Cdkn2c (cyclin-dependent kinase inhibitor 2C) - Rat Genome Database

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Gene: Cdkn2c (cyclin-dependent kinase inhibitor 2C) Rattus norvegicus
Analyze
Symbol: Cdkn2c
Name: cyclin-dependent kinase inhibitor 2C
RGD ID: 2325
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Involved in oligodendrocyte differentiation. Predicted to be located in cytoplasm and nucleus. Orthologous to human CDKN2C (cyclin dependent kinase inhibitor 2C); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cyclin dependent kinase inhibitor 2C; Cyclin dependent kinase inhibitor 2C(p18 inhibits CDK4) see also D5Lev19; Cyclin dependent kinase inhibitor 2C(p18, inhibits CDK4), see also D5Lev19; cyclin-dependent kinase 4 inhibitor C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); p18
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Emca12
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85129,639,736 - 129,645,564 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5129,639,736 - 129,644,891 (-)EnsemblGRCr8
mRatBN7.25124,411,123 - 124,416,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5124,411,124 - 124,416,278 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5127,025,144 - 127,030,301 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05128,748,224 - 128,753,381 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,799,502 - 128,804,659 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05129,347,731 - 129,352,886 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5129,347,732 - 129,352,886 (-)Ensemblrn6Rnor6.0
Rnor_5.05133,181,576 - 133,187,391 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45131,012,524 - 131,017,679 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5123,151,768 - 123,156,925 (-)NCBICelera
RGSC_v3.15131,017,750 - 131,022,905 (-)NCBI
Cytogenetic Map5q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
auraptene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clomipramine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
geraniol  (ISO)
GW 4064  (ISO)
imipramine  (EXP)
isoflavones  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP,ISO)
lidocaine  (EXP)
linalool  (ISO)
luteolin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
myricetin  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nimesulide  (ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sterigmatocystin  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
7. Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation. Tokumoto YM, etal., Dev Biol 2002 May 1;245(1):224-34.
Additional References at PubMed
PMID:7739547   PMID:8001816   PMID:10208428   PMID:11800646   PMID:12477932   PMID:17409423  


Genomics

Comparative Map Data
Cdkn2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85129,639,736 - 129,645,564 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5129,639,736 - 129,644,891 (-)EnsemblGRCr8
mRatBN7.25124,411,123 - 124,416,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5124,411,124 - 124,416,278 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5127,025,144 - 127,030,301 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05128,748,224 - 128,753,381 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,799,502 - 128,804,659 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05129,347,731 - 129,352,886 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5129,347,732 - 129,352,886 (-)Ensemblrn6Rnor6.0
Rnor_5.05133,181,576 - 133,187,391 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45131,012,524 - 131,017,679 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5123,151,768 - 123,156,925 (-)NCBICelera
RGSC_v3.15131,017,750 - 131,022,905 (-)NCBI
Cytogenetic Map5q35NCBI
CDKN2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38150,960,745 - 50,974,634 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl150,960,745 - 50,974,634 (+)Ensemblhg38GRCh38
GRCh37151,426,417 - 51,440,306 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36151,206,955 - 51,212,897 (+)NCBIBuild 36Build 36hg18NCBI36
Celera149,720,878 - 49,726,820 (+)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef149,551,948 - 49,557,890 (+)NCBIHuRef
CHM1_1151,551,919 - 51,557,861 (+)NCBICHM1_1
T2T-CHM13v2.0150,840,624 - 50,854,515 (+)NCBIT2T-CHM13v2.0
Cdkn2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394109,518,073 - 109,523,953 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4109,518,073 - 109,524,386 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384109,660,876 - 109,666,756 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,660,876 - 109,667,189 (-)Ensemblmm10GRCm38
MGSCv374109,333,481 - 109,337,977 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364109,158,808 - 109,163,304 (-)NCBIMGSCv36mm8
Celera4108,000,724 - 108,005,200 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map451.32NCBI
Cdkn2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554648,021,887 - 8,028,241 (-)Ensembl
ChiLan1.0NW_0049554648,022,596 - 8,028,241 (-)NCBIChiLan1.0ChiLan1.0
CDKN2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21175,890,034 - 175,898,033 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,003,649 - 175,036,456 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0150,214,767 - 50,221,465 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1151,704,528 - 51,718,374 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl151,704,528 - 51,718,374 (+)EnsemblpanPan2panpan1.1
CDKN2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11510,219,974 - 10,224,944 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1510,220,185 - 10,224,390 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1510,371,011 - 10,375,935 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01510,351,609 - 10,356,542 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1510,351,820 - 10,356,034 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11510,156,940 - 10,161,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01510,245,354 - 10,250,296 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01510,262,239 - 10,267,163 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdkn2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505865,640,933 - 65,646,533 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365229,769,756 - 9,775,077 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365229,769,761 - 9,775,374 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6161,160,297 - 161,166,529 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16161,160,290 - 161,166,681 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26148,743,931 - 148,749,851 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKN2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12081,964,164 - 81,970,891 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2081,963,562 - 81,968,450 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603335,266,761 - 35,273,493 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkn2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248592,091,734 - 2,097,659 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248592,092,622 - 2,097,628 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdkn2c
33 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:242
Count of miRNA genes:136
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000012088
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5124314582133270832Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
11528624Bss114Bone structure and strength QTL 1146.543e-07femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5129627938131996704Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Lev19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25124,411,616 - 124,411,799 (+)MAPPERmRatBN7.2
Rnor_6.05129,348,225 - 129,348,407NCBIRnor6.0
Rnor_5.05133,182,070 - 133,182,252UniSTSRnor5.0
RGSC_v3.45131,013,018 - 131,013,200UniSTSRGSC3.4
RGSC_v3.45131,013,017 - 131,013,199RGDRGSC3.4
Celera5123,152,262 - 123,152,444UniSTS
Cytogenetic Map5q35UniSTS
AI169557  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85129,639,813 - 129,639,905 (+)Marker Load Pipeline
mRatBN7.25124,411,200 - 124,411,292 (+)MAPPERmRatBN7.2
Rnor_6.05129,347,809 - 129,347,900NCBIRnor6.0
Rnor_5.05133,181,654 - 133,181,745UniSTSRnor5.0
RGSC_v3.45131,012,602 - 131,012,693UniSTSRGSC3.4
Celera5123,151,846 - 123,151,937UniSTS
RH 3.4 Map5810.8UniSTS
Cytogenetic Map5q35UniSTS
PMC141153P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85129,643,714 - 129,643,985 (+)Marker Load Pipeline
mRatBN7.25124,415,101 - 124,415,371 (+)MAPPERmRatBN7.2
Rnor_6.05129,351,710 - 129,351,979NCBIRnor6.0
Rnor_6.05129,360,167 - 129,360,436NCBIRnor6.0
Rnor_5.05133,192,585 - 133,192,854UniSTSRnor5.0
Rnor_5.05133,185,555 - 133,185,824UniSTSRnor5.0
RGSC_v3.45131,016,503 - 131,016,772UniSTSRGSC3.4
Celera5123,155,748 - 123,156,017UniSTS
Cytogenetic Map5q35UniSTS
PMC141153P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25124,411,869 - 124,412,205 (+)MAPPERmRatBN7.2
Rnor_6.05129,348,478 - 129,348,813NCBIRnor6.0
Rnor_5.05133,182,323 - 133,182,658UniSTSRnor5.0
RGSC_v3.45131,013,271 - 131,013,606UniSTSRGSC3.4
Celera5123,152,515 - 123,152,850UniSTS
Cytogenetic Map5q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000012088   ⟹   ENSRNOP00000012088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5129,639,736 - 129,644,891 (-)Ensembl
mRatBN7.2 Ensembl5124,411,124 - 124,416,278 (-)Ensembl
Rnor_6.0 Ensembl5129,347,732 - 129,352,886 (-)Ensembl
RefSeq Acc Id: NM_131902   ⟹   NP_571977
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85129,639,736 - 129,644,891 (-)NCBI
mRatBN7.25124,411,123 - 124,416,278 (-)NCBI
Rnor_6.05129,347,731 - 129,352,886 (-)NCBI
Rnor_5.05133,181,576 - 133,187,391 (-)NCBI
RGSC_v3.45131,012,524 - 131,017,679 (-)RGD
Celera5123,151,768 - 123,156,925 (-)RGD
Sequence:
RefSeq Acc Id: XM_063288321   ⟹   XP_063144391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85129,639,736 - 129,645,564 (-)NCBI
RefSeq Acc Id: NP_571977   ⟸   NM_131902
- UniProtKB: Q8R5G4 (UniProtKB/TrEMBL),   Q8R5G3 (UniProtKB/TrEMBL),   A6JYZ7 (UniProtKB/TrEMBL),   A6JYZ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012088   ⟸   ENSRNOT00000012088
RefSeq Acc Id: XP_063144391   ⟸   XM_063288321
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R5G4-F1-model_v2 AlphaFold Q8R5G4 1-168 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325 AgrOrtholog
BioCyc Gene G2FUF-40345 BioCyc
Ensembl Genes ENSRNOG00000008956 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012088 ENTREZGENE
  ENSRNOT00000012088.9 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7319164 IMAGE-MGC_LOAD
InterPro Ank_Repeat/CDKN_Inhibitor UniProtKB/TrEMBL
  Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
KEGG Report rno:54238 UniProtKB/TrEMBL
MGC_CLONE MGC:105252 IMAGE-MGC_LOAD
NCBI Gene 54238 ENTREZGENE
PANTHER ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 4 INHIBITOR C UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
PhenoGen Cdkn2c PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008956 RatGTEx
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
UniProt A6JYZ6 ENTREZGENE, UniProtKB/TrEMBL
  A6JYZ7 ENTREZGENE
  Q8R5G3 ENTREZGENE
  Q8R5G4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6JYZ7 UniProtKB/TrEMBL
  Q8R5G3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Cdkn2c  cyclin-dependent kinase inhibitor 2C  Cdkn2c  cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cdkn2c  cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)    cyclin dependent kinase inhibitor 2C   Name updated 1299863 APPROVED
2002-11-06 Cdkn2c  cyclin dependent kinase inhibitor 2C     Cyclin dependent kinase inhibitor 2C(p18, inhibits CDK4), see also D5Lev19  Name updated 625702 APPROVED
2002-06-10 Cdkn2c  Cyclin dependent kinase inhibitor 2C(p18, inhibits CDK4), see also D5Lev19      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process functions as a cyclin-dependent kinase inhibitor (CKI) 1298749
gene_process may be part of a cell cycle "timer" mechanism in the terminal differentiation of oligodendrocyte precursor cells 1298749