Csf1<sup>tl</sup> (colony stimulating factor 1; tooth less mutant) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Csf1tl (colony stimulating factor 1; tooth less mutant) Rattus norvegicus
Analyze
Symbol: Csf1tl
Name: colony stimulating factor 1; tooth less mutant
RGD ID: 12910954
Description: A spontaneous tooth less mutation was maintained in inbred Fisher colony maintained at the University of Massachusetts Medical School. The homozygous mutant is a 10-bp insertion near the beginning of the open reading of the Csf1 gene that yields a truncated, nonfunctional protein and an early stop codon.
ASSOCIATED WITH abnormal bone marrow cavity morphology; abnormal long bone morphology; absent teeth; ASSOCIATED WITH Edentulous Mouth; osteopetrosis
Type: allele  of Csf1  
Previously known as: Csf1^[tl]; Csf1tl
Is Marker For: Strains:   LEW-tl   F344tl  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat. Dobbins DE, etal., Biochem Biophys Res Commun 2002 Jun 28;294(5):1114-20.
2. The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification. Van Wesenbeeck L, etal., Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14303-8.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Csf1tl-var1 chr2 195396104 195396105 - GCGCCCCGCG insertion mRatBN7.2
Csf1tl-var1 chr2 210550359 210550360 - GCGCCCCGCG insertion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Csf1tl
F344tl     LEW-tl    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information