Atp8b1 (ATPase phospholipid transporting 8B1) - Rat Genome Database

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Gene: Atp8b1 (ATPase phospholipid transporting 8B1) Rattus norvegicus
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Symbol: Atp8b1
Name: ATPase phospholipid transporting 8B1
RGD ID: 1308488
Description: Enables phosphatidylserine flippase activity. Predicted to be involved in several processes, including apical protein localization; nervous system development; and phospholipid transport. Predicted to act upstream of or within bile acid metabolic process. Located in brush border membrane. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATPase, aminophospholipid transporter, class I, type 8B, member 1; ATPase, Class I, type 8B, member 1; LOC291555; P4-ATPase flippase complex alpha subunit ATP8B1; phospholipid-transporting ATPase IC; probable phospholipid-transporting ATPase IC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81860,286,605 - 60,427,862 (-)NCBIGRCr8
mRatBN7.21858,016,382 - 58,157,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,018,268 - 58,157,396 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1860,100,745 - 60,181,408 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01860,812,277 - 60,893,191 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01858,641,968 - 58,722,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01860,013,388 - 60,152,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,013,382 - 60,095,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01859,223,547 - 59,362,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41860,748,738 - 60,829,650 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11860,822,079 - 60,960,656 (-)NCBI
Celera1856,155,326 - 56,236,232 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Atp8b1Ratbenign recurrent intrahepatic cholestasis 1  ISOATP8B1 (Homo sapiens)14401576DNA:missense mutation:cds:p.I661T (human)RGD 
Atp8b1Ratintrahepatic cholestasis susceptibilityISOATP8B1 (Homo sapiens)1599397 RGD 
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Original Reference(s)
Atp8b1Ratbenign recurrent intrahepatic cholestasis 1  ISOATP8B1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11815775 more ...
Atp8b1Ratgenetic disease  ISOATP8B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:14988830 more ...
Atp8b1Ratimmunodeficiency 12  ISOATP8B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Combined immunodeficiency due to MALT1 deficiencyClinVarPMID:28492532
Atp8b1Ratintrahepatic cholestasis  ISOATP8B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Progressive intrahepatic cholestasisClinVarPMID:11815775 more ...
Atp8b1Ratintrahepatic cholestasis of pregnancy 1  ISOATP8B1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11815775 more ...
Atp8b1Ratisolated microphthalmia 3  ISOATP8B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Isolated microphthalmia 3ClinVarPMID:14662654 more ...
Atp8b1Ratprogressive familial intrahepatic cholestasis  ISOATP8B1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11093741 more ...
Atp8b1Ratprogressive familial intrahepatic cholestasis 1  ISOATP8B1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11093741 more ...
Atp8b1Ratprogressive familial intrahepatic cholestasis 2  ISOATP8B1 (Homo sapiens)8554872ClinVar Annotator: match by term: Progressive familial intrahepatic cholestasis type 2ClinVarPMID:15239083 more ...
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Original Reference(s)
Atp8b1Ratintrahepatic cholestasis  ISOATP8B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18379143
Atp8b1Ratintrahepatic cholestasis of pregnancy  ISOATP8B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Atp8b1Ratprogressive familial intrahepatic cholestasis 1  ISOATP8B1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 

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Original Reference(s)
Atp8b1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOATP8B1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATP8B1 mRNACTDPMID:22079256
Atp8b1Rat1,2-dimethylhydrazine affects expressionISOAtp8b1 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of ATP8B1 mRNACTDPMID:22206623
Atp8b1Rat1-naphthyl isothiocyanate increases expressionISOAtp8b1 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of ATP8B1 mRNACTDPMID:19407337 and PMID:28549656
Atp8b1Rat1-naphthyl isothiocyanate multiple interactionsISOAtp8b1 (Mus musculus)648046418alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ATP8B1 mRNA]CTDPMID:28549656
Atp8b1Rat1-nitropyrene increases expressionISOATP8B1 (Homo sapiens)64804641-nitropyrene results in increased expression of ATP8B1 mRNACTDPMID:19041380
