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49 records found for search term Ndp
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RGD IDSymbolNameDescriptionChrStartStopSpeciesAnnotationsMatchType
1343189NDPnorrin cystine knot growth factor NDPThis gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq, Feb 200X4394877643973390Human316symbol , old_gene_name , COSMIC , name , Human Proteome Mapgene, protein-coding, REVIEWED [RefSeq]
1558298NdpNorrie disease (pseudoglioma) (human)This gene encodes a secreted protein that acts a ligand for multiple different receptors and participates in both Wnt and Wnt-independant signalling. Its activity is important in vascular development of the eye and inner ear. Mutation of the related gene in humans causes Norrie syndrome. [provided bX1675176016778013Mouse210symbol , PhenoGen , old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
1563968Ndpnorrin cystine knot growth factor NDPENCODES a protein that exhibits cytokine activity (ortholog); frizzled binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN decidualization; action potential (ortholog); angiogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH exudative vitrX83795698404019Rat170symbol , old_gene_name , PhenoGen , name , old_gene_symbolgene, protein-coding, PROVISIONAL [RefSeq]
8961118Ndpnorrin cystine knot growth factor NDPENCODES a protein that exhibits cytokine activity (ortholog); frizzled binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN action potential (ortholog); angiogenesis (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED NW_00495551642187034244774Chinchilla92symbol , old_gene_name , namegene, protein-coding, MODEL [RefSeq]
11670174NDPnorrin cystine knot growth factor NDPENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein homodimerization activity (inferred); INVOLVED IN action potential (ortholog); angiogenesis (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED X3639986836424953Bonobo100symbol , old_gene_name , namegene, protein-coding, MODEL [RefSeq]
12246377NDPnorrin cystine knot growth factor NDPENCODES a protein that exhibits cytokine activity (ortholog); frizzled binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN action potential (ortholog); angiogenesis (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED X3794956037975573Dog92symbol , old_gene_name , namegene, protein-coding, MODEL [RefSeq]
12477793Ndpnorrin cystine knot growth factor NDPENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein homodimerization activity (inferred); INVOLVED IN action potential (ortholog); angiogenesis (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED NW_0049365021008016910105155Squirrel100symbol , old_gene_name , namegene, protein-coding, MODEL [RefSeq]
13845440NDPnorrin cystine knot growth factor NDPENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein homodimerization activity (inferred); INVOLVED IN action potential (ortholog); angiogenesis (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED Pig100symbol , old_gene_name , namegene, protein-coding, PROVISIONAL [RefSeq]
18468222NDPnorrin cystine knot growth factor NDPENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein homodimerization activity (inferred); INVOLVED IN action potential (ortholog); angiogenesis (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED Green Monkey100symbol , old_gene_name , namegene, protein-coding, MODEL [RefSeq]
18923007Ndpnorrin cystine knot growth factor NDPENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein homodimerization activity (inferred); INVOLVED IN action potential (ortholog); angiogenesis (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED Naked Mole-Rat100symbol , old_gene_name , namegene, protein-coding, MODEL [RefSeq]
284664818ndpTropical Clawed Frogsymbolgene, null
625964329Ndpnorrin cystine knot growth factor NDPENCODES a protein that exhibits cytokine activity (ortholog); frizzled binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN action potential (ortholog); angiogenesis (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED Black Rat92symbol , namegene, protein-coding, MODEL [RefSeq]
284665340ndp.LAfrican Clawed Frogsymbolgene, null
288083495ndp.SAfrican Clawed Frogsymbolgene, null
6481394NDP-AS1NDP antisense RNA 1X4394973243971552Humansymbol , COSMIC , name , Human Proteome Mapgene, ncrna, VALIDATED [RefSeq]
1623116Calcoco2calcium binding and coiled-coil domain 2Predicted to enable protein homodimerization activity. Predicted to be involved in positive regulation of autophagosome maturation; response to type II interferon; and xenophagy. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and perinuclear region of cytoplasm. Predic119599019596015362Mouse85old_gene_name , old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
