Gene: Lrat (lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)) Mus musculus
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Symbol:
Lrat
Name:
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
Description:
Exhibits O-acyltransferase activity. Involved in several processes, including cellular response to leukemia inhibitory factor; positive regulation of lipid transport; and retinoid metabolic process. Predicted to localize to multivesicular body; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Is expressed in embryo; extraembryonic component; liver; placenta; and yolk sac. Used to study Leber congenital amaurosis 14. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol acyltransferase); PARTICIPATES IN altered retinoid cycle metabolic pathway; retinitis pigmentosa pathway; retinoic acid metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
1300010A18Rik; AI449251; lecithin retinol acyltransferase; phosphatidylcholine--retinol O-acyltransferase; phosphatidylcholine-retinol-O-acyltransferase
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
LRAT (lecithin retinol acyltransferase) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Lrat (lecithin retinol acyltransferase) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Lrat (lecithin retinol acyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
LRAT (lecithin retinol acyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
LRAT (lecithin retinol acyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Lrat (lecithin retinol acyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
LRAT (lecithin retinol acyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
LRAT (lecithin retinol acyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Lrat (lecithin retinol acyltransferase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Lrat (lecithin retinol acyltransferase)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Homo sapiens (human):
LRAT (lecithin retinol acyltransferase)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam|Roundup)
Danio rerio (zebrafish):
lrata (lecithin retinol acyltransferase a)
Alliance
DIOPT (ZFIN|PANTHER|Ensembl Compara|OMA|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam|Roundup)
Danio rerio (zebrafish):
lratb.1
Alliance
DIOPT (ZFIN|Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38.p6 Ensembl 3 82,892,579 - 82,903,973 (-) Ensembl GRCm38 mm10 GRCm38 GRCm38 3 82,892,582 - 82,903,974 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 3 82,696,504 - 82,707,896 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 3 82,978,509 - 82,989,901 (-) NCBI mm8 Celera 3 82,903,193 - 82,914,568 (-) NCBI Celera Cytogenetic Map 3 E3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
breast ductal carcinoma ISO RGD:68515 8554872 ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar cone-rod dystrophy ISO RGD:68515 8554872 ClinVar Annotator: match by term: Rod-cone dystrophy ClinVar PMID:25741868 fundus dystrophy ISO RGD:68515 8554872 ClinVar Annotator: match by term: Retinal dystrophy ClinVar Leber congenital amaurosis ISO RGD:68515 8554872 ClinVar Annotator: match by term: Leber congenital amaurosis ClinVar PMID:24033266 Leber congenital amaurosis ISO RGD:68515 8554872 ClinVar Annotator: match by term: Leber congenital amaurosis ClinVar PMID:28492532 Leber congenital amaurosis ISO RGD:68515 8554872 ClinVar Annotator: match by term: Leber congenital amaurosis ClinVar PMID:25741868 Leber congenital amaurosis ISO RGD:68515 8554872 ClinVar Annotator: match by term: Leber's amaurosis ClinVar Leber congenital amaurosis 1 ISO RGD:68515 8554872 ClinVar Annotator: match by term: Leber congenital amaurosis 1 ClinVar Leber congenital amaurosis 14 ISO RGD:68515 8554872 ClinVar Annotator: match by term: Leber congenital amaurosis 14 ClinVar PMID:25741868 Leber congenital amaurosis 14 ISO RGD:68515 8554872 ClinVar Annotator: match by term: Leber congenital amaurosis 14 ClinVar PMID:22025579 , PMID:28492532 Leber congenital amaurosis 14 ISO RGD:68515 8554872 ClinVar Annotator: match by term: Leber congenital amaurosis 14 ClinVar PMID:28492532 Leber congenital amaurosis 14 ISO RGD:68515 8554872 ClinVar Annotator: match by term: Leber congenital amaurosis 14 ClinVar Leber congenital amaurosis 14 ISO RGD:68515 8554872 ClinVar Annotator: match by synonym: RETINAL DYSTROPHY, EARLY-ONSET SEVERE, LRAT-RELATED ClinVar PMID:11381255 Leber congenital amaurosis 14 ISO RGD:68515 8554872 ClinVar Annotator: match by null ClinVar PMID:17011878 , PMID:18055821 retinitis pigmentosa ISO RGD:68515 8554872 ClinVar Annotator: match by term: Retinitis pigmentosa ClinVar PMID:22025579 , PMID:28492532 retinitis pigmentosa ISO RGD:68515 8554872 ClinVar Annotator: match by term: Retinitis pigmentosa ClinVar PMID:30718709 retinitis pigmentosa ISO RGD:68515 8554872 ClinVar Annotator: match by term: Retinitis Pigmentosa, Recessive ClinVar PMID:25741868 retinitis pigmentosa ISO RGD:68515 8554872 ClinVar Annotator: match by term: Retinitis Pigmentosa, Recessive ClinVar PMID:28492532 retinitis pigmentosa ISO RGD:68515 8554872 ClinVar Annotator: match by OMIM:268000 ClinVar
Imported Annotations - CTD
celiac disease ISO RGD:68515 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30097691 Chemical and Drug Induced Liver Injury ISO RGD:68515 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25226513 Experimental Liver Cirrhosis ISO RGD:68515 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25380136 hepatocellular carcinoma ISO RGD:68515 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28284560 Hereditary Eye Diseases ISO RGD:68515 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16968212 Leber congenital amaurosis ISO RGD:68515 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19339306 Leber hereditary optic neuropathy ISO RGD:68515 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16250670 , PMID:17011878 retinitis pigmentosa ISO RGD:68515 11554173 CTD Direct Evidence: marker/mechanism CTD Vitamin A Deficiency ISO RGD:68515 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16174770 Imported Annotations - MGI
Leber congenital amaurosis 14 IEA 13592920 OMIM:613341 MouseDO Imported Annotations - OMIM
Leber congenital amaurosis 14 ISO RGD:68515 7240710 OMIM
(+)-schisandrin B multiple interactions ISO RGD:68362 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of LRAT mRNA] CTD PMID:31150632 1,1-dichloroethene decreases expression EXP 6480464 vinylidene chloride results in decreased expression of LRAT mRNA CTD PMID:26682919 1-naphthyl isothiocyanate decreases expression ISO RGD:68362 6480464 1-Naphthylisothiocyanate results in decreased expression of LRAT mRNA CTD PMID:25380136 17alpha-ethynylestradiol increases expression ISO RGD:68362 6480464 Ethinyl Estradiol results in increased expression of LRAT mRNA CTD PMID:17557909 17beta-estradiol multiple interactions ISO RGD:68515 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of LRAT mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO RGD:68362 6480464 Tetrachlorodibenzodioxin results in increased activity of LRAT protein CTD PMID:11097864 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:68362 6480464 Tetrachlorodibenzodioxin affects the expression of LRAT mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:68362 6480464 Tetrachlorodibenzodioxin results in increased expression of LRAT mRNA CTD PMID:12606150 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:68362 6480464 [Tetrachlorodibenzodioxin results in increased activity of LRAT protein] which results in increased chemical synthesis of Tretinoin CTD PMID:11097864 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of LRAT mRNA more ... CTD PMID:16292751 , PMID:25975270 2-bromohexadecanoic acid increases expression ISO RGD:68362 6480464 2-bromopalmitate results in increased expression of LRAT mRNA CTD PMID:12576510 4,4'-diaminodiphenylmethane decreases expression ISO RGD:68362 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of LRAT mRNA CTD PMID:25380136 , PMID:30723492 4,4'-sulfonyldiphenol increases expression EXP 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of LRAT mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of LRAT mRNA CTD PMID:28973697 aflatoxin B1 increases methylation ISO RGD:68515 6480464 Aflatoxin B1 results in increased methylation of LRAT gene CTD PMID:28458013 all-trans-retinoic acid increases expression ISO RGD:68515 6480464 Tretinoin results in increased expression of LRAT protein CTD PMID:15982314 all-trans-retinoic acid increases expression ISO RGD:68362 6480464 Tretinoin results in increased expression of LRAT mRNA CTD PMID:21138835 all-trans-retinoic acid decreases expression ISO RGD:68515 6480464 Tretinoin results in decreased expression of LRAT mRNA CTD PMID:21934132 all-trans-retinoic acid multiple interactions ISO RGD:68362 6480464 [Tetrachlorodibenzodioxin results in increased activity of LRAT protein] which results in increased chemical synthesis of Tretinoin CTD PMID:11097864 all-trans-retinol multiple interactions ISO RGD:68515 6480464 [STRA6 protein co-treated with LRAT protein] results in increased uptake of Vitamin A CTD PMID:18316031 all-trans-retinol decreases expression EXP 6480464 Vitamin A results in decreased expression of LRAT mRNA CTD PMID:30944279 all-trans-retinol affects expression ISO RGD:68362 6480464 Vitamin A affects the expression of LRAT mRNA CTD PMID:12576510 all-trans-retinol increases expression EXP 6480464 Vitamin A results in increased expression of LRAT mRNA CTD PMID:16292751 all-trans-retinol multiple interactions EXP 6480464 [Vitamin A co-treated with Tetrachlorodibenzodioxin] results in increased expression of LRAT mRNA, Tetrachlorodibenzodioxin inhibits the reaction [Vitamin A results in increased expression of LRAT mRNA] CTD PMID:16292751 ammonium chloride affects expression ISO RGD:68362 6480464 Ammonium Chloride affects the expression of LRAT mRNA CTD PMID:16483693 arachidonic acid increases expression ISO RGD:68362 6480464 Arachidonic Acid results in increased expression of LRAT mRNA CTD PMID:12576510 arotinoid acid increases expression ISO RGD:68362 6480464 4-(2-(5 more ... CTD PMID:12576510 benzo[a]pyrene increases expression ISO RGD:68515 6480464 Benzo(a)pyrene results in increased expression of LRAT mRNA CTD PMID:22316170 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of LRAT mRNA CTD PMID:22610609 beta-naphthoflavone multiple interactions ISO RGD:68362 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LRAT mRNA CTD PMID:18164116 bisphenol A multiple interactions ISO RGD:68362 6480464 [bisphenol A co-treated with Testosterone] results in decreased expression of LRAT mRNA CTD PMID:26496021 bisphenol A multiple interactions EXP 6480464 [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in decreased expression of CYP2C39 mRNA more ... CTD PMID:28123100 bisphenol A affects response to substance EXP 6480464 LRAT gene mutant form affects the susceptibility to bisphenol A CTD PMID:28123100 bisphenol A affects expression ISO RGD:68362 6480464 bisphenol A affects the expression of LRAT mRNA CTD PMID:25181051 buspirone decreases expression ISO RGD:68362 6480464 Buspirone results in decreased expression of LRAT mRNA CTD PMID:24136188 carbon nanotube affects expression EXP 6480464 Nanotubes, Carbon analog affects the expression of LRAT mRNA CTD PMID:25554681 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of LRAT mRNA, Nanotubes, Carbon results in decreased expression of LRAT mRNA CTD PMID:25554681 , PMID:25620056 chloroprene decreases expression EXP 6480464 Chloroprene results in decreased expression of LRAT mRNA CTD PMID:23125180 clorgyline increases expression ISO RGD:68515 6480464 Clorgyline results in increased expression of LRAT mRNA CTD PMID:19691856 cyproconazole decreases expression EXP 6480464 cyproconazole results in decreased expression of LRAT mRNA CTD PMID:22334560 dibenz[a,h]anthracene increases expression