Mbd1 (methyl-CpG binding domain protein 1) - Rat Genome Database

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Gene: Mbd1 (methyl-CpG binding domain protein 1) Rattus norvegicus
Analyze
Symbol: Mbd1
Name: methyl-CpG binding domain protein 1
RGD ID: 1305980
Description: Enables chromatin binding activity. Involved in several processes, including negative regulation of astrocyte differentiation; regulation of gene expression; and response to estradiol. Located in chromatin. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human MBD1 (methyl-CpG binding domain protein 1); PARTICIPATES IN DNA modification pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC291439; methyl-CpG-binding domain protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81870,145,093 - 70,159,744 (+)NCBIGRCr8
mRatBN7.21867,869,870 - 67,884,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,869,992 - 67,886,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1869,978,196 - 69,992,672 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01870,643,315 - 70,657,818 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01868,509,485 - 68,523,993 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01870,248,568 - 70,263,190 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1870,248,713 - 70,263,164 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01869,390,120 - 69,404,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41871,068,257 - 71,082,734 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11871,141,457 - 71,155,910 (+)NCBI
Celera1866,048,059 - 66,062,538 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mbd1Ratautistic disorder  ISOMbd1 (Mus musculus)9588655 RGD 
Mbd1RatExperimental Seizures  IEP 9587847mRNA:increased expression:dentate gyrusRGD 
Mbd1Ratlung cancer susceptibilityISOMBD1 (Homo sapiens)9588657DNA:snp::c.1221+135T>A (rs140689) (human)RGD 
Mbd1Ratlung cancer susceptibilityISOMBD1 (Homo sapiens)9588651DNA:snps more ...RGD 
Mbd1Rattransient cerebral ischemia  IEP 9587846mRNA:increased expression:hippocampusRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mbd1Ratintellectual disability  ISOMBD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mbd1RatProstatic Neoplasms  ISOMBD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29610475

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mbd1Rat1,2-dichloroethane decreases expressionISOMbd1 (Mus musculus)6480464ethylene dichloride results in decreased expression of MBD1 mRNACTDPMID:28189721 and PMID:28960355
Mbd1Rat1,2-dimethylhydrazine multiple interactionsISOMbd1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MBD1 mRNACTDPMID:22206623
Mbd1Rat1,2-dimethylhydrazine decreases expressionISOMbd1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of MBD1 mRNACTDPMID:22206623
Mbd1Rat17alpha-ethynylestradiol multiple interactionsISOMbd1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MBD1 mRNACTDPMID:17942748
Mbd1Rat17beta-estradiol multiple interactionsISOMBD1 (Homo sapiens)6480464Estradiol inhibits the reaction [sodium arsenite results in increased expression of MBD1 mRNA]CTDPMID:22952798
Mbd1Rat17beta-estradiol increases expressionISOMbd1 (Mus musculus)6480464Estradiol results in increased expression of MBD1 mRNACTDPMID:39298647
Mbd1Rat17beta-estradiol decreases expressionISOMBD1 (Homo sapiens)6480464Estradiol results in decreased expression of MBD1 mRNACTDPMID:22952798
Mbd1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOMbd1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MBD1 mRNACTDPMID:17942748
Mbd1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMbd1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MBD1 mRNACTDPMID:21570461
Mbd1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMbd1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of MBD1 mRNACTDPMID:19770486
Mbd1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMbd1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of MBD1 mRNACTDPMID:17942748
Mbd1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOMbd1 (Mus musculus)64804642 more ...CTDPMID:38648751
Mbd1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of MBD1 mRNACTDPMID:21346803
Mbd1Rat2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one increases expressionISOMbd1 (Mus musculus)6480464Itraconazole results in increased expression of MBD1 mRNACTDPMID:31099283
Mbd1Rat4,4'-sulfonyldiphenol affects expressionISOMbd1 (Mus musculus)6480464bisphenol S affects the expression of MBD1 mRNACTDPMID:39298647
Mbd1Rat4-hydroxyphenyl retinamide increases expressionISOMbd1 (Mus musculus)6480464Fenretinide results in increased expression of MBD1 mRNACTDPMID:28973697
Mbd1Rat5-aza-2'-deoxycytidine increases expressionISOMBD1 (Homo sapiens)6480464Decitabine results in increased expression of MBD1 mRNACTDPMID:19329758
Mbd1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of MBD1 mRNACTDPMID:30047161
Mbd1Ratacrolein multiple interactionsISOMBD1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of and results in increased oxidation of MBD1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of and results in increased oxidation of MBD1 mRNACTDPMID:32699268
Mbd1Rataflatoxin B1 increases expressionISOMbd1 (Mus musculus)6480464Aflatoxin B1 results in increased expression of MBD1 mRNACTDPMID:19770486

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Biological Process
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Cellular Component
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Molecular Function
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RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mbd1RatDNA modification pathway   ISOMBD1 (Homo sapiens)8695954 RGD 

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#
Reference Title
Reference Citation
1. The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Allan AM, etal., Hum Mol Genet. 2008 Jul 1;17(13):2047-57. doi: 10.1093/hmg/ddn102. Epub 2008 Apr 1.
2. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA and Defossez PA, Epigenetics. 2013 Feb;8(2):131-7. doi: 10.4161/epi.23632. Epub 2013 Jan 16.
3. Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain. Cassel S, etal., Mol Pharmacol. 2006 Aug;70(2):487-92. Epub 2006 May 2.
4. Kindling induces the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Francis J, etal., Neuroscience. 2002;113(1):79-87.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. Ghoshal K, etal., J Nutr. 2006 Jun;136(6):1522-7.
7. Methyl-CpG binding domain 1 gene polymorphisms and risk of primary lung cancer. Jang JS, etal., Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2474-80.
8. Transient forebrain ischemia alters the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Jung BP, etal., Neuroscience. 2002;115(2):515-24.
9. Epigenetic regulation of neonatal cardiomyocytes differentiation. Kou CY, etal., Biochem Biophys Res Commun. 2010 Sep 17;400(2):278-83. doi: 10.1016/j.bbrc.2010.08.064. Epub 2010 Aug 22.
10. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. Li X, etal., J Biol Chem. 2008 Oct 10;283(41):27644-52. doi: 10.1074/jbc.M804899200. Epub 2008 Aug 8.
11. Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population. Liu H, etal., Biomarkers. 2008 Sep;13(6):607-17. doi: 10.1080/13547500802168031 .
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Methyl-CpG binding proteins are involved in restricting differentiation plasticity in neurons. Setoguchi H, etal., J Neurosci Res. 2006 Oct;84(5):969-79.
17. Cellular epigenetic modifications of neural stem cell differentiation. Singh RP, etal., Cell Transplant. 2009;18(10):1197-211. doi: 10.3727/096368909X12483162197204. Epub 2009 Aug 5.
18. Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life. Tang WY, etal., Endocrinology. 2012 Jan;153(1):42-55. doi: 10.1210/en.2011-1308. Epub 2011 Nov 22.
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PMID:9774669   PMID:11371345   PMID:12477932   PMID:14519686   PMID:15777793   PMID:17546630   PMID:18604195   PMID:25284789   PMID:29276034   PMID:32638524  



Mbd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81870,145,093 - 70,159,744 (+)NCBIGRCr8
mRatBN7.21867,869,870 - 67,884,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,869,992 - 67,886,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1869,978,196 - 69,992,672 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01870,643,315 - 70,657,818 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01868,509,485 - 68,523,993 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01870,248,568 - 70,263,190 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1870,248,713 - 70,263,164 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01869,390,120 - 69,404,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41871,068,257 - 71,082,734 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11871,141,457 - 71,155,910 (+)NCBI
Celera1866,048,059 - 66,062,538 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
MBD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381850,266,885 - 50,281,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1850,266,882 - 50,281,774 (-)EnsemblGRCh38hg38GRCh38
GRCh371847,793,255 - 47,808,137 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,049,214 - 46,062,142 (-)NCBINCBI36Build 36hg18NCBI36
Celera1844,651,771 - 44,664,698 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1844,647,697 - 44,662,584 (-)NCBIHuRef
CHM1_11847,788,841 - 47,803,733 (-)NCBICHM1_1
T2T-CHM13v2.01850,468,627 - 50,483,509 (-)NCBIT2T-CHM13v2.0
Mbd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391874,400,676 - 74,415,808 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1874,400,676 - 74,415,803 (+)EnsemblGRCm39 Ensembl
GRCm381874,267,605 - 74,282,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1874,267,605 - 74,282,732 (+)EnsemblGRCm38mm10GRCm38
MGSCv371874,427,942 - 74,442,338 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361874,393,660 - 74,408,054 (+)NCBIMGSCv36mm8
Celera1875,497,613 - 75,512,033 (+)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1850.7NCBI
Mbd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540235,319,810 - 35,334,678 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540235,320,755 - 35,334,751 (-)NCBIChiLan1.0ChiLan1.0
MBD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21767,796,740 - 67,809,690 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11853,489,343 - 53,502,163 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01843,647,395 - 43,662,266 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11846,996,905 - 47,009,831 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1846,996,905 - 47,009,831 (-)Ensemblpanpan1.1panPan2
MBD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1778,597,688 - 78,611,303 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl778,597,746 - 78,651,472 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha778,002,061 - 78,017,756 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0778,661,476 - 78,677,177 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl778,661,468 - 78,674,941 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1778,374,132 - 78,389,826 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0778,406,559 - 78,422,248 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0778,691,272 - 78,706,975 (+)NCBIUU_Cfam_GSD_1.0
Mbd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494437,609,864 - 37,629,471 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649712,848,874 - 12,871,639 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649712,848,918 - 12,868,504 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl199,900,801 - 99,917,323 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1199,848,193 - 99,917,347 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21109,589,957 - 109,606,298 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MBD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11830,675,419 - 30,690,111 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1830,675,653 - 30,685,946 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660504,822,001 - 4,835,406 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477813,896,447 - 13,907,656 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477813,892,179 - 13,907,576 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Mbd1
19 total Variants

Predicted Target Of
Summary Value
Count of predictions:392
Count of miRNA genes:213
Interacting mature miRNAs:250
Transcripts:ENSRNOT00000032202
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat

1 to 10 of 46 rows
BF389035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21867,871,332 - 67,871,457 (+)MAPPERmRatBN7.2
Rnor_6.01870,250,024 - 70,250,148NCBIRnor6.0
Rnor_5.01869,391,571 - 69,391,695UniSTSRnor5.0
RGSC_v3.41871,069,568 - 71,069,692UniSTSRGSC3.4
Celera1866,049,370 - 66,049,494UniSTS
RH 3.4 Map18685.3UniSTS
Cytogenetic Map18q12.2UniSTS
RH135120  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81870,157,904 - 70,158,091 (+)Marker Load Pipeline
mRatBN7.21867,882,676 - 67,882,863 (+)MAPPERmRatBN7.2
Rnor_6.01870,261,366 - 70,261,552NCBIRnor6.0
Rnor_5.01869,402,913 - 69,403,099UniSTSRnor5.0
RGSC_v3.41871,080,911 - 71,081,097UniSTSRGSC3.4
Celera1866,060,715 - 66,060,901UniSTS
RH 3.4 Map18685.3UniSTS
Cytogenetic Map18q12.2UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 16 of 16 rows
RefSeq Transcripts NM_001011924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_361462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC081932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000032202   ⟹   ENSRNOP00000037640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,870,022 - 67,884,475 (+)Ensembl
Rnor_6.0 Ensembl1870,248,713 - 70,263,164 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099489   ⟹   ENSRNOP00000097486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,869,992 - 67,886,554 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102132   ⟹   ENSRNOP00000078508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,869,998 - 67,884,485 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111311   ⟹   ENSRNOP00000086562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,869,998 - 67,883,010 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113558   ⟹   ENSRNOP00000097211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1867,869,998 - 67,884,485 (+)Ensembl
RefSeq Acc Id: NM_001011924   ⟹   NP_001011924
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,252 - 70,159,728 (+)NCBI
mRatBN7.21867,870,022 - 67,884,500 (+)NCBI
Rnor_6.01870,248,713 - 70,263,189 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
RGSC_v3.41871,068,257 - 71,082,734 (+)RGD
Celera1866,048,059 - 66,062,538 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254909   ⟹   XP_006254971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,117 - 70,159,744 (+)NCBI
mRatBN7.21867,869,877 - 67,884,501 (+)NCBI
Rnor_6.01870,248,571 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254910   ⟹   XP_006254972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,119 - 70,159,744 (+)NCBI
mRatBN7.21867,869,876 - 67,884,501 (+)NCBI
Rnor_6.01870,248,570 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254911   ⟹   XP_006254973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,093 - 70,159,744 (+)NCBI
mRatBN7.21867,869,877 - 67,884,501 (+)NCBI
Rnor_6.01870,248,571 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254913   ⟹   XP_006254975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,093 - 70,159,744 (+)NCBI
mRatBN7.21867,869,879 - 67,884,501 (+)NCBI
Rnor_6.01870,248,572 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006254914   ⟹   XP_006254976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,119 - 70,159,744 (+)NCBI
mRatBN7.21867,869,879 - 67,884,501 (+)NCBI
Rnor_6.01870,248,572 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600882   ⟹   XP_017456371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,119 - 70,159,744 (+)NCBI
mRatBN7.21867,869,870 - 67,884,501 (+)NCBI
Rnor_6.01870,248,570 - 70,263,190 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600883   ⟹   XP_017456372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,117 - 70,159,744 (+)NCBI
mRatBN7.21867,869,876 - 67,884,501 (+)NCBI
Rnor_6.01870,248,570 - 70,263,190 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096640   ⟹   XP_038952568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,117 - 70,159,744 (+)NCBI
mRatBN7.21867,869,877 - 67,884,501 (+)NCBI
RefSeq Acc Id: XM_063277170   ⟹   XP_063133240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,119 - 70,159,744 (+)NCBI
RefSeq Acc Id: XM_063277171   ⟹   XP_063133241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,119 - 70,159,744 (+)NCBI
RefSeq Acc Id: XM_063277172   ⟹   XP_063133242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,119 - 70,159,744 (+)NCBI
RefSeq Acc Id: XR_361462
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81870,145,117 - 70,159,744 (+)NCBI
mRatBN7.21867,869,877 - 67,884,501 (+)NCBI
Rnor_6.01870,248,571 - 70,263,190 (+)NCBI
Rnor_5.01869,390,120 - 69,404,741 (+)NCBI
Sequence:
1 to 5 of 17 rows
1 to 5 of 17 rows
RefSeq Acc Id: NP_001011924   ⟸   NM_001011924
- UniProtKB: Q66HB8 (UniProtKB/TrEMBL),   A0A8I6GMJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254973   ⟸   XM_006254911
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A3W5 (UniProtKB/TrEMBL),   A0A8I6AS94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254971   ⟸   XM_006254909
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AS94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254972   ⟸   XM_006254910
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AS94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254975   ⟸   XM_006254913
- Peptide Label: isoform X8
- UniProtKB: A0A8I6GMJ2 (UniProtKB/TrEMBL)
- Sequence:
CXXC-type   MBD

