Crhbp (corticotropin releasing hormone binding protein)

Gene: Crhbp (corticotropin releasing hormone binding protein) Chinchilla lanigera

Analyze

Symbol:

Crhbp

Name:

corticotropin releasing hormone binding protein

RGD ID:

8992676

Description:

ENCODES a protein that exhibits corticotropin-releasing hormone binding (ortholog); peptide binding (ortholog); INVOLVED IN behavioral response to ethanol (ortholog); cellular response to calcium ion (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); depressive disorder (ortholog); genetic disease (ortholog); FOUND IN axon terminus (ortholog); dendrite (ortholog); dense core granule (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	23,953,912 - 23,966,352 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955425	23,953,957 - 23,966,207 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cocaine-Related Disorders (ISO)

depressive disorder (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Hermansky-Pudlak syndrome 2 (ISO)

Neurodevelopmental Disorders (ISO)

obesity (ISO)

temporal lobe epilepsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

behavioral response to ethanol (ISO)

cellular response to calcium ion (ISO)

cellular response to cAMP (ISO)

cellular response to cocaine (ISO)

cellular response to estradiol stimulus (ISO)

cellular response to estrogen stimulus (ISO)

cellular response to gonadotropin-releasing hormone (ISO)

cellular response to immobilization stress (ISO)

cellular response to potassium ion (ISO)

cellular response to tumor necrosis factor (ISO)

cellular response to xenobiotic stimulus (ISO)

female pregnancy (ISO)

hormone metabolic process (ISO)

hormone-mediated signaling pathway (ISO)

inflammatory response (ISO)

maternal aggressive behavior (ISO)

negative regulation of corticotropin secretion (ISO)

regulated exocytosis (ISO)

regulation of cellular response to stress (ISO)

regulation of corticotropin secretion (ISO)

synaptic transmission, dopaminergic (ISO)

Cellular Component

axon terminus (ISO)

dendrite (ISO)

dense core granule (ISO)

endoplasmic reticulum (ISO)

extracellular space (ISO)

Golgi apparatus (ISO)

microtubule (ISO)

multivesicular body (ISO)

nucleus (ISO)

perikaryon (ISO)

secondary lysosome (ISO)

secretory granule (ISO)

varicosity (ISO)

Molecular Function

corticotropin-releasing hormone binding (ISO)

peptide binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

corticotropin-releasing hormone signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Crhbp
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	23,953,912 - 23,966,352 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955425	23,953,957 - 23,966,207 (-)	NCBI	ChiLan1.0	ChiLan1.0

CRHBP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	76,953,045 - 76,981,159 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	76,953,045 - 76,981,158 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	76,248,870 - 76,265,296 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	76,284,436 - 76,301,055 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	76,284,435 - 76,301,054	NCBI
Celera	5	72,143,194 - 72,159,812 (+)	NCBI		Celera
Cytogenetic Map	5	q13.3	NCBI
HuRef	5	71,455,341 - 71,471,960 (+)	NCBI		HuRef
CHM1_1	5	75,681,815 - 75,698,436 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	77,434,877 - 77,462,968 (+)	NCBI		T2T-CHM13v2.0

Crhbp
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	95,567,884 - 95,581,339 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	95,567,879 - 95,581,432 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	95,431,376 - 95,444,831 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	95,431,371 - 95,444,924 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	96,201,331 - 96,214,786 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	96,532,075 - 96,545,471 (-)	NCBI		MGSCv36	mm8
Celera	13	99,051,989 - 99,065,285 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	49.5	NCBI

Crhbp
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	28,427,139 - 28,439,446 (-)	NCBI		GRCr8
mRatBN7.2	2	26,692,403 - 26,704,710 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	26,692,403 - 26,704,710 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	33,730,555 - 33,742,870 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	31,830,779 - 31,843,094 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	26,646,279 - 26,658,547 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	25,141,471 - 25,153,334 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	25,141,471 - 25,153,334 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	44,299,507 - 44,311,225 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	25,801,371 - 25,813,457 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	25,721,739 - 25,733,799 (-)	NCBI
Celera	2	22,758,077 - 22,770,045 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

CRHBP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	38,323,975 - 38,341,995 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	36,477,602 - 36,495,622 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	38,327,305 - 38,343,901 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	38,852,934 - 38,869,529 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	38,845,925 - 38,869,549 (-)	Ensembl	panpan1.1		panPan2

CRHBP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	29,726,316 - 29,737,748 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	29,705,031 - 29,758,111 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	30,965,624 - 30,977,333 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	29,645,525 - 29,657,242 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	29,645,521 - 29,657,131 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	29,582,245 - 29,593,950 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	29,562,941 - 29,574,639 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	29,932,261 - 29,943,976 (-)	NCBI		UU_Cfam_GSD_1.0

Crhbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	190,780,826 - 190,794,463 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936549	64,866 - 78,272 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936549	64,866 - 78,272 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRHBP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	85,816,816 - 85,831,179 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	85,814,399 - 85,830,598 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	87,431,375 - 87,447,099 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRHBP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	71,203,335 - 71,223,179 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	71,205,932 - 71,223,172 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	20,043,907 - 20,061,809 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Crhbp
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624869	1,412,499 - 1,423,932 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624869	1,412,541 - 1,423,891 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005386033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01025868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01003989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000014573 ⟹ ENSCLAP00000014415

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955425	23,953,912 - 23,966,352 (-)	Ensembl

RefSeq Acc Id:

XM_005386033 ⟹ XP_005386090

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955425	23,953,957 - 23,966,207 (-)	NCBI