735394Nme1NME/NM23 nucleoside diphosphate kinase 1Predicted to enable several functions, including DNA binding activity; nuclease activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within lactation. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; brain;119384975193859341Mouse406old_gene_name , old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
70497Nme1NME/NM23 nucleoside diphosphate kinase 1ENCODES a protein that exhibits enzyme binding; farnesyl diphosphate kinase activity; gamma-tubulin binding; INVOLVED IN cellular response to fatty acid; cellular response to glucose stimulus; cellular response to xenobiotic stimulus; PARTICIPATES IN adefovir pharmacokinetics pathway; de novo pyrimi107940393979426620Rat351old_gene_namegene, protein-coding, PROVISIONAL [RefSeq]
735393NME1NME/NM23 nucleoside diphosphate kinase 1This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuro175115355951162168Human356old_gene_name , old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
12394063NME1non-metastatic cells 1, protein (NM23A) expressed inENCODES a protein that exhibits 3'-5'-DNA exonuclease activity (ortholog); acetyl-CoA binding (ortholog); ADP binding (ortholog); INVOLVED IN acetyl-CoA catabolic process (ortholog); apoptotic DNA fragmentation (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN adefovir pharmaco92699033626998895Dog134old_gene_namegene, protein-coding, PROVISIONAL [RefSeq]
1642401NME1-NME2NME1-NME2 readthroughThis locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple 175115355951171744Human35old_gene_namegene, protein-coding, VALIDATED [RefSeq]
619877Nme2NME/NM23 nucleoside diphosphate kinase 2ENCODES a protein that exhibits enzyme binding; fatty acid binding; heterocyclic compound binding; INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; cellular response to fatty acid; cellular response to glucose stimulus; PARTICIPATES IN adefovir pharmacokinetics 107939499979400418Rat259old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1346564NME2NME/NM23 nucleoside diphosphate kinase 2Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturall175116553651171744Human254old_gene_name , old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1552274Nme2NME/NM23 nucleoside diphosphate kinase 2Predicted to enable several functions, including anion binding activity; kinase activity; and transcription coactivator activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; negative regulation of myeloid leukocyte differentiation; and ribonucleoside119384064093847082Mouse285old_gene_namegene, protein-coding, VALIDATED [RefSeq]
12238112NME2non-metastatic cells 2, protein (NM23B) expressed inENCODES a protein that exhibits coenzyme A binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to fatty acid (ortholog); cellular respo92700211427005740Dog108old_gene_namegene, protein-coding, PROVISIONAL [RefSeq]
14067043NME2NME/NM23 nucleoside diphosphate kinase 2ENCODES a protein that exhibits coenzyme A binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to fatty acid (ortholog); cellular respoPig108old_gene_namegene, protein-coding, VALIDATED [RefSeq]
733554NME3NME/NM23 nucleoside diphosphate kinase 3Enables nucleoside diphosphate kinase activity. Involved in DNA repair; mitochondrial fusion; and nucleoside triphosphate biosynthetic process. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025]1617703201771543Human148old_gene_name , old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1551685Nme3NME/NM23 nucleoside diphosphate kinase 3Enables nucleoside diphosphate kinase activity. Predicted to be involved in DNA repair; mitochondrial fusion; and nucleoside triphosphate biosynthetic process. Located in ciliary basal body. Is expressed in several structures, including gut; hemolymphoid system gland; nervous system; respiratory sys172511547425116505Mouse170old_gene_name , old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
1318408NME4NME/NM23 nucleoside diphosphate kinase 4The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene 16396729400754Human150old_gene_name , description , old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
61896Nme6NME/NM23 nucleoside diphosphate kinase 6ENCODES a protein that exhibits nucleoside diphosphate kinase activity (ortholog); INVOLVED IN negative regulation of cell growth (ortholog); negative regulation of mitotic nuclear division (ortholog); nucleotide metabolic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficien8118708092118717756Rat112old_gene_namegene, protein-coding, VALIDATED [RefSeq]
62189Nme6NME/NM23 nucleoside diphosphate kinase 6Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of cell growth and negative regulation of mitotic nuclear division. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoi9109661830109672042Mouse121old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1604057NME6NME/NM23 nucleoside diphosphate kinase 6Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 104534828764048301367Human113old_gene_name , descriptiongene, protein-coding, VALIDATED [RefSeq]
