Gp1ba (glycoprotein 1b, alpha polypeptide) - Rat Genome Database

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Gene: Gp1ba (glycoprotein 1b, alpha polypeptide) Mus musculus
Analyze
Symbol: Gp1ba
Name: glycoprotein 1b, alpha polypeptide
RGD ID: 1321027
MGI Page MGI
Description: Involved in blood coagulation and megakaryocyte development. Acts upstream of or within cell morphogenesis and hemostasis. Located in cell surface. Colocalizes with external side of plasma membrane. Is expressed in dorsal root ganglion; embryo; liver; and spinal cord. Used to study Bernard-Soulier syndrome. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome; Bernard-Soulier syndrome type A2; myocardial infarction; non-arteritic anterior ischemic optic neuropathy; and platelet-type bleeding disorder 3. Orthologous to human GP1BA (glycoprotein Ib platelet subunit alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycoprotein Ibalpha; GP; GP-Ib alpha; GPIb; GPIba; GPIbalpha; platelet glycoprotein Ib alpha chain
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,529,928 - 70,534,812 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,529,948 - 70,532,862 (+)EnsemblGRCm39 Ensembl
GRCm381170,639,102 - 70,643,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,639,122 - 70,642,036 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,452,624 - 70,455,560 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,455,317 - 70,458,253 (+)NCBIMGSCv36mm8
Celera1178,190,097 - 78,193,033 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1143.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The variable number of tandem repeat polymorphism of platelet glycoprotein Ibalpha and risk of coronary heart disease. Afshar-Kharghan V, etal., Blood. 2004 Feb 1;103(3):963-5. Epub 2003 Oct 30.
2. Novel genetic abnormalities in Bernard-Soulier syndrome in India. Ali S, etal., Ann Hematol. 2014 Mar;93(3):381-4. doi: 10.1007/s00277-013-1895-x. Epub 2013 Sep 1.
3. Bernard-Soulier syndrome: common ancestry in two African American families with the GP Ib alpha Leu129Pro mutation. Antonucci JV, etal., Am J Hematol. 2000 Oct;65(2):141-8.
4. The vascular biology of the glycoprotein Ib-IX-V complex. Berndt MC, etal., Thromb Haemost. 2001 Jul;86(1):178-88.
5. GPIb VNTR C/C genotype may predict embolic events in infective endocarditis. Daga S, etal., J Heart Valve Dis. 2013 Jan;22(1):133-41.
6. Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα. Dénes Á, etal., Ann Neurol. 2014 May;75(5):670-83. doi: 10.1002/ana.24146. Epub 2014 Apr 14.
7. Inhibition of platelet GPIb alpha and promotion of melanoma metastasis. Erpenbeck L, etal., J Invest Dermatol. 2010 Feb;130(2):576-86. doi: 10.1038/jid.2009.278. Epub 2009 Sep 3.
8. Compound heterozygosity of the GPIbalpha gene associated with Bernard-Soulier syndrome. Gonzalez-Manchon C, etal., Thromb Haemost. 2001 Dec;86(6):1385-91.
9. Risk of macrovascular complications in type 2 diabetes mellitus: endothelial microparticle profiles. Jung KH, etal., Cerebrovasc Dis. 2011;31(5):485-93. doi: 10.1159/000324383. Epub 2011 Mar 16.
10. Genetic Susceptibility to Postdiarrheal Hemolytic-Uremic Syndrome After Shiga Toxin-Producing Escherichia coli Infection: A Centers for Disease Control and Prevention FoodNet Study. Kallianpur AR, etal., J Infect Dis. 2018 Mar 5;217(6):1000-1010. doi: 10.1093/infdis/jix633.
11. Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy. Kanaji S, etal., Mol Ther. 2012 Mar;20(3):625-32. doi: 10.1038/mt.2011.231. Epub 2011 Nov 1.
12. Molecular characterization of two mutations in platelet glycoprotein (GP) Ib alpha in two Finnish Bernard-Soulier syndrome families. Koskela S, etal., Eur J Haematol. 1999 Mar;62(3):160-8.
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. MGD IEA MGD IEA
15. Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease. Miller JL, etal., Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4761-5.
16. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. Nieswandt B, etal., Blood. 2000 Oct 1;96(7):2520-7.
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Identification and functional characterization of a novel 27-bp deletion in the macroglycopeptide-coding region of the GPIBA gene resulting in platelet-type von Willebrand disease. Othman M, etal., Blood. 2005 Jun 1;105(11):4330-6. Epub 2005 Feb 10.
20. Platelet glycoprotein Ibalpha polymorphisms modulate the risk for myocardial infarction. Ozelo MC, etal., Thromb Haemost. 2004 Aug;92(2):384-6.
21. von Willebrand factor promotes leukocyte extravasation. Petri B, etal., Blood. 2010 Nov 25;116(22):4712-9. doi: 10.1182/blood-2010-03-276311. Epub 2010 Aug 17.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Mouse MP Annotation Import Pipeline RGD automated import pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Rossaint J, etal., Nat Commun. 2016 Nov 15;7:13464. doi: 10.1038/ncomms13464.
27. Role of platelet surface receptor abnormalities in the bleeding and thrombotic diathesis of uremic patients on hemodialysis and peritoneal dialysis. Salvati F and Liani M, Int J Artif Organs. 2001 Mar;24(3):131-5.
28. Autosomal dominant macrothrombocytopenia in Italy is most frequently a type of heterozygous Bernard-Soulier syndrome. Savoia A, etal., Blood. 2001 Mar 1;97(5):1330-5.
29. Clinical and genetic aspects of Bernard-Soulier syndrome: searching for genotype/phenotype correlations. Savoia A, etal., Haematologica. 2011 Mar;96(3):417-23. doi: 10.3324/haematol.2010.032631. Epub 2010 Dec 20.
30. Substitution of Val for Met at residue 239 of platelet glycoprotein Ib alpha in Japanese patients with platelet-type von Willebrand disease. Takahashi H, etal., Blood. 1995 Feb 1;85(3):727-33.
31. Surface markers of platelet function in idiopathic nephrotic syndrome in children. Tkaczyk M and Baj Z, Pediatr Nephrol. 2002 Aug;17(8):673-7. Epub 2002 May 17.
32. Novel point mutation in a leucine-rich repeat of the GPIbalpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome affecting two unrelated families: the N41H variant. Vettore S, etal., Haematologica. 2008 Nov;93(11):1743-7. doi: 10.3324/haematol.12830. Epub 2008 Sep 24.
33. Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome. Ware J, etal., J Clin Invest. 1993 Sep;92(3):1213-20.
34. Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbalpha antibodies. Webster ML, etal., Blood. 2006 Aug 1;108(3):943-6.
35. Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. Xiang B, etal., Nat Commun. 2013;4:2657. doi: 10.1038/ncomms3657.
36. Extravasated platelet aggregation contributes to tumor progression via the accumulation of myeloid-derived suppressor cells in gastric cancer with peritoneal metastasis. Yamaguchi T, etal., Oncol Lett. 2020 Aug;20(2):1879-1887. doi: 10.3892/ol.2020.11722. Epub 2020 Jun 10.
37. Improvement of human platelet aggregation post-splenectomy with paraesophagogastric devascularization in chronic hepatitis B patients with cirrhotic hypersplenism. Zhang H, etal., Platelets. 2020 Nov 16;31(8):1019-1027. doi: 10.1080/09537104.2019.1704715. Epub 2019 Dec 18.
38. A large Swiss family with Bernard-Soulier syndrome - Correlation phenotype and genotype. Zieger B, etal., Hamostaseologie. 2009 May;29(2):161-7.
