Rorb (RAR-related orphan receptor B)

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Gene: Rorb (RAR-related orphan receptor B) Rattus norvegicus

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Symbol:

Rorb

Name:

RAR-related orphan receptor B

RGD ID:

1306778

Description:

Enables DNA-binding transcription factor activity and melatonin receptor activity. Involved in several processes, including cellular response to retinoic acid; circadian rhythm; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 15. Orthologous to human RORB (RAR related orphan receptor B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2-methoxyethanol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC309288; nuclear receptor ROR-beta; nuclear receptor RZR-beta; nuclear receptor subfamily 1 group F member 2; RAR-related orphan receptor beta; retinoid-related orphan receptor-beta; transcription factor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RORB (RAR related orphan receptor B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Rorb (RAR-related orphan receptor beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rorb (RAR related orphan receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RORB (RAR related orphan receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RORB (RAR related orphan receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rorb (RAR related orphan receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RORB (RAR related orphan receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RORB (RAR related orphan receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rorb (RAR related orphan receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RORB (RAR related orphan receptor B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rorb (RAR-related orphan receptor beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rorb (RAR-related orphan receptor B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nhr-23	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Hr3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Rorb^{Tn(sb-T2/Bart3)2.304Mcwi}

Genetic Models:

F344-Rorb^{Tn(sb-T2/Bart3)2.304Mcwi}

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	225,790,216 - 225,970,973 (-)	NCBI		GRCr8
mRatBN7.2	1	216,363,629 - 216,544,390 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	216,363,629 - 216,544,390 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	224,690,925 - 224,871,663 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	231,627,471 - 231,808,206 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	224,445,448 - 224,626,180 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	234,252,757 - 234,442,597 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	234,252,757 - 234,435,839 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	241,354,340 - 241,541,103 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	222,545,682 - 222,726,307 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	222,709,413 - 222,890,308 (-)	NCBI
Celera	1	213,658,839 - 213,838,721 (-)	NCBI		Celera
Cytogenetic Map	1	q51	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Childhood Absence Epilepsy 1 (ISO)

endometriosis (ISO)

epilepsy (ISO)

genetic disease (ISO)

idiopathic generalized epilepsy 15 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-methoxyethanol (EXP)

2-methylcholine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

carmustine (EXP)

choline (ISO)

clozapine (EXP)

cocaine (ISO)

Cuprizon (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

haloperidol (EXP)

L-methionine (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methotrexate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

propofol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sevoflurane (ISO)

tebufenozide (ISO)

temozolomide (ISO)

tetrachloromethane (EXP)

triadimefon (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (EXP,ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amacrine cell differentiation (ISO,ISS)

cellular response to retinoic acid (IDA)

circadian rhythm (IEP)

eye photoreceptor cell development (ISO,ISS)

G protein-coupled receptor signaling pathway (IEA)

intracellular receptor signaling pathway (IEA)

negative regulation of DNA-templated transcription (IDA)

negative regulation of osteoblast differentiation (IEA,ISO,ISS)

positive regulation of DNA-templated transcription (IDA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of circadian rhythm (IEA,ISO,ISS)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

response to hormone (IEP)

retina development in camera-type eye (ISO,ISS)

retinal cone cell development (IEA,ISO,ISS)

retinal rod cell development (IEA,ISO,ISS)

retinal rod cell differentiation (ISO)

visual perception (IEA)

Cellular Component

nucleoplasm (ISO,ISS)

nucleus (IBA,IEA,ISO,ISS)

Molecular Function

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO)

DNA-binding transcription factor activity (IDA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (ISO)

melatonin receptor activity (IBA,IDA)

