Lrat (lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)) - Rat Genome Database

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Gene: Lrat (lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)) Mus musculus
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Symbol: Lrat
Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
RGD ID: 68516
MGI Page MGI
Description: Enables O-palmitoyltransferase activity and phosphatidylcholine-retinol O-acyltransferase activity. Involved in lipid storage and retinol metabolic process. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of lipid transport; and vitamin A metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including extraembryonic component; gut; midbrain; reproductive system; and retina. Used to study Leber congenital amaurosis 14. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol acyltransferase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1300010A18Rik; AI449251; lecithin retinol acyltransferase; phosphatidylcholine--retinol O-acyltransferase; phosphatidylcholine-retinol-O-acyltransferase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,799,889 - 82,811,281 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,799,886 - 82,811,280 (-)EnsemblGRCm39 Ensembl
GRCm38382,892,582 - 82,903,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,892,579 - 82,903,973 (-)EnsemblGRCm38mm10GRCm38
MGSCv37382,696,504 - 82,707,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36382,978,509 - 82,989,901 (-)NCBIMGSCv36mm8
Celera382,903,193 - 82,914,568 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
LratMouseretinitis pigmentosa  ISOLRAT (Homo sapiens)8547535 RGD 
LratMouseretinitis pigmentosa  ISOLRAT (Homo sapiens)1599754early-onset severe retinal dystrophy and OMIM:604863RGD 
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LratMousebreast ductal carcinoma  ISOLRAT (Homo sapiens)8554872ClinVar Annotator: match by term: Ductal breast carcinomaClinVar 
LratMousecone-rod dystrophy  ISOLRAT (Homo sapiens)8554872ClinVar Annotator: match by term: Rod-cone dystrophyClinVarPMID:25741868
LratMouseEye Abnormalities  ISOLRAT (Homo sapiens)8554872ClinVar Annotator: match by term: Abnormality of the eyeClinVarPMID:25741868
LratMousefundus dystrophy  ISOLRAT (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:21217109 more ...
LratMousegenetic disease  ISOLRAT (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
LratMouseinvasive ductal carcinoma  ISOLRAT (Homo sapiens)8554872ClinVar Annotator: match by term: Breast cancer and invasive ductalClinVar 
LratMouseLeber congenital amaurosis  ISOLRAT (Homo sapiens)8554872ClinVar Annotator: match by term: Leber congenital amaurosisClinVarPMID:24033266 more ...
LratMouseLeber congenital amaurosis 1  ISOLRAT (Homo sapiens)8554872ClinVar Annotator: match by term: Leber congenital amaurosis 1ClinVarPMID:25324289 more ...
LratMouseLeber congenital amaurosis 14  ISOLRAT (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11381255 more ...
LratMouseretinitis pigmentosa  ISOLRAT (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22025579 more ...
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Original Reference(s)
LratMouseceliac disease  ISOLRAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30097691
LratMouseChemical and Drug Induced Liver Injury  ISOLRAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25226513
LratMouseExperimental Liver Cirrhosis  ISOLRAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
LratMousehepatocellular carcinoma  ISOLRAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28284560
LratMouseHereditary Eye Diseases  ISOLRAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16968212
LratMouseLeber congenital amaurosis  ISOLRAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19339306
LratMouseLeber congenital amaurosis 14  ISOLRAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
LratMouseLeber hereditary optic neuropathy  ISOLRAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16250670 and PMID:17011878
LratMouseretinitis pigmentosa  ISOLRAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
LratMouseVitamin A Deficiency  ISOLRAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16174770
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Original Reference(s)
LratMouseLeber congenital amaurosis 14  IAGP 13592920OMIM:613341MouseDO 
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Original Reference(s)
LratMouseLeber congenital amaurosis 14  ISOLRAT (Homo sapiens)7240710 OMIM 