Atp8b1Rat17beta-estradiol affects expressionISOATP8B1 (Homo sapiens)6480464Estradiol affects the expression of ATP8B1 mRNACTDPMID:22574217
Atp8b1Rat17beta-estradiol increases expressionISOATP8B1 (Homo sapiens)6480464Estradiol results in increased expression of ATP8B1 mRNACTDPMID:31614463
Atp8b1Rat17beta-estradiol increases expressionISOAtp8b1 (Mus musculus)6480464Estradiol results in increased expression of ATP8B1 mRNACTDPMID:39298647
Atp8b1Rat17beta-estradiol multiple interactionsISOATP8B1 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in decreased expression of ATP8B1 mRNA and [Estradiol co-treated with TGFB1 protein] results in decreased expression of ATP8B1 mRNACTDPMID:20660070 and PMID:30165855
Atp8b1Rat17beta-estradiol decreases expressionISOATP8B1 (Homo sapiens)6480464Estradiol results in decreased expression of ATP8B1 mRNACTDPMID:19167446
Atp8b1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of ATP8B1 mRNACTDPMID:22298810 and PMID:34747641
Atp8b1Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Atp8b1Rat3,4-methylenedioxymethamphetamine decreases expressionISOAtp8b1 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ATP8B1 mRNACTDPMID:26251327
Atp8b1Rat4,4'-diaminodiphenylmethane affects expressionISOAtp8b1 (Mus musculus)64804644 and 4'-diaminodiphenylmethane affects the expression of ATP8B1 mRNACTDPMID:18648102
Atp8b1Rat4,4'-sulfonyldiphenol increases expressionISOAtp8b1 (Mus musculus)6480464bisphenol S results in increased expression of ATP8B1 mRNACTDPMID:39298647
Atp8b1Rat4-hydroxyphenyl retinamide increases expressionISOAtp8b1 (Mus musculus)6480464Fenretinide results in increased expression of ATP8B1 mRNACTDPMID:28973697
Atp8b1Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of ATP8B1 mRNACTDPMID:31881176
Atp8b1Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of ATP8B1 mRNACTDPMID:28959563
Atp8b1Rataflatoxin B1 affects expressionISOATP8B1 (Homo sapiens)6480464Aflatoxin B1 affects the expression of ATP8B1 proteinCTDPMID:20106945
Atp8b1Ratall-trans-retinoic acid increases expressionISOATP8B1 (Homo sapiens)6480464Tretinoin results in increased expression of ATP8B1 mRNACTDPMID:21934132

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Biological Process
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Original Reference(s)
Atp8b1Rataminophospholipid translocation involved_inIEAGO:01403461600115GO_REF:0000108GOCGO_REF:0000108
Atp8b1Rataminophospholipid translocation involved_inIEAGO:00152471600115GO_REF:0000108GOCGO_REF:0000108
Atp8b1Rataminophospholipid transport involved_inISOAtp8b1 (Mus musculus)1624291 PMID:20510206RGDPMID:20510206
Atp8b1Rataminophospholipid transport involved_inIEAUniProtKB:Q148W0 and ensembl:ENSMUSP000000254821600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratapical protein localization involved_inIEAUniProtKB:O43520 and ensembl:ENSP000004978961600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratapical protein localization involved_inISOATP8B1 (Homo sapiens)1624291 PMID:27301931RGDPMID:27301931
Atp8b1Ratbile acid and bile salt transport involved_inIEAUniProtKB:Q148W0 and ensembl:ENSMUSP000000254821600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratbile acid and bile salt transport involved_inISOAtp8b1 (Mus musculus)1624291 PMID:19228692RGDPMID:19228692
Atp8b1Ratbile acid metabolic process acts_upstream_of_or_withinIEAUniProtKB:Q148W0 and ensembl:ENSMUSP000000254821600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratbile acid metabolic process acts_upstream_of_or_withinISOAtp8b1 (Mus musculus)1624291MGI:3043815 PMID:14976163RGDPMID:14976163
Atp8b1Ratbiological_process  ND 159840702/2007: no relevant rat dataRGD 
Atp8b1RatGolgi organization involved_inIBAMGI:2444287 and PANTHER:PTN0011843641600115GO_REF:0000033GO_CentralGO_REF:0000033
Atp8b1Ratinner ear receptor cell development involved_inIEAUniProtKB:Q148W0 and ensembl:ENSMUSP000000254821600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratinner ear receptor cell development involved_inISOAtp8b1 (Mus musculus)1624291 PMID:19478059RGDPMID:19478059
Atp8b1Ratnegative regulation of DNA-templated transcription involved_inIEAUniProtKB:O43520 and ensembl:ENSP000004978961600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratnegative regulation of DNA-templated transcription involved_inISOATP8B1 (Homo sapiens)1624291 PMID:16628629RGDPMID:16628629
Atp8b1Ratorganic anion transport involved_inIEAUniProtKB:Q148W0 and ensembl:ENSMUSP000000254821600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratorganic anion transport involved_inISOAtp8b1 (Mus musculus)1624291 PMID:19228692RGDPMID:19228692
Atp8b1Ratphospholipid translocation involved_inISOATP8B1 (Homo sapiens)1624291 PMID:20510206RGDPMID:20510206
