E2f1 (E2F transcription factor 1) - Rat Genome Database

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Gene: E2f1 (E2F transcription factor 1) Rattus norvegicus
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Symbol: E2f1 (Ensembl: Necab3)
Name: E2F transcription factor 1 (Ensembl:N-terminal EF-hand calcium binding protein 3)
RGD ID: 728892
Description: Enables protein kinase binding activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hypoxia; cellular response to nerve growth factor stimulus; and positive regulation of glial cell proliferation. Located in nuclear chromosome. Biomarker of Huntington's disease and pancreatic cancer. Human ortholog(s) of this gene implicated in lung carcinoma (multiple); osteosarcoma; and pancreatic adenocarcinoma (multiple). Orthologous to human E2F1 (E2F transcription factor 1); PARTICIPATES IN cell cycle pathway, mitotic; ceramide signaling pathway; chronic myeloid leukemia pathway; INTERACTS WITH (-)-citrinin; (-)-epigallocatechin 3-gallate; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E2F-1; transcription factor E2F1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,524,739 - 163,535,563 (-)NCBIGRCr8
mRatBN7.23143,064,535 - 143,075,362 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,049,478 - 143,075,361 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3146,931,136 - 146,941,990 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,549,300 - 155,560,154 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,288,668 - 153,299,512 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,062,895 - 150,073,721 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,047,826 - 150,073,721 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,435,530 - 156,446,390 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,032,489 - 145,043,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13144,943,133 - 144,943,246 (-)NCBI
Celera3141,799,009 - 141,809,945 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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E2f1RatAlzheimer's disease  ISOE2F1 (Homo sapiens)10401093protein:increased expression:cerebral cortex and cytoplasm:RGD 
E2f1Ratchronic myeloid leukemia  ISOE2F1 (Homo sapiens)13674165mRNA:increased expression:bloodRGD 
E2f1RatCOVID-19  ISOE2F1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
E2f1Ratdementia  ISOE2F1 (Homo sapiens)10401091associated with Down Syndrome and protein:increased expression:frontal cortexRGD 
E2f1Ratglioblastoma disease_progressionISOE2F1 (Homo sapiens)13702471 RGD 
E2f1Rathigh grade glioma severityISOE2F1 (Homo sapiens)13702468 RGD 
E2f1RatHuntington's disease  IEP 2316262protein:increased expression:brainRGD 
E2f1Ratlung adenocarcinoma  ISOE2F1 (Homo sapiens)13464334mRNA:increased expression:lungRGD 
E2f1Ratlung non-small cell carcinoma severityISOE2F1 (Homo sapiens)9590260 RGD 
E2f1Ratlung non-small cell carcinoma treatmentISOE2F1 (Homo sapiens)13464343 RGD 
E2f1Ratlung non-small cell carcinoma treatmentISOE2F1 (Homo sapiens)13464333 RGD 
E2f1Ratlung non-small cell carcinoma disease_progressionISOE2F1 (Homo sapiens)13464342 RGD 
E2f1Ratlung small cell carcinoma disease_progressionISOE2F1 (Homo sapiens)13464335 RGD 
E2f1Ratlung small cell carcinoma  ISOE2F1 (Homo sapiens)13464344mRNA and protein:increased expression:lungRGD 
E2f1Ratlung small cell carcinoma treatmentISOE2F1 (Homo sapiens)13464337 RGD 
E2f1Ratlung squamous cell carcinoma treatmentISOE2F1 (Homo sapiens)13464332 RGD 
E2f1RatNeoplasm Metastasis severityISOE2F1 (Homo sapiens)151347601protein:increased expression:bone (human)RGD 
E2f1Ratosteosarcoma  ISOE2F1 (Homo sapiens)151347601human cells in mouse modelRGD 
E2f1Ratosteosarcoma severityISOE2F1 (Homo sapiens)151347601protein:increased expression:bone (human)RGD 
E2f1Ratpancreatic adenocarcinoma treatmentISOE2F1 (Homo sapiens)13838736Human cells in a mouse modelRGD 
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E2f1Ratgenetic disease  ISOE2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
E2f1Ratglutathione synthetase deficiency  ISOE2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: PYROGLUTAMIC ACIDURIAClinVarPMID:12638941 more ...
