CSF1 (colony stimulating factor 1) - Rat Genome Database

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Gene: CSF1 (colony stimulating factor 1) Sus scrofa
Analyze
Symbol: CSF1
Name: colony stimulating factor 1
RGD ID: 14196788
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cellular response to parathyroid hormone stimulus (ortholog); homeostasis of number of cells within a tissue (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); amyloidosis (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: colony stimulating factor 1 (macrophage); macrophage colony stimulating factor alpha; macrophage colony stimulating factor beta; macrophage colony-stimulating factor 1; MCSF alpha; MCSFBETA
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,178,475 - 110,197,900 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,178,466 - 110,198,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,592,959 - 120,605,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in mammary gland duct morphogenesis  (IEA,ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to parathyroid hormone stimulus  (ISO)
developmental process involved in reproduction  (IEA)
homeostasis of number of cells within a tissue  (IEA,ISO)
inflammatory response  (IEA)
innate immune response  (IEA)
macrophage colony-stimulating factor signaling pathway  (IEA)
macrophage differentiation  (IEA,ISO)
macrophage homeostasis  (IEA,ISO)
mammary duct terminal end bud growth  (IEA,ISO)
mammary gland fat development  (IEA,ISO)
microglial cell proliferation  (IEA)
monocyte differentiation  (IEA,ISO)
monocyte homeostasis  (IEA,ISO)
myeloid leukocyte migration  (IEA,ISO)
neutrophil homeostasis  (IEA,ISO)
ossification  (ISO)
osteoclast differentiation  (IBA,IEA,ISO)
osteoclast proliferation  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cell-matrix adhesion  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of leukocyte migration  (IEA,ISO)
positive regulation of macrophage chemotaxis  (IEA)
positive regulation of macrophage colony-stimulating factor signaling pathway  (IEA)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of macrophage differentiation  (IBA,IEA,ISO)
positive regulation of macrophage migration  (IEA)
positive regulation of macrophage proliferation  (ISO)
positive regulation of microglial cell migration  (IEA)
positive regulation of monocyte differentiation  (IEA,ISO)
positive regulation of mononuclear cell migration  (ISO)
positive regulation of mononuclear cell proliferation  (IEA)
positive regulation of multicellular organism growth  (IEA,ISO)
positive regulation of odontogenesis of dentin-containing tooth  (IEA,ISO)
positive regulation of osteoclast differentiation  (IEA,ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein metabolic process  (IEA)
positive regulation of Ras protein signal transduction  (IEA,ISO)
Ras protein signal transduction  (IEA,ISO)
regulation of ossification  (IEA,ISO)
response to ischemia  (IEA)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:23260168   PMID:30032202  


Genomics

Comparative Map Data
CSF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,178,475 - 110,197,900 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,178,466 - 110,198,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,592,959 - 120,605,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,910,506 - 109,930,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,910,242 - 109,930,992 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,453,471 - 110,473,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,254,980 - 110,273,878 (+)NCBINCBI36Build 36hg18NCBI36
Build 341110,165,498 - 110,184,397NCBI
Celera1108,699,836 - 108,719,046 (+)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,322,980 - 108,343,084 (+)NCBIHuRef
CHM1_11110,568,036 - 110,588,399 (+)NCBICHM1_1
T2T-CHM13v2.01109,920,642 - 109,941,109 (+)NCBIT2T-CHM13v2.0
Csf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,648,364 - 107,668,048 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,648,364 - 107,667,785 (-)EnsemblGRCm39 Ensembl
GRCm383107,741,048 - 107,760,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,741,048 - 107,760,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,543,966 - 107,563,387 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,869,116 - 107,888,525 (-)NCBIMGSCv36mm8
Celera3110,073,392 - 110,092,813 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
Csf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,065,400 - 198,084,774 (-)NCBIGRCr8
mRatBN7.22195,377,215 - 195,396,608 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,377,215 - 195,411,704 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,018,890 - 203,037,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,901,047 - 200,920,075 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,717,984 - 195,737,022 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,522,370 - 210,550,546 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,522,375 - 210,550,560 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,989,430 - 230,017,945 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,292,765 - 203,307,968 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,255,518 - 203,270,701 (-)NCBI
Celera2188,024,644 - 188,043,645 (-)NCBICelera
Cytogenetic Map2q34NCBI
Csf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543513,404,508 - 13,424,247 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543513,404,236 - 13,423,059 (+)NCBIChiLan1.0ChiLan1.0
CSF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,113,655 - 117,134,103 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11116,261,714 - 116,282,024 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01112,555,755 - 112,575,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,764,916 - 127,864,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,764,916 - 127,781,943 (-)Ensemblpanpan1.1panPan2
CSF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,028,454 - 42,047,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,034,149 - 42,049,371 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,804,295 - 44,823,439 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0642,360,013 - 42,379,162 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,360,330 - 42,379,600 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,092,785 - 42,111,910 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,050,361 - 42,070,486 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0642,485,555 - 42,505,704 (-)NCBIUU_Cfam_GSD_1.0
Csf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,720,989 - 18,742,009 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367041,378,103 - 1,393,542 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367041,372,137 - 1,393,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,615,107 - 23,635,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603834,824,127 - 34,844,440 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247725,663,070 - 5,707,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247725,663,374 - 5,705,965 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CSF1
304 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000039641   ⟹   ENSSSCP00000058295
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4110,178,475 - 110,197,900 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000095148   ⟹   ENSSSCP00000074894
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4110,178,475 - 110,197,900 (-)Ensembl
RefSeq Acc Id: NM_001244523   ⟹   NP_001231452
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14110,184,271 - 110,197,887 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021088653   ⟹   XP_020944312
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14110,178,473 - 110,198,232 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021088654   ⟹   XP_020944313
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14110,178,466 - 110,197,988 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002343023
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14110,178,466 - 110,198,005 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002343024
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14110,178,466 - 110,197,995 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020944313   ⟸   XM_021088654
- Peptide Label: isoform X2
- UniProtKB: A0A4X1TAT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020944312   ⟸   XM_021088653
- Peptide Label: isoform X1
- UniProtKB: A0A287BPE2 (UniProtKB/TrEMBL),   A0A4X1TER7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001231452   ⟸   NM_001244523
- Peptide Label: precursor
- Sequence:
Ensembl Acc Id: ENSSSCP00000058295   ⟸   ENSSSCT00000039641
Ensembl Acc Id: ENSSSCP00000074894   ⟸   ENSSSCT00000095148


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037449 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00035021777 UniProtKB/TrEMBL
  ENSSSCG00040029534 UniProtKB/TrEMBL
  ENSSSCG00045033061 UniProtKB/TrEMBL
  ENSSSCG00055004411 UniProtKB/TrEMBL
  ENSSSCG00065041765 UniProtKB/TrEMBL
  ENSSSCG00070008277 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000039641 ENTREZGENE
  ENSSSCT00000039641.3 UniProtKB/TrEMBL
  ENSSSCT00000095148 ENTREZGENE
  ENSSSCT00000095148.1 UniProtKB/TrEMBL
  ENSSSCT00035028413.1 UniProtKB/TrEMBL
  ENSSSCT00035028417.1 UniProtKB/TrEMBL
  ENSSSCT00040039673.1 UniProtKB/TrEMBL
  ENSSSCT00040039740.1 UniProtKB/TrEMBL
  ENSSSCT00045056428.1 UniProtKB/TrEMBL
  ENSSSCT00045056598.1 UniProtKB/TrEMBL
  ENSSSCT00055008697.1 UniProtKB/TrEMBL
  ENSSSCT00055008711.1 UniProtKB/TrEMBL
  ENSSSCT00065057141.1 UniProtKB/TrEMBL
  ENSSSCT00065057150.1 UniProtKB/TrEMBL
  ENSSSCT00070015992.1 UniProtKB/TrEMBL
  ENSSSCT00070016012.1 UniProtKB/TrEMBL
  ENSSSCT00070016021.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  MCSF-1 UniProtKB/TrEMBL
NCBI Gene CSF1 ENTREZGENE
PANTHER MACROPHAGE COLONY-STIMULATING FACTOR 1 UniProtKB/TrEMBL
  PTHR10058 UniProtKB/TrEMBL
Pfam CSF-1 UniProtKB/TrEMBL
PIRSF MCSF-1 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A287BPE2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TAT3 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TCN4_PIG UniProtKB/TrEMBL
  A0A4X1TER7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Z6P0_PIG UniProtKB/TrEMBL
  A0A8D1E5W2_PIG UniProtKB/TrEMBL
  A0A8D1E6T7_PIG UniProtKB/TrEMBL
  A0A8D1PJB5_PIG UniProtKB/TrEMBL
  A0A8D2C7P7_PIG UniProtKB/TrEMBL
  A0A8W4F7Y2_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87030 ENTREZGENE