nuclear receptor activity (IBA,IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Melatonin affects nuclear orphan receptors mRNA in the rat suprachiasmatic nuclei.	Agez L, etal., Neuroscience. 2007 Jan 19;144(2):522-30. Epub 2006 Oct 24.
2.	A novel isoform of the orphan nuclear receptor RORbeta is specifically expressed in pineal gland and retina.	Andre E, etal., Gene. 1998 Aug 31;216(2):277-83.
3.	Daily oscillation of gene expression in the retina is phase-advanced with respect to the pineal gland.	Bai L, etal., Brain Res. 2008 Apr 8;1203:89-96. Epub 2008 Feb 9.
4.	Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.	Becker-Andre M, etal., J Biol Chem. 1994 Nov 18;269(46):28531-4.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Circadian expression of clock genes and clock-controlled genes in the rat retina.	Kamphuis W, etal., Biochem Biophys Res Commun. 2005 Apr 29;330(1):18-26.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Developmental expression of 'RZR beta, a putative nuclear-melatonin receptor' mRNA in the suprachiasmatic nucleus of the rat.	Park HT, etal., Neurosci Lett. 1996 Oct 11;217(1):17-20.
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta.	Stehlin-Gaon C, etal., Nat Struct Biol. 2003 Oct;10(10):820-5. Epub 2003 Sep 7.

Additional References at PubMed

PMID:7916608	PMID:7935491	PMID:11689423	PMID:16574740	PMID:17303680	PMID:18815614	PMID:19805139	PMID:22189870	PMID:23652001	PMID:27352968

Genomics

Comparative Map Data

Rorb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	225,790,216 - 225,970,973 (-)	NCBI		GRCr8
mRatBN7.2	1	216,363,629 - 216,544,390 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	216,363,629 - 216,544,390 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	224,690,925 - 224,871,663 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	231,627,471 - 231,808,206 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	224,445,448 - 224,626,180 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	234,252,757 - 234,442,597 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	234,252,757 - 234,435,839 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	241,354,340 - 241,541,103 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	222,545,682 - 222,726,307 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	222,709,413 - 222,890,308 (-)	NCBI
Celera	1	213,658,839 - 213,838,721 (-)	NCBI		Celera
Cytogenetic Map	1	q51	NCBI

RORB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	74,497,335 - 74,693,177 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	74,497,335 - 74,693,177 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	77,112,251 - 77,308,093 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	76,302,072 - 76,491,937 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	74,341,852 - 74,531,348	NCBI
Celera	9	47,686,322 - 47,876,161 (+)	NCBI		Celera
Cytogenetic Map	9	q21.13	NCBI
HuRef	9	46,935,089 - 47,124,700 (+)	NCBI		HuRef
CHM1_1	9	77,258,972 - 77,448,757 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	86,650,612 - 86,846,447 (+)	NCBI		T2T-CHM13v2.0

Rorb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	18,907,966 - 19,088,560 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	18,907,969 - 19,088,560 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	18,930,609 - 19,111,196 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	18,930,605 - 19,111,196 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	19,011,058 - 19,185,686 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	19,003,591 - 19,068,140 (-)	NCBI		MGSCv36	mm8
Celera	19	19,627,465 - 19,802,185 (-)	NCBI		Celera
Cytogenetic Map	19	B	NCBI
cM Map	19	13.28	NCBI

Rorb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955512	4,362,287 - 4,541,445 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955512	4,362,287 - 4,541,432 (-)	NCBI	ChiLan1.0	ChiLan1.0

RORB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	73,662,727 - 73,858,291 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	73,668,668 - 73,864,232 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	50,144,836 - 50,340,910 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	73,351,856 - 73,543,036 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	73,469,767 - 73,543,030 (+)	Ensembl	panpan1.1		panPan2

RORB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	83,470,569 - 83,666,200 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	83,476,816 - 83,666,061 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	83,929,462 - 84,129,651 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	83,916,495 - 84,116,525 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	83,921,419 - 84,116,545 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	83,667,160 - 83,867,996 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	83,385,976 - 83,586,352 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	84,146,713 - 84,347,046 (-)	NCBI		UU_Cfam_GSD_1.0