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Original Reference(s)
LratMouse(+)-schisandrin B multiple interactionsISOLrat (Rattus norvegicus)6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of LRAT mRNA]CTDPMID:31150632
LratMouse1,1-dichloroethene decreases expressionEXP 6480464vinylidene chloride results in decreased expression of LRAT mRNACTDPMID:26682919
LratMouse1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of LRAT mRNACTDPMID:22206623
LratMouse1-naphthyl isothiocyanate decreases expressionISOLrat (Rattus norvegicus)64804641-Naphthylisothiocyanate results in decreased expression of LRAT mRNACTDPMID:25380136
LratMouse17alpha-ethynylestradiol increases expressionISOLrat (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of LRAT mRNACTDPMID:17557909
LratMouse17beta-estradiol multiple interactionsISOLRAT (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of LRAT mRNACTDPMID:30165855
LratMouse17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of LRAT mRNACTDPMID:39298647
LratMouse2,3,7,8-tetrachlorodibenzodioxine increases activityISOLrat (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased activity of LRAT proteinCTDPMID:11097864
LratMouse2,3,7,8-tetrachlorodibenzodioxine affects expressionISOLrat (Rattus norvegicus)6480464Tetrachlorodibenzodioxin affects the expression of LRAT mRNACTDPMID:22298810
LratMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOLrat (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of LRAT mRNACTDPMID:12606150 more ...
LratMouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOLrat (Rattus norvegicus)6480464[Tetrachlorodibenzodioxin results in increased activity of LRAT protein] which results in increased chemical synthesis of TretinoinCTDPMID:11097864
LratMouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of LRAT mRNA more ...CTDPMID:16292751 and PMID:25975270
LratMouse2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionEXP 64804642 more ...CTDPMID:38648751
LratMouse2-bromohexadecanoic acid increases expressionISOLrat (Rattus norvegicus)64804642-bromopalmitate results in increased expression of LRAT mRNACTDPMID:12576510
LratMouse4,4'-diaminodiphenylmethane decreases expressionISOLrat (Rattus norvegicus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of LRAT mRNACTDPMID:25380136 and PMID:30723492
LratMouse4,4'-sulfonyldiphenol increases expressionEXP 6480464bisphenol S results in increased expression of LRAT mRNACTDPMID:30951980 and PMID:39298647
LratMouse4-hydroxyphenyl retinamide increases expressionEXP 6480464Fenretinide results in increased expression of LRAT mRNACTDPMID:28973697
LratMouseaflatoxin B1 increases methylationISOLRAT (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of LRAT geneCTDPMID:28458013
LratMouseall-trans-retinoic acid increases expressionISOLRAT (Homo sapiens)6480464Tretinoin results in increased expression of LRAT proteinCTDPMID:15982314
LratMouseall-trans-retinoic acid multiple interactionsEXP 6480464[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of LRAT mRNACTDPMID:36189433

