| 620505 | Crh | corticotropin releasing hormone | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding; corticotropin-releasing hormone receptor 2 binding; INVOLVED IN associative learning; cellular response to cocaine; cellular response to dexamethasone stimulus; PARTICIPATES IN corticotropin-releasing hormone signali ng pathway; long term depression; ASSOCIATED WITH abnormal apoptosis; abnormal blood-brain barrier function; decreased circulating estradiol level; ASSOCIATED WITH alcohol dependence; alcohol use disorder; Alcohol-Related Disorders; FOUND IN extracellular space; neuronal cell body; neuronal dense core vesicle lumen; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; (S)-colchicine | 2 | 104059184 | 104061048 | Rat | 404 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 730946 | CRH | corticotropin releasing hormone | This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropi n releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015] | 8 | 66176376 | 66178464 | Human | 473 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 730947 | Crh | corticotropin releasing hormone | This gene encodes a member of the corticotropin-releasing factor family and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a neuropeptide hormone that binds to the corticotropin releasing hormone receptors (CRH >CRHR1 and CRHR2) to stimulate the release of adrenocorticotropic hormone from the pituitary gland in response to stress. The encoded protein may also regulate angiogenesis and inflammation. Homozygous knockout mice for this gene exhibit reduced corticosterone levels while the offspring of these mice die perinatally. [provided by RefSeq, Aug 2015] | 3 | 19747565 | 19749560 | Mouse | 534 | symbol , PhenoGen , description | gene, protein-coding, REVIEWED [RefSeq] |
| 8982541 | Crh | corticotropin releasing hormone | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN adrenal gland development (ortholog); associative learning (ortholog); cellular response to cocaine (ortholog); PARTICIPATES IN co rticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); FOUND IN extracellular space (ortholog); neuronal cell body (ortholog); neuronal dense core vesicle lumen (ortholog) | NW_004955444 | 12989210 | 12991300 | Chinchilla | 139 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11720441 | CRH | corticotropin releasing hormone | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN adrenal gland development (ortholog); associative learning (ortholog); cellular response to cocaine (ortholog); PARTICIPATES IN co rticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); FOUND IN extracellular space (ortholog); neuronal cell body (ortholog); neuronal dense core vesicle lumen (ortholog) | 8 | 62714721 | 62716979 | Bonobo | 149 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12277402 | CRH | corticotropin releasing hormone | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN adrenal gland development (ortholog); associative learning (ortholog); cellular response to cocaine (ortholog); PARTICIPATES IN co rticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); FOUND IN extracellular space (ortholog); neuronal cell body (ortholog); neuronal dense core vesicle lumen (ortholog); INTERACTS WITH cortisol | 29 | 15831944 | 15840560 | Dog | 150 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12571295 | Crh | corticotropin releasing hormone | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN adrenal gland development (ortholog); associative learning (ortholog); cellular response to cocaine (ortholog); PARTICIPATES IN co rticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); FOUND IN extracellular space (ortholog); neuronal cell body (ortholog); neuronal dense core vesicle lumen (ortholog) | NW_004936496 | 7759656 | 7761555 | Squirrel | 149 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14226532 | CRH | corticotropin releasing hormone | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN adrenal gland development (ortholog); associative learning (ortholog); cellular response to cocaine (ortholog); PARTICIPATES IN co rticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); FOUND IN extracellular space (ortholog); neuronal cell body (ortholog); neuronal dense core vesicle lumen (ortholog) | | | | Pig | 149 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18488347 | CRH | corticotropin releasing hormone | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN adrenal gland development (ortholog); associative learning (ortholog); cellular response to cocaine (ortholog); PARTICIPATES IN co rticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); FOUND IN extracellular space (ortholog); neuronal cell body (ortholog); neuronal dense core vesicle lumen (ortholog) | | | | Green Monkey | 149 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904218 | Crh | corticotropin releasing hormone | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN adrenal gland development (ortholog); associative learning (ortholog); cellular response to cocaine (ortholog); PARTICIPATES IN co rticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); FOUND IN extracellular space (ortholog); neuronal cell body (ortholog); neuronal dense core vesicle lumen (ortholog) | | | | Naked Mole-Rat | 149 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286975571 | crh | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626111965 | Crh | corticotropin releasing hormone | ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN adrenal gland development (ortholog); associative learning (ortholog); cellular response to cocaine (ortholog); PARTICIPATES IN co rticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); FOUND IN extracellular space (ortholog); neuronal cell body (ortholog); neuronal dense core vesicle lumen (ortholog) | | | | Black Rat | 139 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14369706 | crh-1 | | | | | | Roundworm | | symbol | gene, null |
| 14371781 | crh-2 | | | | | | Roundworm | | symbol | gene, null |