E2f1Ratglutatione synthetase deficiency with 5-oxoprolinuria  ISOE2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: 5-OXOPROLINURIA DUE TO GLUTATHIONE SYNTHETASE DEFICIENCYClinVarPMID:12638941 more ...
E2f1Rathypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase  ISOE2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolaseClinVarPMID:15024124 more ...
E2f1Ratlong QT syndrome  ISOE2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: Long QT syndromeClinVarPMID:28492532
E2f1Ratprostate cancer  ISOE2F1 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVar 
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E2f1RatBreast Neoplasms  ISOE2F1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14672398
E2f1RatChemical and Drug Induced Liver Injury  ISOE2F1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30515189
E2f1Ratdisease of cellular proliferation  ISOE2F1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29464002
E2f1Rathepatocellular carcinoma  ISOE2F1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12029619 more ...
E2f1Ratlung non-small cell carcinoma  ISOE2F1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29754146
E2f1Ratmelanoma  ISOE2F1 (Homo sapiens)11554173CTD more ...CTDPMID:15574415 and PMID:16827129
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E2f1RatSjogren's syndrome  ISSE2f1 (Mus musculus)13592920OMIM:270150MouseDO 
E2f1Rattype 1 diabetes mellitus  ISSE2f1 (Mus musculus)13592920OMIM:222100MouseDO 

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E2f1Rat(-)-citrinin increases expressionEXP 6480464Citrinin results in increased expression of E2F1 mRNACTDPMID:23856526
E2f1Rat(-)-epigallocatechin 3-gallate affects methylationEXP 6480464epigallocatechin gallate affects the methylation of E2F1 geneCTDPMID:29381301
E2f1Rat(1->4)-beta-D-glucan multiple interactionsISOE2f1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of E2F1 mRNACTDPMID:36331819
E2f1Rat(25R)-cholest-5-ene-3beta,26-diol increases expressionISOE2F1 (Homo sapiens)648046427-hydroxycholesterol results in increased expression of E2F1 mRNACTDPMID:17872378
E2f1Rat(S)-colchicine decreases expressionISOE2F1 (Homo sapiens)6480464Colchicine results in decreased expression of E2F1 mRNACTDPMID:24211769
E2f1Rat(S)-naringenin multiple interactionsISOE2F1 (Homo sapiens)6480464[naringenin co-treated with bisphenol A] results in increased expression of E2F1 mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of E2F1 mRNACTDPMID:36235125
E2f1Rat(S)-nicotine increases expressionISOE2F1 (Homo sapiens)6480464Nicotine results in increased expression of E2F1 proteinCTDPMID:20061081
E2f1Rat(S)-nicotine multiple interactionsISOE2F1 (Homo sapiens)6480464MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein] more ...CTDPMID:16601104 more ...
E2f1Rat1,2-dimethylhydrazine increases expressionISOE2f1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of E2F1 mRNACTDPMID:22206623
E2f1Rat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile decreases expressionEXP 6480464Citalopram results in decreased expression of E2F1 mRNACTDPMID:28467792
E2f1Rat1-chloro-2,4-dinitrobenzene affects expressionISOE2f1 (Mus musculus)6480464Dinitrochlorobenzene affects the expression of E2F1 mRNACTDPMID:22302311
E2f1Rat1-methyltryptophan multiple interactionsISOE2F1 (Homo sapiens)64804641-methyltryptophan inhibits the reaction [indeno(1 more ...CTDPMID:35687267
E2f1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of E2F1 mRNACTDPMID:30723492
E2f1Rat17alpha-ethynylestradiol multiple interactionsISOE2f1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of E2F1 mRNACTDPMID:17942748
E2f1Rat17alpha-ethynylestradiol increases expressionISOE2f1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of E2F1 mRNACTDPMID:14976129 and PMID:17942748
E2f1Rat17beta-estradiol increases expressionISOE2f1 (Mus musculus)6480464Estradiol results in increased expression of E2F1 mRNA and Estradiol results in increased expression of E2F1 proteinCTDPMID:23684557 and PMID:25210133
E2f1Rat17beta-estradiol decreases expressionISOE2f1 (Mus musculus)6480464Estradiol results in decreased expression of E2F1 mRNACTDPMID:39298647
E2f1Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of E2F1 mRNACTDPMID:32145629
E2f1Rat17beta-estradiol affects expressionISOE2F1 (Homo sapiens)6480464Estradiol affects the expression of E2F1 proteinCTDPMID:28880708
E2f1Rat17beta-estradiol increases activityISOE2F1 (Homo sapiens)6480464Estradiol results in increased activity of E2F1 proteinCTDPMID:27592001

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Biological Process
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E2f1Ratanoikis acts_upstream_of_or_withinIEAUniProtKB:Q61501 and ensembl:ENSMUSP000000994341600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1Ratanoikis acts_upstream_of_or_withinISOE2f1 (Mus musculus)1624291 PMID:14667810RGDPMID:14667810
E2f1Ratcellular response to fatty acid  IEP 2316259 RGD 
E2f1Ratcellular response to hypoxia  IEP 2316261 RGD 
E2f1Ratcellular response to nerve growth factor stimulus  IDA 8693614 RGD 
E2f1Ratcellular response to xenobiotic stimulus acts_upstream_of_or_withinIEAUniProtKB:Q61501 and ensembl:ENSMUSP000000994341600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1Ratcellular response to xenobiotic stimulus acts_upstream_of_or_withinISOE2f1 (Mus musculus)1624291 PMID:24726645RGDPMID:24726645
E2f1RatDNA damage checkpoint signaling involved_inISSUniProtKB:Q010941600115GO_REF:0000024UniProtGO_REF:0000024
E2f1RatDNA damage checkpoint signaling involved_inISOE2F1 (Homo sapiens)1624291 PMID:12717439RGDPMID:12717439
E2f1RatDNA damage checkpoint signaling involved_inIEAUniProtKB:Q01094 and ensembl:ENSP000003455711600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1RatDNA-templated transcription involved_inISSUniProtKB:Q615011600115GO_REF:0000024UniProtGO_REF:0000024
E2f1RatDNA-templated transcription involved_inISOE2f1 (Mus musculus)1624291 PMID:11672531RGDPMID:11672531
E2f1RatDNA-templated transcription involved_inIEAUniProtKB:Q61501 and ensembl:ENSMUSP000000994341600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1Ratforebrain development acts_upstream_of_or_withinISOE2f1 (Mus musculus)1624291MGI:1857424 PMID:15525772RGDPMID:15525772
E2f1Ratforebrain development acts_upstream_of_or_withinIEAUniProtKB:Q61501 and ensembl:ENSMUSP000000994341600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1RatG1/S transition of mitotic cell cycle  TAS 625751 RGD 
E2f1Ratintrinsic apoptotic signaling pathway by p53 class mediator acts_upstream_of_or_withinIEAUniProtKB:Q61501 and ensembl:ENSMUSP000000994341600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1Ratintrinsic apoptotic signaling pathway by p53 class mediator acts_upstream_of_or_withinISOE2f1 (Mus musculus)1624291 PMID:11095619RGDPMID:11095619
E2f1Ratintrinsic apoptotic signaling pathway in response to DNA damage involved_inISSUniProtKB:Q010941600115GO_REF:0000024UniProtGO_REF:0000024
E2f1Ratintrinsic apoptotic signaling pathway in response to DNA damage involved_inISOE2F1 (Homo sapiens)1624291 PMID:12717439RGDPMID:12717439
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Cellular Component
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E2f1Ratcentrosome located_inIEAUniProtKB:Q01094 and ensembl:ENSP000003455711600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1Ratcentrosome located_inISOE2F1 (Homo sapiens)1624291 RGDGO_REF:0000052
E2f1Ratchromatin located_inIEAUniProtKB:Q01094 and ensembl:ENSP000003455711600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1Ratchromatin located_inISOE2f1 (Mus musculus)1624291 PMID:12007404RGDPMID:12007404
E2f1Ratchromatin located_inISOE2F1 (Homo sapiens)1624291 PMID:21454377RGDPMID:21454377
E2f1Ratchromatin located_inIEAUniProtKB:Q61501 and ensembl:ENSMUSP000000994341600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1Ratcytoplasm located_inIEAUniProtKB:Q61501 and ensembl:ENSMUSP000000994341600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1Ratcytoplasm located_inISOE2f1 (Mus musculus)1624291 PMID:8918469RGDPMID:8918469
E2f1Ratnuclear chromosome located_inIDA 151356618PMID:24250814UniProt 
E2f1Ratnucleoplasm located_inIEAUniProtKB:Q01094 and ensembl:ENSP000003455711600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1Ratnucleoplasm located_inISOE2F1 (Homo sapiens)1624291 RGDGO_REF:0000052
E2f1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
E2f1Ratnucleus located_inIEAUniProtKB:Q61501 and ensembl:ENSMUSP000000994341600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1Ratnucleus is_active_inISOE2f1 (Mus musculus)1624291 PMID:10082561RGDPMID:10082561
E2f1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
E2f1Ratnucleus located_inISOE2f1 (Mus musculus)1624291 PMID:10082561 and PMID:8918469RGDPMID:10082561 and PMID:8918469
E2f1Ratnucleus located_inIEAUniProtKB:Q01094 and ensembl:ENSP000003455711600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1Ratnucleus located_inISOE2F1 (Homo sapiens)1624291 PMID:12717439 more ...RGDPMID:12717439 more ...
E2f1Ratnucleus is_active_inISOE2F1 (Homo sapiens)1624291 PMID:28992046RGDPMID:28992046
E2f1Ratprotein-containing complex part_ofISOE2F1 (Homo sapiens)1624291 PMID:23629655RGDPMID:23629655
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Molecular Function
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E2f1Ratcalcium ion binding enablesIEAInterPro:IPR0020481600115GO_REF:0000002InterProGO_REF:0000002
E2f1Ratcis-regulatory region sequence-specific DNA binding enablesISOE2F1 (Homo sapiens)1624291 PMID:15735762RGDPMID:15735762
E2f1Ratcis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:Q01094 and ensembl:ENSP000003455711600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1RatDNA binding enablesISOE2F1 (Homo sapiens)1624291 PMID:11418595 more ...RGDPMID:11418595 more ...
E2f1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
E2f1RatDNA binding enablesIEAUniProtKB:Q01094 and ensembl:ENSP000003455711600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1RatDNA-binding transcription activator activity enablesIEAUniProtKB:Q01094 and ensembl:ENSP000003455711600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1RatDNA-binding transcription activator activity enablesISOE2f1 (Mus musculus)1624291 PMID:35263589RGDPMID:35263589
E2f1RatDNA-binding transcription activator activity enablesIEAUniProtKB:Q61501 and ensembl:ENSMUSP000000994341600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1RatDNA-binding transcription activator activity enablesISSUniProtKB:Q010941600115GO_REF:0000024UniProtGO_REF:0000024
E2f1RatDNA-binding transcription activator activity enablesISOE2F1 (Homo sapiens)1624291 PMID:17062573 and PMID:28992046RGDPMID:17062573 and PMID:28992046
E2f1RatDNA-binding transcription factor activity  TAS 625751 RGD 
E2f1RatDNA-binding transcription factor activity enablesIEAUniProtKB:Q61501 and ensembl:ENSMUSP000000994341600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1RatDNA-binding transcription factor activity enablesIEAUniProtKB:Q01094 and ensembl:ENSP000003455711600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1RatDNA-binding transcription factor activity enablesISOE2f1 (Mus musculus)1624291 PMID:10779331 more ...RGDPMID:10779331 more ...