Atp8b1Ratphospholipid translocation involved_inIEAUniProtKB:O43520 and ensembl:ENSP000004978961600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
1 to 20 of 36 rows

  
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Original Reference(s)
Atp8b1Ratapical plasma membrane located_inIEAUniProtKB:O43520 and ensembl:ENSP000004978961600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratapical plasma membrane located_inIEAUniProtKB-SubCell:SL-00151600115GO_REF:0000044UniProtGO_REF:0000044
Atp8b1Ratapical plasma membrane located_inISOATP8B1 (Homo sapiens)1624291 PMID:11682026 and PMID:20512993RGDPMID:11682026 and PMID:20512993
Atp8b1Ratbrush border membrane  IDA 1599400 RGD 
Atp8b1Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Atp8b1Ratcytosol located_inIEAUniProtKB:O43520 and ensembl:ENSP000004978961600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratcytosol located_inISOATP8B1 (Homo sapiens)1624291 RGDGO_REF:0000052
Atp8b1Ratendoplasmic reticulum located_inIEAUniProtKB:O43520 and ensembl:ENSP000004978961600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratendoplasmic reticulum located_inIEAUniProtKB-SubCell:SL-00951600115GO_REF:0000044UniProtGO_REF:0000044
Atp8b1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Atp8b1Ratendoplasmic reticulum located_inISOATP8B1 (Homo sapiens)1624291 PMID:21914794RGDPMID:21914794
Atp8b1RatGolgi apparatus located_inIEAUniProtKB:O43520 and ensembl:ENSP000004978961600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
Atp8b1RatGolgi apparatus located_inIEAUniProtKB-SubCell:SL-01321600115GO_REF:0000044UniProtGO_REF:0000044
Atp8b1RatGolgi apparatus located_inISOATP8B1 (Homo sapiens)1624291 PMID:20947505RGDPMID:20947505
Atp8b1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Atp8b1Ratmembrane located_inIEAInterPro:IPR001757 and InterPro:IPR0065391600115GO_REF:0000002InterProGO_REF:0000002
Atp8b1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Atp8b1Ratnuclear body located_inIEAUniProtKB:O43520 and ensembl:ENSP000004978961600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratnuclear body located_inISOATP8B1 (Homo sapiens)1624291 RGDGO_REF:0000052
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Molecular Function
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Original Reference(s)
Atp8b1Rataminophospholipid flippase activity enablesIEAUniProtKB:Q148W0 and ensembl:ENSMUSP000000254821600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Rataminophospholipid flippase activity enablesISOAtp8b1 (Mus musculus)1624291 PMID:20510206RGDPMID:20510206
Atp8b1RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Atp8b1RatATP binding enablesIEAUniRule:UR0001437631600115GO_REF:0000104UniProtGO_REF:0000104
Atp8b1RatATP binding enablesIEAInterPro:IPR001757 and InterPro:IPR0065391600115GO_REF:0000002InterProGO_REF:0000002
Atp8b1RatATP hydrolysis activity enablesIEAInterPro:IPR0017571600115GO_REF:0000002InterProGO_REF:0000002
Atp8b1RatATPase-coupled intramembrane lipid transporter activity enablesIBACGD:CAL0000173967 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Atp8b1RatATPase-coupled intramembrane lipid transporter activity enablesIEAEC:7.6.2.11600115GO_REF:0000003UniProtGO_REF:0000003
Atp8b1RatATPase-coupled intramembrane lipid transporter activity enablesIEAInterPro:IPR0065391600115GO_REF:0000002InterProGO_REF:0000002
Atp8b1Ratcardiolipin binding enablesIEAUniProtKB:Q148W0 and ensembl:ENSMUSP000000254821600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratcardiolipin binding enablesISOAtp8b1 (Mus musculus)1624291 PMID:20852622RGDPMID:20852622
Atp8b1Ratlipid transporter activity enablesISOAtp8b1 (Mus musculus)1624291 PMID:20852622RGDPMID:20852622
Atp8b1Ratlipid transporter activity enablesIEAUniProtKB:Q148W0 and ensembl:ENSMUSP000000254821600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratmagnesium ion binding enablesIEAInterPro:IPR0065391600115GO_REF:0000002InterProGO_REF:0000002
Atp8b1Ratmagnesium ion binding enablesIEAUniRule:UR0001437631600115GO_REF:0000104UniProtGO_REF:0000104
Atp8b1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Atp8b1Ratnucleotide binding enablesIEAInterPro:IPR0232991600115GO_REF:0000002InterProGO_REF:0000002
Atp8b1Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Atp8b1Ratphosphatidylcholine flippase activity enablesIEAUniProtKB:O43520 and ensembl:ENSP000004978961600115GO_REF:0000107EnsemblGO_REF:0000107
Atp8b1Ratphosphatidylcholine flippase activity enablesISOATP8B1 (Homo sapiens)1624291 PMID:25315773 and PMID:25947375RGDPMID:25315773 and PMID:25947375
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#
Reference Title
Reference Citation
1. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Bull LN, etal., Nat Genet. 1998 Mar;18(3):219-24.
2. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Cai SY, etal., Gastroenterology. 2009 Mar;136(3):1060-9. doi: 10.1053/j.gastro.2008.10.025. Epub 2008 Nov 1.
3. FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte. Eppens EF, etal., J Hepatol. 2001 Oct;35(4):436-43.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Recurrent familial intrahepatic cholestasis in the Faeroe Islands. Phenotypic heterogeneity but genetic homogeneity. Tygstrup N, etal., Hepatology. 1999 Feb;29(2):506-8. doi: 10.1002/hep.510290214.
12. Familial intrahepatic cholestasis 1: studies of localization and function. Ujhazy P, etal., Hepatology. 2001 Oct;34(4 Pt 1):768-75.
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PMID:14976163   PMID:16628629   PMID:19478059   PMID:19731236   PMID:20510206   PMID:20512993   PMID:20852622   PMID:20947505   PMID:21914794   PMID:24643366   PMID:26240149  



Atp8b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81860,286,605 - 60,427,862 (-)NCBIGRCr8
mRatBN7.21858,016,382 - 58,157,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1858,018,268 - 58,157,396 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1860,100,745 - 60,181,408 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01860,812,277 - 60,893,191 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01858,641,968 - 58,722,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01860,013,388 - 60,152,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1860,013,382 - 60,095,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01859,223,547 - 59,362,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41860,748,738 - 60,829,650 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11860,822,079 - 60,960,656 (-)NCBI
Celera1856,155,326 - 56,236,232 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
ATP8B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381857,646,426 - 57,803,315 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1857,646,426 - 57,803,315 (-)EnsemblGRCh38hg38GRCh38
GRCh371855,313,658 - 55,470,547 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361853,464,656 - 53,550,037 (-)NCBINCBI36Build 36hg18NCBI36
Build 341853,466,585 - 53,550,037NCBI
Celera1852,031,466 - 52,187,934 (-)NCBICelera
Cytogenetic Map18q21.31ENTREZGENE
HuRef1852,024,999 - 52,180,652 (-)NCBIHuRef
CHM1_11855,309,031 - 55,466,164 (-)NCBICHM1_1
T2T-CHM13v2.01857,847,030 - 58,003,571 (-)NCBIT2T-CHM13v2.0
Atp8b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391864,662,050 - 64,794,342 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1864,662,038 - 64,794,338 (-)EnsemblGRCm39 Ensembl
GRCm381864,528,979 - 64,661,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1864,528,967 - 64,661,267 (-)EnsemblGRCm38mm10GRCm38
MGSCv371864,688,633 - 64,820,654 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361864,654,348 - 64,786,369 (-)NCBIMGSCv36mm8
Celera1865,795,381 - 65,929,579 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1837.49NCBI
Atp8b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540241,996,001 - 42,113,895 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540241,994,993 - 42,113,380 (-)NCBIChiLan1.0ChiLan1.0
ATP8B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21775,183,233 - 75,337,189 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11860,875,498 - 61,029,604 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01851,035,483 - 51,187,461 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11854,370,844 - 54,522,158 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1854,370,447 - 54,522,196 (-)Ensemblpanpan1.1panPan2
ATP8B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1118,156,664 - 18,279,131 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl118,156,410 - 18,277,904 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha119,140,072 - 19,262,621 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0118,037,713 - 18,160,586 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl118,037,170 - 18,160,558 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1118,094,570 - 18,217,205 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0117,992,383 - 18,114,996 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0118,261,266 - 18,383,909 (+)NCBIUU_Cfam_GSD_1.0
Atp8b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494431,413,185 - 31,471,774 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364976,652,185 - 6,713,034 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364976,652,240 - 6,712,960 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP8B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1162,936,581 - 163,061,612 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11162,936,209 - 163,063,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ATP8B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11821,930,150 - 22,086,371 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1821,930,837 - 22,088,480 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660603,481,874 - 3,637,247 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp8b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247923,156,367 - 3,287,751 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247923,154,512 - 3,287,681 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Atp8b1