619880Nme7NME/NM23 family member 7ENCODES a protein that exhibits 3'-5'-DNA exonuclease activity (ortholog); nucleoside diphosphate kinase activity (ortholog); protein kinase activity (ortholog); INVOLVED IN brain development (ortholog); cellular response to leukemia inhibitory factor (ortholog); cilium assembly (ortholog); PARTICIP137919046279319890Rat191old_gene_namegene, protein-coding, PROVISIONAL [RefSeq]
733959NME7NME/NM23 family member 7This gene encodes a member of the non-metastatic expressed family of nucleoside diphosphate kinases. Members of this family are enzymes that catalyzes phosphate transfer from nucleoside triphosphates to nucleoside diphosphates. This protein contains two kinase domains, one of which is involved in au1169132531169367797Human157old_gene_namegene, protein-coding, REVIEWED [RefSeq]
733960Nme7NME/NM23 family member 7Predicted to enable 3'-5' exonuclease activity and protein kinase activity. Involved in flagellated sperm motility. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; epithelial cilium movement involved in extracellular fluid movement; and intrac1164135091164264870Mouse176old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1343010NME5NME/NM23 family member 5Enables 3'-5' exonuclease activity. Involved in spermatid development. Predicted to be located in 9+2 motile cilium. Predicted to be part of radial spoke. Predicted to be active in cilium. Implicated in primary ciliary dyskinesia. [provided by Alliance of Genome Resources, Jul 2025]5138115175138139428Human148old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1623132Nme5NME/NM23 family member 5Predicted to enable 3'-5' exonuclease activity. Involved in spermatid development. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and v183469568734712168Mouse112old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1318409Nme4NME/NM23 nucleoside diphosphate kinase 4Predicted to enable cardiolipin binding activity and nucleoside diphosphate kinase activity. Predicted to be involved in lipid transport. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and trigeminal ganglion. Orthologous to h172631070826314650Mouse163old_gene_name , old_gene_symbolgene, protein-coding, PROVISIONAL [RefSeq]
1594734Nme2-ps1NME/NM23 nucleoside diphosphate kinase 2, pseudogene 1INTERACTS WITH ammonium chloride201117895011179551Rat1old_gene_namegene, pseudo, INFERRED [RefSeq]
1595422Nme2-ps7NME/NM23 nucleoside diphosphate kinase 2, pseudogene 723520494235207505Ratold_gene_namegene, pseudo, MODEL [RefSeq]
1565403Nme2-ps8NME/NM23 nucleoside diphosphate kinase 2, pseudogene 8INTERACTS WITH methoxychlor8108002561108003149Rat1old_gene_namegene, pseudo, MODEL [RefSeq]
1583004Nme5NME/NM23 family member 5ENCODES a protein that exhibits 3'-5'-DNA exonuclease activity (ortholog); nucleoside diphosphate kinase activity (ortholog); INVOLVED IN cilium assembly (ortholog); DNA catabolic process (ortholog); epithelial cilium movement involved in extracellular fluid movement (ortholog); ASSOCIATED WITH Here182643770526454828Rat77old_gene_namegene, protein-coding, VALIDATED [RefSeq]
1591334Nme4NME/NM23 nucleoside diphosphate kinase 4ENCODES a protein that exhibits GTPase binding; protein-containing complex binding; cardiolipin binding (ortholog); INVOLVED IN intermembrane phospholipid transfer (ortholog); lipid transport (ortholog); protein hexamerization (ortholog); PARTICIPATES IN cardiolipin metabolic pathway; de novo pyrimi101561910615622961Rat144old_gene_namegene, protein-coding, PROVISIONAL [RefSeq]
1351599CARD8caspase recruitment domain family member 8The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role194820314848255946Human112old_gene_name , old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
1601886CALCOCO2calcium binding and coiled-coil domain 2This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for174883103548865245Human87old_gene_name , old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
1316988ENAHENAH actin regulatorThis gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene 1225486829225653878Human144old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
1332566EnahENAH actin regulatorEnables SH3 domain binding activity and profilin binding activity. Involved in actin filament organization and actin polymerization-dependent cell motility. Acts upstream of or within actin polymerization or depolymerization; cellular response to leukemia inhibitory factor; and nervous system develo1181723949181848132Mouse182old_gene_symbolgene, protein-coding, VALIDATED [RefSeq]
731754GABBR2gamma-aminobutyric acid type B receptor subunit 2The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity 99828810998708935Human1189old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]
1352693SLC9A6solute carrier family 9 member A6This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, ChX135973837136047269Human300old_gene_symbolgene, protein-coding, REVIEWED [RefSeq]