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Gene: Klhl9 (kelch-like family member 9) Rattus norvegicus

Analyze

Symbol:

Klhl9

Name:

kelch-like family member 9

RGD ID:

1304814

Description:

Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination and regulation of cytokinesis. Predicted to be located in midbody. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KLHL9 (kelch like family member 9); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

kelch-like 9; kelch-like 9 (Drosophila); kelch-like protein 9; LOC313348; RGD1304814; similar to Hypothetical protein KIAA1354

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KLHL9 (kelch like family member 9)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Klhl9 (kelch-like 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Klhl9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KLHL9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KLHL9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Klhl9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KLHL9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Klhl9 (kelch like family member 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KLHL9 (kelch like family member 9)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Klhl9 (kelch-like 9)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	klhl13 (kelch-like family member 13)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	klhl13	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	108,449,492 - 108,453,676 (-)	NCBI		GRCr8
mRatBN7.2	5	103,333,747 - 103,337,931 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	5	105,682,082 - 105,686,266 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	107,472,529 - 107,476,713 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	107,540,336 - 107,544,540 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	107,323,258 - 107,327,442 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	107,323,258 - 107,327,442 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	111,299,120 - 111,303,304 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	108,196,981 - 108,201,165 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	108,203,022 - 108,206,163 (-)	NCBI
Celera	5	102,067,020 - 102,071,204 (-)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

5-fluorouracil (ISO)

all-trans-retinoic acid (ISO)

antimycin A (ISO)

aristolochic acid A (ISO)

avobenzone (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

captan (ISO)

CGP 52608 (ISO)

cisplatin (EXP)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

elemental selenium (ISO)

fenthion (ISO)

folic acid (ISO)

folpet (ISO)

glyphosate (EXP)

hydralazine (ISO)

indometacin (ISO)

ketamine (EXP)

methapyrilene (EXP)

methidathion (ISO)

methylmercury chloride (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

quercetin (ISO)

rimonabant (ISO)

rotenone (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

tebufenpyrad (ISO)

temozolomide (ISO)

titanium dioxide (ISO)

tributylstannane (EXP)

trichloroethene (EXP,ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein ubiquitination (IBA,ISO)

regulation of cytokinesis (IBA,ISO)

Cellular Component

Cul3-RING ubiquitin ligase complex (IBA,ISO)

midbody (ISO)

Molecular Function

cullin family protein binding (IBA,ISO)

protein binding (ISO)

ubiquitin-protein transferase activity (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:14528312	PMID:17543862	PMID:19995937

Genomics

Comparative Map Data

Klhl9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	108,449,492 - 108,453,676 (-)	NCBI		GRCr8
mRatBN7.2	5	103,333,747 - 103,337,931 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	5	105,682,082 - 105,686,266 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	107,472,529 - 107,476,713 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	107,540,336 - 107,544,540 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	107,323,258 - 107,327,442 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	107,323,258 - 107,327,442 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	111,299,120 - 111,303,304 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	108,196,981 - 108,201,165 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	108,203,022 - 108,206,163 (-)	NCBI
Celera	5	102,067,020 - 102,071,204 (-)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI

KLHL9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	21,329,665 - 21,335,404 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	21,320,024 - 21,335,404 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	21,329,664 - 21,335,403 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	21,321,018 - 21,325,429 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	21,321,019 - 21,325,371	NCBI
Celera	9	21,269,331 - 21,273,742 (-)	NCBI		Celera
Cytogenetic Map	9	p21.3	NCBI
HuRef	9	21,294,476 - 21,298,889 (-)	NCBI		HuRef
CHM1_1	9	21,330,834 - 21,335,247 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	21,343,833 - 21,349,574 (-)	NCBI		T2T-CHM13v2.0

Klhl9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	88,636,529 - 88,640,745 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	88,636,529 - 88,640,702 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	88,718,292 - 88,722,508 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	88,718,292 - 88,722,465 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	88,364,196 - 88,368,412 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	88,190,813 - 88,193,692 (-)	NCBI		MGSCv36	mm8
Celera	4	87,227,411 - 87,231,634 (-)	NCBI		Celera
Cytogenetic Map	4	C4	NCBI
cM Map	4	42.02	NCBI