708 total Variants

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:51
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000038652
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 62 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185229287559796643Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184671876359796643Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat

1 to 10 of 62 rows
D18Chm97  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,085,512 - 58,085,730 (+)MAPPERmRatBN7.2
Rnor_6.01860,081,657 - 60,081,874NCBIRnor6.0
Rnor_5.01859,291,816 - 59,292,033UniSTSRnor5.0
RGSC_v3.41860,815,969 - 60,816,186UniSTSRGSC3.4
Celera1856,222,551 - 56,222,768UniSTS
Cytogenetic Map18q12.1UniSTS
RH140076  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,018,069 - 58,018,280 (+)MAPPERmRatBN7.2
Rnor_6.01860,015,049 - 60,015,259NCBIRnor6.0
Rnor_5.01859,225,208 - 59,225,418UniSTSRnor5.0
RGSC_v3.41860,748,540 - 60,748,750UniSTSRGSC3.4
Celera1856,155,128 - 56,155,338UniSTS
RH 3.4 Map18569.2UniSTS
Cytogenetic Map18q12.1UniSTS
AU049633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21858,046,279 - 58,046,462 (+)MAPPERmRatBN7.2
Rnor_6.01860,042,430 - 60,042,612NCBIRnor6.0
Rnor_5.01859,252,589 - 59,252,771UniSTSRnor5.0
RGSC_v3.41860,776,742 - 60,776,924UniSTSRGSC3.4
Celera1856,183,329 - 56,183,513UniSTS
Cytogenetic Map18q12.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000038652   ⟹   ENSRNOP00000038207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1858,018,268 - 58,157,396 (-)Ensembl
Rnor_6.0 Ensembl1860,013,382 - 60,095,354 (-)Ensembl
RefSeq Acc Id: NM_001106140   ⟹   NP_001099610
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,288,464 - 60,369,384 (-)NCBI
mRatBN7.21858,018,268 - 58,099,197 (-)NCBI
Rnor_6.01860,015,247 - 60,095,334 (-)NCBI
Rnor_5.01859,223,547 - 59,362,294 (-)NCBI
RGSC_v3.41860,748,738 - 60,829,650 (-)RGD
Celera1856,155,326 - 56,236,232 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254842   ⟹   XP_006254904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81860,286,605 - 60,427,862 (-)NCBI
mRatBN7.21858,016,382 - 58,157,213 (-)NCBI
Rnor_6.01860,013,388 - 60,152,920 (-)NCBI
Rnor_5.01859,223,547 - 59,362,294 (-)NCBI
Sequence:
Protein RefSeqs NP_001099610 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254904 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4AA47 (Get FASTA)   NCBI Sequence Viewer  
  EDM14675 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038207
RefSeq Acc Id: NP_001099610   ⟸   NM_001106140
- UniProtKB: A0A8L2QJ69 (UniProtKB/TrEMBL),   A6IXP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254904   ⟸   XM_006254842
- Peptide Label: isoform X1
- UniProtKB: D4AA47 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038207   ⟸   ENSRNOT00000038652
Name Modeler Protein Id AA Range Protein Structure
AF-D4AA47-F1-model_v2 AlphaFold D4AA47 1-1251 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-7253 BioCyc
Ensembl Genes ENSRNOG00000024952 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000038652 ENTREZGENE
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot
InterPro ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  P-type_ATPase_IV UniProtKB/Swiss-Prot
  P-type_ATPase_N UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
  P_typ_ATPase_c UniProtKB/Swiss-Prot
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot
NCBI Gene 291555 ENTREZGENE
PANTHER PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE UniProtKB/Swiss-Prot
  PTHR24092:SF48 UniProtKB/Swiss-Prot
Pfam Cation_ATPase UniProtKB/Swiss-Prot
  E1-E2_ATPase UniProtKB/Swiss-Prot
  PhoLip_ATPase_C UniProtKB/Swiss-Prot
  PhoLip_ATPase_N UniProtKB/Swiss-Prot
PhenoGen Atp8b1 PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000024952 RatGTEx
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81660 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
UniProt A0A8L2QJ69 ENTREZGENE, UniProtKB/TrEMBL
  A6IXP4 ENTREZGENE, UniProtKB/TrEMBL
  AT8B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp8b1  ATPase phospholipid transporting 8B1  Atp8b1  ATPase, aminophospholipid transporter, class I, type 8B, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-30 Atp8b1  ATPase, aminophospholipid transporter, class I, type 8B, member 1  Atp8b1  ATPase, Class I, type 8B, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Atp8b1  ATPase, Class I, type 8B, member 1   Atp8b1_predicted  ATPase, Class I, type 8B, member 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Atp8b1_predicted  ATPase, Class I, type 8B, member 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED