Srebf1 (sterol regulatory element binding transcription factor 1) - Rat Genome Database

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Gene: Srebf1 (sterol regulatory element binding transcription factor 1) Rattus norvegicus
Analyze
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
RGD ID: 69423
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including cellular response to insulin stimulus; response to glucagon; and response to progesterone. Part of protein-containing complex. Biomarker of alcoholic hepatitis; diabetic neuropathy; kidney disease; lipid storage disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease; disease of metabolism; and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1); PARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; insulin signaling pathway; INTERACTS WITH (+)-catechin; (-)-cotinine; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADD-1; ADD1; adipocyte determination- and differentiation-dependent factor 1; SREBP-1; SREBP-1c; Srebp1; sterol regulatory element binding factor 1; sterol regulatory element-binding protein 1; sterol regulatory element-binding transcription factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Srebf1_v1   Srebf1_v2  
Is Marker For: Strains:   SHR.BN-(D10Mgh3-Srebf1)/Ipcv  
QTLs:   Hpcl2  
Candidate Gene For: Hpcl1 Hpcl2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,507,152 - 45,529,164 (-)NCBIGRCr8
mRatBN7.21045,007,637 - 45,029,650 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,007,637 - 45,029,650 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,707,833 - 49,729,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,198,201 - 49,220,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,701,803 - 44,723,821 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,570,996 - 46,593,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,570,996 - 46,593,009 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,326,015 - 46,348,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,461,684 - 46,483,646 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,264,866 - 44,286,830 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Srebf1Ratalcoholic hepatitis treatmentIEP 15036816 RGD 
Srebf1Ratatherosclerosis treatmentISOSrebf1 (Mus musculus)401842363 RGD 
Srebf1Ratatherosclerosis treatmentISOSrebf1 (Mus musculus)401850587 RGD 
Srebf1Ratatherosclerosis treatmentISOSrebf1 (Mus musculus)401827839 RGD 
Srebf1Ratatherosclerosis treatmentISOSrebf1 (Mus musculus)401842381 RGD 
Srebf1Ratcoronary artery disease susceptibilityISOSREBF1 (Homo sapiens)401827912DNA:SNP and haplotype:: -36delG (human)RGD 
Srebf1Ratcoronary artery disease severityISOSREBF1 (Homo sapiens)401842364mRNA:decreased expression:blood serum (human)RGD 
Srebf1Ratcoronary artery disease disease_progressionISOSREBF1 (Homo sapiens)401842368associated with type 2 diabetes mellitus and mRNA:increased expression:epicardial fat (human)RGD 
Srebf1RatDiabetic Nephropathies  ISOSrebf1 (Mus musculus)2308815associated with Diabetes Mellitus more ...RGD 
Srebf1RatDiabetic Nephropathies  ISOSREBF1 (Homo sapiens)2308811 RGD 
Srebf1RatDiabetic Nephropathies  ISOSrebf1 (Mus musculus)1581418associated with Diabetes Mellitus more ...RGD 
Srebf1RatDiabetic Nephropathies  ISOSrebf1 (Mus musculus)2308811associated with Diabetes Mellitus and ExperimentalRGD 
Srebf1RatDiabetic Nephropathies  IEP 2308806associated with Diabetes Mellitus more ...RGD 
Srebf1Ratdiabetic neuropathy  IEP 2308808associated with Diabetes Mellitus and Insulin-DependentRGD 
Srebf1Ratdisease of metabolism  ISOSrebf1 (Mus musculus)1581420mRNA and protein:decreased expression:liverRGD 
Srebf1Ratdisease of metabolism susceptibilityISOSREBF1 (Homo sapiens)2308809DNA:SNPsRGD 
Srebf1RatExperimental Diabetes Mellitus  IEP 2308804mRNA more ...RGD 
Srebf1RatExperimental Diabetes Mellitus treatmentIEP 401850547 RGD 
Srebf1Ratfamilial hyperlipidemia treatmentISOSrebf1 (Mus musculus)401842366 RGD 
Srebf1RatFetal Growth Retardation  IEP 2308805 RGD 
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Srebf1Ratautistic disorder  ISOSREBF1 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Srebf1RatBirt-Hogg-Dube syndrome  ISOSREBF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Birt-Hogg-Dube syndromeClinVarPMID:20188345 and PMID:28492532
Srebf1Ratcommon variable immunodeficiency 2  ISOSREBF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency more ...ClinVarPMID:28492532
Srebf1Ratgenetic disease  ISOSREBF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868
Srebf1RatIchthyosis Follicularis, Atrichia, and Photophobia Syndrome 2  ISOSREBF1 (Homo sapiens)8554872ClinVar Annotator: match by term: IFAP syndrome 2ClinVarPMID:25741868 more ...