Additional References at PubMed
PMID:9410473   PMID:9657748   PMID:10706630   PMID:11071623   PMID:11318612   PMID:11858495   PMID:11937271   PMID:12087105   PMID:12200373   PMID:12477932   PMID:15271795   PMID:16179345  
PMID:16757682   PMID:16961609   PMID:17003372   PMID:17075060   PMID:17095718   PMID:17382885   PMID:17494758   PMID:18184798   PMID:18187573   PMID:18487513   PMID:19017648   PMID:19036705  
PMID:19243017   PMID:19332769   PMID:19443707   PMID:19808696   PMID:20650879   PMID:21037087   PMID:21873635   PMID:22019589   PMID:22037602   PMID:22101895   PMID:22174152   PMID:22720736  
PMID:23176290   PMID:23241410   PMID:23336709   PMID:23343833   PMID:23348738   PMID:23742235   PMID:23812299   PMID:23926302   PMID:24051142   PMID:24504734   PMID:24553181   PMID:24642468  
PMID:25104056   PMID:25293780   PMID:25550202   PMID:25774504   PMID:25892224   PMID:26185093   PMID:26204458   PMID:26232171   PMID:26748875   PMID:27148783   PMID:27206768   PMID:27903864  
PMID:28148841   PMID:28375155   PMID:28555620   PMID:28576878   PMID:28643773   PMID:29794068   PMID:29802205   PMID:29930006   PMID:30429161   PMID:30586735   PMID:30700416   PMID:31826978  
PMID:31902309   PMID:31974202   PMID:32161256   PMID:32325033   PMID:32870970   PMID:33176450   PMID:34971661   PMID:35277420  


Genomics

Comparative Map Data
Gp1ba
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,529,928 - 70,534,812 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,529,948 - 70,532,862 (+)EnsemblGRCm39 Ensembl
GRCm381170,639,102 - 70,643,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,639,122 - 70,642,036 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,452,624 - 70,455,560 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,455,317 - 70,458,253 (+)NCBIMGSCv36mm8
Celera1178,190,097 - 78,193,033 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1143.2NCBI
GP1BA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,932,277 - 4,935,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,932,277 - 4,935,023 (+)EnsemblGRCh38hg38GRCh38
GRCh37174,835,572 - 4,838,318 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,776,372 - 4,779,067 (+)NCBINCBI36Build 36hg18NCBI36
Build 34174,776,371 - 4,779,066NCBI
Celera174,850,477 - 4,853,133 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,723,218 - 4,725,913 (+)NCBIHuRef
CHM1_1174,844,928 - 4,847,662 (+)NCBICHM1_1
T2T-CHM13v2.0174,822,661 - 4,825,369 (+)NCBIT2T-CHM13v2.0
Gp1ba
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,831,901 - 55,856,729 (+)NCBIGRCr8
mRatBN7.21055,352,938 - 55,355,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,352,899 - 55,356,774 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,033,557 - 60,036,423 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,522,063 - 59,524,929 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,021,168 - 55,024,034 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,260,680 - 57,263,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,260,680 - 57,263,546 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,004,387 - 57,010,497 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,519,338 - 57,522,204 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1054,498,496 - 54,501,362 (+)NCBICelera
Cytogenetic Map10q24NCBI
Gp1ba
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,333,575 - 10,346,989 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,333,537 - 10,347,488 (+)NCBIChiLan1.0ChiLan1.0
GP1BA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,542,533 - 12,547,695 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,494,488 - 14,516,053 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,980,083 - 4,983,219 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,968,328 - 4,970,711 (+)NCBIpanpan1.1PanPan1.1panPan2
GP1BA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,681,605 - 31,683,261 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,819,615 - 31,822,278 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,785,030 - 31,787,703 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,785,476 - 31,787,513 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,751,569 - 31,754,227 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,711,274 - 31,713,938 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,887,650 - 31,890,313 (-)NCBIUU_Cfam_GSD_1.0
Gp1ba
