Gabrg2 (gamma-aminobutyric acid type A receptor subunit gamma 2) - Rat Genome Database

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Gene: Gabrg2 (gamma-aminobutyric acid type A receptor subunit gamma 2) Rattus norvegicus
Analyze
Symbol: Gabrg2
Name: gamma-aminobutyric acid type A receptor subunit gamma 2
RGD ID: 61966
Description: Enables GABA-A receptor activity and chloride channel activity. Contributes to GABA receptor activity. Involved in several processes, including GABAergic synaptic transmission; cellular response to zinc ion; and response to anesthetic. Located in cell surface; dendrite membrane; and inhibitory synapse. Part of GABA receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Biomarker of fetal alcohol spectrum disorder and hepatic encephalopathy. Human ortholog(s) of this gene implicated in alcohol dependence; alcoholic liver cirrhosis; amphetamine abuse; brain disease (multiple); and heroin dependence. Orthologous to human GABRG2 (gamma-aminobutyric acid type A receptor subunit gamma2); INTERACTS WITH 1-bromopropane; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GABA(A) receptor subunit gamma-2; GABAAR subunit gamma-2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor subunit gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid receptor subunit gamma-2; gamma-aminobutyric acid type A receptor gamma 2 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81026,876,926 - 26,965,523 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1026,876,926 - 26,965,523 (-)EnsemblGRCr8
mRatBN7.21026,374,693 - 26,463,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1026,374,694 - 26,464,346 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1031,110,673 - 31,199,341 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01030,599,199 - 30,687,869 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01026,085,907 - 26,174,565 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01027,090,913 - 27,179,786 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1027,092,827 - 27,179,900 (-)Ensemblrn6Rnor6.0
Rnor_5.01026,934,991 - 27,024,440 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41027,037,561 - 27,126,074 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1025,891,936 - 25,979,598 (-)NCBICelera
RGSC_v3.11027,038,609 - 27,127,123 (-)NCBI
Cytogenetic Map10q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-isoborneol  (ISO)
(+)-pilocarpine  (ISO)
(R)-camphor  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1-(2-methoxyphenyl)piperazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
1-bromopropane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,6-Dimethylphenol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dibromo-2-(2,4-dibromophenoxy)phenol  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-ethyl-4-methylpiperidine-2,6-dione  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-Methoxyflavanone  (ISO)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (EXP)
alpha-hexachlorocyclohexane  (ISO)
Alphaxolone  (EXP)
amphetamine  (ISO)
anthracenes  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzodiazepine  (ISO)
bicuculline  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bromoform  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP)
camphor  (ISO)
carisoprodol  (ISO)
carvone  (ISO)
CGP 52608  (ISO)
cocaine  (EXP,ISO)
cypermethrin  (ISO)
delta-hexachlorocyclohexane  (ISO)
dexamethasone  (ISO)
diazepam  (EXP,ISO)
dieldrin  (EXP,ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
Etizolam  (EXP)
etomidate  (EXP,ISO)
famotidine  (EXP)
felbamate  (ISO)
fenvalerate  (EXP)
fipronil  (ISO)
flumazenil  (ISO)
flunitrazepam  (ISO)
flurotyl  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
gamma-aminobutyric acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
hexobarbital  (EXP)
ketamine  (EXP)
lanthanum atom  (ISO)
lead(0)  (ISO)
levonorgestrel  (EXP)
lipopolysaccharide  (ISO)
Lorazepam  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menthone  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (EXP)
Methylone  (ISO)
midazolam  (ISO)
morphine  (ISO)
muscimol  (ISO)
nicotine  (ISO)
Niflumic acid  (EXP)
o-cresol  (EXP)
p-menthan-3-ol  (ISO)
pentetrazol  (ISO)
pentobarbital  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
picrotoxin  (EXP,ISO)
picrotoxinin  (ISO)
poly(I:C)  (EXP)
pregnenolone sulfate  (EXP)
propofol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
tert-Butylbicyclophosphorothionate  (ISO)
Testosterone propionate  (ISO)
theophylline  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topiramate  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zaleplon  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zolpidem  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Downregulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons. Bekdash RA and Harrison NL, Brain Behav. 2015 Aug;5(8):e00355. doi: 10.1002/brb3.355. Epub 2015 Jun 2.
2. Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function. Bianchi MT and Macdonald RL, J Physiol 2002 Oct 1;544(Pt 1):3-18.
3. The short splice variant of the gamma 2 subunit acts as an external modulator of GABA(A) receptor function. Boileau AJ, etal., J Neurosci. 2010 Apr 7;30(14):4895-903. doi: 10.1523/JNEUROSCI.5039-09.2010.
4. Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. Cagetti E, etal., Mol Pharmacol. 2003 Jan;63(1):53-64. doi: 10.1124/mol.63.1.53.
5. Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+. Draguhn A, etal., Neuron 1990 Dec;5(6):781-8.
6. Interaction of GABA receptor/channel rho(1) and gamma(2) subunit. Ekema GM, etal., Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2326-33.
7. GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. Enoch MA, etal., PLoS One. 2012;7(1):e29369. doi: 10.1371/journal.pone.0029369. Epub 2012 Jan 13.
8. Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon. Facciolo RM, etal., Exp Brain Res 2002 Feb;142(4):504-11.
9. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. Fu Z, etal., J Neurophysiol. 2003 Dec;90(6):3950-7. Epub 2003 Aug 20.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GABAA receptors: structure, function, pharmacology, and related disorders. Ghit A, etal., J Genet Eng Biotechnol. 2021 Aug 21;19(1):123. doi: 10.1186/s43141-021-00224-0.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Graf ER, etal., Cell. 2004 Dec 29;119(7):1013-26.
14. A splice-site mutation in GABRG2 associated with childhood absence epilepsy and febrile convulsions. Kananura C, etal., Arch Neurol 2002 Jul;59(7):1137-41.
15. Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis. Khan AJ, etal., Mutat Res. 2009 May 12;664(1-2):55-63. doi: 10.1016/j.mrfmmm.2009.02.009. Epub 2009 Feb 28.
16. Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer. Laverty D, etal., Nature. 2019 Jan;565(7740):516-520. doi: 10.1038/s41586-018-0833-4. Epub 2019 Jan 2.
17. Expression of gamma-aminobutyric acid A receptor subunits alpha1, beta1, gamma2 mRNA in rats with hepatic encephalopathy. Li XQ, etal., World J Gastroenterol. 2005 Jun 7;11(21):3319-22.
18. Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication. Liang J, etal., J Neurosci. 2007 Nov 7;27(45):12367-77. doi: 10.1523/JNEUROSCI.2786-07.2007.
19. Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Lieberman R, etal., Alcohol. 2018 Feb;66:45-53. doi: 10.1016/j.alcohol.2017.08.005. Epub 2017 Aug 12.
20. Gender-specific contribution of the GABA(A) subunit genes on 5q33 in methamphetamine use disorder. Lin SK, etal., Pharmacogenomics J. 2003;3(6):349-55. doi: 10.1038/sj.tpj.6500203.
21. Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population. Loh EW, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):439-43. doi: 10.1002/ajmg.b.30429.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. Nusser Z, etal., J Neurosci. 1998 Mar 1;18(5):1693-703.
25. Androgens predispose males to GABAA-mediated excitotoxicity in the developing hippocampus. Nuñez JL and McCarthy MM, Exp Neurol. 2008 Apr;210(2):699-708. doi: 10.1016/j.expneurol.2008.01.001. Epub 2008 Jan 19.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol. Petrie J, etal., Alcohol Clin Exp Res. 2001 Jun;25(6):819-28.
28. Haplotype-based localization of an alcohol dependence gene to the 5q34 {gamma}-aminobutyric acid type A gene cluster. Radel M, etal., Arch Gen Psychiatry. 2005 Jan;62(1):47-55. doi: 10.1001/archpsyc.62.1.47.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry.PG - 241-57 Saha S, etal., Mol Cell Neurosci 2001 Jan;17(1):241-57.
33. Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. Shivers BD, etal., Neuron 1989 Sep;3(3):327-37.
34. Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Smith KR, etal., Mol Cell Neurosci. 2010 Aug;44(4):330-41. doi: 10.1016/j.mcn.2010.04.004. Epub 2010 Apr 22.
35. The gamma 2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the alpha 1 and beta 2/3 subunits in hippocampus, cerebellum and globus pallidus. Somogyi P, etal., Neuropharmacology. 1996;35(9-10):1425-44.
36. Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABA A receptors and increases behavioral sensitivity to gaboxadol. Volgin DV, Neurosci Lett. 2008 Jul 11;439(2):182-6. doi: 10.1016/j.neulet.2008.05.011. Epub 2008 May 8.
37. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Yamasaki T, etal., Neuron. 2017 Mar 8;93(5):1138-1152.e6. doi: 10.1016/j.neuron.2017.02.023.
38. The gamma-subunit governs the susceptibility of recombinant gamma-aminobutyric acid type A receptors to block by the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N). Zarnowska ED, etal., Anesth Analg. 2005 Aug;101(2):401-406. doi: 10.1213/01.ANE.0000155264.67729.E4.
39. Structure of a human synaptic GABAA receptor. Zhu S, etal., Nature. 2018 Jul;559(7712):67-72. doi: 10.1038/s41586-018-0255-3. Epub 2018 Jun 27.
Additional References at PubMed
PMID:1312131   PMID:1312132   PMID:1379501   PMID:1966765   PMID:2165521   PMID:9682826   PMID:10900017   PMID:12145412   PMID:12477932   PMID:12574411   PMID:12812758   PMID:15182195  
PMID:15282269   PMID:15659595   PMID:15850489   PMID:16248887   PMID:16740643   PMID:17148443   PMID:17208003   PMID:18094250   PMID:18281286   PMID:18292084   PMID:18305175   PMID:18585436  
PMID:18675324   PMID:18922788   PMID:19261880   PMID:19358834   PMID:19501070   PMID:19703932   PMID:20823221   PMID:20937799   PMID:21439793   PMID:21924329   PMID:22572883   PMID:22806324  
PMID:23909897   PMID:24141149   PMID:24218551   PMID:24425869   PMID:24573278   PMID:25193658   PMID:25489750   PMID:27129275   PMID:31894752   PMID:32428626   PMID:32579917   PMID:33958479  


Genomics

Comparative Map Data
Gabrg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81026,876,926 - 26,965,523 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1026,876,926 - 26,965,523 (-)EnsemblGRCr8
mRatBN7.21026,374,693 - 26,463,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1026,374,694 - 26,464,346 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1031,110,673 - 31,199,341 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01030,599,199 - 30,687,869 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01026,085,907 - 26,174,565 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01027,090,913 - 27,179,786 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1027,092,827 - 27,179,900 (-)Ensemblrn6Rnor6.0
Rnor_5.01026,934,991 - 27,024,440 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41027,037,561 - 27,126,074 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1025,891,936 - 25,979,598 (-)NCBICelera
RGSC_v3.11027,038,609 - 27,127,123 (-)NCBI
Cytogenetic Map10q21NCBI
GABRG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385162,067,465 - 162,155,539 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5162,000,057 - 162,162,977 (+)Ensemblhg38GRCh38
GRCh375161,494,471 - 161,582,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365161,427,295 - 161,515,106 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345161,427,294 - 161,515,106NCBI
Celera5157,525,645 - 157,613,546 (+)NCBICelera
Cytogenetic Map5q34NCBI
HuRef5156,587,110 - 156,675,113 (+)NCBIHuRef
CHM1_15160,927,088 - 161,014,986 (+)NCBICHM1_1
T2T-CHM13v2.05162,596,314 - 162,684,391 (+)NCBIT2T-CHM13v2.0
Gabrg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391141,801,017 - 41,891,684 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1141,801,030 - 41,891,684 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381141,910,190 - 42,000,857 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1141,910,203 - 42,000,857 (-)Ensemblmm10GRCm38
MGSCv371141,723,697 - 41,814,180 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361141,753,618 - 41,844,101 (-)NCBIMGSCv36mm8
Celera1145,722,009 - 45,812,211 (-)NCBICelera
Cytogenetic Map11A5NCBI
cM Map1124.8NCBI
Gabrg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540815,765,984 - 15,857,244 (+)Ensembl
ChiLan1.0NW_00495540815,766,161 - 15,857,121 (+)NCBIChiLan1.0ChiLan1.0
GABRG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24157,231,806 - 157,325,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15155,371,352 - 155,472,434 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05157,436,113 - 157,529,586 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15164,135,166 - 164,222,179 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5164,068,122 - 164,222,179 (+)EnsemblpanPan2panpan1.1
GABRG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1448,794,770 - 48,901,859 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl448,796,852 - 48,901,548 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha448,687,383 - 48,794,507 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0449,225,668 - 49,333,872 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl449,225,441 - 49,333,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1449,035,654 - 49,142,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0449,167,827 - 49,274,742 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0449,689,277 - 49,797,598 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gabrg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213103,160,016 - 103,220,841 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365151,607,722 - 1,671,336 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365151,609,370 - 1,670,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1661,441,632 - 61,543,361 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11661,441,622 - 61,543,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21666,516,866 - 66,618,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABRG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12364,422,519 - 64,512,124 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2364,422,391 - 64,513,652 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603413,092,532 - 13,182,379 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabrg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473327,504,660 - 27,594,039 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473327,506,827 - 27,593,750 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gabrg2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1924,779,273 - 24,866,208 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gabrg2