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Biological Process
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Original Reference(s)
LratMouse1,2-diacyl-sn-glycero-3-phosphocholine metabolic process acts_upstream_of_or_withinTAS 2290270 PMID:11108736MGIPMID:11108736
LratMousecellular response to leukemia inhibitory factor acts_upstream_of_or_withinIEP 2290270 PMID:20439489MGIPMID:20439489
LratMouselipid storage involved_inIMPMGI:30389352290270 PMID:14684738 and PMID:16115871MGIPMID:14684738 and PMID:16115871
LratMousepositive regulation of lipid transport acts_upstream_of_or_withinIGIMGI:107742 and MGI:19214022290270 PMID:23105095MGIPMID:23105095
LratMouseresponse to bacterium acts_upstream_of_or_withinIEP 2290270 PMID:23012479MGIPMID:23012479
LratMouseresponse to retinoic acid  ISOLrat (Rattus norvegicus)9068941 RGDPMID:19700416 and REF_RGD_ID:6484694
LratMouseresponse to retinoic acid involved_inIEAUniProtKB:Q9JI61 and ensembl:ENSRNOP000000350532290270 EnsemblGO_REF:0000107
LratMouseresponse to vitamin A  ISOLrat (Rattus norvegicus)9068941 RGDPMID:19700416 and REF_RGD_ID:6484694
LratMouseresponse to vitamin A involved_inIEAUniProtKB:Q9JI61 and ensembl:ENSRNOP000000350532290270 EnsemblGO_REF:0000107
LratMouseretinoid metabolic process involved_inIMPMGI:30389352290270 PMID:16115871MGIPMID:16115871
LratMouseretinoid metabolic process involved_inIMPMGI:21814122290270 PMID:10487743MGIPMID:10487743
LratMouseretinol metabolic process involved_inISOLrat (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
LratMouseretinol metabolic process involved_inISOUniProtKB:O952372290270 GO_CentralGO_REF:0000119
LratMouseretinol metabolic process acts_upstream_of_or_withinIMPMGI:30389352290270 PMID:18093970MGIPMID:18093970
LratMouseretinol metabolic process acts_upstream_of_or_withinIGIMGI:978792290270 PMID:18093970MGIPMID:18093970
LratMouseretinol metabolic process involved_inISSUniProtKB:O952372290270 UniProtGO_REF:0000024
LratMouseretinol metabolic process involved_inIBAPANTHER:PTN002928202 more ...2290270 GO_CentralGO_REF:0000033
LratMouseretinol metabolic process  ISOLrat (Rattus norvegicus)9068941 RGDPMID:14642897 more ...
LratMouseretinol metabolic process involved_inIMP 2290270 PMID:28758396UniProtPMID:28758396
LratMouseretinol metabolic process involved_inIEAUniPathway:UPA009122290270 UniProtGO_REF:0000041
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Cellular Component
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Original Reference(s)
LratMouseendoplasmic reticulum located_inIDA 2290270 PMID:28758396UniProtPMID:28758396
LratMouseendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00972290270 UniProtGO_REF:0000044
LratMousemultivesicular body  ISOLrat (Rattus norvegicus)9068941 RGDPMID:18544127 and REF_RGD_ID:6893660
LratMousemultivesicular body located_inISOLrat (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
LratMousemultivesicular body located_inIEAUniProtKB-SubCell:SL-01742290270 UniProtGO_REF:0000044
LratMouseperinuclear region of cytoplasm located_inIEAUniProtKB-SubCell:SL-01982290270 UniProtGO_REF:0000044
LratMouseperinuclear region of cytoplasm located_inISOLrat (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
LratMouseperinuclear region of cytoplasm  ISOLrat (Rattus norvegicus)9068941 RGDPMID:18544127 and REF_RGD_ID:6893660
LratMouserough endoplasmic reticulum located_inIEAUniProtKB-SubCell:SL-02352290270 UniProtGO_REF:0000044
LratMouserough endoplasmic reticulum is_active_inIBAPANTHER:PTN002928202 and Lrat (Rattus norvegicus)2290270 GO_CentralGO_REF:0000033
LratMouserough endoplasmic reticulum located_inISOLrat (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
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Molecular Function
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Original Reference(s)
LratMouseO-acyltransferase activity enablesIDA 2290270 PMID:11108736MGIPMID:11108736
LratMouseO-palmitoyltransferase activity enablesIDA 2290270 PMID:10487743 and PMID:11108736MGIPMID:10487743 and PMID:11108736
LratMousephosphatidylcholine-retinol O-acyltransferase activity enablesIMPMGI:30389352290270 PMID:16115871MGIPMID:16115871
LratMousephosphatidylcholine-retinol O-acyltransferase activity enablesIMP 2290270 PMID:28758396UniProtPMID:28758396
LratMousephosphatidylcholine-retinol O-acyltransferase activity enablesISSUniProtKB:O952372290270 UniProtGO_REF:0000024
LratMousephosphatidylcholine-retinol O-acyltransferase activity enablesIBAPANTHER:PTN002928202 more ...2290270 GO_CentralGO_REF:0000033
LratMousephosphatidylcholine-retinol O-acyltransferase activity  ISOLrat (Rattus norvegicus)9068941 RGDPMID:14642897 more ...
LratMousephosphatidylcholine-retinol O-acyltransferase activity enablesISOLrat (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
LratMousephosphatidylcholine-retinol O-acyltransferase activity enablesISOUniProtKB:O952372290270 GO_CentralGO_REF:0000119
LratMouseprotein binding enablesISOUniProtKB:O603619068941 PMID:28514442 and PMID:33961781IntActPMID:28514442 and PMID:33961781
LratMouseprotein binding enablesISOUniProtKB:P62952 more ...9068941 PMID:32296183IntActPMID:32296183
LratMouseretinoic acid binding  ISOLrat (Rattus norvegicus)9068941 RGDPMID:8460936 more ...
LratMouseretinoic acid binding enablesIEAUniProtKB:Q9JI61 and ensembl:ENSRNOP000000350532290270 EnsemblGO_REF:0000107
LratMouseretinoic acid binding enablesISOLrat (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
LratMouseretinol binding  ISOLrat (Rattus norvegicus)9068941 RGDPMID:2253789 more ...
LratMouseretinol binding enablesISOLrat (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
LratMouseretinol binding enablesIEAUniProtKB:Q9JI61 and ensembl:ENSRNOP000000350532290270 EnsemblGO_REF:0000107
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RGD Manual Annotations