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,122,017 - 53,125,833 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366772,774,076 - 2,779,660 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GP1BA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,975,874 - 51,977,757 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,975,810 - 51,979,428 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,042,717 - 54,048,185 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GP1BA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,412,693 - 4,415,841 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605917,217,911 - 17,221,384 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gp1ba
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247868,789,496 - 8,794,897 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gp1ba
76 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:272
Count of miRNA genes:173
Interacting mature miRNAs:184
Transcripts:ENSMUST00000055184, ENSMUST00000108551
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse

Markers in Region
U91967  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,641,731 - 70,641,829UniSTSGRCm38
MGSCv371170,455,233 - 70,455,331UniSTSGRCm37
Celera1178,192,706 - 78,192,804UniSTS
Cytogenetic Map11B4UniSTS
cM Map1142.0UniSTS
Whitehead/MRC_RH11907.48UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000055184   ⟹   ENSMUSP00000057563
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,529,948 - 70,532,862 (+)Ensembl
GRCm38.p6 Ensembl1170,639,122 - 70,642,036 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108551   ⟹   ENSMUSP00000104191
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,529,970 - 70,532,646 (+)Ensembl
GRCm38.p6 Ensembl1170,639,144 - 70,641,820 (+)Ensembl
RefSeq Acc Id: NM_010326   ⟹   NP_034456
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,529,948 - 70,534,812 (+)NCBI
GRCm381170,639,122 - 70,643,986 (+)NCBI
MGSCv371170,452,624 - 70,455,560 (+)RGD
Celera1178,190,097 - 78,193,033 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532232   ⟹   XP_006532295
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,529,928 - 70,532,701 (+)NCBI
GRCm381170,639,102 - 70,641,875 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_034456 (Get FASTA)   NCBI Sequence Viewer  
  XP_006532295 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53320 (Get FASTA)   NCBI Sequence Viewer  
  AAI37766 (Get FASTA)   NCBI Sequence Viewer  
  EDL12587 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000057563
  ENSMUSP00000057563.7
  ENSMUSP00000104191
  ENSMUSP00000104191.3
GenBank Protein O35930 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_034456   ⟸   NM_010326
- Peptide Label: precursor
- UniProtKB: Q5SX47 (UniProtKB/Swiss-Prot),   O35930 (UniProtKB/Swiss-Prot),   A2CFB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532295   ⟸   XM_006532232
- Peptide Label: isoform X1
- UniProtKB: Q5SX47 (UniProtKB/Swiss-Prot),   O35930 (UniProtKB/Swiss-Prot),   A2CFB8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000104191   ⟸   ENSMUST00000108551
RefSeq Acc Id: ENSMUSP00000057563   ⟸   ENSMUST00000055184
Protein Domains
LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35930-F1-model_v2 AlphaFold O35930 1-734 view protein structure

Promoters
RGD ID:6821006
Promoter ID:MM_KWN:8238
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Spleen
Transcripts:ENSMUST00000108551,   NM_010326
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361170,452,184 - 70,452,684 (+)MPROMDB
RGD ID:8675346
Promoter ID:EPDNEW_M15703
Type:initiation region
Name:Gp1ba_1
Description:Mus musculus glycoprotein 1b, alpha polypeptide , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381170,639,133 - 70,639,193EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333744 AgrOrtholog
Ensembl Genes ENSMUSG00000050675 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000055184 ENTREZGENE
  ENSMUST00000055184.7 UniProtKB/Swiss-Prot
  ENSMUST00000108551 ENTREZGENE
  ENSMUST00000108551.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1333744 ENTREZGENE
NCBI Gene 14723 ENTREZGENE
PANTHER IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gp1ba PhenoGen
PRINTS LEURICHRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2CFB8 ENTREZGENE, UniProtKB/TrEMBL
  GP1BA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5SX47 ENTREZGENE
UniProt Secondary Q5SX47 UniProtKB/Swiss-Prot