417 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:20
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000004619
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102342212132490778Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat

Markers in Region
D10Uia8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21026,406,389 - 26,406,593 (+)MAPPERmRatBN7.2
Rnor_6.01027,122,614 - 27,122,817NCBIRnor6.0
Rnor_5.01026,966,653 - 26,966,856UniSTSRnor5.0
RGSC_v3.41027,067,123 - 27,067,326UniSTSRGSC3.4
Celera1025,921,441 - 25,921,644UniSTS
Cytogenetic Map10q21UniSTS
BE120391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21026,374,724 - 26,374,884 (+)MAPPERmRatBN7.2
Rnor_6.01027,090,945 - 27,091,104NCBIRnor6.0
Rnor_5.01026,935,023 - 26,935,182UniSTSRnor5.0
RGSC_v3.41027,035,481 - 27,035,640UniSTSRGSC3.4
Celera1025,889,856 - 25,890,015UniSTS
RH 3.4 Map10277.0UniSTS
Cytogenetic Map10q21UniSTS
G45867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21026,452,448 - 26,452,705 (+)MAPPERmRatBN7.2
Rnor_6.01027,168,023 - 27,168,279NCBIRnor6.0
Rnor_5.01027,012,688 - 27,012,944UniSTSRnor5.0
RGSC_v3.41027,114,843 - 27,115,099UniSTSRGSC3.4
Celera1025,968,373 - 25,968,623UniSTS
Cytogenetic Map10q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 7 7 139 43 33 16 14 16 3 73 35 122 7 48 17 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000004619   ⟹   ENSRNOP00000004619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1026,876,926 - 26,965,523 (-)Ensembl
mRatBN7.2 Ensembl1026,374,694 - 26,464,346 (-)Ensembl
Rnor_6.0 Ensembl1027,093,025 - 27,179,254 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082445   ⟹   ENSRNOP00000072234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1026,876,926 - 26,965,523 (-)Ensembl
mRatBN7.2 Ensembl1026,376,200 - 26,464,346 (-)Ensembl
Rnor_6.0 Ensembl1027,092,827 - 27,179,900 (-)Ensembl
RefSeq Acc Id: NM_001393775   ⟹   NP_001380704
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81026,876,926 - 26,965,523 (-)NCBI
mRatBN7.21026,374,693 - 26,463,937 (-)NCBI
RefSeq Acc Id: NM_183327   ⟹   NP_899156
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81026,876,926 - 26,965,523 (-)NCBI
mRatBN7.21026,374,693 - 26,463,937 (-)NCBI
Rnor_6.01027,093,025 - 27,179,254 (-)NCBI
Rnor_5.01026,934,991 - 27,024,440 (-)NCBI
RGSC_v3.41027,037,561 - 27,126,074 (-)RGD
Celera1025,891,936 - 25,979,598 (-)RGD
Sequence:
RefSeq Acc Id: NP_899156   ⟸   NM_183327
- Peptide Label: isoform 2 precursor
- UniProtKB: P18508 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072234   ⟸   ENSRNOT00000082445
Ensembl Acc Id: ENSRNOP00000004619   ⟸   ENSRNOT00000004619
RefSeq Acc Id: NP_001380704   ⟸   NM_001393775
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6PW52 (UniProtKB/TrEMBL),   A0A0G2K2G4 (UniProtKB/TrEMBL)
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18508-F1-model_v2 AlphaFold P18508 1-466 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61966 AgrOrtholog
BioCyc Gene G2FUF-25475 BioCyc
Ensembl Genes ENSRNOG00000003241 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004619 ENTREZGENE
  ENSRNOT00000082445 ENTREZGENE
  ENSRNOT00000082445.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312477 IMAGE-MGC_LOAD
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot
  GABBAg2_rcpt UniProtKB/Swiss-Prot
  GABBAg_rcpt UniProtKB/Swiss-Prot
  Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
KEGG Report rno:29709 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109285 IMAGE-MGC_LOAD
NCBI Gene 29709 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PharmGKB GABRG2 RGD
PhenoGen Gabrg2 PhenoGen
PRINTS GABAARECEPTR UniProtKB/Swiss-Prot
  GABAARGAMMA UniProtKB/Swiss-Prot
  GABAARGAMMA2 UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003241 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A0A0G2K2G4 ENTREZGENE, UniProtKB/TrEMBL
  GBRG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q562A9_RAT UniProtKB/TrEMBL
  Q6PW52 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabrg2  gamma-aminobutyric acid type A receptor subunit gamma 2  Gabrg2  gamma-aminobutyric acid type A receptor gamma 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabrg2  gamma-aminobutyric acid type A receptor gamma 2 subunit  Gabrg2  gamma-aminobutyric acid (GABA) A receptor, gamma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Gabrg2  gamma-aminobutyric acid (GABA) A receptor, gamma 2  Gabrg2  gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Gabrg2  gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2  Gabrg2  gamma-aminobutyric acid A receptor, gamma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gabrg2  gamma-aminobutyric acid A receptor, gamma 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to both cytoplasmic and subsynaptic sites of NTS neurons 625528
gene_expression mRNA is expressed in high amounts in nucleus tractus solitarii and protein expression is seen in many areas of the medulla like cuneate, gracile, olivary and spinal trigeminal nuclei 625528
gene_other gamma subunit confers GABAA receptor insensitivity to inhibition by zinc ions 728419
gene_process may mediate inhibitory GABA responses in nucleus tractus solitarii (NTS) in the brain 625528