Rorb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	130,696,123 - 130,878,474 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936503	10,295,167 - 10,470,813 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936503	10,294,530 - 10,473,070 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RORB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	227,574,648 - 227,772,671 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	227,573,972 - 227,776,806 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	254,597,054 - 254,678,939 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RORB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	85,545,609 - 85,735,804 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	85,545,608 - 85,732,780 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	73,986,850 - 74,183,347 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rorb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624811	2,076,437 - 2,277,040 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624811	2,076,474 - 2,281,933 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rorb
883 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	17
Count of miRNA genes:	13
Interacting mature miRNAs:	16
Transcripts:	ENSRNOT00000018137
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8693637	Alc29	Alcohol consumption QTL 29	2.7	0.258	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	207987464	234238494	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	197814409	242814409	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	197697768	242697768	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	201554356	246554356	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	214537555	238757011	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	216255568	260522016	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	206081677	251081677	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	184550676	229550676	Rat
8693661	Alc34	Alcohol consumption QTL 34	2.2	0.611	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	207987464	228627600	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	201554356	246554356	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	185145134	221264292	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	201554356	246554356	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	213707201	252085212	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	201554356	246554356	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	197814409	242814409	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
734768	Niddm59	Non-insulin dependent diabetes mellitus QTL 59			body mass (VT:0001259)	body weight (CMO:0000012)	1	213843987	258843987	Rat
1358890	Bp259	Blood pressure QTL 259	3.06		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	210702053	260522016	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	196248093	241248093	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	197814409	242814409	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	182623426	219932796	Rat
1549910	Bw54	Body weight QTL 54		0.05	body mass (VT:0001259)	body weight (CMO:0000012)	1	214647894	259647894	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	214647894	259647894	Rat
1357399	Bw45	Body weight QTL 45	3.05		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	1	206329708	251329708	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
1357404	Bw42	Body weight QTL 42	4.49	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	206329708	251329708	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	210702053	240947965	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	199368955	224569684	Rat
1331790	Bp201	Blood pressure QTL 201	3.127		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	198211513	225126682	Rat
10059587	Bw173	Body weight QTL 173	3.23	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	1	202069611	247069611	Rat
2292216	Bw80	Body weight QTL 80	3.23	0.0019	body mass (VT:0001259)	body weight (CMO:0000012)	1	213533809	243914901	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	206329708	222745518	Rat
1300168	Bp170	Blood pressure QTL 170	2.76		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	207702246	228581766	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	197697768	238755659	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	196248093	241248093	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	188377360	224054420	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
634340	Hcar5	Hepatocarcinoma resistance QTL 5	8		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	214537555	226660468	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	197670404	242670404	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	203995416	244113296	Rat
8693618	Alc25	Alcohol consumption QTL 25	3	0.28	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	207987464	228627600	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	216255568	260522016	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	201554356	246554356	Rat

Markers in Region

BE101543

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	216,468,641 - 216,468,816 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	234,328,635 - 234,328,809	NCBI	Rnor6.0
Rnor_5.0	1	241,430,218 - 241,430,392	UniSTS	Rnor5.0
RGSC_v3.4	1	222,650,557 - 222,650,731	UniSTS	RGSC3.4
Celera	1	213,762,975 - 213,763,149	UniSTS
Cytogenetic Map	1	q43	UniSTS

BE102396

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	216,477,175 - 216,477,332 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	234,320,121 - 234,320,277	NCBI	Rnor6.0
Rnor_5.0	1	241,421,704 - 241,421,860	UniSTS	Rnor5.0
RGSC_v3.4	1	222,659,089 - 222,659,245	UniSTS	RGSC3.4
Celera	1	213,771,507 - 213,771,663	UniSTS
RH 3.4 Map	9	757.99	UniSTS
Cytogenetic Map	1	q43	UniSTS

Genetic Models

This gene Rorb is modified in the following models/strains:

F344-Rorb^{Tn(sb-T2/Bart3)2.304Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
7	8	13	113	45	44	19	19	19	6	125	53	93	39	56	25

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001270958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002728869	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L14610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018137 ⟹ ENSRNOP00000018137

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	216,363,629 - 216,433,514 (-)	Ensembl
Rnor_6.0 Ensembl	1	234,363,994 - 234,435,478 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091814 ⟹ ENSRNOP00000070178

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	216,363,629 - 216,544,390 (-)	Ensembl
Rnor_6.0 Ensembl	1	234,252,757 - 234,435,839 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105442 ⟹ ENSRNOP00000084427

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	216,363,629 - 216,420,412 (-)	Ensembl

RefSeq Acc Id:

