RGD Reference Report - Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation.

Authors: Tokumoto, YM  Apperly, JA  Gao, FB  Raff, MC 
Citation: Tokumoto YM, etal., Dev Biol 2002 May 1;245(1):224-34.
RGD ID: 1298749
Pubmed: PMID:11969268   (View Abstract at PubMed)
DOI: DOI:10.1006/dbio.2002.0626   (Journal Full-text)

A cell-intrinsic timer helps control when rodent oligodendrocyte precursor cells (OPCs) exit the cell cycle and terminally differentiate when cultured in platelet-derived growth factor (PDGF) and thyroid hormone (TH). There is evidence that the cyclin-dependent kinase inhibitor (CKI) p27/Kip1 (p27) is a component of this TH-regulated timer, as it increases as OPCs proliferate and is required for the timer to operate accurately. Here, we provide evidence that another CKI, p18/INK (p18), may also be a component of the timer: it increases as OPCs proliferate, and its overexpression in OPCs accelerates the timer, causing the cells to differentiate prematurely. We also show that the overexpression of p27 accelerates the timer and that the increases in both p27 and p18 that occur in proliferating OPCs are controlled posttranscriptionally. By contrast, we show that the overexpression of either p18 or p27 in OPCs proliferating in PDGF and the absence of TH greatly slows the cell cycle but fails to accelerate the spontaneous differentiation that normally occurs independently of TH.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cdkn2cRatoligodendrocyte differentiation  IEP  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cdkn2cRatcyclin-dependent protein serine/threonine kinase inhibitor activity  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdkn2c  (cyclin-dependent kinase inhibitor 2C)

Objects referenced in this article
Gene Cdkn1b cyclin-dependent kinase inhibitor 1B Rattus norvegicus

Additional Information