,322 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605559,088,230 - 59,104,345 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myoc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477110,065,788 - 10,080,680 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477110,066,170 - 10,080,257 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MYOC
133 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 10 6 3 5 6 7
Low 4 3 6 3 1 2 1 3 6
Below cutoff 1 2 4 4 4 4 7

Sequence


RefSeq Acc Id: ENSCAFT00000023685   ⟹   ENSCAFP00000021988
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl727,335,314 - 27,346,820 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845001728   ⟹   ENSCAFP00845001366
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl727,136,391 - 27,148,079 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845001747   ⟹   ENSCAFP00845001380
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl727,136,587 - 27,148,064 (+)Ensembl
RefSeq Acc Id: NM_001048030   ⟹   NP_001041495
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1727,335,314 - 27,346,821 (+)NCBI
Dog10K_Boxer_Tasha726,857,046 - 26,868,545 (+)NCBI
ROS_Cfam_1.0727,136,587 - 27,148,065 (+)NCBI
UMICH_Zoey_3.1726,988,106 - 26,999,596 (+)NCBI
UNSW_CanFamBas_1.0727,022,462 - 27,033,986 (+)NCBI
UU_Cfam_GSD_1.0727,264,790 - 27,276,291 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001041495   ⟸   NM_001048030
- Peptide Label: precursor
- UniProtKB: Q3Y9M0 (UniProtKB/Swiss-Prot),   Q2PT31 (UniProtKB/Swiss-Prot),   A0A8C0SIK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000021988   ⟸   ENSCAFT00000023685
RefSeq Acc Id: ENSCAFP00845001380   ⟸   ENSCAFT00845001747
RefSeq Acc Id: ENSCAFP00845001366   ⟸   ENSCAFT00845001728
Protein Domains
Olfactomedin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014924 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030000902 UniProtKB/Swiss-Prot
  ENSCAFG00040013735 UniProtKB/TrEMBL
  ENSCAFG00805008334 UniProtKB/Swiss-Prot
  ENSCAFG00845001014 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023685.5 UniProtKB/Swiss-Prot
  ENSCAFT00000105334.1 UniProtKB/TrEMBL
  ENSCAFT00030001544.1 UniProtKB/Swiss-Prot
  ENSCAFT00040025431.1 UniProtKB/TrEMBL
  ENSCAFT00805015252 UniProtKB/Swiss-Prot
  ENSCAFT00845001728.1 UniProtKB/TrEMBL
  ENSCAFT00845001747 ENTREZGENE
  ENSCAFT00845001747.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.1490 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Olfac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:490344 UniProtKB/Swiss-Prot
NCBI Gene MYOC ENTREZGENE
PANTHER OLFACTOMEDIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23192:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam OLF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE OLF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART OLF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0SIK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MH55_CANLF UniProtKB/TrEMBL
  A0A8P0TKZ7_CANLF UniProtKB/TrEMBL
  MYOC_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
  Q3Y9M0 ENTREZGENE
UniProt Secondary Q3Y9M0 UniProtKB/Swiss-Prot
VGNC ID VGNC:43576 ENTREZGENE