Sequence:

show sequence

AAAATGTGTGACAGAGCTGGACCTCGTCATCACCACGCACTTTGTCACTAAGACAGGGTAACCC
ATGGTAACTAAGCTCCTGCTGTGAAGGGGCAGACAGCCTCTCCTCCCTGCAGCTCTATAAAAGG
GACCCAGCAAAGGGACCCTCCCAGCTTCTGGCTCTCAGCCCTGGGCAGGTGCAGGAAGGAGAGC
CCGGCTCTGAGGCAGAGCTCACGGGCAGACGAAGGAAGGCCAGCATGCCACCCAACCGCAAGCT
CCAGTGTCACTTCGTCCTCCTCGTCCTGGCGGCTCTGAGAGGGGACAGCCGGTACCTAGAGCTG
CAGGACGCCGCGGACTACGACCCTCTCCTGCTCTTCAGCGCCAGCCCGAAGCGGGAGTTGGCCG
GGGAGCAGCCGTACCGCCGCGCGCTGCGGTGCCTGGACATGCTGAGCCTGCCCGGCCAGTTCAC
GTTCACCGCGGCGCGGCCGCAGCTGCACTGCGCCGCCTTCTTCATCGGTGAGGCGGAGGAGCTG
CTGTCCATCCGCTTCGACCTGGTGTCCATCGACTGCAGGCGCGGAGACTTCCTGAAGGTATTTG
ATGGCTGGATTCTCAAGGGGGAGAAATTCCCCAGTTCCCAGGATCACCCTCTCCCCACCACTGA
TCGGTACACAGACTTCTGTGAGAGTGGTTTCAGCCAGAGGAGCATCAGATCCTCCCAGAATGTG
GCCATGATCTTCTTCCGGGTTCATGAACCAGGAAATGGATTCACATTAACCATAAAGACAGATC
CCAACCTCTTTCCTTGTAATGTCATCTCTCAGACCCCAAGTGGAAGGTTCACCCTGGTGGTTCC
TCGCCAGCATCGGAACTGCAGCTTTTCCATCATTTATCCAGTGGTAATCAAAATATCGGATCTC
ACCCTGGGACATGTGCATGGTCTTCAGTTAAAAAAATCCTCAGCAGGCTGTGGAGGAATCGGAG
ACTTTGTGGAGCTGCTGGGAGGAACTGGCCTGGATCCTTCCAAGATGCTGCCTTTAGCTGATCT
CTGCTACCCCTTTCATGGCCCTGCCCAACTGAAAATTGGCTGTGACAACTCTGTGGTGCGCATG
GTCTCCAGTGGAAAACACATCAATCGTGTGACGTTTGAATATCACCAGCTGGAACCATATGAAC
TGGAGAACCCAACCGGAAACAGCATCCCGGAATTCTGTTCCTCTGGTCTTTGAATATAACCAGC
TCCATAACCGCCGTGCTGCTAGCTAAGTGAATTCTCAAAGGCTCTTTGTACATAGTTCTGATGA
GCAGCTAGTGAAAAGCCTTTCATACCAATCAGTATTCCCAACTGTGAACACACACACACACAAC
CACATATAAAGTTTTGTATCTTGCTTCCTTTTTGTTTGTAATATATCTAAGACATGGAGAAAAT
GAGCCCCGATGGTAAACAATGCATTTTAGTTGGAAATGTTGGTAGTTCTTTGGTACGTTACAGA
TCTGAACTGGTAAGACAGACATAAAGCAATGGGTGATGAACGTTGGCATCTCAAGGGAAAAGAC
TATAAAGAAAAGAAAATGGTGGCATTCATAGTTTTATTACAGAAAATTTTCAAAGTCTTGTGTA
CACCAAAGGAGTTGCATCTGTTTACTTTTTGTTTATAATTTTGTTTACAATAGGTAGAAGTTGT
AATTGTTATTTATTTGTAATACTTGTTTGTAACAAAACTTTGTAGCATGGAAAAAACTTTCCAT
CCACAAATATAAATGTGAATAAATATATTCAGAATGTTGGCACCTTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005386090	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000014415
	ENSCLAP00000014415.1

RefSeq Acc Id:

XP_005386090 ⟸ XM_005386033

- UniProtKB:

A0A8C2VF03 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPPNRKLQCHFVLLVLAALRGDSRYLELQDAADYDPLLLFSASPKRELAGEQPYRRALRCLDML
SLPGQFTFTAARPQLHCAAFFIGEAEELLSIRFDLVSIDCRRGDFLKVFDGWILKGEKFPSSQD
HPLPTTDRYTDFCESGFSQRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPSG
RFTLVVPRQHRNCSFSIIYPVVIKISDLTLGHVHGLQLKKSSAGCGGIGDFVELLGGTGLDPSK
MLPLADLCYPFHGPAQLKIGCDNSVVRMVSSGKHINRVTFEYHQLEPYELENPTGNSIPEFCSS
GL

hide sequence

RefSeq Acc Id:

ENSCLAP00000014415 ⟸ ENSCLAT00000014573

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000009942	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000014573	ENTREZGENE
	ENSCLAT00000014573.1	UniProtKB/TrEMBL
InterPro	CRF-bd	UniProtKB/TrEMBL
	Sperma_CUB_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Crhbp	ENTREZGENE
PANTHER	CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN	UniProtKB/TrEMBL
	PTHR10278	UniProtKB/TrEMBL
Pfam	CRF-BP	UniProtKB/TrEMBL
PIRSF	CRF_bd	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49854	UniProtKB/TrEMBL
UniProt	A0A8C2VF03	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

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