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Gene: Lrat (lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)) Mus musculus
Symbol: Lrat
Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
Description: Exhibits O-acyltransferase activity. Involved in several processes, including cellular response to leukemia inhibitory factor; positive regulation of lipid transport; and retinoid metabolic process. Predicted to localize to multivesicular body; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Is expressed in embryo; extraembryonic component; liver; placenta; and yolk sac. Used to study Leber congenital amaurosis 14. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol acyltransferase); PARTICIPATES IN altered retinoid cycle metabolic pathway; retinitis pigmentosa pathway; retinoic acid metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1300010A18Rik; AI449251; lecithin retinol acyltransferase; phosphatidylcholine--retinol O-acyltransferase; phosphatidylcholine-retinol-O-acyltransferase
Homo sapiens (human) : LRAT (lecithin retinol acyltransferase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lrat (lecithin retinol acyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrat (lecithin retinol acyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : LRAT (lecithin retinol acyltransferase)
Canis lupus familiaris (dog) : LRAT (lecithin retinol acyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrat (lecithin retinol acyltransferase)
Sus scrofa (pig) : LRAT (lecithin retinol acyltransferase)
Chlorocebus sabaeus (African green monkey) : LRAT (lecithin retinol acyltransferase)
Heterocephalus glaber (naked mole-rat) : Lrat (lecithin retinol acyltransferase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl382,892,579 - 82,903,973 (-)EnsemblGRCm38mm10GRCm38
GRCm38382,892,582 - 82,903,974 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37382,696,504 - 82,707,896 (-)NCBIGRCm37mm9NCBIm37
MGSCv36382,978,509 - 82,989,901 (-)NCBImm8
Celera382,903,193 - 82,914,568 (-)NCBICelera
Cytogenetic Map3E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lrat
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68516
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.