Gp1ba (glycoprotein Ib platelet subunit alpha) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Gp1ba (glycoprotein Ib platelet subunit alpha) Rattus norvegicus
Analyze
Symbol: Gp1ba
Name: glycoprotein Ib platelet subunit alpha
RGD ID: 1310239
Description: Involved in positive regulation of leukocyte tethering or rolling. Predicted to be located in cell surface and plasma membrane. Predicted to be part of glycoprotein Ib-IX-V complex. Predicted to be active in external side of plasma membrane; extracellular matrix; and extracellular space. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome; Bernard-Soulier syndrome type A2; myocardial infarction; non-arteritic anterior ischemic optic neuropathy; and platelet-type bleeding disorder 3. Orthologous to human GP1BA (glycoprotein Ib platelet subunit alpha); PARTICIPATES IN platelet aggregation pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glycoprotein 1b, alpha polypeptide; glycoprotein 1b, alpha polypeptide (predicted); glycoprotein Ib (platelet), alpha polypeptide; glycoprotein Ib platelet alpha subunit; Gp1ba_predicted; LOC287460; LOC691992; platelet glycoprotein Ib alpha chain; similar to glycoprotein 1b, alpha polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,831,901 - 55,856,729 (+)NCBIGRCr8
mRatBN7.21055,352,938 - 55,355,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,352,899 - 55,356,774 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,033,557 - 60,036,423 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,522,063 - 59,524,929 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,021,168 - 55,024,034 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,260,680 - 57,263,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,260,680 - 57,263,546 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,004,387 - 57,010,497 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,519,338 - 57,522,204 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1054,498,496 - 54,501,362 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The variable number of tandem repeat polymorphism of platelet glycoprotein Ibalpha and risk of coronary heart disease. Afshar-Kharghan V, etal., Blood. 2004 Feb 1;103(3):963-5. Epub 2003 Oct 30.
2. Novel genetic abnormalities in Bernard-Soulier syndrome in India. Ali S, etal., Ann Hematol. 2014 Mar;93(3):381-4. doi: 10.1007/s00277-013-1895-x. Epub 2013 Sep 1.
3. Bernard-Soulier syndrome: common ancestry in two African American families with the GP Ib alpha Leu129Pro mutation. Antonucci JV, etal., Am J Hematol. 2000 Oct;65(2):141-8.
4. The vascular biology of the glycoprotein Ib-IX-V complex. Berndt MC, etal., Thromb Haemost. 2001 Jul;86(1):178-88.
5. GPIb VNTR C/C genotype may predict embolic events in infective endocarditis. Daga S, etal., J Heart Valve Dis. 2013 Jan;22(1):133-41.
6. Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα. Dénes Á, etal., Ann Neurol. 2014 May;75(5):670-83. doi: 10.1002/ana.24146. Epub 2014 Apr 14.
7. Inhibition of platelet GPIb alpha and promotion of melanoma metastasis. Erpenbeck L, etal., J Invest Dermatol. 2010 Feb;130(2):576-86. doi: 10.1038/jid.2009.278. Epub 2009 Sep 3.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Compound heterozygosity of the GPIbalpha gene associated with Bernard-Soulier syndrome. Gonzalez-Manchon C, etal., Thromb Haemost. 2001 Dec;86(6):1385-91.
11. Risk of macrovascular complications in type 2 diabetes mellitus: endothelial microparticle profiles. Jung KH, etal., Cerebrovasc Dis. 2011;31(5):485-93. doi: 10.1159/000324383. Epub 2011 Mar 16.
12. Genetic Susceptibility to Postdiarrheal Hemolytic-Uremic Syndrome After Shiga Toxin-Producing Escherichia coli Infection: A Centers for Disease Control and Prevention FoodNet Study. Kallianpur AR, etal., J Infect Dis. 2018 Mar 5;217(6):1000-1010. doi: 10.1093/infdis/jix633.
13. Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy. Kanaji S, etal., Mol Ther. 2012 Mar;20(3):625-32. doi: 10.1038/mt.2011.231. Epub 2011 Nov 1.
14. Molecular characterization of two mutations in platelet glycoprotein (GP) Ib alpha in two Finnish Bernard-Soulier syndrome families. Koskela S, etal., Eur J Haematol. 1999 Mar;62(3):160-8.
15. A revised model of platelet aggregation. Kulkarni S, etal., J Clin Invest. 2000 Mar;105(6):783-91.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease. Miller JL, etal., Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4761-5.
18. Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhesion through platelet-dependent mechanisms. Morisaki H, etal., Anesthesiology. 2002 Sep;97(3):701-9. doi: 10.1097/00000542-200209000-00025.
19. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. Nieswandt B, etal., Blood. 2000 Oct 1;96(7):2520-7.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Identification and functional characterization of a novel 27-bp deletion in the macroglycopeptide-coding region of the GPIBA gene resulting in platelet-type von Willebrand disease. Othman M, etal., Blood. 2005 Jun 1;105(11):4330-6. Epub 2005 Feb 10.
