RGD Reference Report - Extravasated platelet aggregation contributes to tumor progression via the accumulation of myeloid-derived suppressor cells in gastric cancer with peritoneal metastasis. - Rat Genome Database

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Extravasated platelet aggregation contributes to tumor progression via the accumulation of myeloid-derived suppressor cells in gastric cancer with peritoneal metastasis.

Authors: Yamaguchi, Takahisa  Fushida, Sachio  Kinoshita, Jun  Okazaki, Mitsuyoshi  Ishikawa, Satoko  Ohbatake, Yoshinao  Terai, Shiro  Okamoto, Koichi  Nakanuma, Shinichi  Makino, Isamu  Nakamura, Keishi  Miyashita, Tomoharu  Tajima, Hidehiro  Takamura, Hiroyuki  Ninomiya, Itasu  Ohta, Tetsuo 
Citation: Yamaguchi T, etal., Oncol Lett. 2020 Aug;20(2):1879-1887. doi: 10.3892/ol.2020.11722. Epub 2020 Jun 10.
RGD ID: 42722625
Pubmed: PMID:32724431   (View Abstract at PubMed)
PMCID: PMC7377031   (View Article at PubMed Central)
DOI: DOI:10.3892/ol.2020.11722   (Journal Full-text)

Extravasated platelet aggregation (EPA) serves an important role in the cancer microenvironment during cancer progression, and has been demonstrated to interact with tumor cells in several types of cancer. EPA induces epithelial-mesenchymal transition (EMT) via transforming growth factor-β, and also recruits immunosuppressive cells, including regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSCs). However, the role of EPA in gastric cancer with peritoneal metastasis remains unknown. The present study analyzed the association between EPA and prognosis in patients with gastric cancer with peritoneal metastasis. The present study evaluated 62 patients diagnosed with advanced gastric cancer with peritoneal metastasis between 2001 and 2016. EPA, EMT, Treg cells and MDSCs in peritoneal metastatic lesions were detected by immunohistochemical evaluation of CD42b, SNAIL, FOXP3 and CD33, respectively. CD42b expression was observed in 56.5% (35/62) of peritoneal metastatic lesions. CD42b expression in peritoneal metastatic lesions was associated with poor overall survival compared with lower frequencies (hazard ratio, 2.03; 95% confidence interval, 1.12-3.69; P=0.018). SNAIL, FOXP3 and CD33 expression were not associated with overall survival, but CD33 expression was markedly higher in CD42b-positive patients (P=0.022). These results indicated that EPA affects immunosuppression by recruiting MDSCs in the tumor microenvironment via the secretion of soluble factors, resulting in tumor progression. EPA may be a novel therapeutic target for gastric cancer with peritoneal metastasis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
peritoneum cancer sexual_dimorphismIEP 42722625associated with stomach cancer and protein:altered expression:peritoneum (human)RGD 
peritoneum cancer sexual_dimorphismISOGP1BA (Homo sapiens)42722625; 42722625associated with stomach cancer and protein:altered expression:peritoneum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gp1ba  (glycoprotein Ib platelet subunit alpha)

Genes (Mus musculus)
Gp1ba  (glycoprotein 1b, alpha polypeptide)

Genes (Homo sapiens)
GP1BA  (glycoprotein Ib platelet subunit alpha)


Additional Information