EXP 6480464 1 more ... CTD PMID:26377693 diethylstilbestrol increases expression ISO RGD:68362 6480464 Diethylstilbestrol results in increased expression of LRAT mRNA CTD PMID:21658437 dioxygen multiple interactions EXP 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of LRAT mRNA CTD PMID:30529165 dopamine increases expression ISO RGD:68362 6480464 Dopamine results in increased expression of LRAT mRNA CTD PMID:21983523 dorsomorphin multiple interactions ISO RGD:68515 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRAT mRNA CTD PMID:27188386 entinostat increases expression ISO RGD:68515 6480464 entinostat results in increased expression of LRAT mRNA CTD PMID:27188386 epoxiconazole decreases expression EXP 6480464 epoxiconazole results in decreased expression of LRAT mRNA CTD PMID:22334560 ethanol multiple interactions ISO RGD:68515 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of LRAT mRNA CTD PMID:23378141 ethanol increases expression ISO RGD:68515 6480464 Ethanol results in increased expression of LRAT mRNA CTD PMID:23378141 , PMID:28986285 fenoldopam increases expression ISO RGD:68362 6480464 Fenoldopam results in increased expression of LRAT mRNA CTD PMID:21983523 folic acid multiple interactions ISO RGD:68515 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of LRAT mRNA CTD PMID:23378141 furan increases expression ISO RGD:68362 6480464 furan results in increased expression of LRAT mRNA CTD PMID:25539665 more ... furan decreases methylation ISO RGD:68362 6480464 furan results in decreased methylation of LRAT gene CTD PMID:27387713 glafenine decreases expression ISO RGD:68362 6480464 Glafenine results in decreased expression of LRAT mRNA CTD PMID:24136188 isoprenaline decreases expression EXP 6480464 Isoproterenol results in decreased expression of LRAT mRNA CTD PMID:20003209 isotretinoin increases expression ISO RGD:68515 6480464 Isotretinoin results in increased expression of LRAT protein CTD PMID:15982314 linoleic acid increases expression ISO RGD:68362 6480464 Linoleic Acid results in increased expression of LRAT mRNA CTD PMID:12576510 manganese atom increases expression ISO RGD:68362 6480464 Manganese results in increased expression of LRAT mRNA CTD PMID:26745496 manganese(0) increases expression ISO RGD:68362 6480464 Manganese results in increased expression of LRAT mRNA CTD PMID:26745496 manganese(II) chloride increases expression ISO RGD:68362 6480464 manganese chloride results in increased expression of LRAT mRNA CTD PMID:26745496 N-nitrosodiethylamine increases response to substance EXP 6480464 LRAT protein results in increased susceptibility to Diethylnitrosamine CTD PMID:21278145 N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of LRAT mRNA CTD PMID:24535843 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of LRAT mRNA CTD PMID:24535843 N-nitrosodiethylamine multiple interactions ISO RGD:68362 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LRAT mRNA CTD PMID:18164116 N-nitrosodimethylamine decreases expression ISO RGD:68362 6480464 Dimethylnitrosamine results in decreased expression of LRAT mRNA CTD PMID:25380136 nefazodone decreases expression ISO RGD:68362 6480464 nefazodone results in decreased expression of LRAT mRNA CTD PMID:24136188 nickel sulfate decreases expression EXP 6480464 nickel sulfate results in decreased expression of LRAT mRNA CTD PMID:16100012 nimesulide decreases expression ISO RGD:68362 6480464 nimesulide results in decreased expression of LRAT mRNA CTD PMID:24136188 nitrofen increases expression ISO RGD:68362 6480464 nitrofen results in increased expression of LRAT protein CTD PMID:24972641 nitrofen decreases expression ISO RGD:68362 6480464 nitrofen results in decreased expression of LRAT mRNA CTD PMID:17203325 , PMID:26720608 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of LRAT mRNA CTD PMID:17562736 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:68515 6480464 perfluorooctane sulfonic acid results in decreased expression of LRAT mRNA CTD PMID:27153767 phenobarbital multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of LRAT mRNA CTD PMID:24535843 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of LRAT mRNA CTD PMID:23091169 phenylmercury acetate multiple interactions ISO RGD:68515 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRAT mRNA CTD PMID:27188386 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of LRAT mRNA CTD PMID:18445702 potassium dichromate affects expression EXP 6480464 Potassium Dichromate affects the expression of LRAT mRNA CTD PMID:23608068 propiconazole decreases expression EXP 6480464 propiconazole results in decreased expression of LRAT mRNA CTD PMID:22334560 retinyl acetate multiple interactions EXP 6480464 [LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in decreased expression of CYP2C39 mRNA more ... CTD PMID:24614237 , PMID:28123100 rotenone decreases expression ISO RGD:68362 6480464 Rotenone results in decreased expression of LRAT mRNA CTD PMID:28374803 SB 431542 multiple interactions ISO RGD:68515 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LRAT mRNA CTD PMID:27188386 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of LRAT mRNA CTD PMID:23221170 , PMID:29341224 silicon dioxide decreases expression ISO RGD:68515 6480464 Silicon Dioxide results in decreased expression of LRAT mRNA CTD PMID:25351596 sodium dichromate increases expression ISO RGD:68362 6480464 sodium bichromate results in increased expression of LRAT mRNA CTD PMID:22561333 sunitinib increases expression ISO RGD:68515 6480464 Sunitinib results in increased expression of LRAT mRNA CTD PMID:31533062 testosterone multiple interactions ISO RGD:68362 6480464 [bisphenol A co-treated with Testosterone] results in decreased expression of LRAT mRNA CTD PMID:26496021 tetrachloroethene increases expression EXP 6480464 Tetrachloroethylene results in increased expression of LRAT mRNA CTD PMID:28973375 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of LRAT mRNA CTD PMID:27339419 tetrachloromethane decreases expression ISO RGD:68362 6480464 Carbon Tetrachloride results in decreased expression of LRAT mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:68362 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of LRAT mRNA] CTD PMID:31150632 thioacetamide multiple interactions EXP 6480464 retinol acetate inhibits the reaction [LRAT gene mutant form results in decreased susceptibility to Thioacetamide] CTD PMID:24614237 thioacetamide decreases response to substance EXP 6480464 LRAT gene mutant form results in decreased susceptibility to Thioacetamide CTD PMID:24614237 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of LRAT mRNA CTD PMID:23409001 more ... titanium dioxide decreases expression ISO RGD:68362 6480464 titanium dioxide results in decreased expression of LRAT mRNA CTD PMID:30012374 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of LRAT mRNA CTD PMID:25549359 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of LRAT mRNA CTD PMID:28973375 triclosan decreases expression ISO RGD:68515 6480464 Triclosan results in decreased expression of LRAT mRNA CTD PMID:30510588 triphenyl phosphate decreases expression ISO RGD:68362 6480464 triphenyl phosphate results in decreased expression of LRAT mRNA CTD PMID:30589522 troglitazone increases expression ISO RGD:68362 6480464 troglitazone results in increased expression of LRAT mRNA CTD PMID:21515302 valdecoxib decreases expression ISO RGD:68362 6480464 valdecoxib results in decreased expression of LRAT mRNA CTD PMID:24136188 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of LRAT mRNA CTD PMID:17963808 valproic acid increases expression ISO RGD:68515 6480464 Valproic Acid results in increased expression of LRAT mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:68515 6480464 Valproic Acid affects the expression of LRAT mRNA CTD PMID:25979313 vinclozolin increases expression ISO RGD:68362 6480464 vinclozolin results in increased expression of LRAT mRNA CTD PMID:23034163 zaragozic acid A decreases expression ISO RGD:68362 6480464 squalestatin 1 results in decreased expression of LRAT mRNA CTD PMID:27225895 zaragozic acid A increases expression EXP 6480464 squalestatin 1 results in increased expression of LRAT mRNA CTD PMID:27225895
Biological Process 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process TAS 2290270 (MGI:MGI:1928450, PMID:11108736) MGI MGI:MGI:1928450 , PMID:11108736 cellular response to leukemia inhibitory factor IEP 2290270 (MGI:MGI:4822296, PMID:20439489) MGI MGI:MGI:4822296 , PMID:20439489 positive regulation of lipid transport IGI MGI:MGI:107742 , MGI:MGI:1921402 2290270 (MGI:MGI:5571260, PMID:23105095) MGI MGI:MGI:5571260 , PMID:23105095 response to bacterium IEP 2290270 (MGI:MGI:5448596, PMID:23012479) MGI MGI:MGI:5448596 , PMID:23012479 response to retinoic acid ISO RGD:68362 9068941 RGD PMID:19700416 , REF_RGD_ID:6484694 response to vitamin A ISO RGD:68362 9068941 RGD PMID:19700416 , REF_RGD_ID:6484694 retinol metabolic process IMP MGI:MGI:3038935 2290270 (MGI:MGI:3775853, PMID:18093970) MGI MGI:MGI:3775853 , PMID:18093970 retinol metabolic process IMP 2290270 (MGI:MGI:6414681, PMID:28758396) UniProt MGI:MGI:6414681 , PMID:28758396 retinol metabolic process ISO RGD:68362 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 retinol metabolic process ISO UniProtKB:O95237 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 retinol metabolic process IGI MGI:MGI:97879 2290270 (MGI:MGI:3775853, PMID:18093970) MGI MGI:MGI:3775853 , PMID:18093970 visual perception IEA UniProtKB-KW:KW-0844 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 vitamin A metabolic process IDA 2290270 (MGI:MGI:1928450, PMID:11108736) MGI MGI:MGI:1928450 , PMID:11108736 vitamin A metabolic process IMP 2290270 (MGI:MGI:6414681, PMID:28758396) UniProt MGI:MGI:6414681 , PMID:28758396 vitamin A metabolic process ISO RGD:68362 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Cellular Component cytoplasm IEA UniProtKB-KW:KW-0963 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 endoplasmic reticulum IDA 2290270 (MGI:MGI:6414681, PMID:28758396) UniProt MGI:MGI:6414681 , PMID:28758396 endosome IEA UniProtKB-KW:KW-0967 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 intracellular membrane-bounded organelle ISO RGD:68362 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 multivesicular body ISO RGD:68362 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 perinuclear region of cytoplasm ISO RGD:68362 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 rough endoplasmic reticulum ISO RGD:68362 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Molecular Function lecithin:11-cis retinol acyltransferase activity IEA EC:2.3.1.135 2290270 UniProtKB GO_REF:0000003, MGI:MGI:2152096 O-acyltransferase activity IDA 2290270 (MGI:MGI:1928450, PMID:11108736) MGI MGI:MGI:1928450 , PMID:11108736 phosphatidylcholine-retinol O-acyltransferase activity ISO UniProtKB:O95237 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 phosphatidylcholine-retinol O-acyltransferase activity IMP 2290270 (MGI:MGI:6414681, PMID:28758396) UniProt MGI:MGI:6414681 , PMID:28758396 phosphatidylcholine-retinol O-acyltransferase activity ISO RGD:68362 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein binding ISO UniProtKB:Q9Y320 9068941 (PMID:32296183) IntAct PMID:32296183 protein binding ISO UniProtKB:Q7Z5P4 9068941 (PMID:32296183) IntAct PMID:32296183 protein binding ISO UniProtKB:P62952 9068941 (PMID:32296183) IntAct PMID:32296183 retinoic acid binding ISO RGD:68362 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 retinol binding ISO RGD:68362 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 transferase activity IEA UniProtKB-KW:KW-0808 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 transferase activity, transferring acyl groups IEA UniProtKB-KW:KW-0012 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194
Gene-Chemical Interaction Annotations