| 288083298 | crh.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 286975769 | crh.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 11049142 | Crhem1Ionsz | corticotropin releasing hormone; CRISPR/Cas9 system induced mutant 1, Institute of Neuroscience, Chinese Academy of Sciences | CRISPR/Cas9 system was used to generate this mutant; sgRNA+Cas9+ plasmid was injected into zygote of SD rat that added a GFP-Cre-2A behind the last exon of Crh. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 401976373 | Crhtm1(Cre)Kji | | | | | | Rat | | symbol | gene, allele |
| 730852 | Crhbp | corticotropin releasing hormone binding protein | Enables corticotropin-releasing hormone binding activity. Involved in several processes, including cellular response to cAMP; cellular response to estradiol stimulus; and cellular response to gonadotropin-releasing hormone. Acts upstream of or within hormone metabolic process. Located in extracellul ar space and nucleus. Is expressed in adrenal gland; central nervous system; eye; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in depressive disorder and opioid abuse. Orthologous to human CRHBP (corticotropin releasing hormone binding protein). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 95567884 | 95581339 | Mouse | 194 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733139 | Crhr2 | corticotropin releasing hormone receptor 2 | Enables corticotrophin-releasing factor receptor activity and hormone activity. Acts upstream of or within G protein-coupled receptor signaling pathway and negative regulation of angiogenesis. Predicted to be located in cell body fiber; perikaryon; and varicosity. Predicted to be active in axon term inus; dendrite; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 55067033 | 55110001 | Mouse | 220 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 61276 | Crhr1 | corticotropin releasing hormone receptor 1 | ENCODES a protein that exhibits corticotropin-releasing hormone binding; corticotropin-releasing hormone receptor activity; G protein-coupled receptor activity; INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled recep tor signaling pathway; behavioral response to cocaine; PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; long term depression; ASSOCIATED WITH increased alcohol consumption; increased thigmotaxis; ASSOCIATED WITH Binge Drinking; Cocaine-Related Disorders; depressive disorder; FOUND IN apical part of cell; dendrite; multivesicular body; INTERACTS WITH (R)-noradrenaline; 2,4,6-trinitrobenzenesulfonic acid; ammonium chloride | 10 | 89540192 | 89583466 | Rat | 235 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 2403 | Crhbp | corticotropin releasing hormone binding protein | ENCODES a protein that exhibits corticotropin-releasing hormone binding; peptide binding; INVOLVED IN cellular response to cocaine; cellular response to estradiol stimulus; cellular response to estrogen stimulus; PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH depr essive disorder; nicotine withdrawal syndrome; obesity; FOUND IN axon terminus; cytoplasm; dendrite; INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 2 | 28427139 | 28439446 | Rat | 179 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 730851 | CRHBP | corticotropin releasing hormone binding protein | Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008] | 5 | 76953045 | 76981159 | Human | 153 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 734061 | CRHR1 | corticotropin releasing hormone receptor 1 | This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse phy siological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016] | 17 | 45784320 | 45835828 | Human | 225 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 737026 | Crhr1 | corticotropin releasing hormone receptor 1 | The protein encoded by this gene is a G-protein coupled receptor that binds corticotropin-releasing factor (CRH) and urocortin (UCN) with high affinity. The encoded protein upregulates adenylate cyclase activity and intracellular cAMP levels. This protein is ess ential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response, and obesity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] | 11 | 104021289 | 104066349 | Mouse | 289 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 70547 | Crhr2 | corticotropin releasing hormone receptor 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor activity; peptide hormone binding; corticotrophin-releasing factor receptor activity (ortholog); INVOLVED IN actin filament organization; catecholamine biosynthetic process; cellular response to glucocorticoid stimulus; PARTICI PATES IN protein kinase A (PKA) signaling pathway; corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; ASSOCIATED WITH alcohol preference; ASSOCIATED WITH Anorexia; colitis; depressive disorder; FOUND IN axon; axon terminus; cell body fiber; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium acetate | 4 | 85553163 | 85596203 | Rat | 177 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733138 | CRHR2 | corticotropin releasing hormone receptor 2 | The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH ht:700;'>CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011] | 7 | 30651942 | 30700103 | Human | 155 | symbol , old_gene_name , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 598153625 | CRH1 | | | | | | Yeast | | symbol | gene, null |
