Nol11 (nucleolar protein 11) - Rat Genome Database

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Gene: Nol11 (nucleolar protein 11) Rattus norvegicus
Analyze
Symbol: Nol11
Name: nucleolar protein 11
RGD ID: 1584081
Description: Predicted to be involved in maturation of SSU-rRNA and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to be part of t-UTP complex. Predicted to be active in nucleolus. Orthologous to human NOL11 (nucleolar protein 11); INTERACTS WITH (+)-schisandrin B; bisphenol A; tetrachloromethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC688885; similar to Nucleolar protein 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81092,621,482 - 92,641,394 (-)NCBIGRCr8
mRatBN7.21092,119,000 - 92,141,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1092,121,833 - 92,141,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1097,180,103 - 97,200,063 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01096,643,105 - 96,663,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01092,044,582 - 92,064,556 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01095,388,223 - 95,408,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1095,388,888 - 95,407,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01095,127,723 - 95,146,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41096,556,787 - 96,569,562 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1090,789,487 - 90,809,050 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nol11RatDevelopmental Disabilities  ISONOL11 (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:28942966

1 to 20 of 45 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nol11Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of NOL11 mRNA]CTDPMID:31150632
Nol11Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISONol11 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of NOL11 mRNACTDPMID:21570461
Nol11Rat2-methylcholine affects expressionISONOL11 (Homo sapiens)6480464beta-methylcholine affects the expression of NOL11 mRNACTDPMID:21179406
Nol11Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISONOL11 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NOL11 mRNACTDPMID:28628672
Nol11Rataflatoxin B1 increases methylationISONOL11 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of NOL11 geneCTDPMID:27153756
Nol11Ratall-trans-retinoic acid decreases expressionISONOL11 (Homo sapiens)6480464Tretinoin results in decreased expression of NOL11 mRNACTDPMID:33167477
Nol11Ratatrazine decreases expressionISONOL11 (Homo sapiens)6480464Atrazine results in decreased expression of NOL11 mRNACTDPMID:22378314
Nol11Ratbenzo[a]pyrene increases expressionISONol11 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of NOL11 mRNACTDPMID:22228805
Nol11Ratbenzo[a]pyrene diol epoxide I decreases expressionISONOL11 (Homo sapiens)64804647 more ...CTDPMID:19150397 and PMID:20382639
Nol11Ratbis(2-ethylhexyl) phthalate increases expressionISONol11 (Mus musculus)6480464Diethylhexyl Phthalate results in increased expression of NOL11 mRNACTDPMID:34319233
Nol11Ratbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of NOL11 mRNACTDPMID:25181051
Nol11Ratbisphenol A decreases expressionISONOL11 (Homo sapiens)6480464bisphenol A results in decreased expression of NOL11 mRNA and bisphenol A results in decreased expression of NOL11 proteinCTDPMID:29275510 and PMID:37567409
Nol11Ratbisphenol F multiple interactionsISONOL11 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NOL11 mRNACTDPMID:28628672
Nol11RatCGP 52608 multiple interactionsISONOL11 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to NOL11 gene]CTDPMID:28238834
Nol11Ratchlorpyrifos decreases expressionISONol11 (Mus musculus)6480464Chlorpyrifos results in decreased expression of NOL11 mRNACTDPMID:37019170
Nol11Ratchromium(6+) affects expressionISONol11 (Mus musculus)6480464chromium hexavalent ion affects the expression of NOL11 mRNACTDPMID:28472532
Nol11Ratcopper(II) sulfate decreases expressionISONOL11 (Homo sapiens)6480464Copper Sulfate results in decreased expression of NOL11 mRNACTDPMID:19549813
Nol11RatDDE increases expressionISONOL11 (Homo sapiens)6480464Dichlorodiphenyl Dichloroethylene results in increased expression of NOL11 mRNACTDPMID:38568856
Nol11Ratdexamethasone multiple interactionsISONOL11 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NOL11 mRNACTDPMID:28628672
Nol11Ratdicrotophos decreases expressionISONOL11 (Homo sapiens)6480464dicrotophos results in decreased expression of NOL11 mRNACTDPMID:28302478

1 to 20 of 45 rows

Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nol11Ratnucleolus located_inISONOL11 (Homo sapiens) and UniProtKB:Q9H8H0-11624291 RGDGO_REF:0000052
Nol11Ratnucleolus is_active_inIBAPANTHER:PTN001437223 and UniProtKB:Q9H8H01600115GO_REF:0000033GO_CentralGO_REF:0000033
Nol11Ratnucleolus located_inISONOL11 (Homo sapiens)1624291 PMID:22916032RGDPMID:22916032
Nol11Ratt-UTP complex part_ofISONOL11 (Homo sapiens)1624291 PMID:22916032RGDPMID:22916032

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nol11Ratprotein binding enablesISONOL11 (Homo sapiens)1624291UniProtKB:P22087 more ...RGDPMID:22916032 more ...