E2f1RatDNA-binding transcription factor activity enablesISOE2F1 (Homo sapiens)1624291 PMID:15731768RGDPMID:15731768
E2f1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q01094 and ensembl:ENSP000003455711600115GO_REF:0000107EnsemblGO_REF:0000107
E2f1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0011766 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
E2f1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOE2F1 (Homo sapiens)1624291 PMID:20040599RGDPMID:20040599
E2f1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISSUniProtKB:Q010941600115GO_REF:0000024UniProtGO_REF:0000024
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Imported Annotations - KEGG (archival)

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E2f1Ratcell cycle pathway, mitotic  IEA 6907045 KEGGrno:04110
E2f1Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
E2f1Ratchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
E2f1Ratglioma pathway  IEA 6907045 KEGGrno:05214
E2f1Ratmelanoma pathway  IEA 6907045 KEGGrno:05218
E2f1Ratnon-small cell lung carcinoma pathway   IEA 6907045 KEGGrno:05223
E2f1Ratpancreatic cancer pathway   IEA 6907045 KEGGrno:05212
E2f1Ratprostate cancer pathway   IEA 6907045 KEGGrno:05215
E2f1Ratsmall cell lung carcinoma pathway  IEA 6907045 KEGGrno:05222
E2f1Raturinary bladder cancer pathway  IEA 6907045 KEGGrno:05219
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Reference Title
Reference Citation
1. Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. Alonso MM, etal., J Natl Cancer Inst. 2005 Nov 2;97(21):1589-600. doi: 10.1093/jnci/dji340.
2. Gamma-linolenic acid alters Ku80, E2F1, and bax expression and induces micronucleus formation in C6 glioma cells in vitro. Benadiba M, etal., IUBMB Life. 2009 Mar;61(3):244-51.
3. Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression. Chen L, etal., J Biol Chem. 2013 May 17;288(20):14510-21. doi: 10.1074/jbc.M113.458737. Epub 2013 Mar 29.
4. The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study. Chen S, etal., Int J Biol Macromol. 2017 Sep;102:718-728. doi: 10.1016/j.ijbiomac.2017.03.123. Epub 2017 Mar 23.
5. Gene expression profile of circulating CD34(+) cells and granulocytes in chronic myeloid leukemia. Cokic VP, etal., Blood Cells Mol Dis. 2015 Dec;55(4):373-81. doi: 10.1016/j.bcmd.2015.08.002. Epub 2015 Aug 7.
6. Knockdown of E2f1 by RNA interference impairs proliferation of rat cells in vitro. Dos Reis Vasques L, etal., Genet Mol Biol. 2010 Jan;33(1):17-22. doi: 10.1590/S1415-47572009005000104. Epub 2010 Mar 1.
7. Differential expression of members of the E2F family of transcription factors in rodent testes. El-Darwish KS, etal., Reprod Biol Endocrinol. 2006 Dec 5;4:63.
8. Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma. Eymin B, etal., Oncogene. 2001 Mar 29;20(14):1678-87. doi: 10.1038/sj.onc.1204242.
9. Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. Fajas L, etal., J Clin Invest 2004 May;113(9):1288-95.
10. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Field SJ, etal., Cell 1996 May 17;85(4):549-61.
11. Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells. Fujita N, etal., Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H204-12.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas. Gorgoulis VG, etal., J Pathol. 2002 Oct;198(2):142-56. doi: 10.1002/path.1121.
15. Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. Iglesias A, etal., J Clin Invest 2004 May;113(10):1398-407.
16. The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretion. Iwata TN, etal., PLoS One. 2013 Nov 8;8(11):e78841. doi: 10.1371/journal.pone.0078841. eCollection 2013.
17. Altered distribution of cell cycle transcriptional regulators during Alzheimer disease. Jordan-Sciutto KL, etal., J Neuropathol Exp Neurol. 2002 Apr;61(4):358-67.
18. Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis. Jordan-Sciutto KL, etal., J Neurosci. 2002 Mar 15;22(6):2185-95.
19. Adenovirus-mediated E2F-1 gene transfer in nonsmall-cell lung cancer induces cell growth arrest and apoptosis. Kuhn H, etal., Eur Respir J. 2002 Sep;20(3):703-9.
20. Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors. Lee JS, etal., J Clin Oncol. 2010 Jun 1;28(16):2660-7. doi: 10.1200/JCO.2009.25.0977. Epub 2010 Apr 26.
1 to 20 of 44 rows
PMID:3951992   PMID:7797074   PMID:8673024   PMID:8918469   PMID:10082561   PMID:10597240   PMID:10779331   PMID:11004506   PMID:11071387   PMID:11095619   PMID:11331592   PMID:11418595  
PMID:11672531   PMID:12007404   PMID:12717439   PMID:12893818   PMID:14514686   PMID:14593116   PMID:14667810   PMID:15073182   PMID:15158336   PMID:15525772   PMID:15565177   PMID:15722552  
PMID:15731768   PMID:15735762   PMID:15766563   PMID:15990448   PMID:16360038   PMID:16717102   PMID:17062573   PMID:17102628   PMID:17404573   PMID:17482685   PMID:17555552   PMID:17989570  
PMID:18348166   PMID:18364697   PMID:18541936   PMID:18818403   PMID:19545562   PMID:20040599   PMID:20176812   PMID:20224733   PMID:20299467   PMID:21454377   PMID:21614651   PMID:21641965  
PMID:21937878   PMID:21964190   PMID:22476863   PMID:22592528   PMID:22848730   PMID:23332764   PMID:23629655   PMID:24014029   PMID:24453336   PMID:24726645   PMID:26306672   PMID:28125090  
PMID:29936143   PMID:34342400   PMID:35457270   PMID:36111777   PMID:37403456  



E2f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,524,739 - 163,535,563 (-)NCBIGRCr8
mRatBN7.23143,064,535 - 143,075,362 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,049,478 - 143,075,361 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3146,931,136 - 146,941,990 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,549,300 - 155,560,154 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,288,668 - 153,299,512 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,062,895 - 150,073,721 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,047,826 - 150,073,721 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,435,530 - 156,446,390 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,032,489 - 145,043,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13144,943,133 - 144,943,246 (-)NCBI
Celera3141,799,009 - 141,809,945 (-)NCBICelera
Cytogenetic Map3q41NCBI
E2F1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,675,477 - 33,686,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,675,477 - 33,686,385 (-)EnsemblGRCh38hg38GRCh38
GRCh372032,263,283 - 32,274,191 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,727,150 - 31,737,854 (-)NCBINCBI36Build 36hg18NCBI36
Build 342031,727,149 - 31,737,854NCBI
Celera2029,016,324 - 29,027,242 (-)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2029,049,266 - 29,060,184 (-)NCBIHuRef
CHM1_12032,164,384 - 32,175,302 (-)NCBICHM1_1
T2T-CHM13v2.02035,402,008 - 35,412,916 (-)NCBIT2T-CHM13v2.0
E2f1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,401,320 - 154,411,812 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,401,327 - 154,411,812 (-)EnsemblGRCm39 Ensembl
GRCm382154,559,400 - 154,569,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,559,407 - 154,569,892 (-)EnsemblGRCm38mm10GRCm38
MGSCv372154,385,375 - 154,395,588 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362154,251,080 - 154,261,293 (-)NCBIMGSCv36mm8
Celera2160,474,227 - 160,486,251 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.79NCBI
E2f1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542227,633,827 - 27,642,241 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542227,638,625 - 27,643,261 (+)NCBIChiLan1.0ChiLan1.0
E2F1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,366,654 - 39,382,253 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12039,359,755 - 39,370,541 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02029,963,083 - 29,973,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12031,103,764 - 31,115,211 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2031,103,764 - 31,110,604 (-)Ensemblpanpan1.1panPan2
E2F1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,895,149 - 22,904,689 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,878,402 - 22,904,656 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2422,540,395 - 22,549,906 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02423,581,877 - 23,591,392 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,581,862 - 23,616,878 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,874,367 - 22,883,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,967,923 - 22,977,434 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,399,012 - 23,408,523 (-)NCBIUU_Cfam_GSD_1.0
E2f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,848,495 - 171,859,005 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365616,896,063 - 6,900,026 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365616,894,827 - 6,901,058 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
E2F1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1737,178,599 - 37,189,883 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11737,178,587 - 37,190,118 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21742,116,195 - 42,125,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
E2F1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1237,968,541 - 37,980,461 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,968,556 - 37,980,326 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605088,901,404 - 88,913,369 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
E2f1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248425,602,432 - 5,612,951 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248425,602,432 - 5,612,951 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in E2f1
13 total Variants

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:137
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000022428
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 33 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat

1 to 10 of 33 rows
D3Mgh29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,087,759 - 143,087,884 (+)MAPPERmRatBN7.2
Rnor_6.03150,086,036 - 150,086,160NCBIRnor6.0
Rnor_5.03156,458,570 - 156,458,694UniSTSRnor5.0
RGSC_v3.43145,055,522 - 145,055,647RGDRGSC3.4
RGSC_v3.43145,055,523 - 145,055,647UniSTSRGSC3.4
RGSC_v3.15151,483,686 - 151,484,060RGD
Celera3141,820,568 - 141,820,692UniSTS
SHRSP x BN Map367.6099RGD
SHRSP x BN Map367.6099UniSTS
FHH x ACI Map384.7199RGD
Cytogenetic Map3q41UniSTS
UniSTS:234576  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,068,189 - 143,068,402 (+)MAPPERmRatBN7.2
Rnor_6.03150,066,550 - 150,066,762NCBIRnor6.0
Rnor_5.03156,439,185 - 156,439,397UniSTSRnor5.0
RGSC_v3.43145,036,144 - 145,036,356UniSTSRGSC3.4
Celera3141,802,800 - 141,803,012UniSTS
Cytogenetic Map3q41UniSTS
PMC152357P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,075,010 - 143,075,096 (+)MAPPERmRatBN7.2
Rnor_6.03150,073,371 - 150,073,456NCBIRnor6.0
Rnor_5.03156,446,040 - 156,446,125UniSTSRnor5.0
RGSC_v3.43145,043,379 - 145,043,464UniSTSRGSC3.4
Celera3141,809,595 - 141,809,680UniSTS
Cytogenetic Map3q41UniSTS
PMC152357P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83163,535,408 - 163,535,488 (+)Marker Load Pipeline
mRatBN7.23143,075,205 - 143,075,286 (+)MAPPERmRatBN7.2
Rnor_6.03150,073,566 - 150,073,646NCBIRnor6.0
Rnor_5.03156,446,235 - 156,446,315UniSTSRnor5.0
RGSC_v3.43145,043,574 - 145,043,654UniSTSRGSC3.4
Celera3141,809,790 - 141,809,870UniSTS
Cytogenetic Map3q41UniSTS
E2f1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23143,065,743 - 143,066,412 (+)MAPPERmRatBN7.2
Rnor_6.03150,064,104 - 150,064,772NCBIRnor6.0
Rnor_5.03156,436,739 - 156,437,407UniSTSRnor5.0
RGSC_v3.43145,033,698 - 145,034,366UniSTSRGSC3.4
Celera3141,800,218 - 141,800,886UniSTS
Cytogenetic Map3q41UniSTS


The following Strains have been annotated to E2f1
SD    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000022115   ⟹   ENSRNOP00000022115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,049,478 - 143,063,951 (-)Ensembl
Rnor_6.0 Ensembl3150,047,826 - 150,062,311 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000022428   ⟹   ENSRNOP00000022428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,049,478 - 143,075,361 (-)Ensembl
Rnor_6.0 Ensembl3150,062,895 - 150,073,721 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086933   ⟹   ENSRNOP00000070039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3143,049,478 - 143,063,951 (-)Ensembl
Rnor_6.0 Ensembl3150,048,341 - 150,064,438 (-)Ensembl
RefSeq Acc Id: NM_001100778   ⟹   NP_001094248
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,524,739 - 163,535,563 (-)NCBI
mRatBN7.23143,064,535 - 143,075,361 (-)NCBI
Rnor_6.03150,062,895 - 150,073,721 (-)NCBI
Rnor_5.03156,435,530 - 156,446,390 (-)NCBI
RGSC_v3.43145,032,489 - 145,043,729 (-)RGD
Celera3141,799,009 - 141,809,945 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105617   ⟹   XP_038961545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83163,526,006 - 163,535,560 (-)NCBI
mRatBN7.23143,065,806 - 143,075,362 (-)NCBI
Protein RefSeqs NP_001094248 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961545 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA09641 (Get FASTA)   NCBI Sequence Viewer  
  EDL85956 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022428
GenBank Protein O09139 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001094248   ⟸   NM_001100778
- UniProtKB: O09139 (UniProtKB/Swiss-Prot),   A6KHZ9 (UniProtKB/TrEMBL),   A0A8L2QBV4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022428   ⟸   ENSRNOT00000022428
Ensembl Acc Id: ENSRNOP00000022115   ⟸   ENSRNOT00000022115
Ensembl Acc Id: ENSRNOP00000070039   ⟸   ENSRNOT00000086933
RefSeq Acc Id: XP_038961545   ⟸   XM_039105617
- Peptide Label: isoform X1
ABM   E2F/DP family winged-helix DNA-binding   EF-hand

Name Modeler Protein Id AA Range Protein Structure
AF-O09139-F1-model_v2 AlphaFold O09139 1-432 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692575
Promoter ID:EPDNEW_R3100
Type:single initiation site
Name:E2f1_1
Description:E2F transcription factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03150,073,687 - 150,073,747EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-47169 BioCyc
Ensembl Genes ENSRNOG00000016708 Ensembl
  ENSRNOG00000072439 ENTREZGENE
Ensembl Transcript ENSRNOT00000022428 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  6.10.250.540 UniProtKB/Swiss-Prot
InterPro E2F UniProtKB/Swiss-Prot
  E2F-DP_heterodim UniProtKB/Swiss-Prot
  E2F_CC-MB UniProtKB/Swiss-Prot
  E2F_WHTH_DNA-bd_dom UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:399489 UniProtKB/Swiss-Prot
NCBI Gene 399489 ENTREZGENE
PANTHER PTHR12081 UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR E2F1 UniProtKB/Swiss-Prot
Pfam E2F_CC-MB UniProtKB/Swiss-Prot
  E2F_TDP UniProtKB/Swiss-Prot
PharmGKB E2F1 RGD
PhenoGen E2f1 PhenoGen
RatGTEx ENSRNOG00000016708 RatGTEx
  ENSRNOG00000072439 RatGTEx
SMART E2F_TDP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF144074 UniProtKB/Swiss-Prot
  SSF46785 UniProtKB/Swiss-Prot
UniProt A0A0G2JWW3_RAT UniProtKB/TrEMBL
  A0A8L2QBV4 ENTREZGENE, UniProtKB/TrEMBL
  A6KHZ9 ENTREZGENE, UniProtKB/TrEMBL
  E2F1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 E2f1  E2F transcription factor 1      Symbol and Name status set to approved 1299863 APPROVED

Note Type Note Reference
gene_disease associated with atherosclerosis, hypertension, and restenosis after injury 625751
gene_expression expressed in vascular smooth muscle cells, fibroblasts and Saos-2 cell line 625751
gene_function transcription factor 625751
gene_process controls G1/S transition of eukaryotic cells by monitoring the regulation of transcription of growth-related genes 625751
gene_process involved in induction of S phase progression in quiescent cells 625751
gene_product member of transcriptional factor family 625751
gene_regulation RNA expression levels were downregulated in quiescent cells 625751
gene_regulation fetal bovine serum [FBS] induced upregulation of E2f1 mRNA and protein levels by inducing free E2f1 binding onto its promoter 625751