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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61966
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gabrg2
Name: gamma-aminobutyric acid type A receptor subunit gamma 2
Acc ID: CHEBI:3419
Term: carisoprodol
Definition: A carbamate ester that is the mono-N-isopropyl derivative of meprobamate (which is a significant metabolite). Carisoprodol interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alteration in pain perception. It is used as a muscle relaxant in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.
Chemical ID: MESH:D002328
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gabrg2multiple interactionsISOGABRG2 (Homo sapiens)6480464CTDBemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]PMID:19244096
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