Klhl9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955472	12,851,352 - 12,854,245 (-)	NCBI	ChiLan1.0	ChiLan1.0

KLHL9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	103,197,022 - 103,201,449 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	103,202,967 - 103,207,394 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	21,191,847 - 21,196,242 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	21,809,412 - 21,813,812 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	21,811,230 - 21,813,251 (-)	Ensembl	panpan1.1		panPan2

KLHL9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	40,792,064 - 40,796,433 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	40,792,603 - 40,794,456 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	39,465,303 - 39,469,495 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	41,735,006 - 41,739,198 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	11	40,414,965 - 40,419,157 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	40,292,449 - 40,296,641 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	40,906,715 - 40,910,907 (+)	NCBI		UU_Cfam_GSD_1.0

Klhl9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	155,196,833 - 155,201,259 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936652	2,866,340 - 2,870,759 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KLHL9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	201,585,965 - 201,591,830 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	201,587,241 - 201,591,830 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	224,955,237 - 224,959,819 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Klhl9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	25,158,528 - 25,160,381 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	25,156,647 - 25,160,895 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Klhl9
11 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	172
Count of miRNA genes:	127
Interacting mature miRNAs:	141
Transcripts:	ENSRNOT00000008510
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	68984307	104251008	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
61380	Edpm5	Estrogen-dependent pituitary mass QTL 5	4.5	0.92	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	5	68984307	104251008	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1298070	Scl18	Serum cholesterol level QTL 18	3.7		blood LDL cholesterol amount (VT:0000181)	calculated plasma low density lipoprotein cholesterol level (CMO:0001245)	5	79584860	124584860	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	94858972	143070159	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
1598859	Cm66	Cardiac mass QTL 66	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	79584860	124584860	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	97570330	136479578	Rat
1582212	Livw2	Liver weight QTL 2	3.5	0.0004	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	5	99016066	119085810	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	87468046	132468046	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
7394708	Emca11	Estrogen-induced mammary cancer QTL 11			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	99753548	113061097	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
1598846	Bp293	Blood pressure QTL 293	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	79584860	124584860	Rat
1358909	Kidm25	Kidney mass QTL 25	1.87		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	90067849	128034027	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
631527	Tls1	T-lymphoma susceptibility QTL 1	0	0.001	thymus integrity trait (VT:0010555)	post-insult time to onset of T-cell lymphoma (CMO:0001907)	5	90450144	135450144	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
1600362	Mcs19	Mammary carcinoma susceptibility QTL 19	2.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	99485997	103690167	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	84132602	129132602	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	64719390	109719390	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	66174080	124160948	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	58829236	128034027	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	68984307	104251008	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	87765973	132765973	Rat
1358889	Bp261	Blood pressure QTL 261	2.86		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	90067849	128034027	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	59793528	113558156	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000008510 ⟹ ENSRNOP00000061990

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	107,323,258 - 107,327,442 (+)	Ensembl

RefSeq Acc Id:

NM_001107944 ⟹ NP_001101414

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	108,449,492 - 108,453,676 (-)	NCBI
mRatBN7.2	5	103,333,747 - 103,337,931 (-)	NCBI
Rnor_6.0	5	107,323,258 - 107,327,442 (+)	NCBI
Rnor_5.0	5	111,299,120 - 111,303,304 (+)	NCBI
RGSC_v3.4	5	108,196,981 - 108,201,165 (-)	RGD
Celera	5	102,067,020 - 102,071,204 (-)	RGD

Sequence:

show sequence

TCCGGAAGGTCGAGCTGGGCGTCGGTGCTAGGCCGCCGTTCTAGGCCCAAGTCGGAATTCCAGG
CCCTGCTCCAAGCCAAGCCGGTGGCCGCAGAGACACATCGAAGACCGCAGAAGTCGCAGCCGCA
GCTCGCTGAGGTGCTGAACCTTGGAGGGCGGCAGCCCGGGTGCGCAGGCCGTGACGGCCCCTCC
CCCACCCTGAGCGCAGCGGCGAAGGACGACAACCCGGGCCGGACGAGGTGAAGCGGTCACGTAA
CTGCCTCAGGTGATGACTCACCGACTCTACTGTCAGATTTGACGTGCGTGGTGCTGCTGCAGGG
CGGACGTCGGTGTGCCCAGTGCGGTGCTGCGGCGACCGCTTGCCTGTTCGGCGGCCCTGCGTTT
CCCCAGAGCGTTCTCTTTGTAACGTCTGCGGCCTGCAGCTTGCTGCGAGCTCCGGGTTCTCCCA
TGAAGGTGTCGCTCGGTAACGGCGAGATGGGCGTCTCTGCCCACCTGCAGCCTTGCAAGGCTGG
AACTACGCGGTTTTTTACCAGCAATACGCACAGTTCTGTTGTATTGCAAGGCTTTGATCAGCTC
AGAATAGAGGGACTGCTTTGTGACGTGACTCTGGTACCAGGCGATGGAGAGGAAATCTTCCCAG
TTCATAGAGCCATGATGGCGTCTGCCAGTGATTATTTCAAGGCCATGTTCACAGGAGGAATGAA
GGAGAAAGATCTAATGTGCATTAAGCTTCATGGGGTGAACAAAGTTGGTCTGAAGAAAATCATT
GATTTTATTTATACTGCAAAACTCTCTCTCAATATGGACAATCTTCAGGATACTCTTGAGGCTG
CCAGCTTTCTACAGATCTTGCCGGTTTTGGATTTTTGTAAAGTATTTCTTATATCTGGTGTCTC
CTTAGATAACTGTGTTGAGGTTGGACGGATTGCTAACACCTACAATCTTATAGAAGTGGATAAA
TACGTAAATAATTTCATCCTGAAGAACTTTCCTGCCTTGTTGAGTACCGGGGAGTTTCTAAAAC
TCCCCTTTGAACGGCTTGCCTTTGTGCTTTCCAGCAATAGTCTCAAGCACTGTTCTGAACTTGA
ACTCTTCAAGGCAGCCTGCCGCTGGTTGAGGCTGGAAGACCCTCGGATGGACTATGCTGCAAAA
TTAATGAAGAATATTCGCTTCCCACTGATGACGCCACAGGATCTCATCAACTATGTGCAGACAG
TAGATTTCATGAGAACTGACAATACCTGTGTGAATTTACTTTTGGAAGCAAGCAATTACCAAAT
GATGCCATATATGCAGCCAGTGATGCAGTCAGACAGAACTGCCATTCGATCAGATTCTACTCAT
TTGGTTACGTTAGGAGGAGTTTTGAGGCAACAGCTGGTTGTAAGTAAAGAGTTACGGATGTACG
ACGAAAGGGCGCAGGAGTGGAAATCGTTAGCCCCTATGGATGCTCCTCGATACCAGCACGGCAT
TGCTGTTATTGGAAACTTCCTTTATGTAGTTGGTGGTCAGAGTAATTATGACACAAAAGGAAAA
ACTGCTGTTGATACAGTCTTCAGATTTGATCCTCGTTATAATAAGTGGATGCAGGTGGCATCAT
TAAACGAAAAGCGCACATTTTTTCACCTGAGTGCACTCAAAGGACATTTATATGCAGTTGGTGG
ACGCAGTGCAGCTGGTGAACTGGCCACAGTAGAATGTTACAACCCAAGAATGAATGAATGGAGC
TATGTTGCAAAAATGAGTGAACCCCACTATGGCCATGCTGGAACAGTATATGGGGGTTTAATGT
ATATATCCGGAGGAATTACCCATGACACTTTCCAAAATGAGCTCATGTGTTTTGACCCAGATAC
AGACAAATGGACACAGAAGGCTCCTATGACTACAGTCCGAGGTCTGCATTGCATGTGTACAGTT
GGAGACAAGCTGTATGTCATTGGTGGCAACCATTTCAGAGGAACAAGTGATTATGATGATGTCC
TAAGCTGCGAATACTATTCGCCAACTCTTGACCAGTGGACACCAATTGCTGCTATGCTAAGAGG
TCAGAGTGATGTTGGAGTTGCGGTCTTCGAAAACAAAATCTACGTTGTTGGTGGATATTCTTGG
AATAACCGCTGCATGGTAGAAATTGTCCAGAAATATGACCCAGAAAAAGATGAGTGGCATAAAG
TTTTTGATCTTCCAGAGTCACTTGGTGGCATTCGGGCTTGCACTCTCACAGTTTTTCCACCTGA
AGAAAACCCTGGGTCACCTTCTAGAGAATCACCTCTTTCAGCACCTTCAGATCATTCTTAGATT
CAAGGTGTAATACCTTTTCAGTGTATCAGGGATGGTGTTGTACTTCCCCTTCAATTGTCTCTCC
TTATTGCTACAGTTAATAGACAAAAAGGTAACTTAGGTTTTTTTTTTTGTTGTTGTTTGTTTGG
CTTCAAATTGTTTATTAGATGGCTAACAAGTGCATTTTGAAAAGTATTAAATATATTCAGCTGT
TTAACAAGTGAAAAAGATACATAGAAAATTAGATGTTTTTTGTAGTGTTACATATGTCAAATTG
TAGATCATAGTAAATGTGTAATGATGTCTATTATACTAAAAAATTGAAACATTTGATTTGACTG
AAACATTAAGTGGAGGCCCCTGTTCTAATCTAGAATAAAGATTGCCAGGTACCGCTACCTCCCT
CTTGGATAGTTTTGGACAATCTGTTAAACTAGGCTGTGTGATTAGTCTTAGAATATTTGAAGTT
TCTTAGGTAGTCAGAAATAGTGACAAAATTAGCGAGAAGAAACAGGTCAGGATTTGTTATCACT
GGAGGAAAAATAATAGATGTGTACACTAGTCAGATACACTCACACAAAACTTTGTGTGTACATA
TATATAAACTTTTAGACTTGGTAAAAACTTCAATTGTAGTGAAAATGACCTTATATTTTCTTCC
AGAAAGCAGCTAATTTTATTTCAATGAAAATTCAATACCAGAGAGTCCATGTCTAAAGTCTTAT
ACAGAATTTAGATGCTAAGGGCTACAACAAACTAAATTGACAGCCAAATTTGTCATTTAATGGA
ATCGTTTCTTTAAATAAAATTTAATTAGTTTTTCTGTATATTCTGTAGTTACATGCCTATAGAT
TATTTAGCAGAAGGCAAGTTTAGATTTTTTTTATCATTAACTTTTTAACCTGTGAAATTCAGGA
GTTAAGGAAGGCAAAGAAGCATTTTCAACAAAGCTCCGGGATTTTAAGTTTAGTCCTGCCTTAG
TCTCTCTGACCTGTTTATTATGTGATTTTGAGTGATTTCTGGTGCTGCTGTAGCTGGTAAGCAT
CCAGTAATGTGTGAGCTGCCTCAAGGCTGTGATCTGAGCAAACAGAGACACACCCTGTTCTGCA
TCTAATCAGAAATAGGCCTTTTTAGCCTTGACTCAAGGATAGAACCAACTTCAGGTCCTCTAAG
AAGTCAGCTGGTTTCTTTAAGGCCGTGCTTTAGTAGGTAGACCTTCAGTCTTCATTACTGTGGG
AATACTTTCTGACTGAGAATTACTGGGGAAAATCTTACAGGGAACTTATCAGATAAATGGAATT
ACAATGTCCCTTGGTAATGAGTGATACTGAATATGTACTTTCCTGGGAAAATTGTTCAACTGAA
GGAAAAAATAGACACACACACACACACACACACACACACACACACACACACACACGCATGTCTA
GCCCTGACAGTGCCAGAGTGTAAATCAGGAGCAATGCCATTAACAGTCCTTTAATGTAATTCAA
AAGGATTTGGCTTCTGGCATCTGAACTTTACTTACTGCCCATACATACATGTGTTGATTCATTT
TAATGCTTTTCATGATTTCTTCATTAACAGAATTTTCATACTTTGTTTTTTTAAAATGACTCCA
TTTTTTTTTTTGTTGTTGTTGTTAACTTCAGACATATTTGAGTGCTTTTAGAAGTTAAGGTAAA
AATTGCTACTAACTTTGTGTATTGAATAAGCAAGCAAGAAATTGCATCCTGATTTTTTTTTCTT
TTTTATTAATAGTAAGGTTGAATACTTGTGTATTTTGAAAAGCTACATTTTCTCTTTGGTCAAA
TGTTAATGTCCTTGTGATATCTTTTGGAGTTGCTTTGTTTTTCATATCAAGTTACAGGATCTCT
TTATATAATAAAACTACTTAACCAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101414	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68717	(Get FASTA)	NCBI Sequence Viewer
	EDL97739	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000082058.1

RefSeq Acc Id:

NP_001101414 ⟸ NM_001107944

- UniProtKB:

B5DEL5 (UniProtKB/TrEMBL), A0A8I5ZU85 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGEEIFP
VHRAMMASASDYFKAMFTGGMKEKDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEA
ASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLK
LPFERLAFVLSSNSLKHCSELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQT
VDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMY
DERAQEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVAS
LNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLM
YISGGITHDTFQNELMCFDPDTDKWTQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDV
LSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHK
VFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS

hide sequence

Ensembl Acc Id:

ENSRNOP00000061990 ⟸ ENSRNOT00000008510

Protein Domains

BTB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DEL5-F1-model_v2	AlphaFold	B5DEL5	1-617	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693830

Promoter ID:

EPDNEW_R4355

Type:

initiation region

Name:

Klhl9_1

Description:

kelch-like family member 9

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	107,323,255 - 107,323,315	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304814	AgrOrtholog
BioCyc Gene	G2FUF-40807	BioCyc
Ensembl Genes	ENSRNOG00000006335	Ensembl
	ENSRNOG00000014029	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000106563.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.420	UniProtKB/TrEMBL
	2.120.10.80	UniProtKB/TrEMBL
InterPro	BACK	UniProtKB/TrEMBL
	BTB/POZ-like	UniProtKB/TrEMBL
	BTB/POZ_fold	UniProtKB/TrEMBL
	Kelch-like_gigaxonin	UniProtKB/TrEMBL
	Kelch-typ_b-propeller	UniProtKB/TrEMBL
	Kelch_1	UniProtKB/TrEMBL
KEGG Report	rno:313348	UniProtKB/TrEMBL
NCBI Gene	313348	ENTREZGENE
PANTHER	KELCH-LIKE PROTEIN 13	UniProtKB/TrEMBL
	KELCH-LIKE PROTEIN 9	UniProtKB/TrEMBL
	LD33804P	UniProtKB/TrEMBL
Pfam	BACK	UniProtKB/TrEMBL
	BTB	UniProtKB/TrEMBL
	Kelch_1	UniProtKB/TrEMBL
PhenoGen	Klhl9	PhenoGen
PIRSF	Kelch-like_protein_gigaxonin	UniProtKB/TrEMBL
PROSITE	BTB	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006335	RatGTEx
	ENSRNOG00000014029	RatGTEx
SMART	BACK	UniProtKB/TrEMBL
	BTB	UniProtKB/TrEMBL
	Kelch	UniProtKB/TrEMBL
Superfamily-SCOP	BTB/POZ_fold	UniProtKB/TrEMBL
	SSF117281	UniProtKB/TrEMBL
UniProt	A0A8I5ZU85	ENTREZGENE, UniProtKB/TrEMBL
	B5DEL5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-02-06	Klhl9	kelch-like family member 9	Klhl9	kelch-like 9 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Klhl9	kelch-like 9 (Drosophila)	Klhl9_predicted	kelch-like 9 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Klhl9_predicted	kelch-like 9 (Drosophila) (predicted)	RGD1304814_predicted	similar to Hypothetical protein KIAA1354 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1304814_predicted	similar to Hypothetical protein KIAA1354 (predicted)	LOC313348_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC313348_predicted	similar to Hypothetical protein KIAA1354 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)