Srebf1Ratichthyosis follicularis-alopecia-photophobia syndrome 1  ISOSREBF1 (Homo sapiens)8554872ClinVar Annotator: match by term: IFAP syndrome 1 and with or without BRESHECK syndromeClinVarPMID:25741868 more ...
Srebf1RatJoubert syndrome 1  ISOSREBF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial aplasia of the vermisClinVarPMID:28492532
Srebf1Ratobesity  ISOSREBF1 (Homo sapiens)8554872ClinVar Annotator: match by term: ObesityClinVarPMID:25741868
Srebf1RatPotocki-Lupski syndrome  ISOSREBF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Potocki-Lupski syndromeClinVarPMID:28837307
Srebf1RatSmith-Magenis syndrome  ISOSREBF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Smith-Magenis syndromeClinVarPMID:25087610
Srebf1RatUrban Schosser Spohn Syndrome  ISOSREBF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary mucoepithelial dysplasiaClinVarPMID:25741868 more ...
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Srebf1Ratend stage renal disease  ISOSREBF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19878707
Srebf1RatExperimental Diabetes Mellitus  ISOSREBF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10900012 and PMID:23090186
Srebf1RatExperimental Liver Cirrhosis  ISOSREBF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Srebf1Rathepatocellular carcinoma  ISOSREBF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14563831 and PMID:21147110
Srebf1RatInsulin Resistance  ISOSREBF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22658938
Srebf1Ratmetabolic dysfunction-associated steatotic liver disease  ISOSREBF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23603006 and PMID:24633463
Srebf1Ratobesity  ISOSREBF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10900012
Srebf1Ratsteatotic liver disease  ISOSREBF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24469900
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Srebf1RatIchthyosis Follicularis, Atrichia, and Photophobia Syndrome 2  ISOSREBF1 (Homo sapiens)7240710 OMIM 
Srebf1RatUrban Schosser Spohn Syndrome  ISOSREBF1 (Homo sapiens)7240710 OMIM 

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Srebf1Rat(+)-catechin multiple interactionsEXP 6480464Catechin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]CTDPMID:23365609
Srebf1Rat(+)-isolariciresinol decreases expressionISOSREBF1 (Homo sapiens)6480464isolariciresinol results in decreased expression of SREBF1 mRNACTDPMID:35755389
Srebf1Rat(+)-pinoresinol decreases expressionISOSREBF1 (Homo sapiens)6480464pinoresinol results in decreased expression of SREBF1 proteinCTDPMID:31610126
Srebf1Rat(+)-pinoresinol multiple interactionsISOSREBF1 (Homo sapiens)6480464[loliolide co-treated with pinoresinol] results in decreased expression of SREBF1 proteinCTDPMID:31610126
Srebf1Rat(-)-cotinine multiple interactionsEXP 6480464[Nicotine results in increased abundance of Cotinine] which results in increased expression of SREBF1 mRNACTDPMID:29617909
Srebf1Rat(-)-demecolcine decreases expressionISOSREBF1 (Homo sapiens)6480464Demecolcine results in decreased expression of SREBF1 mRNACTDPMID:23649840
Srebf1Rat(-)-epigallocatechin 3-gallate decreases expressionISOSREBF1 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of SREBF1 mRNACTDPMID:20816778
Srebf1Rat(-)-epigallocatechin 3-gallate decreases expression ISOSrebf1 (Mus musculus)401827839(-)-epigallocatechin 3-gallate decreases expression of Srebf1 mRNA in liverRGD 
Srebf1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOSrebf1 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [1 more ...CTDPMID:30092300