NM_001270958 ⟹ NP_001257887

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	225,790,216 - 225,970,973 (-)	NCBI
mRatBN7.2	1	216,363,629 - 216,544,390 (-)	NCBI
Rnor_6.0	1	234,252,757 - 234,435,839 (+)	NCBI
Rnor_5.0	1	241,354,340 - 241,541,103 (+)	NCBI
Celera	1	213,658,839 - 213,838,721 (-)	NCBI

Sequence:

show sequence

CTCTCTTGCTCCCTTCCTCTCTGCAACTGAACAGTGAAATTTCACATTGTGGATCCGCTAACAG
GCACAGATGTCATGTGAAAGCGCACATGCTCTGCCATCCATGCCGCCTTTCTTTCTTTCCTGTT
TCCTTTTTTTCACCCCTTGATAATTCTCCCTCTTCTTTGTAACTAACAAAACCACCACCAACTC
CTCCTCCTGCCGCTGCCCTTCTCCTCCTCCTCAGTCTAAGTGATCACAAAAGAAATCTCCGAGC
CCGAGGCGGTGGCATTTTTTTTTTTTTAAAGCAAGCACATTGGAGAGAAAGAAAAAAGAAACAA
ACAAACAAACAAAAGCAAAACAAAACCCAGGCACCAGCCAGCTAGGACATTTTTTTTTCCACAC
TGCCTGAAAACAAACAAACAGCCATCAGAAACAGTCATCAGCAACAGCATCAAAACTGTTAGCT
TAGCGGCGGCGGCCACCGTCACCCTGTGGCCACGACATCTGCCTAAAGGGATGCTTCTCTCAGC
GGAGCAGTTCTACGCCGACCGCCTTCTTCCCTCGTGCTGAGCGGGATTTTTGGGTTCTCTGGGG
TTCGGGCTGGGAGCTTCATGACTACACGGAGCAGGACAGCGGCCACATCATGCGAGCACAAATT
GAAGTGATACCATGCAAAATTTGTGGCGATAAATCCTCCGGGATCCACTACGGAGTCATCACGT
GTGAAGGCTGCAAGGGATTCTTCAGGAGGAGCCAGCAGAACAATGCCTCTTACTCCTGCCCAAG
GCAGAGAAACTGTTTAATTGACAGAACCAACAGGAACCGTTGCCAACACTGCCGCCTGCAGAAG
TGTCTTGCCCTAGGAATGTCAAGAGATGCTGTGAAGTTTGGGAGGATGTCCAAGAAGCAGCGGG
ACAGCCTGTATGCTGAGGTGCAGAAGCATCAGCAGAGGCTGCAGGAGCAGCGGCAGCAGCAGAG
TGGGGAGGCAGAGGCCCTTGCCAGGGTGTACAGCAGCAGCATTAGCAATGGCCTCAGCAACCTG
AACACCGAGACCGGCGGCACATACGCCAACGGGCACGTCATTGACCTGCCCAAGTCCGAGGGTT
ACTACAACATAGATTCCGGTCAACCGTCTCCCGATCAGTCAGGACTGGACATGACTGGAATCAA
ACAGATAAAGCAAGAACCTATCTATGACCTCACATCCGTACCCAACTTGTTTACCTATAGCTCT
TTCAACAACGGGCAGTTAGCTCCCGGGATAACAATGTCTGAGATCGATCGAATTGCACAGAACA
TCATTAAGTCCCATTTGGAGACGTGCCAGTACACAATGGAAGAGCTCCATCAGCTGGCATGGCA
GACCCACACCTATGAGGAAATAAAGGCATATCAAAGCAAGTCCAGGGAGGCTCTGTGGCAGCAG
TGTGCCATCCAGATCACCCACGCCATCCAATATGTGGTGGAGTTCGCAAAGCGGATAACAGGCT
TCATGGAGCTGTGTCAGAACGATCAGATCTTACTTCTGAAGTCAGGTTGCTTGGAAGTGGTTTT
AGTGAGAATGTGCCGTGCCTTCAACCCATTAAACAACACTGTTCTGTTTGAAGGAAAATATGGA
GGAATGCAAATGTTCAAAGCCTTAGGTTCTGATGACCTAGTGAATGAAGCATTTGACTTTGCGA
AGAATCTGTGTTCCTTGCAGCTGACCGAGGAAGAGATTGCTCTGTTCTCCTCTGCTGTTCTGAT
ATCCCCAGACCGAGCCTGGCTGTTAGAACCAAGAAAAGTCCAGAAGCTTCAGGAAAAAATTTAT
TTTGCACTTCAACATGTGATTCAGAAGAATCACCTGGATGATGAGACCCTGGCAAAGTTAATAG
CCAAGATACCAACTATCACGGCAGTCTGCAACTTGCATGGGGAGAAGCTACAGGTATTTAAGCA
GTCTCATCCAGACATAGTGAATACACTGTTTCCTCCATTGTACAAGGAGCTCTTTAATCCTGAC
TGTGCTGCGGTCTGCAAATGAAGGGGACGAGAACTCTCAGAGTCATGGAATGCATCGCCGTTAA
GACAAAAGCAATGTGTTCATGGGGACTTAAGGAAAATGTCACTACTGCAACATTAGGAATGTCC
TGCACTTAATAGAAATATTTTTCACCGCTACAGTTTGAAGAATGTAAATATGCACCTGAGTGGG
GCTCTTCTGTTTGTTCGTTTGTTGTTTGTTTGTTTTTGAAATGATCATAAATATACAAATATAG
GACACTGGGTGTTATCTTTTTTAATTTTATTCGGGTATGTTTTGGAGACAACTGTTTATAGAAT
TTTATTGTAGATATATACAAGAACAGAGCCGTACTTTACACGATTACTTTTCCCGTTGATTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001257887	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA42095	(Get FASTA)	NCBI Sequence Viewer
	EDM12987	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018137.4
	ENSRNOP00000070178.1
	ENSRNOP00000084427.1
GenBank Protein	P45446	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001257887 ⟸ NM_001270958

- UniProtKB:

A0A0G2JX88 (UniProtKB/TrEMBL), A0A8I5ZY30 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQH
CRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISN
GLSNLNTETGGTYANGHVIDLPKSEGYYNIDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNL
FTYSSFNNGQLAPGITMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSRE
ALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLF
EGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLLEPRKVQKL
QEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPDIVNTLFPPLYKE
LFNPDCAAVCK

hide sequence

Ensembl Acc Id:

ENSRNOP00000018137 ⟸ ENSRNOT00000018137

Ensembl Acc Id:

ENSRNOP00000070178 ⟸ ENSRNOT00000091814

Ensembl Acc Id:

ENSRNOP00000084427 ⟸ ENSRNOT00000105442

Protein Domains

NR LBD Nuclear receptor

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P45446-F1-model_v2	AlphaFold	P45446	1-470	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690804

Promoter ID:

EPDNEW_R1329

Type:

multiple initiation site

Name:

Rorb_1

Description:

RAR-related orphan receptor B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	234,252,741 - 234,252,801	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306778	AgrOrtholog
BioCyc Gene	G2FUF-56192	BioCyc
Ensembl Genes	ENSRNOG00000013413	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018137.7	UniProtKB/TrEMBL
	ENSRNOT00000091814.2	UniProtKB/TrEMBL
	ENSRNOT00000105442.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.565.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.50.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	NHR-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NR_DBD_ROR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nucl_hrmn_rcpt_lig-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nuclear_hrmn_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ROR_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_hrmn_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_NHR/GATA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:309288	UniProtKB/TrEMBL
NCBI Gene	309288	ENTREZGENE
PANTHER	NUCLEAR HORMONE RECEPTOR HR3-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUCLEAR RECEPTOR ROR-BETA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Hormone_recep	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	zf-C4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Rorb	PhenoGen
PRINTS	RORNUCRECPTR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	STRDHORMONER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	STROIDFINGER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	NR_LBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUCLEAR_REC_DBD_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NUCLEAR_REC_DBD_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013413	RatGTEx
SMART	HOLI	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZnF_C4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF48508	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JX88	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZY30	ENTREZGENE, UniProtKB/TrEMBL
	F1LQ88_RAT	UniProtKB/TrEMBL
	P45446	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-23	Rorb	RAR-related orphan receptor B	Rorb	RAR-related orphan receptor beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Rorb	RAR-related orphan receptor beta	Rorb_predicted	RAR-related orphan receptor beta (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Rorb_predicted	RAR-related orphan receptor beta (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM