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Gene: C8a (complement C8 alpha chain) Rattus norvegicus

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Symbol:

C8a

Name:

complement C8 alpha chain

RGD ID:

1308355

Description:

Enables complement binding activity. Predicted to be involved in complement activation. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in type I complement component 8 deficiency. Orthologous to human C8A (complement C8 alpha chain); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Entamoebiasis pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

complement component 8 alpha subunit; complement component 8, alpha polypeptide; complement component C8 alpha chain; LOC298288

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	C8A (complement C8 alpha chain)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	C8a (complement component 8, alpha polypeptide)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	C8a (complement C8 alpha chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	C8A (complement C8 alpha chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	C8A (complement C8 alpha chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	C8a (complement C8 alpha chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	C8A (complement C8 alpha chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	C8A (complement C8 alpha chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	C8a (complement C8 alpha chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	C8B (complement C8 beta chain)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	C8A (complement C8 alpha chain)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	C8a (complement component 8, alpha polypeptide)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	c8a (complement component 8, alpha polypeptide)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	c8a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	124,812,131 - 124,866,631 (-)	NCBI		GRCr8
mRatBN7.2	5	119,583,168 - 119,637,675 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	119,583,174 - 119,637,754 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	122,209,001 - 122,265,865 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	123,934,362 - 123,988,908 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	123,985,608 - 124,040,156 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	124,348,536 - 124,403,117 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	124,348,461 - 124,403,195 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	128,207,204 - 128,261,785 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	125,776,549 - 125,831,049 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	125,783,597 - 125,836,315 (-)	NCBI
Celera	5	118,140,155 - 118,194,619 (-)	NCBI		Celera
Cytogenetic Map	5	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

meningitis (ISO)

myocardial infarction (IEP)

Neisseriaceae Infections (ISO)

primary immunodeficiency disease (ISO)

type I complement component 8 deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-diaminodiphenylmethane (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP,ISO)

dichloroacetic acid (ISO)

dicrotophos (ISO)

diquat (ISO)

disodium selenite (ISO)

endosulfan (EXP)

flutamide (EXP)

genistein (ISO)

methidathion (ISO)

methotrexate (ISO)

methoxychlor (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N,N-diethyl-m-toluamide (EXP)

N-Nitrosopyrrolidine (ISO)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

nitrofen (EXP)

O-methyleugenol (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

permethrin (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

quercetin (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

tolcapone (EXP)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

complement activation (IBA,ISO)

complement activation, alternative pathway (IEA)

complement activation, classical pathway (IEA)

innate immune response (IEA)

killing of cells of another organism (IEA)

Cellular Component

extracellular region (IDA)

extracellular space (IBA,IDA)

membrane attack complex (IBA,ISO)

plasma membrane (ISO)

Molecular Function

complement binding (IPI)

protein binding (ISO)

protein-containing complex binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

coagulation cascade pathway (IEA)

complement system pathway (IEA)

Entamoebiasis pathway (IEA)

prion disease pathway (IEA)

systemic lupus erythematosus pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Binding of human and rat CD59 to the terminal complement complexes.	Lehto T, etal., Immunology. 1997 Jan;90(1):121-8.
4.	Biosynthesis of C8 by hepatocytes. Differential expression and intracellular association of the alpha-gamma- and beta-subunits.	Ng SC and Sodetz JM, J Immunol. 1987 Nov 1;139(9):3021-7.
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	CD59 homologue regulates complement-dependent cytolysis of rat Schwann cells.	Sawant-Mane S, etal., J Neuroimmunol. 1996 Sep;69(1-2):63-71.
10.	Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium.	Vakeva A, etal., Am J Pathol. 1994 Jun;144(6):1357-68.
11.	Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration.	Xiong ZQ, etal., J Neurosci. 2003 Feb 1;23(3):955-60.

Additional References at PubMed

PMID:12413696	PMID:18178252	PMID:22516433	PMID:22832194	PMID:23533145

Genomics

Comparative Map Data

C8a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	124,812,131 - 124,866,631 (-)	NCBI		GRCr8
mRatBN7.2	5	119,583,168 - 119,637,675 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	119,583,174 - 119,637,754 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	122,209,001 - 122,265,865 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	123,934,362 - 123,988,908 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	123,985,608 - 124,040,156 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	124,348,536 - 124,403,117 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	124,348,461 - 124,403,195 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	128,207,204 - 128,261,785 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	125,776,549 - 125,831,049 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	125,783,597 - 125,836,315 (-)	NCBI
Celera	5	118,140,155 - 118,194,619 (-)	NCBI		Celera
Cytogenetic Map	5	q34	NCBI

C8A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	56,854,797 - 56,918,223 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	56,854,768 - 56,918,223 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	57,320,470 - 57,383,896 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	57,093,065 - 57,156,482 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	57,032,499 - 57,095,915	NCBI
Celera	1	55,604,960 - 55,668,425 (+)	NCBI		Celera
Cytogenetic Map	1	p32.2	NCBI
HuRef	1	55,432,491 - 55,495,955 (+)	NCBI		HuRef
CHM1_1	1	57,435,807 - 57,499,133 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	56,733,342 - 56,796,778 (+)	NCBI		T2T-CHM13v2.0

C8a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	104,672,876 - 104,733,684 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	104,672,876 - 104,733,595 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	104,815,679 - 104,876,487 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	104,815,679 - 104,876,398 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	104,488,284 - 104,549,003 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	104,313,615 - 104,374,314 (-)	NCBI		MGSCv36	mm8
Celera	4	103,167,290 - 103,227,258 (-)	NCBI		Celera
Cytogenetic Map	4	C6	NCBI
cM Map	4	48.69	NCBI

C8a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955464	2,806,859 - 2,874,444 (-)	NCBI	ChiLan1.0	ChiLan1.0

C8A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	169,907,938 - 169,972,744 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	169,060,240 - 169,125,031 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	56,137,596 - 56,201,975 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	57,847,726 - 57,912,392 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	57,847,726 - 57,912,392 (+)	Ensembl	panpan1.1		panPan2

C8A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	52,584,707 - 52,649,612 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	52,584,934 - 52,653,794 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	52,652,606 - 52,717,495 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	52,771,937 - 52,837,096 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	52,772,165 - 52,837,073 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	52,716,162 - 52,781,185 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	52,662,064 - 52,726,979 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	52,946,897 - 53,012,011 (-)	NCBI		UU_Cfam_GSD_1.0

C8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	70,671,119 - 70,730,228 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936522	4,686,081 - 4,745,175 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936522	4,686,306 - 4,745,175 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

C8A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	155,464,852 - 155,530,472 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	155,464,855 - 155,530,473 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	143,217,805 - 143,266,588 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

C8A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	76,045,027 - 76,111,402 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	76,043,594 - 76,110,710 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	41,189,026 - 41,252,020 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

C8a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624862	3,232,463 - 3,288,640 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624862	3,234,826 - 3,288,574 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in C8a
259 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	901
Count of miRNA genes:	307
Interacting mature miRNAs:	409
Transcripts:	ENSRNOT00000067850
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1298070	Scl18	Serum cholesterol level QTL 18	3.7		blood LDL cholesterol amount (VT:0000181)	calculated plasma low density lipoprotein cholesterol level (CMO:0001245)	5	79584860	124584860	Rat
7794739	Bp372	Blood pressure QTL 372		0.0058	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	117913688	125222967	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	94858972	143070159	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1582230	Bw78	Body weight QTL 78	3.2	0.0016	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	5	119085612	128034027	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
1598859	Cm66	Cardiac mass QTL 66	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	79584860	124584860	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	97570330	136479578	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	87468046	132468046	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	105999803	150999803	Rat
1598846	Bp293	Blood pressure QTL 293	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	79584860	124584860	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	103689353	148689353	Rat
1358909	Kidm25	Kidney mass QTL 25	1.87		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	90067849	128034027	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
631527	Tls1	T-lymphoma susceptibility QTL 1	0	0.001	thymus integrity trait (VT:0010555)	post-insult time to onset of T-cell lymphoma (CMO:0001907)	5	90450144	135450144	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	84132602	129132602	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	66174080	124160948	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	58829236	128034027	Rat
1358889	Bp261	Blood pressure QTL 261	2.86		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	90067849	128034027	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	87765973	132765973	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat

Markers in Region

D5Rhm4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	119,592,239 - 119,592,384 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	124,357,602 - 124,357,746	NCBI	Rnor6.0
Rnor_5.0	5	128,216,270 - 128,216,414	UniSTS	Rnor5.0
RGSC_v3.4	5	125,785,615 - 125,785,759	UniSTS	RGSC3.4
Celera	5	118,149,222 - 118,149,370	UniSTS
Cytogenetic Map	5	q34	UniSTS

RH130236

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	119,583,218 - 119,583,398 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	124,348,581 - 124,348,760	NCBI	Rnor6.0
Rnor_5.0	5	128,207,249 - 128,207,428	UniSTS	Rnor5.0
RGSC_v3.4	5	125,776,594 - 125,776,773	UniSTS	RGSC3.4
Celera	5	118,140,200 - 118,140,379	UniSTS
RH 3.4 Map	5	717.8	UniSTS
Cytogenetic Map	5	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
4	8	17	42	82	84	59	17	59	4	145	46	29	28	48	25

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211202	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000067850 ⟹ ENSRNOP00000063871

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	119,583,174 - 119,637,754 (-)	Ensembl
Rnor_6.0 Ensembl	5	124,348,461 - 124,403,195 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104652 ⟹ ENSRNOP00000091027

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	119,583,174 - 119,637,598 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116050 ⟹ ENSRNOP00000081094

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	119,583,406 - 119,637,754 (-)	Ensembl

RefSeq Acc Id:

NM_001106670 ⟹ NP_001100140

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	124,812,131 - 124,866,631 (-)	NCBI
mRatBN7.2	5	119,583,174 - 119,637,675 (-)	NCBI
Rnor_6.0	5	124,348,536 - 124,403,117 (-)	NCBI
Rnor_5.0	5	128,207,204 - 128,261,785 (-)	NCBI
RGSC_v3.4	5	125,776,549 - 125,831,049 (-)	RGD
Celera	5	118,140,155 - 118,194,619 (-)	RGD

Sequence:

show sequence

TTCTTTTCCATAGATGCTAAGTGGTGACTTCTGGATGAGATGTTTACAGTTGCTTTCTTTGGTT
TGTCTCTGATGGCATGGCACTCCGGGGTAACTGCACAAGAGAAGGTGAACCAGCGGGTCACCCG
AGCTGTGACCCCAGGAGCGGTTGCCTGTCAGTTGAGTGACTGGTCAGAATGGACAGATTGTTTT
CCATGTCAGAACGAAAAGTACCGATACCGGAGCCTCTTGCAGCCAAGCAAGTTTGGAGGAACCA
TCTGCAGTGGTGATATATGGGATAAGGCCAACTGTGACAGCCCCACACCTTGTCTAAGGCAAGC
ACAGTGTGGACAGGATTTCCAGTGTAGAGAGACAGGTCGCTGCCTGAAACGCCACCTGGTATGC
AATGGAGATCAGGACTGCCTTGATGGCTCTGATGAGGATAACTGTGATGATGCCAGGGTCATTG
AAGATGATTGCCGTCAGTATGAACCAATCCCAGGATCAGAAAGGGCAGCCTTGGGGTACAATAT
CCTGACTCAAGAAGAAGGCCAGAGTGTGTATGATGCTAAGTATTATGGAGGCCAGTGTGAAACT
GTGTACAATGGAGACTGGAGAAGGCTGCAGTACGACCCCACCTGTGAGCGCCTCTACTATGGGG
AGGATGAGAAATACTTCCGGAAGCCCTACAACTTCCTTAAGTACCACTTTGAAGCCCTGGCGGA
TACTTTAATCTCTTCAGAGTTTTATGATGATGCAAATGACCTTTTTTCTAAGATACAGAGGGAC
AAATCCCAGTCAAATAGTGTAACATTTGGCATAAGCCCAGCAAAAAGTCCTATCACACTAGACG
CGTCCGTATCCTGGTCCGATGAATCTTCCTTCATGAAGGAGTTAAGCAAGTATAATGAGAAGAA
ATATAGCTTCATGAGAGTGTCCACGAAGGTACAGACGGCACATTTTAAGATGAGGAGGCACAAT
ATTGTGCTGGATGAAGGGATGATGGAGTCACTGATGGAGCTCCCAGAGCAGTTTAACTACGGCA
TGTACTCCAAGTTCATCAATGACTATGGCACCCACTACATCACCTCTGGAACCATGGGTGGCAT
TTACGAATATGTTCTGGTGCTTGACAAAGAGAAAATGAGAATTCATGGCATTACTGTGGAAGAT
GTCAAAAAATGCATCGGAGGTGGCGTTGGCCTGCAGTTTGGAGAGAAAATAATTGGTGAAGGAG
ATTTATCAGGAGAGTCTTGTGTCATGACTGGAGATGGCAACCAGGACAAAAGGAAGAAGGACTT
GGCAGTGGAGGACATCATTTCTCGGGTACAAGGTGGAAGTTCTCGCTGGAGCACTGGCTTGGCA
CACAACAGCAGTGCTATTACATACCGGTCTTGGGGGAGATCATTAAAGTATAACCCTGTTGTTA
TCGATTTTGAGATGCAGCCCATCTATCAGCTACTGCAGCACACAAACCTGGGGCCTCTGGAGAC
TAAACGTCGGAACCTGCGCAGGGCTTTGGACCAGTACCTGATGGAATTTAATGCCTGCCGCTGT
GGGCCCTGCTTCAACAATGGGGTACCCATACTCGAGGGCACCAGCTGCTCGTGTCAATGTAGCA
TGGGCCGGCAGGGCCCTGCCTGTGAGAGCATGGTATTGGAAGCGATGGAGGGAGCCAAAGCTGA
TGGTCGTTGGAGCTGCTGGAGTTCCTGGTCAGAGTGTAGAGGAGGGTCCCGGGAGAGGAGGAGA
CAGTGCAACAATCCAGCACCCCAGAATGGAGGTGCCCCATGCCTAGGGAAGAGCCTGCAGACCC
AGGCCTGCTGAGTAGCTCTGGAGGCAGACTTGGAAGGAAGCTGTAGATGCTGCTGCCTGTCCTG
GCTGCTGGTTAGGACTGATTGCTGCTCTGAGTAAATGCAAACCCACGAAGGCTGTTCCCTTCAC
ACACTCATTTTTTTTTCTAGTACCAACCTCATAATCTTTAGCCTCTACCAATAACCTGGCTCTA
GGTTGCCTCCTTGTCCCAGAGGGTCGCTACCCTTTACATCTCAGAACCACCTCCCTATCTTATT
CCATTCAGGATGCTCAATAATAAACTGGGTGTGGTTTAGACACATCAGAAATAATTCCTCACAA
TTCTGGAGGCATAAACTGCAAGATGAAGGTTCCAGCAGGTCTAGGGTCTGGAGAGGCTGTGTTC
TATTTTATATATGTCCTTTCATTGGGTTATTACATGGCAGAGGGGTAGCAAGTCTCTAGGTCCT
CTTTAGTAAGGACACCAGTCCTACTCATGAGAATGTTGCCTTTATGACTTCATCATCTCCCGAA
GTCCAGCCTCCTCTTTTGACACTGGGTGTAGGTCTTCCATGTGGAGAACTTAGAGAGACCTCAA
CATTCAGACCCCAGAATATCTTTTGTTACTCTCTCTCAGTAAGCAATCATATTTGAAGGCATCA
TATTTGAAGGCAGAAACTGGGCCAGTTTTATTCAGCATAGCGTCTTTAGATGCGAAGGCTATGC
ATTGCAGACTGTAGGGGATCTCATCAGCAATGGTTGCTGGACAAGCAGACAGATCAAGAGTCAG
TTCATGGGTGAGGTCTGTACTGGTCAGTCTTGCAGAGCTGTGGGTGGACTTGGAAGGGTCAATC
AGTAAAGATCAACATCCATTCTCTGATCTTCTCAAGAAGAGCCAGTCACAGCAGCCAGCCTAGT
GTTCCTACATACTCTAAACCATGTGCATGTTCAGCATTGACTTAATTGGGGTTTCTCCTGCCAT
GAGAAAACATCATGAGTAAAAGCAACTGGGGCAAAAAGGGTTAACTTCAGCTTGCATGCCCCAC
TCGCAGTCTATCATGAAAAGAAGTCAGAGCAGGAACTCAAGTCAGGAACCTGGTGGCAGGAACT
GAAGCAGAGATCATAGAGGGGTGCTGCTTACTGACTTCCTCCTCATAATTTTCTCTGCCTGTTA
GGTATGGCAACACCCAGAGTGAACTGGGCCCTCCCACATTAATCAGTAATTTTTAAAAAACAGT
TCACTACAGACTTGCTCAGAGGCCAGTCTAGTGGGCTCCCTCTACCCCTAACTGAAGTTCCCTC
TTCCAAAATGTGTCAAGTTGATGAAAAACTAGATAAATCAACAACCCAGGCTTACCCTTGGCTT
CTCTTTGAAGTTGGTAGACTTTGTAGATATGAAGCCTTCAGAAACAGAGGGCAACTGTATAAAT
GAAAAAGAGGAGGATCTTGGGCTACTGGGAATAAATTATTGACATCAACATATGTAGCATCCAA
GTGATTGCTGAGGGAGAACAAGTCAAGAGAGTGCAGTCTTCACATGTTATATATACATCAGGGG
CAGCAAGTGCAGGGTCTATCTGATCTGGATGGACTTTTAACAGATCAGCAGGGAGGAGACTTTT
GAAGAGGAAATCCATCTTGATACAAAGCCAGATGGTGAGACAGAACATGGGGACCGGGAACTCG
CAGGTGAATGTGTTGGACATTGGGGACTGGGAAAAACAGTAACAAAGTCAGGGTGTGTAAGACC
CACCTCAGTGCCTGCCACATGGCAAATCATTACCATCATTGTTGTTATTTCCATTGTGAAAACG
TGGTTCAGAATTTTATCTAAATAAACTTGGCTCTTCTAGCTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100140	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL97880	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000063871.2
	ENSRNOP00000081094.1
	ENSRNOP00000091027.1

