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Gene: Dhrsx (dehydrogenase/reductase X-linked) Rattus norvegicus
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Symbol:
Dhrsx
Name:
dehydrogenase/reductase X-linked
RGD ID:
1305017
Description:
Predicted to enable dolichal reductase (NADPH) activity and polyprenol dehydrogenase (NAD+) activity. Predicted to be involved in positive regulation of autophagy. Predicted to be active in extracellular region and lipid droplet. Orthologous to human DHRSX (dehydrogenase/reductase X-linked); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
dehydrogenase/reductase (SDR family) X chromosome; dehydrogenase/reductase (SDR family) X-linked; dehydrogenase/reductase SDR family member on chromosome X; LOC288525
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 12 21,413,563 - 21,418,319 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 12 21,413,575 - 21,418,319 (+) Ensembl GRCr8 mRatBN7.2 12 16,299,768 - 16,304,553 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 12 16,299,808 - 16,304,552 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 12 17,116,744 - 17,121,495 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 12 17,740,468 - 17,745,219 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 12 16,803,395 - 16,808,132 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 12 18,516,858 - 18,521,235 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 12 18,516,946 - 18,521,892 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 12 20,501,826 - 20,506,189 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 12 16,807,161 - 16,810,619 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 12 18,049,537 - 18,053,151 (+) NCBI Celera RGSC_v3.1 12 16,837,082 - 16,841,642 (+) NCBI Cytogenetic Map 12 q11 NCBI
JBrowse:
Imported Disease Annotations - ClinVar
Imported Disease Annotations - OMIM
Only show annotations with direct experimental evidence (0 objects hidden)
Dhrsx Rat 1,2-dimethylhydrazine multiple interactions EXP 6480464 [APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of DHRSX mRNA CTD PMID:27840820 Dhrsx Rat 1,2-dimethylhydrazine decreases expression ISO Dhrsx (Mus musculus) 6480464 1,2-Dimethylhydrazine results in decreased expression of DHRSX mRNA CTD PMID:22206623 Dhrsx Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Dhrsx (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of DHRSX mRNA CTD PMID:21570461 Dhrsx Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of DHRSX mRNA CTD PMID:33387578|PMID:34747641 Dhrsx Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of DHRSX mRNA CTD PMID:21215274|PMID:32109520 Dhrsx Rat 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... CTD PMID:36041667 Dhrsx Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of DHRSX mRNA CTD PMID:30047161 Dhrsx Rat aflatoxin B1 decreases expression ISO DHRSX (Homo sapiens) 6480464 Aflatoxin B1 results in decreased expression of DHRSX mRNA CTD PMID:21641981|PMID:22100608 Dhrsx Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of DHRSX mRNA CTD PMID:30047161 Dhrsx Rat arsenous acid increases expression ISO DHRSX (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of DHRSX mRNA CTD PMID:26705709 Dhrsx Rat benzo[a]pyrene decreases expression ISO Dhrsx (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of DHRSX mRNA CTD PMID:27195522 Dhrsx Rat benzo[a]pyrene decreases expression ISO DHRSX (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of DHRSX mRNA CTD PMID:20064835|PMID:22316170|PMID:26238291|PMID:32234424 Dhrsx Rat benzo[a]pyrene diol epoxide I decreases expression ISO DHRSX (Homo sapiens) 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DHRSX mRNA CTD PMID:26238291 Dhrsx Rat bisphenol A increases expression ISO DHRSX (Homo sapiens) 6480464 bisphenol A results in increased expression of DHRSX mRNA CTD PMID:25047013 Dhrsx Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... CTD PMID:36041667 Dhrsx Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of DHRSX mRNA CTD PMID:25181051 Dhrsx Rat bisphenol F increases expression ISO Dhrsx (Mus musculus) 6480464 bisphenol F results in increased expression of DHRSX mRNA CTD PMID:38685157 Dhrsx Rat bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... CTD PMID:36041667 Dhrsx Rat clofibrate decreases expression ISO Dhrsx (Mus musculus) 6480464 Clofibrate results in decreased expression of DHRSX mRNA CTD PMID:17585979 Dhrsx Rat copper(II) sulfate decreases expression ISO DHRSX (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of DHRSX mRNA CTD PMID:19549813 Dhrsx Rat dextran sulfate increases expression ISO Dhrsx (Mus musculus) 6480464 Dextran Sulfate results in increased expression of DHRSX mRNA CTD PMID:35093514 Dhrsx Rat diarsenic trioxide increases expression ISO DHRSX (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of DHRSX mRNA CTD PMID:26705709 Dhrsx Rat dorsomorphin multiple interactions ISO DHRSX (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Dhrsx Rat doxorubicin decreases expression ISO DHRSX (Homo sapiens) 6480464 Doxorubicin results in decreased expression of DHRSX mRNA CTD PMID:29803840 Dhrsx Rat endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of DHRSX mRNA CTD PMID:29391264 Dhrsx Rat fenthion increases expression ISO Dhrsx (Mus musculus) 6480464 Fenthion results in increased expression of DHRSX mRNA CTD PMID:34813904 Dhrsx Rat finasteride increases expression EXP 6480464 Finasteride results in increased expression of DHRSX mRNA CTD PMID:24136188 Dhrsx Rat folic acid decreases expression ISO Dhrsx (Mus musculus) 6480464 Folic Acid results in decreased expression of DHRSX mRNA CTD PMID:25629700 Dhrsx Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of DHRSX mRNA CTD PMID:33387578 Dhrsx Rat indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of DHRSX mRNA CTD PMID:21396975 Dhrsx Rat methidathion increases expression ISO Dhrsx (Mus musculus) 6480464 methidathion results in increased expression of DHRSX mRNA CTD PMID:34813904 Dhrsx Rat methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of DHRSX mRNA CTD PMID:30047161 Dhrsx Rat methylmercury chloride decreases expression ISO DHRSX (Homo sapiens) 6480464 methylmercuric chloride results in decreased expression of DHRSX mRNA CTD PMID:28001369 Dhrsx Rat O-methyleugenol decreases expression ISO DHRSX (Homo sapiens) 6480464 methyleugenol results in decreased expression of DHRSX mRNA CTD PMID:32234424 Dhrsx Rat ozone multiple interactions ISO DHRSX (Homo sapiens) 6480464 [Air Pollutants results in increased abundance of Ozone] which affects the expression of DHRSX mRNA CTD PMID:35430440 Dhrsx Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of DHRSX mRNA CTD PMID:33387578 Dhrsx Rat SB 431542 multiple interactions ISO DHRSX (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Dhrsx Rat silicon dioxide decreases expression ISO DHRSX (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of DHRSX mRNA CTD PMID:25895662 Dhrsx Rat sodium arsenite decreases expression ISO Dhrsx (Mus musculus) 6480464 sodium arsenite results in decreased expression of DHRSX mRNA CTD PMID:37682722 Dhrsx Rat sulfadimethoxine decreases expression EXP 6480464 Sulfadimethoxine results in decreased expression of DHRSX mRNA CTD PMID:30047161 Dhrsx Rat sunitinib increases expression ISO DHRSX (Homo sapiens) 6480464 Sunitinib results in increased expression of DHRSX mRNA CTD PMID:31533062 Dhrsx Rat tetrachloroethene decreases expression ISO Dhrsx (Mus musculus) 6480464 Tetrachloroethylene results in decreased expression of DHRSX mRNA CTD PMID:28973375 Dhrsx Rat thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of DHRSX mRNA CTD PMID:34492290 Dhrsx Rat titanium dioxide increases expression ISO Dhrsx (Mus musculus) 6480464 titanium dioxide results in increased expression of DHRSX mRNA CTD PMID:29264374 Dhrsx Rat titanium dioxide increases methylation ISO Dhrsx (Mus musculus) 6480464 titanium dioxide results in increased methylation of DHRSX gene CTD PMID:35295148 Dhrsx Rat titanium dioxide decreases methylation ISO Dhrsx (Mus musculus) 6480464 titanium dioxide results in decreased methylation of DHRSX gene; titanium dioxide results in decreased methylation more ... CTD PMID:35295148 Dhrsx Rat triadimefon decreases expression EXP 6480464 triadimefon results in decreased expression of DHRSX mRNA CTD PMID:30047161 Dhrsx Rat trichostatin A decreases expression ISO DHRSX (Homo sapiens) 6480464 trichostatin A results in decreased expression of DHRSX mRNA CTD PMID:24935251 Dhrsx Rat triphenyl phosphate affects expression ISO DHRSX (Homo sapiens) 6480464 triphenyl phosphate affects the expression of DHRSX mRNA CTD PMID:37042841 Dhrsx Rat valproic acid decreases expression ISO DHRSX (Homo sapiens) 6480464 Valproic Acid results in decreased expression of DHRSX mRNA CTD PMID:23179753|PMID:24383497|PMID:26272509|PMID:28001369|PMID:29154799 Dhrsx Rat valproic acid multiple interactions ISO DHRSX (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386
QTLs in Region (GRCr8)
2312418 Kidm41 Kidney mass QTL 41 3.7 0.0001 kidney mass (VT:0002707) single kidney wet weight to body weight ratio (CMO:0000622) 12 5921918 25247790 Rat 61443 Btemp2 Thermal response to stress QTL 2 3.3 0.000094 body temperature trait (VT:0005535) core body temperature (CMO:0001036) 12 20139028 26430640 Rat 70213 Niddm27 Non-insulin dependent diabetes mellitus QTL 27 3.72 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 12 11200494 52308831 Rat 2306789 Ean6 Experimental allergic neuritis QTL 6 4.9 nervous system integrity trait (VT:0010566) experimental autoimmune neuritis severity score (CMO:0001528) 12 1 29775522 Rat 8552964 Pigfal17 Plasma insulin-like growth factor 1 level QTL 17 3.5 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 12 11200494 52308831 Rat 7411641 Foco19 Food consumption QTL 19 27.7 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 12 11200494 52308831 Rat 5684888 Pia42 Pristane induced arthritis QTL 42 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 12 3489416 48489416 Rat 1331739 Hrtrt14 Heart rate QTL 14 3.56232 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 12 1 38687564 Rat 1641928 Alcrsp5 Alcohol response QTL 5 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 12 18473041 52308831 Rat 8552912 Pigfal6 Plasma insulin-like growth factor 1 level QTL 6 5 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 12 11200497 52308831 Rat 1549829 Scl48 Serum cholesterol level QTL 48 5 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 12 15264248 52308831 Rat 61331 Eau2 Experimental allergic uveoretinitis QTL 2 0.0005 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) 12 1 33700600 Rat 10059594 Kidm46 Kidney mass QTL 46 3.79 0.025 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 12 11743528 52308831 Rat 8552918 Pigfal7 Plasma insulin-like growth factor 1 level QTL 7 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 12 11200494 52308831 Rat 2293684 Bmd26 Bone mineral density QTL 26 4.4 0.0002 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 12 1 38635130 Rat 6893681 Bw109 Body weight QTL 109 2.3 0.004 body mass (VT:0001259) body weight (CMO:0000012) 12 1 28133365 Rat 1302792 Scl21 Serum cholesterol level QTL 21 3.8 0.0011 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 12 12233000 30490641 Rat 61404 Bw120 Body weight QTL 120 5.1 body mass (VT:0001259) body mass index (BMI) (CMO:0000105) 12 17464979 46784661 Rat 1300174 Bw15 Body weight QTL 15 2.93 body mass (VT:0001259) body weight loss (CMO:0001399) 12 1 28606299 Rat 1331786 Kidm11 Kidney mass QTL 11 3.571 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) 12 16187438 52308831 Rat 1331787 Rf41 Renal function QTL 41 2.998 kidney blood vessel physiology trait (VT:0100012) absolute change in renal blood flow rate (CMO:0001168) 12 1 33700556 Rat 2293699 Bss49 Bone structure and strength QTL 49 5.61 0.0001 lumbar vertebra size trait (VT:0010518) lumbar vertebra trabecular cross-sectional area (CMO:0001692) 12 16135029 52308831 Rat 1331761 Bp218 Blood pressure QTL 218 2.973 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 12 16187438 51213550 Rat 1331763 Wbc2 White blood cell count QTL 2 3.162 leukocyte quantity (VT:0000217) total white blood cell count (CMO:0000365) 12 11200494 52308831 Rat 61416 Pia4 Pristane induced arthritis QTL 4 8.4 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) 12 18749469 36488809 Rat 7204484 Bp358 Blood pressure QTL 358 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 12 1 24849755 Rat 7411547 Bw129 Body weight QTL 129 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 6 11200494 52308831 Rat 7387292 Kidm42 Kidney mass QTL 42 3.03 0.0004 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 12 1 41361854 Rat 61421 Cia12 Collagen induced arthritis QTL 12 4.6 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 12 18749469 34312613 Rat 1298081 Cia25 Collagen induced arthritis QTL 25 4.7 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 12 2747694 47747694 Rat 2303569 Gluco44 Glucose level QTL 44 2 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 12 18473041 52308831 Rat 2303568 Bw88 Body weight QTL 88 3 body mass (VT:0001259) body weight (CMO:0000012) 12 1 28606299 Rat 2303575 Insul14 Insulin level QTL 14 4 blood insulin amount (VT:0001560) blood insulin level (CMO:0000349) 12 3087180 48087180 Rat 7411588 Foco6 Food consumption QTL 6 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 12 11200494 52308831 Rat 7243862 Mcs30 Mammary carcinoma susceptibility QTL 30 8.62 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 12 5633306 50633306 Rat 2300186 Bmd59 Bone mineral density QTL 59 7.1 0.0001 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) 12 16135029 52308831 Rat 2293086 Iddm30 Insulin dependent diabetes mellitus QTL 30 3.82 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 12 7901625 33938215 Rat 7411597 Foco10 Food consumption QTL 10 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 12 11200494 52308831 Rat 1331755 Bp219 Blood pressure QTL 219 3.041 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 12 16187438 33700556 Rat