Ndp (norrin cystine knot growth factor NDP) - Rat Genome Database

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Pathways
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Gene: Ndp (norrin cystine knot growth factor NDP) Heterocephalus glaber
Analyze
Symbol: Ndp
Name: norrin cystine knot growth factor NDP
RGD ID: 18923007
Description: ENCODES a protein that exhibits cytokine activity (inferred); frizzled binding (inferred); protein homodimerization activity (inferred); INVOLVED IN action potential (ortholog); angiogenesis (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH autistic disorder (ortholog); Brunner syndrome (ortholog); Coats disease (ortholog); FOUND IN cell surface (inferred); collagen-containing extracellular matrix (inferred); extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NDP, norrin cystine knot growth factor; Norrin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476211,409,727 - 11,435,811 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476211,409,837 - 11,435,709 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IEA,ISO)
angiogenesis  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cone retinal bipolar cell differentiation  (IEA,ISO)
decidualization  (ISO)
dendrite development  (IEA,ISO)
dendritic spine development  (IEA,ISO)
endothelial cell differentiation  (IEA,ISO)
establishment of blood-brain barrier  (IEA,ISO)
establishment of blood-retinal barrier  (IEA,ISO)
exploration behavior  (IEA,ISO)
extracellular matrix-cell signaling  (IEA)
gene expression  (IEA,ISO)
glutathione metabolic process  (IEA,ISO)
glycine metabolic process  (IEA,ISO)
inflammatory response  (IEA,ISO)
lens development in camera-type eye  (IEA,ISO)
microglia differentiation  (IEA,ISO)
microglial cell proliferation  (IEA,ISO)
mitotic cell cycle  (IEA,ISO)
neural retina development  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neuron differentiation  (IEA,ISO)
Norrin signaling pathway  (IEA)
optic nerve development  (IEA,ISO)
placenta development  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
protein localization  (IEA,ISO)
protein targeting to lysosome  (IEA,ISO)
protein ubiquitination  (IEA,ISO)
re-entry into mitotic cell cycle  (IEA,ISO)
response to axon injury  (IEA,ISO)
response to hypoxia  (IEA,ISO)
retina blood vessel maintenance  (IEA,ISO)
retina development in camera-type eye  (IEA,ISO)
retina layer formation  (IEA,ISO)
retina morphogenesis in camera-type eye  (IEA,ISO)
retina vasculature development in camera-type eye  (IEA,ISO)
retina vasculature morphogenesis in camera-type eye  (IEA,ISO)
retinal blood vessel morphogenesis  (IEA,ISO)
retinal ganglion cell axon guidance  (IEA,ISO)
retinal pigment epithelium development  (IEA,ISO)
retinal rod cell differentiation  (IEA,ISO)
serine family amino acid metabolic process  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
tricarboxylic acid cycle  (IEA,ISO)
ubiquitin-dependent endocytosis  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ndp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476211,409,727 - 11,435,811 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476211,409,837 - 11,435,709 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NDP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X43,948,776 - 43,973,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX43,948,776 - 43,973,395 (-)EnsemblGRCh38hg38GRCh38
GRCh37X43,808,022 - 43,832,636 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X43,692,966 - 43,717,788 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X43,564,279 - 43,589,004NCBI
CeleraX47,947,782 - 47,972,683 (-)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX41,537,322 - 41,562,014 (-)NCBIHuRef
CHM1_1X43,841,148 - 43,866,049 (-)NCBICHM1_1
T2T-CHM13v2.0X43,354,970 - 43,379,584 (-)NCBIT2T-CHM13v2.0
Ndp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X16,751,760 - 16,778,013 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX16,751,760 - 16,778,013 (-)EnsemblGRCm39 Ensembl
GRCm38X16,885,521 - 16,911,774 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX16,885,521 - 16,911,774 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X16,462,647 - 16,488,890 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X16,042,480 - 16,068,723 (-)NCBIMGSCv36mm8
CeleraX14,501,428 - 14,528,313 (-)NCBICelera
Cytogenetic MapXA1.2NCBI
cM MapX12.07NCBI
Ndp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X8,379,569 - 8,404,019 (+)NCBIGRCr8
mRatBN7.2X5,796,487 - 5,820,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX5,796,487 - 5,820,934 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX5,849,552 - 5,874,029 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X9,325,362 - 9,349,843 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X5,645,547 - 5,669,996 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X6,791,090 - 6,815,586 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,791,136 - 6,815,583 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,273,733 - 6,281,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X7,591,522 - 7,615,969 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X17,416,946 - 17,441,393 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX6,291,036 - 6,315,505 (+)NCBICelera
Cytogenetic MapXq11NCBI
Ndp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555164,218,703 - 4,244,846 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555164,218,703 - 4,244,774 (+)NCBIChiLan1.0ChiLan1.0
NDP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X45,598,907 - 45,624,024 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X45,602,261 - 45,627,401 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X36,399,868 - 36,424,953 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X44,224,161 - 44,249,067 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX44,224,161 - 44,249,067 (-)Ensemblpanpan1.1panPan2
NDP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X37,949,560 - 37,975,573 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX37,950,489 - 37,975,346 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX25,177,615 - 25,203,684 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X38,037,857 - 38,063,932 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X38,078,999 - 38,105,057 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X38,061,990 - 38,088,102 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X38,157,025 - 38,183,125 (-)NCBIUU_Cfam_GSD_1.0
Ndp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X30,239,407 - 30,264,429 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650210,080,145 - 10,105,328 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650210,080,169 - 10,105,155 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX39,208,119 - 39,235,758 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X39,208,115 - 39,235,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X43,540,096 - 43,551,795 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NDP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X41,122,064 - 41,148,097 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX41,121,874 - 41,147,567 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660766,340,796 - 6,365,938 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000012169   ⟹   ENSHGLP00000012037
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476211,409,727 - 11,435,811 (+)Ensembl
RefSeq Acc Id: XM_004849992   ⟹   XP_004850049
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476211,409,839 - 11,435,709 (+)NCBI
RefSeq Acc Id: XM_004849993   ⟹   XP_004850050
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476211,409,837 - 11,435,709 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004850049 (Get FASTA)   NCBI Sequence Viewer  
  XP_004850050 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA99619 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000012037
  ENSHGLP00100002189
GenBank Protein JAN95992 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004850050   ⟸   XM_004849993
- UniProtKB: G5ARF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004850049   ⟸   XM_004849992
- UniProtKB: G5ARF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000012037   ⟸   ENSHGLT00000012169


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008619 Ensembl, ENTREZGENE
  ENSHGLG00100001707 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000012169 ENTREZGENE
  ENSHGLT00100002237 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/TrEMBL
  Norrie_dis UniProtKB/TrEMBL
KEGG Report hgl:101723959 UniProtKB/TrEMBL
NCBI Gene Ndp ENTREZGENE
PANTHER NORRIN UniProtKB/TrEMBL
  PTHR28611 UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/TrEMBL
PRINTS NORRIEDSEASE UniProtKB/TrEMBL
PROSITE CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
UniProt G5ARF9 ENTREZGENE, UniProtKB/TrEMBL