Foxl3 (forkhead box L3) - Rat Genome Database

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Gene: Foxl3 (forkhead box L3) Rattus norvegicus
Analyze
Symbol: Foxl3
Name: forkhead box L3
RGD ID: 1594158
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human FOXL3 (forkhead box L3); INTERACTS WITH 4,4'-sulfonyldiphenol (ortholog); chlorpyrifos (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: forkhead box L1-like; LOC680273; similar to Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,926,266 - 20,928,893 (-)NCBIGRCr8
mRatBN7.21215,812,177 - 15,814,534 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,812,674 - 15,814,534 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01217,902,045 - 17,904,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,902,521 - 17,904,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,893,918 - 19,896,110 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41216,332,382 - 16,334,529 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1217,564,618 - 17,566,783 (-)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Foxl3Rat4,4'-sulfonyldiphenol decreases methylationISOFoxl3 (Mus musculus)6480464bisphenol S results in decreased methylation of FOXL3 exonCTDPMID:33297965
Foxl3Ratchlorpyrifos decreases expressionISOFoxl3 (Mus musculus)6480464Chlorpyrifos results in decreased expression of FOXL3 mRNACTDPMID:32715474


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Foxl3Ratanatomical structure morphogenesis involved_inIBAFB:FBgn0000659 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Foxl3Ratcell differentiation involved_inIBAFB:FBgn0000659 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Foxl3Ratregulation of DNA-templated transcription involved_inIEAInterPro:IPR001766 and InterPro:IPR0304561600115GO_REF:0000002InterProGO_REF:0000002
Foxl3Ratregulation of transcription by RNA polymerase II involved_inIBAFB:FBgn0000659 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Foxl3Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Foxl3Ratnucleus located_inIEAUniRule:UR0004137411600115GO_REF:0000104UniProtGO_REF:0000104
Foxl3Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Foxl3RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Foxl3RatDNA binding enablesIEAUniRule:UR0004137411600115GO_REF:0000104UniProtGO_REF:0000104
Foxl3RatDNA-binding transcription factor activity enablesIEAInterPro:IPR001766 and InterPro:IPR0304561600115GO_REF:0000002InterProGO_REF:0000002
Foxl3RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0000659 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Foxl3RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAMGI:1096329 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Foxl3Ratsequence-specific DNA binding enablesIEAInterPro:IPR001766 and InterPro:IPR0304561600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Foxl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,926,266 - 20,928,893 (-)NCBIGRCr8
mRatBN7.21215,812,177 - 15,814,534 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,812,674 - 15,814,534 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01217,902,045 - 17,904,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,902,521 - 17,904,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,893,918 - 19,896,110 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41216,332,382 - 16,334,529 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1217,564,618 - 17,566,783 (-)NCBICelera
Cytogenetic Map12q11NCBI
FOXL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387290,170 - 291,488 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7290,170 - 294,422 (+)EnsemblGRCh38hg38GRCh38
GRCh377330,136 - 331,454 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map7p22.3NCBI
T2T-CHM13v2.07389,757 - 391,075 (+)NCBIT2T-CHM13v2.0
Foxl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,805,640 - 138,807,486 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,805,835 - 138,807,374 (+)EnsemblGRCm39 Ensembl
GRCm385138,819,865 - 138,821,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,820,080 - 138,821,619 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,295,436 - 139,297,573 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,073,124 - 139,075,261 (+)NCBIMGSCv36mm8
Celera5135,875,410 - 135,876,949 (+)NCBICelera
Cytogenetic Map5G2NCBI
FOXL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v265,192,561 - 5,196,804 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1753,517,253 - 53,521,492 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07410,952 - 415,195 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FOXL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha617,904,716 - 17,906,692 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,562,267 - 16,564,243 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,562,678 - 16,564,300 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,364,717 - 16,366,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,291,171 - 16,293,145 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,581,214 - 16,583,190 (-)NCBIUU_Cfam_GSD_1.0
FOXL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12821,267,915 - 21,272,871 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666090147,372 - 151,683 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Foxl3
6 total Variants

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:61
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000060192
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 48 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat

1 to 10 of 48 rows
LOC783396  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21215,813,530 - 15,813,680 (+)MAPPERmRatBN7.2
Rnor_6.01217,903,251 - 17,903,400NCBIRnor6.0
Rnor_5.01219,895,107 - 19,895,256UniSTSRnor5.0
RGSC_v3.41216,332,974 - 16,333,123UniSTSRGSC3.4
Celera1217,565,686 - 17,565,835UniSTS
Cytogenetic Map12q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 2 28 34 16 19 1 17 1 1 64 51 30 7 33 18



Ensembl Acc Id: ENSRNOT00000060192   ⟹   ENSRNOP00000056938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1215,812,674 - 15,814,534 (-)Ensembl
Rnor_6.0 Ensembl1217,902,521 - 17,904,254 (-)Ensembl
RefSeq Acc Id: XM_039089973   ⟹   XP_038945901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81220,926,266 - 20,928,326 (-)NCBI
mRatBN7.21215,812,177 - 15,814,534 (-)NCBI
RefSeq Acc Id: XM_063271735   ⟹   XP_063127805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81220,926,266 - 20,928,893 (-)NCBI
Protein RefSeqs NP_001419357 (Get FASTA)   NCBI Sequence Viewer  
  NP_001419358 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945901 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127805 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056938
  ENSRNOP00000056938.2
Ensembl Acc Id: ENSRNOP00000056938   ⟸   ENSRNOT00000060192
RefSeq Acc Id: XP_038945901   ⟸   XM_039089973
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063127805   ⟸   XM_063271735
- Peptide Label: isoform X1
Fork-head

Name Modeler Protein Id AA Range Protein Structure
AF-F1LWK1-F1-model_v2 AlphaFold F1LWK1 1-216 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19873 BioCyc
Ensembl Genes ENSRNOG00000039296 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060192 ENTREZGENE
  ENSRNOT00000060192.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro FOX_domain-containing UniProtKB/TrEMBL
  TF_fork_head UniProtKB/TrEMBL
  TF_fork_head_CS_2 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene 680273 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN UniProtKB/TrEMBL
  FORKHEAD BOX PROTEIN L3 UniProtKB/TrEMBL
Pfam Fork_head UniProtKB/TrEMBL
PhenoGen Foxl3 PhenoGen
PRINTS FORKHEAD UniProtKB/TrEMBL
PROSITE FORK_HEAD_2 UniProtKB/TrEMBL
  FORK_HEAD_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039296 RatGTEx
SMART SM00339 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt F1LWK1 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Foxl3  forkhead box L3  LOC680273  similar to Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680273  similar to Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7)      Symbol and Name status set to provisional 70820 PROVISIONAL