Name Modeler Protein Id AA Range Protein Structure
AF-Q66HB8-F1-model_v2 AlphaFold Q66HB8 1-533 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700865
Promoter ID:EPDNEW_R11388
Type:initiation region
Name:Mbd1_1
Description:methyl-CpG binding domain protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01870,248,700 - 70,248,760EPDNEW


1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-7032 BioCyc
Ensembl Genes ENSRNOG00000024104 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019573 ENTREZGENE
  ENSRNOT00000032202 ENTREZGENE
  ENSRNOT00000032202.5 UniProtKB/TrEMBL
  ENSRNOT00000099489.1 UniProtKB/TrEMBL
  ENSRNOT00000102132 ENTREZGENE
  ENSRNOT00000102132.1 UniProtKB/TrEMBL
  ENSRNOT00000111311.1 UniProtKB/TrEMBL
  ENSRNOT00000113558 ENTREZGENE
  ENSRNOT00000113558.1 UniProtKB/TrEMBL
Gene3D-CATH Methyl-cpg-binding Protein 2, Chain A UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114194 IMAGE-MGC_LOAD
InterPro DNA-bd_integrase-typ UniProtKB/TrEMBL
  Methyl_CpG_DNA-bd UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/TrEMBL
KEGG Report rno:291439 UniProtKB/TrEMBL
MGC_CLONE MGC:93958 IMAGE-MGC_LOAD
NCBI Gene 291439 ENTREZGENE
PANTHER METHYL-CPG BINDING PROTEIN, MBD UniProtKB/TrEMBL
  METHYL-CPG-BINDING DOMAIN PROTEIN 1 UniProtKB/TrEMBL
Pfam MBD UniProtKB/TrEMBL
  zf-CXXC UniProtKB/TrEMBL
PhenoGen Mbd1 PhenoGen
PROSITE MBD UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024104 RatGTEx
SMART MBD UniProtKB/TrEMBL
Superfamily-SCOP DNA-binding_integrase-type UniProtKB/TrEMBL
UniProt A0A8I5ZMU8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3W5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AS94 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMJ2 ENTREZGENE, UniProtKB/TrEMBL
  Q66HB8 ENTREZGENE, UniProtKB/TrEMBL
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Mbd1  methyl-CpG binding domain protein 1  Mbd1_predicted  methyl-CpG binding domain protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mbd1_predicted  methyl-CpG binding domain protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED