RGD Reference Report - Novel mutations in the MYOC/GLC1A gene in a large group of glaucoma patients. - Rat Genome Database

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Novel mutations in the MYOC/GLC1A gene in a large group of glaucoma patients.

Authors: Michels-Rautenstrauss, K  Mardin, C  Wakili, N  Junemann, AM  Villalobos, L  Mejia, C  Soley, GC  Azofeifa, J  Ozbey, S  Naumann, GO  Reis, A  Rautenstrauss, B 
Citation: Michels-Rautenstrauss K, etal., Hum Mutat. 2002 Dec;20(6):479-80.
RGD ID: 7401186
Pubmed: (View Article at PubMed) PMID:12442283
DOI: Full-text: DOI:10.1002/humu.9092

Mutations at the myocilin (MYOC) gene within the GLC1A locus have been revealed in 2-4% of patients suffering primary open angle glaucoma (POAG) worldwide. In our ongoing glaucoma study six hundred eighty two persons have been screened for MYOC mutations. The first group consisted of 453 patients from a long-term clinical study diagnosed either with juvenile OAG (JOAG), POAG, ocular hypertension (OHT) or normal tension glaucoma (NTG) plus 22 cases of secondary glaucoma. This group, and additional 83 healthy controls, is part of a long term study with repeated clinical examinations at the University of Erlangen-Nurnberg. An additional sample of 124 glaucoma patients or at risk persons referred from other sources were included in the mutation screening. Five novel mutations, namely Gly434Ser, Asn450Asp, Val251Ala, Ile345Met and Ser393Asn, could be identified as cause of preperimetric POAG, JOAG, normal tension POAG and POAG. Myocilin mutations were identified similar with previous reports with other ethnic populations at the rate of 11/341 (3.2%) probands.

Annotation

Disease Annotations    
juvenile glaucoma  (IAGP,ISO)

Phenotype Annotations    

Human Phenotype
Objects Annotated

Genes (Rattus norvegicus)
Myoc  (myocilin)

Genes (Mus musculus)
Myoc  (myocilin)

Genes (Homo sapiens)
MYOC  (myocilin)


Additional Information