| 621063 | Csf1 | colony stimulating factor 1 | ENCODES a protein that exhibits identical protein binding; cytokine activity (ortholog); growth factor activity (ortholog); INVOLVED IN cellular response to parathyroid hormone stimulus; macrophage differentiation; ossification; PARTICIPATES IN cytokine mediated signaling pathway; rheumatoid arthrit is pathway; ASSOCIATED WITH abnormal bone marrow cavity morphology; abnormal long bone morphology; absent teeth; ASSOCIATED WITH Albuminuria; anti-basement membrane glomerulonephritis; Edentulous Mouth; FOUND IN extracellular region; extracellular space; CSF1-CSF1R complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 2 | 198065400 | 198084774 | Rat | 430 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731066 | CSF1 | colony stimulating factor 1 | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] | 1 | 109910506 | 109930992 | Human | 421 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 731067 | Csf1 | colony stimulating factor 1 (macrophage) | Enables macrophage colony-stimulating factor receptor binding activity and protein homodimerization activity. Involved in several processes, including macrophage colony-stimulating factor signaling pathway; microglial cell proliferation; and positive regulation of gene expression. Acts upstream of o r within several processes, including macrophage homeostasis; mammary gland development; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 107648364 | 107668048 | Mouse | 640 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8890510 | Csf1 | colony stimulating factor 1 | ENCODES a protein that exhibits cytokine activity (ortholog); growth factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cell surface receptor protein tyrosine kinase signaling pathway (ortholog); cellular r esponse to parathyroid hormone stimulus (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); amyloidosis (ortholog); FOUND IN CSF1-CSF1R complex (ortholog); extracellular region (ortholog); extracellular space (ortholog) | NW_004955435 | 13404236 | 13423059 | Chinchilla | 112 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 11941382 | CSF1 | colony stimulating factor 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to parathyroid hormone stimulus (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH acute kidney f ailure (ortholog); Albuminuria (ortholog); amyloidosis (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog) | 1 | 112555755 | 112575894 | Bonobo | 131 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12085643 | CSF1 | colony stimulating factor 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to parathyroid hormone stimulus (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH acute kidney f ailure (ortholog); Albuminuria (ortholog); amyloidosis (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog) | 6 | 42028454 | 42047028 | Dog | 131 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12650506 | Csf1 | colony stimulating factor 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to parathyroid hormone stimulus (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH acute kidney f ailure (ortholog); Albuminuria (ortholog); amyloidosis (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog) | NW_004936704 | 1372137 | 1393355 | Squirrel | 113 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14196788 | CSF1 | colony stimulating factor 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to parathyroid hormone stimulus (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH acute kidney f ailure (ortholog); Albuminuria (ortholog); amyloidosis (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); INTERACTS WITH graphene oxide | | | | Pig | 132 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 14375790 | CSF1 | | | | | | Yeast | | symbol | gene, null |
| 18462590 | CSF1 | colony stimulating factor 1 | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to parathyroid hormone stimulus (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH acute kidney f ailure (ortholog); Albuminuria (ortholog); amyloidosis (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog) | | | | Green Monkey | 130 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920999 | Csf1 | colony stimulating factor 1 | ENCODES a protein that exhibits identical protein binding (ortholog); macrophage colony-stimulating factor receptor binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cell surface receptor protein tyrosine kinase signaling pathway (ortholog); cellular response to parathyroid hormone stimulus (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); amyloidosis (ortholog); FOUND IN CSF1-CSF1R complex (ortholog); extracellular region (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 125 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 20865719 | CSF1 | colony stimulating factor 1 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 285575445 | csf1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625990978 | Csf1 | colony stimulating factor 1 | ENCODES a protein that exhibits cytokine activity (ortholog); growth factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cell surface receptor protein tyrosine kinase signaling pathway (ortholog); cellular r esponse to parathyroid hormone stimulus (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); amyloidosis (ortholog); FOUND IN CSF1-CSF1R complex (ortholog); extracellular region (ortholog); extracellular space (ortholog) | | | | Black Rat | 112 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 285576577 | csf1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12910954 | Csf1tl | colony stimulating factor 1; tooth less mutant | ASSOCIATED WITH abnormal bone marrow cavity morphology; abnormal long bone morphology; absent teeth; ASSOCIATED WITH Edentulous Mouth; osteopetrosis | | | | Rat | 7 | symbol , description , old_gene_symbol | gene, allele |
| 2425 | Csf1r | colony stimulating factor 1 receptor | ENCODES a protein that exhibits protein phosphatase binding; cytokine binding (ortholog); macrophage colony-stimulating factor receptor activity (ortholog); INVOLVED IN cardiac muscle cell proliferation; cellular response to macrophage colony-stimulating factor stimulus; cellular response to transfo rming growth factor beta stimulus; PARTICIPATES IN cytokine mediated signaling pathway; endocytosis pathway; ASSOCIATED WITH abnormal brain development; abnormal corpus callosum size; absent teeth; ASSOCIATED WITH anti-basement membrane glomerulonephritis; Binge Drinking; bone development disease; FOUND IN cell body; perikaryon; cell surface (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate | 18 | 56834152 | 56860804 | Rat | 524 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10412 | Csf1r | colony stimulating factor 1 receptor | Enables several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of intracellular signal transduction; and protein phosphorylation. Located in cell surface and plasma membrane. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and limb. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia; diabetes mellitus; gastrointestinal system cancer (multiple); lung cancer (multiple); and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 61238644 | 61264211 | Mouse | 547 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 737004 | CSF1R | colony stimulating factor 1 receptor | The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase th rough a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017] | 5 | 150053295 | 150113365 | Human | 647 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8926938 | Csf1r | colony stimulating factor 1 receptor | ENCODES a protein that exhibits cytokine binding (ortholog); macrophage colony-stimulating factor receptor activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN axon guidance (ortholog); cardiac muscle cell proliferation (ortholog); cell population proliferation (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ortholog); FOUND IN cell body (ortholog); cell surface (ortholog); CSF1-CSF1R complex (ortholog) | NW_004955415 | 4434486 | 4462505 | Chinchilla | 181 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 11783153 | CSF1R | colony stimulating factor 1 receptor | ENCODES a protein that exhibits protein phosphatase binding (ortholog); INVOLVED IN cardiac muscle cell proliferation (ortholog); cellular response to macrophage colony-stimulating factor stimulus (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); ASSOCIATED WITH a cute kidney failure (ortholog); acute myeloid leukemia (ortholog); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ortholog); FOUND IN cell body (ortholog); perikaryon (ortholog) | 5 | 145478725 | 145537858 | Bonobo | 213 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12304144 | CSF1R | colony stimulating factor 1 receptor | ENCODES a protein that exhibits protein phosphatase binding (ortholog); INVOLVED IN cardiac muscle cell proliferation (ortholog); cellular response to macrophage colony-stimulating factor stimulus (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); ASSOCIATED WITH a cute kidney failure (ortholog); acute myeloid leukemia (ortholog); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ortholog); FOUND IN cell body (ortholog); perikaryon (ortholog) | 4 | 58980699 | 59010683 | Dog | 213 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12639817 | Csf1r | colony stimulating factor 1 receptor | ENCODES a protein that exhibits protein phosphatase binding (ortholog); INVOLVED IN cardiac muscle cell proliferation (ortholog); cellular response to macrophage colony-stimulating factor stimulus (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); ASSOCIATED WITH a cute kidney failure (ortholog); acute myeloid leukemia (ortholog); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ortholog); FOUND IN cell body (ortholog); perikaryon (ortholog) | NW_004936504 | 4898947 | 4927195 | Squirrel | 209 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14209790 | CSF1R | colony stimulating factor 1 receptor | ENCODES a protein that exhibits protein phosphatase binding (ortholog); INVOLVED IN cardiac muscle cell proliferation (ortholog); cellular response to macrophage colony-stimulating factor stimulus (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); ASSOCIATED WITH c olon polyps; ASSOCIATED WITH familial adenomatous polyposis; acute kidney failure (ortholog); acute myeloid leukemia (ortholog); FOUND IN cell body (ortholog); perikaryon (ortholog) | | | | Pig | 212 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18489955 | CSF1R | colony stimulating factor 1 receptor | ENCODES a protein that exhibits protein phosphatase binding (ortholog); INVOLVED IN cardiac muscle cell proliferation (ortholog); cellular response to macrophage colony-stimulating factor stimulus (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); ASSOCIATED WITH a cute kidney failure (ortholog); acute myeloid leukemia (ortholog); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ortholog); FOUND IN cell body (ortholog); perikaryon (ortholog) | | | | Green Monkey | 207 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18912091 | Csf1r | colony stimulating factor 1 receptor | ENCODES a protein that exhibits protein homodimerization activity (ortholog); protein phosphatase binding (ortholog); INVOLVED IN axon guidance (ortholog); cardiac muscle cell proliferation (ortholog); cell population proliferation (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); acute m yeloid leukemia (ortholog); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ortholog); FOUND IN cell body (ortholog); cell surface (ortholog); perikaryon (ortholog) | | | | Naked Mole-Rat | 195 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235930 | csf1r | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626122092 | Csf1r | colony stimulating factor 1 receptor | ENCODES a protein that exhibits cytokine binding (ortholog); macrophage colony-stimulating factor receptor activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN axon guidance (ortholog); cardiac muscle cell proliferation (ortholog); cell population proliferation (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ortholog); FOUND IN cell body (ortholog); cell surface (ortholog); CSF1-CSF1R complex (ortholog) | | | | Black Rat | 181 | symbol , description | gene, protein-coding, MODEL [RefSeq] |
| 1614465 | Csf1r-ps | colony stimulating factor 1 receptor (granulocyte), pseudogene | | 19 | 60067777 | 60070742 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 15038937 | Csf1r-rs | colony stimulating factor 1 receptor (granulocyte), related sequence | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 126781692 | Csf1rtm(EGFP)Tset | colony stimulating factor 1 receptor; target mutant, Tset | ASSOCIATED WITH abnormal brain development; abnormal corpus callosum size; absent teeth; ASSOCIATED WITH bone development disease; infertility; lymphopenia | | | | Rat | 27 | symbol , description | gene, allele |
| 730906 | STAT5B | signal transducer and activator of transcription 5B | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008] | 17 | 42199177 | 42288370 | Human | 538 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1602184 | IL34 | interleukin 34 | Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008] | 16 | 70579899 | 70660682 | Human | 102 | description | gene, protein-coding, VALIDATED [RefSeq] |