RefSeq Acc Id:	NP_001100140 ⟸ NM_001106670
- Peptide Label:	precursor
- UniProtKB:	D3ZWD6 (UniProtKB/TrEMBL), A6JRT8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFTVAFFGLSLMAWHSGVTAQEKVNQRVTRAVTPGAVACQLSDWSEWTDCFPCQNEKYRYRSLL QPSKFGGTICSGDIWDKANCDSPTPCLRQAQCGQDFQCRETGRCLKRHLVCNGDQDCLDGSDED NCDDARVIEDDCRQYEPIPGSERAALGYNILTQEEGQSVYDAKYYGGQCETVYNGDWRRLQYDP TCERLYYGEDEKYFRKPYNFLKYHFEALADTLISSEFYDDANDLFSKIQRDKSQSNSVTFGISP AKSPITLDASVSWSDESSFMKELSKYNEKKYSFMRVSTKVQTAHFKMRRHNIVLDEGMMESLME LPEQFNYGMYSKFINDYGTHYITSGTMGGIYEYVLVLDKEKMRIHGITVEDVKKCIGGGVGLQF GEKIIGEGDLSGESCVMTGDGNQDKRKKDLAVEDIISRVQGGSSRWSTGLAHNSSAITYRSWGR SLKYNPVVIDFEMQPIYQLLQHTNLGPLETKRRNLRRALDQYLMEFNACRCGPCFNNGVPILEG TSCSCQCSMGRQGPACESMVLEAMEGAKADGRWSCWSSWSECRGGSRERRRQCNNPAPQNGGAP CLGKSLQTQAC hide sequence

Ensembl Acc Id:

ENSRNOP00000063871 ⟸ ENSRNOT00000067850

Ensembl Acc Id:

ENSRNOP00000091027 ⟸ ENSRNOT00000104652

Ensembl Acc Id:

ENSRNOP00000081094 ⟸ ENSRNOT00000116050

Protein Domains

MACPF

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZWD6-F1-model_v2	AlphaFold	D3ZWD6	1-587	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693871

Promoter ID:

EPDNEW_R4396

Type:

initiation region

Name:

C8a_1

Description:

complement C8 alpha chain

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	124,403,157 - 124,403,217	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308355	AgrOrtholog
BioCyc Gene	G2FUF-40491	BioCyc
Ensembl Genes	ENSRNOG00000007697	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000067850.3	UniProtKB/TrEMBL
	ENSRNOT00000104652.1	UniProtKB/TrEMBL
	ENSRNOT00000116050.1	UniProtKB/TrEMBL
Gene3D-CATH	2.20.100.10	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
InterPro	C8A_B_C6_EGF-like	UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/TrEMBL
	MAC_perforin	UniProtKB/TrEMBL
	MACPF	UniProtKB/TrEMBL
	MACPF_CS	UniProtKB/TrEMBL
	Thrombospondin_1_rpt	UniProtKB/TrEMBL
	TSP1_rpt_sf	UniProtKB/TrEMBL
KEGG Report	rno:298288	UniProtKB/TrEMBL
NCBI Gene	298288	ENTREZGENE
PANTHER	COMPLEMENT COMPONENT C6	UniProtKB/TrEMBL
	PTHR45742:SF1	UniProtKB/TrEMBL
Pfam	C8A_B_C6_EGF-like	UniProtKB/TrEMBL
	Ldl_recept_a	UniProtKB/TrEMBL
	MACPF	UniProtKB/TrEMBL
	TSP_1	UniProtKB/TrEMBL
PhenoGen	C8a	PhenoGen
PRINTS	COMPLEMENTC9	UniProtKB/TrEMBL
	TSP1REPEAT	UniProtKB/TrEMBL
PROSITE	LDLRA_1	UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/TrEMBL
	MACPF_1	UniProtKB/TrEMBL
	MACPF_2	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007697	RatGTEx
SMART	LDLa	UniProtKB/TrEMBL
	MACPF	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
Superfamily-SCOP	LDL_rcpt_classA_cys-rich	UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
UniProt	A0A8I5ZRH5_RAT	UniProtKB/TrEMBL
	A0A8I6ACZ6_RAT	UniProtKB/TrEMBL
	A6JRT8	ENTREZGENE, UniProtKB/TrEMBL
	D3ZWD6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-18	C8a	complement C8 alpha chain	C8a	complement component 8 alpha subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-08	C8a	complement component 8 alpha subunit	C8a	complement component 8, alpha polypeptide	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	C8a	complement component 8, alpha polypeptide	C8a_predicted	complement component 8, alpha polypeptide (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	C8a_predicted	complement component 8, alpha polypeptide (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)