22. Platelet glycoprotein Ibalpha polymorphisms modulate the risk for myocardial infarction. Ozelo MC, etal., Thromb Haemost. 2004 Aug;92(2):384-6.
23. von Willebrand factor promotes leukocyte extravasation. Petri B, etal., Blood. 2010 Nov 25;116(22):4712-9. doi: 10.1182/blood-2010-03-276311. Epub 2010 Aug 17.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Rossaint J, etal., Nat Commun. 2016 Nov 15;7:13464. doi: 10.1038/ncomms13464.
29. Role of platelet surface receptor abnormalities in the bleeding and thrombotic diathesis of uremic patients on hemodialysis and peritoneal dialysis. Salvati F and Liani M, Int J Artif Organs. 2001 Mar;24(3):131-5.
30. Autosomal dominant macrothrombocytopenia in Italy is most frequently a type of heterozygous Bernard-Soulier syndrome. Savoia A, etal., Blood. 2001 Mar 1;97(5):1330-5.
31. Clinical and genetic aspects of Bernard-Soulier syndrome: searching for genotype/phenotype correlations. Savoia A, etal., Haematologica. 2011 Mar;96(3):417-23. doi: 10.3324/haematol.2010.032631. Epub 2010 Dec 20.
32. Substitution of Val for Met at residue 239 of platelet glycoprotein Ib alpha in Japanese patients with platelet-type von Willebrand disease. Takahashi H, etal., Blood. 1995 Feb 1;85(3):727-33.
33. Surface markers of platelet function in idiopathic nephrotic syndrome in children. Tkaczyk M and Baj Z, Pediatr Nephrol. 2002 Aug;17(8):673-7. Epub 2002 May 17.
34. Novel point mutation in a leucine-rich repeat of the GPIbalpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome affecting two unrelated families: the N41H variant. Vettore S, etal., Haematologica. 2008 Nov;93(11):1743-7. doi: 10.3324/haematol.12830. Epub 2008 Sep 24.
35. Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome. Ware J, etal., J Clin Invest. 1993 Sep;92(3):1213-20.
36. Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbalpha antibodies. Webster ML, etal., Blood. 2006 Aug 1;108(3):943-6.
37. Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. Xiang B, etal., Nat Commun. 2013;4:2657. doi: 10.1038/ncomms3657.
38. Extravasated platelet aggregation contributes to tumor progression via the accumulation of myeloid-derived suppressor cells in gastric cancer with peritoneal metastasis. Yamaguchi T, etal., Oncol Lett. 2020 Aug;20(2):1879-1887. doi: 10.3892/ol.2020.11722. Epub 2020 Jun 10.
39. Improvement of human platelet aggregation post-splenectomy with paraesophagogastric devascularization in chronic hepatitis B patients with cirrhotic hypersplenism. Zhang H, etal., Platelets. 2020 Nov 16;31(8):1019-1027. doi: 10.1080/09537104.2019.1704715. Epub 2019 Dec 18.
40. A large Swiss family with Bernard-Soulier syndrome - Correlation phenotype and genotype. Zieger B, etal., Hamostaseologie. 2009 May;29(2):161-7.
Additional References at PubMed
PMID:9410473   PMID:10706630   PMID:12855810   PMID:15297306   PMID:19017648   PMID:19443707   PMID:20650879   PMID:21037087   PMID:23382103   PMID:23533145  


Genomics

Comparative Map Data
Gp1ba
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,831,901 - 55,856,729 (+)NCBIGRCr8
mRatBN7.21055,352,938 - 55,355,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,352,899 - 55,356,774 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,033,557 - 60,036,423 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,522,063 - 59,524,929 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,021,168 - 55,024,034 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,260,680 - 57,263,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,260,680 - 57,263,546 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,004,387 - 57,010,497 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,519,338 - 57,522,204 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1054,498,496 - 54,501,362 (+)NCBICelera
Cytogenetic Map10q24NCBI
GP1BA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,932,277 - 4,935,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,932,277 - 4,935,023 (+)EnsemblGRCh38hg38GRCh38
GRCh37174,835,572 - 4,838,318 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,776,372 - 4,779,067 (+)NCBINCBI36Build 36hg18NCBI36
Build 34174,776,371 - 4,779,066NCBI
Celera174,850,477 - 4,853,133 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,723,218 - 4,725,913 (+)NCBIHuRef
CHM1_1174,844,928 - 4,847,662 (+)NCBICHM1_1
T2T-CHM13v2.0174,822,661 - 4,825,369 (+)NCBIT2T-CHM13v2.0
Gp1ba
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,529,928 - 70,534,812 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,529,948 - 70,532,862 (+)EnsemblGRCm39 Ensembl
GRCm381170,639,102 - 70,643,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,639,122 - 70,642,036 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,452,624 - 70,455,560 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,455,317 - 70,458,253 (+)NCBIMGSCv36mm8
Celera1178,190,097 - 78,193,033 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1143.2NCBI
Gp1ba
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,333,575 - 10,346,989 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,333,537 - 10,347,488 (+)NCBIChiLan1.0ChiLan1.0
GP1BA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,542,533 - 12,547,695 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,494,488 - 14,516,053 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,980,083 - 4,983,219 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,968,328 - 4,970,711 (+)NCBIpanpan1.1PanPan1.1panPan2