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:22658674   PMID:22681889   PMID:22916032  



Nol11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81092,621,482 - 92,641,394 (-)NCBIGRCr8
mRatBN7.21092,119,000 - 92,141,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1092,121,833 - 92,141,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1097,180,103 - 97,200,063 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01096,643,105 - 96,663,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01092,044,582 - 92,064,556 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01095,388,223 - 95,408,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1095,388,888 - 95,407,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01095,127,723 - 95,146,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41096,556,787 - 96,569,562 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1090,789,487 - 90,809,050 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
NOL11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381767,717,936 - 67,744,531 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1767,717,931 - 67,744,531 (+)EnsemblGRCh38hg38GRCh38
GRCh371765,714,052 - 65,740,647 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361763,144,523 - 63,170,728 (+)NCBINCBI36Build 36hg18NCBI36
Celera1762,286,138 - 62,312,332 (+)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1761,098,786 - 61,124,685 (+)NCBIHuRef
CHM1_11765,777,968 - 65,803,880 (+)NCBICHM1_1
T2T-CHM13v2.01768,593,485 - 68,619,780 (+)NCBIT2T-CHM13v2.0
Nol11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911107,057,477 - 107,080,207 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11107,057,489 - 107,080,207 (-)EnsemblGRCm39 Ensembl
GRCm3811107,166,651 - 107,189,381 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11107,166,663 - 107,189,381 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711107,027,974 - 107,050,695 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611106,982,750 - 107,005,350 (-)NCBIMGSCv36mm8
Celera11118,897,960 - 118,921,315 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1170.19NCBI
Nol11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554786,863,635 - 6,892,743 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554786,863,203 - 6,891,549 (+)NCBIChiLan1.0ChiLan1.0
NOL11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21983,741,681 - 83,767,848 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11788,563,056 - 88,589,027 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01761,650,662 - 61,676,657 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11766,849,998 - 66,875,775 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1766,849,998 - 66,875,775 (+)Ensemblpanpan1.1panPan2
NOL11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1912,817,669 - 12,845,632 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl912,818,714 - 12,846,484 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha913,712,536 - 13,740,307 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0914,475,714 - 14,503,246 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl914,476,368 - 14,503,197 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1913,428,748 - 13,456,548 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0914,082,060 - 14,109,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0914,080,318 - 14,108,271 (+)NCBIUU_Cfam_GSD_1.0
Nol11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560213,719,511 - 13,746,259 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365415,448,658 - 5,475,020 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365415,448,346 - 5,475,064 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOL11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1214,035,689 - 14,058,414 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11214,035,649 - 14,058,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21214,570,768 - 14,593,278 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOL11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11653,720,229 - 53,747,715 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1653,720,571 - 53,747,658 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607724,661,026 - 24,688,480 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nol11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624870707,020 - 732,667 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624870706,755 - 732,541 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nol11
101 total Variants

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:74
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000071743, ENSRNOT00000073484
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 79 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat

1 to 10 of 79 rows
AW526267  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21092,122,202 - 92,122,412 (+)MAPPERmRatBN7.2
Rnor_6.01095,388,624 - 95,388,833NCBIRnor6.0
Rnor_5.01095,128,124 - 95,128,333UniSTSRnor5.0
Celera1090,789,888 - 90,790,097UniSTS
RH 3.4 Map10992.7UniSTS
Cytogenetic Map10q32.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000077888   ⟹   ENSRNOP00000071766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,121,833 - 92,141,677 (-)Ensembl
Rnor_6.0 Ensembl1095,388,888 - 95,407,997 (-)Ensembl
RefSeq Acc Id: NM_001402074   ⟹   NP_001389003
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,621,482 - 92,641,394 (-)NCBI
mRatBN7.21092,121,769 - 92,141,684 (-)NCBI
RefSeq Acc Id: NM_001402075   ⟹   NP_001389004
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,621,482 - 92,641,394 (-)NCBI
mRatBN7.21092,121,769 - 92,141,684 (-)NCBI
Protein RefSeqs NP_001389003 (Get FASTA)   NCBI Sequence Viewer  
  NP_001389004 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071766.2
Ensembl Acc Id: ENSRNOP00000071766   ⟸   ENSRNOT00000077888
RefSeq Acc Id: NP_001389004   ⟸   NM_001402075
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001389003   ⟸   NM_001402074
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K1A9 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K1A9-F1-model_v2 AlphaFold A0A0G2K1A9 1-717 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697856
Promoter ID:EPDNEW_R8374
Type:multiple initiation site
Name:Nol11_1
Description:nucleolar protein 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01095,408,010 - 95,408,070EPDNEW


1 to 16 of 16 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-22908 BioCyc
Ensembl Genes ENSRNOG00000052934 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077888.2 UniProtKB/TrEMBL
InterPro NOL11 UniProtKB/TrEMBL
  Nol11_C UniProtKB/TrEMBL
  NUC205 UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene 688885 ENTREZGENE
PANTHER NUCLEOLAR PROTEIN 11 UniProtKB/TrEMBL
  PTHR15633 UniProtKB/TrEMBL
Pfam Nol11_C UniProtKB/TrEMBL
  NUC205 UniProtKB/TrEMBL
PhenoGen Nol11 PhenoGen
RatGTEx ENSRNOG00000052934 RatGTEx
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A0G2K1A9 ENTREZGENE, UniProtKB/TrEMBL
1 to 16 of 16 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Nol11  nucleolar protein 11  LOC688235  similar to Nucleolar protein 11  Data merged from RGD:1591190 1643240 APPROVED
2008-03-06 Nol11  nucleolar protein 11  LOC688885  similar to Nucleolar protein 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC688235  similar to Nucleolar protein 11      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC688885  similar to Nucleolar protein 11      Symbol and Name status set to provisional 70820 PROVISIONAL