| 8992676 | Crhbp | corticotropin releasing hormone binding protein | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); peptide binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cellular response to calcium ion (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN corticotropin-releasing hormone si gnaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); anxiety disorder (ortholog); Binge Drinking (ortholog); FOUND IN axon terminus (ortholog); cytoplasm (ortholog); dendrite (ortholog) | NW_004955425 | 23953957 | 23966207 | Chinchilla | 87 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11824075 | CRHBP | corticotropin releasing hormone binding protein | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); peptide binding (ortholog); INVOLVED IN cellular response to cocaine (ortholog); cellular response to immobilization stress (ortholog); hormone metabolic process (ortholog); PARTICIPATES IN corticotropin-releasing ho rmone signaling pathway; ASSOCIATED WITH anxiety disorder (ortholog); Binge Drinking (ortholog); cocaine abuse (ortholog); FOUND IN axon terminus (ortholog); cytoplasm (ortholog); dendrite (ortholog) | 5 | 38327305 | 38343901 | Bonobo | 85 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12336899 | CRHBP | corticotropin releasing hormone binding protein | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); peptide binding (ortholog); INVOLVED IN cellular response to cocaine (ortholog); cellular response to immobilization stress (ortholog); hormone metabolic process (ortholog); PARTICIPATES IN corticotropin-releasing ho rmone signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); anxiety disorder (ortholog); Binge Drinking (ortholog); FOUND IN axon terminus (ortholog); cytoplasm (ortholog); dendrite (ortholog) | 3 | 29726316 | 29737748 | Dog | 85 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12528684 | Crhbp | corticotropin releasing hormone binding protein | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); peptide binding (ortholog); INVOLVED IN cellular response to cocaine (ortholog); cellular response to immobilization stress (ortholog); hormone metabolic process (ortholog); PARTICIPATES IN corticotropin-releasing ho rmone signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); anxiety disorder (ortholog); Binge Drinking (ortholog); FOUND IN axon terminus (ortholog); cytoplasm (ortholog); dendrite (ortholog) | NW_004936549 | 64866 | 78272 | Squirrel | 85 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13997572 | CRHBP | corticotropin releasing hormone binding protein | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); peptide binding (ortholog); INVOLVED IN cellular response to cocaine (ortholog); cellular response to immobilization stress (ortholog); hormone metabolic process (ortholog); PARTICIPATES IN corticotropin-releasing ho rmone signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); anxiety disorder (ortholog); Binge Drinking (ortholog); FOUND IN axon terminus (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Pig | 85 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18526098 | CRHBP | corticotropin releasing hormone binding protein | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); peptide binding (ortholog); INVOLVED IN cellular response to cocaine (ortholog); cellular response to immobilization stress (ortholog); hormone metabolic process (ortholog); PARTICIPATES IN corticotropin-releasing ho rmone signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); anxiety disorder (ortholog); Binge Drinking (ortholog); FOUND IN axon terminus (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Green Monkey | 85 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18919649 | Crhbp | corticotropin releasing hormone binding protein | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); peptide binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cellular response to calcium ion (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN corticotropin-releasing hormone si gnaling pathway; ASSOCIATED WITH anxiety disorder (ortholog); Binge Drinking (ortholog); cocaine abuse (ortholog); FOUND IN axon terminus (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Naked Mole-Rat | 85 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253750 | crhbp | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625988915 | Crhbp | corticotropin releasing hormone binding protein | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); peptide binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cellular response to calcium ion (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN corticotropin-releasing hormone si gnaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); anxiety disorder (ortholog); Binge Drinking (ortholog); FOUND IN axon terminus (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Black Rat | 87 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 8759849 | Crhr1 | corticotropin releasing hormone receptor 1 | ENCODES a protein that exhibits corticotrophin-releasing factor receptor activity (ortholog); corticotropin-releasing hormone binding (ortholog); corticotropin-releasing hormone receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortho log); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); adrenal gland development (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN apical part of cell (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | NW_004955478 | 10380185 | 10390838 | Chinchilla | 101 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12027617 | CRHR1 | corticotropin releasing hormone receptor 1 | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); corticotropin-releasing hormone receptor activity (ortholog); G protein-coupled receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylat e cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); adrenal gland development (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN apical part of cell (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | 17 | 11261435 | 11313630 | Bonobo | 122 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12391168 | CRHR1 | corticotropin releasing hormone receptor 1 | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); corticotropin-releasing hormone receptor activity (ortholog); G protein-coupled receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylat e cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); behavioral response to cocaine (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN apical part of cell (ortholog); dendrite (ortholog); multivesicular body (ortholog) | 9 | 9708696 | 9763281 | Dog | 116 | symbol , ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12656806 | Crhr1 | corticotropin releasing hormone receptor 1 | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); corticotropin-releasing hormone receptor activity (ortholog); G protein-coupled receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylat e cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); behavioral response to cocaine (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN apical part of cell (ortholog); dendrite (ortholog); multivesicular body (ortholog) | NW_004936541 | 2288847 | 2333129 | Squirrel | 124 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14002713 | CRHR1 | corticotropin releasing hormone receptor 1 | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); corticotropin-releasing hormone receptor activity (ortholog); G protein-coupled receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylat e cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); behavioral response to cocaine (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN apical part of cell (ortholog); dendrite (ortholog); multivesicular body (ortholog) | | | | Pig | 119 | symbol , ensembl_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18714121 | CRHR1 | corticotropin releasing hormone receptor 1 | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); corticotropin-releasing hormone receptor activity (ortholog); G protein-coupled receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylat e cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); behavioral response to cocaine (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN apical part of cell (ortholog); dendrite (ortholog); multivesicular body (ortholog) | | | | Green Monkey | 120 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907691 | Crhr1 | corticotropin releasing hormone receptor 1 | ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); corticotropin-releasing hormone receptor activity (ortholog); G protein-coupled receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylat e cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); adrenal gland development (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN apical part of cell (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 118 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 8765976 | Crhr2 | corticotropin releasing hormone receptor 2 | ENCODES a protein that exhibits corticotrophin-releasing factor receptor activity (ortholog); corticotropin-releasing hormone receptor activity (ortholog); hormone activity (ortholog); INVOLVED IN actin filament organization (ortholog); catecholamine biosynthetic process (ortholog); cellular respons e to glucocorticoid stimulus (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell body fiber (ortholog) | NW_004955410 | 31830333 | 31874384 | Chinchilla | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11821631 | CRHR2 | corticotropin releasing hormone receptor 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor activity (ortholog); hormone activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN actin filament organization (ortholog); catecholamine biosynthetic process (ortholog); cellular response to glucocorticoid stimul us (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell body fiber (ortholog) | 7 | 31265619 | 31313902 | Bonobo | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12227584 | CRHR2 | corticotropin releasing hormone receptor 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor activity (ortholog); hormone activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN actin filament organization (ortholog); catecholamine biosynthetic process (ortholog); cellular response to glucocorticoid stimul us (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell body fiber (ortholog) | 14 | 43366849 | 43414398 | Dog | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12497735 | Crhr2 | corticotropin releasing hormone receptor 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor activity (ortholog); hormone activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN actin filament organization (ortholog); catecholamine biosynthetic process (ortholog); cellular response to glucocorticoid stimul us (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell body fiber (ortholog) | NW_004936478 | 6901098 | 6947719 | Squirrel | 96 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14100500 | CRHR2 | corticotropin releasing hormone receptor 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor activity (ortholog); hormone activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN actin filament organization (ortholog); catecholamine biosynthetic process (ortholog); cellular response to glucocorticoid stimul us (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell body fiber (ortholog) | | | | Pig | 94 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18516709 | CRHR2 | corticotropin releasing hormone receptor 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor activity (ortholog); hormone activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN actin filament organization (ortholog); catecholamine biosynthetic process (ortholog); cellular response to glucocorticoid stimul us (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell body fiber (ortholog) | | | | Green Monkey | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904678 | Crhr2 | corticotropin releasing hormone receptor 2 | ENCODES a protein that exhibits corticotropin-releasing hormone receptor activity (ortholog); hormone activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN actin filament organization (ortholog); catecholamine biosynthetic process (ortholog); cellular response to glucocorticoid stimul us (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell body fiber (ortholog) | | | | Naked Mole-Rat | 95 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 329329991 | crhr2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934044 | crhr2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935066 | crhr2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935945 | crhr2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596935971 | crhr2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596936024 | crhr2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596936047 | crhr2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625868096 | Crhr2 | corticotropin releasing hormone receptor 2 | ENCODES a protein that exhibits corticotrophin-releasing factor receptor activity (ortholog); corticotropin-releasing hormone receptor activity (ortholog); hormone activity (ortholog); INVOLVED IN actin filament organization (ortholog); catecholamine biosynthetic process (ortholog); cellular respons e to glucocorticoid stimulus (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); anxiety disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell body fiber (ortholog) | | | | Black Rat | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232402 | crhbp.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255963 | crhbp.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 284572311 | crhr1.1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155240787 | crhr1.2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155241713 | crhr1.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232136 | crhr1.2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12743481 | LINC02210-CRHR1 | LINC02210-CRHR1 readthrough | This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. [provided by RefSeq, Dec 2016] | 17 | 45620346 | 45835828 | Human | 12 | symbol , ensembl_gene_symbol , old_gene_name , COSMIC , name , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1348993 | CRIP1 | cysteine rich protein 1 | Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008] | 14 | 105486886 | 105488947 | Human | 143 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1614474 | Crip1 | cysteine-rich protein 1 | Predicted to enable peptide binding activity and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to UV-B; intrinsic apoptotic signaling pathway in response to DNA damage; and response to zinc ion. Predicted to be located in cytoplasm. Is expresse d in several structures, including genitourinary system; gut; hemolymphoid system gland; integumental system; and limb segment. Orthologous to human CRIP1 (cysteine rich protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 113115632 | 113117499 | Mouse | 148 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 708415 | Carhsp1 | calcium regulated heat stable protein 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); INVOLVED IN regulation of mRNA stability (ortholog); ASSOCIATED WITH Experimental Diabetes Mellitus; FOUND IN cytoplasmic exosome (RNase complex) (ortholog); cytosol (ortholog); P granule (ortholog); INTERACTS WITH 17alpha-ethynylestrad iol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 10 | 7453602 | 7467218 | Rat | 161 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733909 | CARHSP1 | calcium regulated heat stable protein 1 | Enables mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in P granule; cytoplasmic exosome (RNase complex); and cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 8852942 | 8869006 | Human | 163 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1604378 | GSE1 | Gse1 coiled-coil protein | This gene encodes a proline-rich protein with coiled coil domains that may be a subunit of a BRAF35-HDAC (BHC) histone deacetylase complex. This gene may function as an oncogene in breast cancer and enhanced expression of the encoded protein has been observed in breast cancer patients. [provided by RefSeq, May 2017] | 16 | 85169512 | 85676200 | Human | 105 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1332093 | Carhsp1 | calcium regulated heat stable protein 1 | Predicted to enable mRNA 3'-UTR binding activity. Involved in regulation of mRNA stability. Located in P granule and cytosol. Part of cytoplasmic exosome (RNase complex). Is expressed in dorsal root ganglion; genitourinary system; limb; neural tube; and telencephalon. Orthologous to human CARHSP1 (c alcium regulated heat stable protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 8476444 | 8490017 | Mouse | 160 | old_gene_name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306767 | Tpd52 | tumor protein D52 | ENCODES a protein that exhibits calcium ion binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN B cell differentiation (ortholog); positive regulation of cell population proliferation (ortholog); ASSOCIATED WITH Neoplasm Recurrence, Loc al (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 94642514 | 94723442 | Rat | 167 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1603265 | LINC02210 | long intergenic non-protein coding RNA 2210 | INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; acrylamide | 17 | 45620329 | 45646231 | Human | 23 | old_gene_name , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 14175467 | C1QBP | complement C1q binding protein | ENCODES a protein that exhibits adrenergic receptor binding (ortholog); complement component C1q complex binding (ortholog); mitochondrial ribosome binding (ortholog); INVOLVED IN positive regulation of mitochondrial translation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); combined oxida tive phosphorylation deficiency 33 (ortholog); genetic disease (ortholog); FOUND IN extracellular space (ortholog); GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog) | | | | Pig | 104 | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 731575 | CALR | calreticulin | Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020] | 19 | 12938609 | 12944489 | Human | 653 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 11669617 | LOC100988926 | putative uncharacterized protein encoded by CRHR1-IT1 | | 17 | 11096522 | 11113667 | Bonobo | | name | gene, protein-coding, MODEL [RefSeq] |
| 18430234 | LOC103243847 | putative uncharacterized protein encoded by CRHR1-IT1 | | | | | Green Monkey | | name | gene, pseudo, MODEL [RefSeq] |