GP1BA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,681,605 - 31,683,261 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,819,615 - 31,822,278 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,785,030 - 31,787,703 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,785,476 - 31,787,513 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,751,569 - 31,754,227 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,711,274 - 31,713,938 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,887,650 - 31,890,313 (-)NCBIUU_Cfam_GSD_1.0
Gp1ba
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,122,017 - 53,125,833 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366772,774,076 - 2,779,660 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GP1BA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,975,874 - 51,977,757 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,975,810 - 51,979,428 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,042,717 - 54,048,185 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GP1BA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,412,693 - 4,415,841 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605917,217,911 - 17,221,384 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gp1ba
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247868,789,496 - 8,794,897 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gp1ba
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:379
Count of miRNA genes:222
Interacting mature miRNAs:261
Transcripts:ENSRNOT00000035445
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105379738558445852Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)105527369660677262Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 10 3 10
Low 3 23 34 18 16 18 8 11 16 10 18 11 8
Below cutoff 18 9 9 9 25 15 18

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000035445   ⟹   ENSRNOP00000053510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1055,352,899 - 55,356,774 (+)Ensembl
Rnor_6.0 Ensembl1057,260,680 - 57,263,546 (+)Ensembl
RefSeq Acc Id: NM_001109654   ⟹   NP_001103124
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,851,559 - 55,854,425 (+)NCBI
mRatBN7.21055,352,938 - 55,355,804 (+)NCBI
Rnor_6.01057,260,680 - 57,263,546 (+)NCBI
Rnor_5.01057,004,387 - 57,010,497 (+)NCBI
RGSC_v3.41057,519,338 - 57,522,204 (+)RGD
Celera1054,498,496 - 54,501,362 (+)RGD
Sequence:
RefSeq Acc Id: XM_063269910   ⟹   XP_063125980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,831,901 - 55,856,729 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001103124 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125980 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM05027 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053510
  ENSRNOP00000053510.2
Reference Protein Sequences
RefSeq Acc Id: NP_001103124   ⟸   NM_001109654
- Peptide Label: precursor
- UniProtKB: A6HG72 (UniProtKB/TrEMBL),   D3ZQU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000053510   ⟸   ENSRNOT00000035445
RefSeq Acc Id: XP_063125980   ⟸   XM_063269910
- Peptide Label: isoform X1
- UniProtKB: A6HG72 (UniProtKB/TrEMBL),   D3ZQU7 (UniProtKB/TrEMBL)
Protein Domains
LRRCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQU7-F1-model_v2 AlphaFold D3ZQU7 1-717 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697368
Promoter ID:EPDNEW_R7891
Type:single initiation site
Name:Gp1ba_1
Description:glycoprotein Ib platelet alpha subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01057,260,718 - 57,260,778EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310239 AgrOrtholog
BioCyc Gene G2FUF-24442 BioCyc
Ensembl Genes ENSRNOG00000025959 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035445 ENTREZGENE
  ENSRNOT00000035445.5 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
KEGG Report rno:691992 UniProtKB/TrEMBL
NCBI Gene Gp1ba ENTREZGENE
PANTHER ANTIGEN BSP, PUTATIVE-RELATED UniProtKB/TrEMBL
  PLATELET GLYCOPROTEIN IB ALPHA CHAIN UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
PhenoGen Gp1ba PhenoGen
PRINTS LEURICHRPT UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025959 RatGTEx
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt A6HG72 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQU7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Gp1ba  glycoprotein Ib platelet subunit alpha  Gp1ba  glycoprotein Ib platelet alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 Gp1ba  glycoprotein Ib platelet alpha subunit  Gp1ba  glycoprotein Ib (platelet), alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Gp1ba  glycoprotein Ib (platelet), alpha polypeptide  Gp1ba  glycoprotein 1b, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Gp1ba  glycoprotein 1b, alpha polypeptide  LOC687719  similar to glycoprotein 1b, alpha polypeptide  Data merged from RGD:1597565 1643240 APPROVED
2008-04-30 Gp1ba  glycoprotein 1b, alpha polypeptide  Gp1ba_predicted  glycoprotein 1b, alpha polypeptide  'predicted' is removed 2292626 APPROVED
2007-04-18   glycoprotein 1b, alpha polypeptide  Gp1ba_predicted  glycoprotein 1b, alpha polypeptide (predicted)  Name updated 1299863 PROVISIONAL
2007-04-18 Gp1ba_predicted  glycoprotein 1b, alpha polypeptide (predicted)  LOC691992  similar to glycoprotein 1b, alpha polypeptide  Data merged from RGD:1593300 737654 PROVISIONAL
2006-11-20 LOC691992  similar to glycoprotein 1b, alpha polypeptide      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC687719  similar to glycoprotein 1b, alpha polypeptide      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Gp1ba_predicted  glycoprotein 1b, alpha polypeptide (predicted)      Symbol and Name status set to approved 70820 APPROVED