  

Imported Annotations - SMPDB

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Original Reference(s)
LratMouseretinol metabolic pathway   ISOLRAT (Homo sapiens)10402751 SMPDBSMP:00074
LratMousevitamin A deficiency pathway  ISOLRAT (Homo sapiens)10402751 SMPDBSMP:00336

Imported Annotations - KEGG (archival)

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Original Reference(s)
LratMouseretinol metabolic pathway   IEA 6907045 KEGGmmu:00830
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Original Reference(s)
LratMouseabnormal eye electrophysiology  IAGP 5509061 MGIPMID:18055784
LratMouseabnormal retina cone cell outer segment morphology  IAGP 5509061 MGIPMID:18296659
LratMouseabnormal retina photoreceptor morphology  IAGP 5509061 MGIPMID:18296659
LratMouseabnormal retina rod cell outer segment morphology  IAGP 5509061 MGIPMID:21224384
LratMouseabnormal retinol level  IAGP 5509061 MGIPMID:16174770
LratMouseabnormal testis morphology  IAGP 5509061 MGIPMID:16174770
LratMouseabnormal vitamin A level  IAGP 5509061 MGIPMID:16174770
LratMouseabnormal vitamin A level  IAGP 5509061 MGIPMID:18055784
LratMouseabnormal vitamin A metabolism  IAGP 5509061 MGIPMID:14684738
LratMousedecreased retina photoreceptor cell number  IAGP 5509061 MGIPMID:21224384
LratMousedilated seminiferous tubule  IAGP 5509061 MGIPMID:16174770
LratMouseoligozoospermia  IAGP 5509061 MGIPMID:16174770
LratMousepreweaning lethality, incomplete penetrance  IEA 5509061 MGI 
LratMouseretina cone cell degeneration  IAGP 5509061 MGIPMID:18296659
LratMouseretina degeneration  IAGP 5509061 MGIPMID:21224384
LratMouseretina photoreceptor degeneration  IAGP 5509061 MGIPMID:18296659
LratMouseretina photoreceptor degeneration  IAGP 5509061 MGIPMID:23221340
LratMouseretina photoreceptor degeneration  IAGP 5509061 MGIPMID:21224384
LratMouseretina rod cell degeneration  IAGP 5509061 MGIPMID:18296659
LratMouseretina rod cell degeneration  IAGP 5509061 MGIPMID:21224384
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Reference Title
Reference Citation
1. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
2. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Kiser PD, etal., Biochim Biophys Acta. 2012 Jan;1821(1):137-51. Epub 2011 Apr 5.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy. Thompson DA, etal., Nat Genet. 2001 Jun;28(2):123-4.
17. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Wright AF, etal., Nat Rev Genet. 2010 Apr;11(4):273-84. doi: 10.1038/nrg2717.
18. Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. Wu L and Ross AC, J Lipid Res. 2010 Feb;51(2):378-87. Epub 2009 Aug 20.
19. Lecithin:retinol acyltransferase from mouse and rat liver. CDNA cloning and liver-specific regulation by dietary vitamin a and retinoic acid. Zolfaghari R and Ross AC, J Lipid Res 2000 Dec;41(12):2024-34.
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PMID:10349636   PMID:10487743   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14681479   PMID:14684738   PMID:16115871   PMID:16141072   PMID:16141073   PMID:16174770  
PMID:16216874   PMID:16250670   PMID:16566595   PMID:16707424   PMID:16788071   PMID:16934000   PMID:17114808   PMID:17270348   PMID:17504753   PMID:18055784   PMID:18093970   PMID:18195010  
PMID:18296659   PMID:18348983   PMID:18400900   PMID:18455147   PMID:18606814   PMID:18713813   PMID:19304658   PMID:19339306   PMID:19471114   PMID:19549509   PMID:19665987   PMID:19812372  
PMID:19901021   PMID:20040693   PMID:20061533   PMID:20356843   PMID:20404157   PMID:20439489   PMID:20628054   PMID:20881313   PMID:21076393   PMID:21224384   PMID:21285397   PMID:21555576  
PMID:21677750   PMID:21873635   PMID:21925467   PMID:22116467   PMID:22531707   PMID:22637576   PMID:22739378   PMID:22918645   PMID:23012479   PMID:23105095   PMID:23221340   PMID:23249702  
PMID:23349206   PMID:23583843   PMID:23839944   PMID:23871845   PMID:23988655   PMID:24005908   PMID:24106281   PMID:24129572   PMID:24186946   PMID:24194600   PMID:24401276   PMID:24664772  
PMID:24706832   PMID:25317684   PMID:25416279   PMID:25602705   PMID:25721651   PMID:25974161   PMID:26062936   PMID:26139608   PMID:26387748   PMID:26405179   PMID:26876013   PMID:27084391  
PMID:27462111   PMID:27815220   PMID:28758396   PMID:29453250   PMID:30115683   PMID:31562240   PMID:32290105   PMID:32492112   PMID:32535965   PMID:32768676   PMID:35921818   PMID:35959865  
PMID:36152631   PMID:36891060   PMID:38355793  



Lrat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,799,889 - 82,811,281 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,799,886 - 82,811,280 (-)EnsemblGRCm39 Ensembl
GRCm38382,892,582 - 82,903,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,892,579 - 82,903,973 (-)EnsemblGRCm38mm10GRCm38
MGSCv37382,696,504 - 82,707,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36382,978,509 - 82,989,901 (-)NCBIMGSCv36mm8
Celera382,903,193 - 82,914,568 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.81NCBI
LRAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384154,740,838 - 154,753,120 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4154,626,945 - 154,753,120 (+)EnsemblGRCh38hg38GRCh38
GRCh374155,661,990 - 155,674,272 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,884,613 - 155,893,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 344156,022,767 - 156,031,875NCBI
Celera4152,996,143 - 153,005,248 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4151,405,746 - 151,414,958 (+)NCBIHuRef
CHM1_14155,643,059 - 155,652,147 (+)NCBICHM1_1
T2T-CHM13v2.04158,072,645 - 158,084,927 (+)NCBIT2T-CHM13v2.0
Lrat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82170,562,148 - 170,571,212 (-)NCBIGRCr8
mRatBN7.22168,264,093 - 168,273,155 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,266,877 - 168,273,619 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2175,454,144 - 175,463,229 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,475,076 - 173,484,161 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,076,492 - 168,085,579 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,896,304 - 181,905,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,896,305 - 181,905,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02201,310,924 - 201,319,986 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,636,382 - 174,645,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12174,586,488 - 174,595,550 (-)NCBI
Celera2162,290,825 - 162,299,887 (-)NCBICelera
Cytogenetic Map2q34NCBI
Lrat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554712,603,678 - 2,609,079 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554712,603,395 - 2,610,988 (+)NCBIChiLan1.0ChiLan1.0
LRAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23152,653,378 - 152,665,654 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14153,008,750 - 153,021,026 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04147,110,568 - 147,119,706 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14158,928,607 - 158,937,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4158,928,607 - 158,937,747 (+)Ensemblpanpan1.1panPan2
LRAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,399,773 - 52,409,590 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,399,544 - 52,406,176 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,744,532 - 52,752,466 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01553,086,516 - 53,094,290 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1553,087,735 - 53,096,027 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11552,341,249 - 52,349,017 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01552,447,030 - 52,454,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01552,762,096 - 52,769,963 (+)NCBIUU_Cfam_GSD_1.0
Lrat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,044,997 - 38,054,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365761,492,297 - 1,501,917 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365761,491,480 - 1,498,568 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,409,461 - 74,419,681 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1874,412,226 - 74,428,713 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,710,192 - 78,726,673 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,297,114 - 101,304,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,297,691 - 101,302,520 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603780,952,291 - 80,959,916 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248532,936,109 - 2,945,101 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248532,936,426 - 2,941,993 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Lrat
629 total Variants

Predicted Target Of
Summary Value
Count of predictions:1373
Count of miRNA genes:657
Interacting mature miRNAs:835
Transcripts:ENSMUST00000029632
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 38 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse

1 to 10 of 38 rows
BE197763  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38382,892,870 - 82,892,955UniSTSGRCm38
MGSCv37382,696,792 - 82,696,877UniSTSGRCm37
Celera382,903,481 - 82,903,566UniSTS
Cytogenetic Map3E3UniSTS
Whitehead/MRC_RH3824.37UniSTS
AI449251  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38382,896,612 - 82,896,717UniSTSGRCm38
MGSCv37382,700,534 - 82,700,639UniSTSGRCm37
Celera382,907,223 - 82,907,328UniSTS
Cytogenetic Map3E3UniSTS
Whitehead/MRC_RH3810.08UniSTS
Lrat  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3E3UniSTS
cM Map3 UniSTS
Lrat  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3E3UniSTS
Lrat  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3E3UniSTS







Ensembl Acc Id: ENSMUST00000029632   ⟹   ENSMUSP00000029632
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl382,799,886 - 82,811,280 (-)Ensembl
GRCm38.p6 Ensembl382,892,579 - 82,903,973 (-)Ensembl
RefSeq Acc Id: NM_023624   ⟹   NP_076113
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39382,799,889 - 82,811,281 (-)NCBI
GRCm38382,892,582 - 82,903,974 (-)ENTREZGENE
MGSCv37382,696,504 - 82,707,896 (-)RGD
Celera382,903,193 - 82,914,568 (-)RGD
cM Map3 ENTREZGENE
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_076113 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF97787 (Get FASTA)   NCBI Sequence Viewer  
  AAI41376 (Get FASTA)   NCBI Sequence Viewer  
  AAI41379 (Get FASTA)   NCBI Sequence Viewer  
  BAB23696 (Get FASTA)   NCBI Sequence Viewer  
  EDL15427 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000029632
  ENSMUSP00000029632.7
GenBank Protein Q9JI60 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_076113   ⟸   NM_023624
- UniProtKB: Q9JI60 (UniProtKB/Swiss-Prot),   B2RUR5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000029632   ⟸   ENSMUST00000029632
LRAT

Name Modeler Protein Id AA Range Protein Structure
AF-Q9JI60-F1-model_v2 AlphaFold Q9JI60 1-231 view protein structure

RGD ID:6834041
Promoter ID:MM_KWN:34679
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000072001,   UC008PPB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36382,707,591 - 82,708,091 (-)MPROMDB
RGD ID:6880966
Promoter ID:EPDNEW_M3934
Type:multiple initiation site
Name:Lrat_1
Description:Mus musculus lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase), mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38382,903,972 - 82,904,032EPDNEW


1 to 16 of 16 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000028003 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029632 ENTREZGENE
  ENSMUST00000029632.7 UniProtKB/Swiss-Prot
Gene3D-CATH endopeptidase domain like (from Nostoc punctiforme) UniProtKB/Swiss-Prot
InterPro LRAT UniProtKB/Swiss-Prot
  LRAT_dom UniProtKB/Swiss-Prot
KEGG Report mmu:79235 UniProtKB/Swiss-Prot
MGD MGI:1891259 ENTREZGENE
NCBI Gene Lrat ENTREZGENE
PANTHER LECITHIN RETINOL ACYLTRANSFERASE UniProtKB/Swiss-Prot
  PTHR46678 UniProtKB/Swiss-Prot
Pfam LRAT UniProtKB/Swiss-Prot
PhenoGen Lrat PhenoGen
PROSITE LRAT UniProtKB/Swiss-Prot
UniProt B2RUR5 ENTREZGENE, UniProtKB/TrEMBL
  LRAT_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
1 to 16 of 16 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Lrat  lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)  1300010A18Rik  RIKEN cDNA 1300010A18 gene  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 1300010A18Rik  RIKEN cDNA 1300010A18 gene  Lrat  lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)  Symbol and/or name change 5135510 APPROVED