Srebf1Rat(2,4,5-trichlorophenoxy)acetic acid increases expressionISOSrebf1 (Mus musculus)64804642 more ...CTDPMID:18579281
Srebf1Rat(25R)-cholest-5-ene-3beta,26-diol decreases expressionEXP 648046427-hydroxycholesterol results in decreased expression of SREBF1 mRNA and 27-hydroxycholesterol results in decreased expression of SREBF1 proteinCTDPMID:28167099
Srebf1Rat(R)-carnitine multiple interactionsEXP 6480464Carnitine inhibits the reaction [Stavudine results in increased expression of SREBF1 mRNA]CTDPMID:18299183
Srebf1Rat(R)-carnitine decreases expressionEXP 6480464Carnitine results in decreased expression of SREBF1 proteinCTDPMID:25669660
Srebf1Rat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]CTDPMID:22464149
Srebf1Rat(S)-nicotine decreases expressionISOSREBF1 (Homo sapiens)6480464Nicotine results in decreased expression of SREBF1 mRNACTDPMID:18247414
Srebf1Rat(S)-nicotine increases expressionISOSrebf1 (Mus musculus)6480464Nicotine results in increased expression of SREBF1 mRNACTDPMID:31622651
Srebf1Rat(S)-nicotine multiple interactionsEXP 6480464[Nicotine results in increased abundance of Cotinine] which results in increased expression of SREBF1 mRNACTDPMID:29617909
Srebf1Rat(S)-nicotine increases expressionEXP 6480464Nicotine results in increased expression of SREBF1 mRNACTDPMID:29155039
Srebf1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionISOSrebf1 (Mus musculus)6480464o and p'-DDT affects the expression of SREBF1 mRNACTDPMID:18925944
Srebf1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of SREBF1 mRNACTDPMID:17984292

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Biological Process
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Srebf1Ratcellular response to fatty acid  IEP 7242708palmitateRGD 
Srebf1Ratcellular response to insulin stimulus  IEP 2308847 RGD 
Srebf1Ratcellular response to insulin stimulus  IEP 401842379 RGD 
Srebf1Ratcellular response to insulin stimulus  IEP 2308803 RGD 
Srebf1Ratcellular response to starvation involved_inIDA 8553473PMID:16407292HGNC-UCL 
Srebf1Ratcellular response to starvation involved_inIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1Ratcellular response to starvation involved_inISOSrebf1 (Mus musculus)1624291 PMID:16407292RGDPMID:16407292
Srebf1Ratcholesterol biosynthetic process acts_upstream_ofIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1Ratcholesterol biosynthetic process acts_upstream_ofISOSrebf1 (Mus musculus)1624291MGI:2177958 PMID:9329978RGDPMID:9329978
Srebf1Ratcholesterol metabolic process involved_inIEAUniProtKB-KW:KW-01531600115GO_REF:0000043UniProtGO_REF:0000043
Srebf1Ratcholesterol metabolic process  IMP 1643359 RGD 
Srebf1Ratcircadian rhythm involved_inISOSrebf1 (Mus musculus)1624291 PMID:19786558RGDPMID:19786558
Srebf1Ratcircadian rhythm involved_inIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1Ratfat cell differentiation acts_upstream_of_or_withinISOSrebf1 (Mus musculus)1624291 PMID:22331133RGDPMID:22331133
Srebf1Ratfat cell differentiation acts_upstream_of_or_withinIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1Ratinsulin receptor signaling pathway acts_upstream_of_or_withinIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1Ratinsulin receptor signaling pathway acts_upstream_of_or_withinISOSrebf1 (Mus musculus)1624291 PMID:17074803RGDPMID:17074803
Srebf1Ratinsulin secretion acts_upstream_ofISOSrebf1 (Mus musculus)1624291MGI:2177773 PMID:16890542RGDPMID:16890542
Srebf1Ratinsulin secretion acts_upstream_ofIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1Ratintracellular receptor signaling pathway involved_inIEAGO:00048791600115GO_REF:0000108GOCGO_REF:0000108
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Cellular Component
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Srebf1Ratcytoplasm located_inISOSrebf1 (Mus musculus)1624291 PMID:16100574 and PMID:21459323RGDPMID:16100574 and PMID:21459323
Srebf1Ratcytoplasm located_inISSUniProtKB:Q9WTN31600115GO_REF:0000024UniProtGO_REF:0000024
Srebf1Ratcytoplasm located_inIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Srebf1Ratendoplasmic reticulum located_inISOSREBF1 (Homo sapiens) and UniProtKB:P36956-11624291 PMID:12202038RGDPMID:12202038
Srebf1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Srebf1Ratendoplasmic reticulum membrane located_inTAS 1600115Reactome:R-NUL-9625366ReactomeReactome:R-NUL-9625366
Srebf1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Srebf1RatER to Golgi transport vesicle membrane located_inIEAUniProtKB-SubCell:SL-00781600115GO_REF:0000044UniProtGO_REF:0000044
Srebf1RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
Srebf1RatGolgi membrane located_inIEAUniProtKB-SubCell:SL-01341600115GO_REF:0000044UniProtGO_REF:0000044
Srebf1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Srebf1Ratmembrane located_inIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1Ratmembrane located_inISOSrebf1 (Mus musculus)1624291 PMID:11090130RGDPMID:11090130
Srebf1Ratnucleoplasm located_inISOSREBF1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Srebf1Ratnucleoplasm located_inIEAUniProtKB:P36956 and ensembl:ENSP000002616461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1Ratnucleus located_inISOSREBF1 (Homo sapiens) and UniProtKB:P36956-11624291 PMID:12202038RGDPMID:12202038
Srebf1Ratnucleus located_inIEAUniProtKB:P36956 and ensembl:ENSP000002616461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Srebf1Ratnucleus located_inIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Srebf1Ratchromatin binding enablesISOSrebf1 (Mus musculus)1624291 PMID:15637161 more ...RGDPMID:15637161 more ...
Srebf1Ratchromatin binding  IDA 8693606 RGD 
Srebf1Ratchromatin binding enablesIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1RatDNA binding enablesISSUniProtKB:Q9WTN31600115GO_REF:0000024UniProtGO_REF:0000024
Srebf1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Srebf1RatDNA binding enablesIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1RatDNA binding enablesISOSrebf1 (Mus musculus)1624291 PMID:11829742 and PMID:19244231RGDPMID:11829742 and PMID:19244231
Srebf1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIDA 8553473PMID:16407292NTNU_SB 
Srebf1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P36956 and ensembl:ENSP000002616461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOSREBF1 (Homo sapiens)1624291 PMID:31501273RGDPMID:31501273
Srebf1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOSREBF1 (Homo sapiens) and UniProtKB:P36956-31624291 PMID:24296663RGDPMID:24296663
Srebf1RatDNA-binding transcription factor activity enablesISSUniProtKB:P369568553473PMID:16407292HGNC-UCL 
Srebf1RatDNA-binding transcription factor activity enablesIEAUniProtKB:P36956 and ensembl:ENSP000002616461600115GO_REF:0000107EnsemblGO_REF:0000107
Srebf1RatDNA-binding transcription factor activity enablesISOSREBF1 (Homo sapiens)1624291 PMID:16407292RGDPMID:16407292
Srebf1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISSUniProtKB:P369561600115GO_REF:0000024UniProtGO_REF:0000024
Srebf1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOSrebf1 (Mus musculus) and PR:Q9WTN3-11624291 PMID:21531336 more ...RGDPMID:21531336 more ...
Srebf1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0261283 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Srebf1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOSrebf1 (Mus musculus)1624291 PMID:22331133RGDPMID:22331133
Srebf1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISSUniProtKB:P36956-PRO_00003140291600115GO_REF:0000024UniProtGO_REF:0000024
Srebf1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q9WTN3 and ensembl:ENSMUSP000000208461600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
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Srebf1Ratsterol regulatory element-binding protein signaling pathway   ISOSREBF1 (Homo sapiens)2317203 RGD 

Imported Annotations - KEGG (archival)

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Srebf1Ratinsulin signaling pathway   IEA 6907045 KEGGrno:04910

Imported Annotations - PID (archival)

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Srebf1RatmTOR signaling pathway   ISOSREBF1 (Homo sapiens)6484113 PIDPID:200096
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Srebf1Ratdecreased cholesterol level  IAGP 1643359 RGD 

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Reference Title
Reference Citation
1. Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47. Amemiya-Kudo M, etal., J Biol Chem. 2005 Oct 14;280(41):34577-89. Epub 2005 Jul 29.
2. Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors. Boizard M, etal., J Biol Chem. 1998 Oct 30;273(44):29164-71.
3. Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue. Bonzon-Kulichenko E, etal., Endocrinology. 2009 Jan;150(1):169-78. Epub 2008 Sep 18.
4. Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways. Botolin D, etal., J Lipid Res. 2006 Jan;47(1):181-92. Epub 2005 Oct 12.
5. HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus. Carper MJ, etal., Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E558-67. Epub 2008 Jan 2.
6. Arctium lappa L. polysaccharide can regulate lipid metabolism in type 2 diabetic rats through the SREBP-1/SCD-1 axis. Chen M, etal., Carbohydr Res. 2020 Aug;494:108055. doi: 10.1016/j.carres.2020.108055. Epub 2020 Jun 7.
7. Protective effect of Chinese prescription Kangen-karyu and its crude drug Tanjin against age-related lipidosis in rats. Cho EJ, etal., J Pharm Pharmacol. 2007 May;59(5):687-94.
8. Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. Costet P, etal., J Biol Chem. 2006 Mar 10;281(10):6211-8. Epub 2006 Jan 6.
9. Programmed upregulation of adipogenic transcription factors in intrauterine growth-restricted offspring. Desai M, etal., Reprod Sci. 2008 Oct;15(8):785-96.
10. Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. Doddapattar P, etal., Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3.
11. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Foretz M, etal., Mol Cell Biol. 1999 May;19(5):3760-8.
12. [Effects of wheat bran fiber on lipid metabolism in ApoE~(-/-) mice]. Gao H, etal., Wei Sheng Yan Jiu. 2019 Jul;48(4):601-605.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
16. Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis. Hu YB, etal., Drug Des Devel Ther. 2018 Jul 16;12:2213-2221. doi: 10.2147/DDDT.S170518. eCollection 2018.
17. Involvement of glomerular SREBP-1c in diabetic nephropathy. Ishigaki N, etal., Biochem Biophys Res Commun. 2007 Dec 21;364(3):502-8. Epub 2007 Oct 16.
18. Calorie restriction modulates renal expression of sterol regulatory element binding proteins, lipid accumulation, and age-related renal disease. Jiang T, etal., J Am Soc Nephrol. 2005 Aug;16(8):2385-94. Epub 2005 Jun 8.
19. In vivo and in vitro effects of SREBP-1 on diabetic renal tubular lipid accumulation and RNAi-mediated gene silencing study. Jun H, etal., Histochem Cell Biol. 2009 Mar;131(3):327-45. Epub 2008 Dec 2.
20. Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1. Jung YA, etal., Exp Mol Med. 2014 Jan 24;46(1):e73. doi: 10.1038/emm.2013.143.
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1 to 10 of 12 rows
PMID:7739539   PMID:8336713   PMID:9329978   PMID:11739104   PMID:11829742   PMID:12016216   PMID:12031952   PMID:12031958   PMID:12202038   PMID:12242332   PMID:12488438   PMID:12600983  
PMID:12764144   PMID:12771318   PMID:12865412   PMID:12941932   PMID:14505487   PMID:14654692   PMID:14668913   PMID:14674713   PMID:14744869   PMID:14988441   PMID:15001432   PMID:15037635  
PMID:15039461   PMID:15123649   PMID:15123720   PMID:15249218   PMID:15266058   PMID:15280151   PMID:15281019   PMID:15330762   PMID:15358760   PMID:15561928   PMID:15637161   PMID:15896314  
PMID:16002205   PMID:16046411   PMID:16091421   PMID:16092054   PMID:16100574   PMID:16380121   PMID:16554040   PMID:16772326   PMID:16787385   PMID:16834571   PMID:16890542   PMID:17074803  
PMID:17296605   PMID:17313375   PMID:17449871   PMID:17456898   PMID:17632011   PMID:17636037   PMID:18060044   PMID:18157544   PMID:18178930   PMID:18635549   PMID:18665039   PMID:18989661  
PMID:19125418   PMID:19244231   PMID:19299314   PMID:19366697   PMID:19375767   PMID:19564420   PMID:19616615   PMID:19672729   PMID:19682972   PMID:19716432   PMID:19786558   PMID:19966780  
PMID:20005944   PMID:20041157   PMID:20211032   PMID:20589757   PMID:20615871   PMID:21036148   PMID:21038676   PMID:21167679   PMID:21459323   PMID:21540177   PMID:21652712   PMID:21731709  
PMID:21757781   PMID:21906525   PMID:21986124   PMID:22031849   PMID:22093779   PMID:22292946   PMID:22331133   PMID:22415588   PMID:22511764   PMID:22645024   PMID:22898567   PMID:23028851  
PMID:23065593   PMID:23106379   PMID:23239524   PMID:23257266   PMID:23295202   PMID:23542164   PMID:23583293   PMID:23610160   PMID:23823476   PMID:23913732   PMID:24296663   PMID:24362725  
PMID:24425205   PMID:24625548   PMID:24912190   PMID:25046614   PMID:25348957   PMID:25398788   PMID:25616173   PMID:25796423   PMID:25847140   PMID:26218603   PMID:26327595   PMID:26437365  
1 to 10 of 12 rows



Srebf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,507,152 - 45,529,164 (-)NCBIGRCr8
mRatBN7.21045,007,637 - 45,029,650 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,007,637 - 45,029,650 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,707,833 - 49,729,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01049,198,201 - 49,220,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,701,803 - 44,723,821 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,570,996 - 46,593,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,570,996 - 46,593,009 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,326,015 - 46,348,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,461,684 - 46,483,646 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,264,866 - 44,286,830 (-)NCBICelera
Cytogenetic Map10q22NCBI
SREBF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381717,811,334 - 17,836,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1717,810,399 - 17,837,002 (-)EnsemblGRCh38hg38GRCh38
GRCh371717,714,648 - 17,740,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,656,111 - 17,681,050 (-)NCBINCBI36Build 36hg18NCBI36
Build 341717,656,110 - 17,681,050NCBI
Celera1718,654,135 - 18,680,982 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1717,466,908 - 17,494,061 (-)NCBIHuRef
CHM1_11717,723,458 - 17,749,109 (-)NCBICHM1_1
T2T-CHM13v2.01717,757,927 - 17,783,669 (-)NCBIT2T-CHM13v2.0
Srebf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,089,910 - 60,113,407 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,089,915 - 60,113,407 (-)EnsemblGRCm39 Ensembl
GRCm381160,199,084 - 60,224,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,199,089 - 60,222,581 (-)EnsemblGRCm38mm10GRCm38
MGSCv371160,012,591 - 60,034,106 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,015,284 - 60,036,799 (-)NCBIMGSCv36mm8
Celera1166,655,030 - 66,676,425 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.81NCBI
Srebf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577171,425 - 186,046 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577171,425 - 183,669 (+)NCBIChiLan1.0ChiLan1.0
SREBF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21952,328,005 - 52,355,769 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11757,040,217 - 57,065,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01733,458,196 - 33,484,643 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,405,794 - 38,432,045 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,405,794 - 38,432,045 (+)Ensemblpanpan1.1panPan2
SREBF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,663,809 - 41,686,764 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,663,773 - 41,686,776 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,802,335 - 41,825,236 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,769,693 - 41,792,654 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl541,769,687 - 41,925,702 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1541,737,352 - 41,760,245 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,684,736 - 41,707,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,876,687 - 41,899,587 (+)NCBIUU_Cfam_GSD_1.0
Srebf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,447,521 - 61,458,579 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367411,406,521 - 1,419,776 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367411,408,669 - 1,419,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SREBF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,733,907 - 60,751,267 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,733,967 - 60,750,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SREBF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,847,603 - 16,874,239 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1616,845,491 - 16,859,554 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660594,037,449 - 4,063,735 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srebf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,602,261 - 3,623,465 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,602,103 - 3,623,922 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Srebf1
112 total Variants

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:43
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000004753, ENSRNOT00000047053
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 70 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat

1 to 10 of 70 rows
PMC134715P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,014,834 - 45,014,914 (+)MAPPERmRatBN7.2
Rnor_6.01046,578,194 - 46,578,273NCBIRnor6.0
Rnor_5.01046,333,213 - 46,333,292UniSTSRnor5.0
RGSC_v3.41046,468,873 - 46,468,952UniSTSRGSC3.4
Celera1044,272,064 - 44,272,143UniSTS
Cytogenetic Map10q22UniSTS
RH132247  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,007,766 - 45,007,976 (+)MAPPERmRatBN7.2
Rnor_6.01046,571,126 - 46,571,335NCBIRnor6.0
Rnor_5.01046,326,145 - 46,326,354UniSTSRnor5.0
RGSC_v3.41046,461,805 - 46,462,014UniSTSRGSC3.4
Celera1044,264,996 - 44,265,205UniSTS
RH 3.4 Map10524.79UniSTS
Cytogenetic Map10q22UniSTS


The following Strains have been annotated to Srebf1
SHR.BN-(D10Mgh3-Srebf1)/Ipcv    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000004753   ⟹   ENSRNOP00000004753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1045,007,637 - 45,019,495 (-)Ensembl
Rnor_6.0 Ensembl1046,570,996 - 46,582,854 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000047053   ⟹   ENSRNOP00000050057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1045,007,637 - 45,029,650 (-)Ensembl
Rnor_6.0 Ensembl1046,570,996 - 46,593,009 (-)Ensembl
RefSeq Acc Id: NM_001276707   ⟹   NP_001263636
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,507,152 - 45,529,164 (-)NCBI
mRatBN7.21045,007,637 - 45,029,650 (-)NCBI
Rnor_6.01046,570,996 - 46,593,009 (-)NCBI
Rnor_5.01046,326,015 - 46,348,035 (-)NCBI
Celera1044,264,866 - 44,286,830 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001276708   ⟹   NP_001263637
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,507,152 - 45,519,010 (-)NCBI
mRatBN7.21045,007,637 - 45,019,495 (-)NCBI
Rnor_6.01046,570,996 - 46,582,854 (-)NCBI
Rnor_5.01046,326,015 - 46,348,035 (-)NCBI
Celera1044,264,866 - 44,276,706 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063269911   ⟹   XP_063125981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,508,552 - 45,529,163 (-)NCBI
1 to 12 of 12 rows
Protein RefSeqs NP_001263636 (Get FASTA)   NCBI Sequence Viewer  
  NP_001263637 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125981 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG28733 (Get FASTA)   NCBI Sequence Viewer  
  AAG28734 (Get FASTA)   NCBI Sequence Viewer  
  EDM04632 (Get FASTA)   NCBI Sequence Viewer  
  EDM04633 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004753
  ENSRNOP00000004753.6
  ENSRNOP00000050057
  ENSRNOP00000050057.3
GenBank Protein P56720 (Get FASTA)   NCBI Sequence Viewer  
1 to 12 of 12 rows
RefSeq Acc Id: NP_001263636   ⟸   NM_001276707
- Peptide Label: isoform 1 precursor
- UniProtKB: Q99PI6 (UniProtKB/Swiss-Prot),   Q99PI7 (UniProtKB/Swiss-Prot),   P56720 (UniProtKB/Swiss-Prot),   A6HF27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001263637   ⟸   NM_001276708
- Peptide Label: isoform 2
- UniProtKB: A6HF28 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004753   ⟸   ENSRNOT00000004753
Ensembl Acc Id: ENSRNOP00000050057   ⟸   ENSRNOT00000047053
RefSeq Acc Id: XP_063125981   ⟸   XM_063269911
- Peptide Label: isoform X1
bHLH

Name Modeler Protein Id AA Range Protein Structure
AF-P56720-F1-model_v2 AlphaFold P56720 1-1134 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697246
Promoter ID:EPDNEW_R7770
Type:multiple initiation site
Name:Srebf1_2
Description:sterol regulatory element binding transcription factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7771  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01046,582,882 - 46,582,942EPDNEW
RGD ID:13697247
Promoter ID:EPDNEW_R7771
Type:initiation region
Name:Srebf1_1
Description:sterol regulatory element binding transcription factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7770  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01046,593,003 - 46,593,063EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24862 BioCyc
Ensembl Genes ENSRNOG00000003463 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004753 ENTREZGENE
  ENSRNOT00000004753.6 UniProtKB/Swiss-Prot
  ENSRNOT00000047053 ENTREZGENE
  ENSRNOT00000047053.7 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:78968 UniProtKB/Swiss-Prot
NCBI Gene 78968 ENTREZGENE
PANTHER STEROL REGULATORY ELEMENT-BINDING PROTEIN UniProtKB/Swiss-Prot
  STEROL REGULATORY ELEMENT-BINDING PROTEIN 1 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PhenoGen Srebf1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003463 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
TIGR TC217415
UniProt A6HF27 ENTREZGENE, UniProtKB/TrEMBL
  A6HF28 ENTREZGENE, UniProtKB/TrEMBL
  P56720 ENTREZGENE
  Q99PI6 ENTREZGENE
  Q99PI7 ENTREZGENE
  SRBP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q99PI6 UniProtKB/Swiss-Prot
  Q99PI7 UniProtKB/Swiss-Prot
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-11 Srebf1  sterol regulatory element binding transcription factor 1  Srebf1  sterol regulatory element binding factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Srebf1  sterol regulatory element binding factor 1      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_cellular_localization precursor form localizes to the endoplasmic reticulum and nuclear envelope and mature form localizes to the nucleus 625517
gene_disease may play a role in streptozotocin-induced diabetes based on observed increase in renal expression 625517
gene_process enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis 68688
gene_process enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis 68702
gene_process enhances transcription of genes encoding enzymes of unsaturated fatty acid biosynthesis 625517
gene_process regulates genes involved in fatty acid and triglyceride metabolism 68688
gene_process regulates genes involved in fatty acid and triglyceride metabolism 68702
gene_process regulates genes involved in fatty acid and triglyceride metabolism 625517
gene_process mediates increased lipid synthesis, triglyceride accumulation, mesangial expansion, glomerulosclerosis, and proteinuria through increasing the expression of transforming growth factor and vascular endothelial growth factor 625517
gene_product member of the basic helix-loop-helix-leucine zipper family 625517
gene_product active protein contains 500 amino acids 625517
gene_transcript two splice variants have been identified 625517