Lrat (lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lrat (lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)) Mus musculus
Analyze
Symbol: Lrat
Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
RGD ID: 68516
MGI Page MGI
Description: Enables phosphatidylcholine-retinol O-acyltransferase activity. Involved in retinol metabolic process. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of lipid transport; and vitamin A metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including extraembryonic component; gut; midbrain; reproductive system; and retina. Used to study Leber congenital amaurosis 14. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol acyltransferase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1300010A18Rik; AI449251; lecithin retinol acyltransferase; phosphatidylcholine--retinol O-acyltransferase; phosphatidylcholine-retinol-O-acyltransferase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,799,889 - 82,811,281 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,799,886 - 82,811,280 (-)EnsemblGRCm39 Ensembl
GRCm38382,892,582 - 82,903,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,892,579 - 82,903,973 (-)EnsemblGRCm38mm10GRCm38
MGSCv37382,696,504 - 82,707,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36382,978,509 - 82,989,901 (-)NCBIMGSCv36mm8
Celera382,903,193 - 82,914,568 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-bromohexadecanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
ammonium chloride  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buspirone  (ISO)
cadmium dichloride  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
clorgyline  (ISO)
cyproconazole  (EXP)
dibenz[a,h]anthracene  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
fenoldopam  (ISO)
fenthion  (EXP)
folic acid  (ISO)
folpet  (EXP)
furan  (ISO)
glafenine  (ISO)
glyphosate  (EXP)
iron dichloride  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
linoleic acid  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nickel sulfate  (EXP)
nimesulide  (ISO)
nitrofen  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
propiconazole  (EXP)
resveratrol  (ISO)
retinyl acetate  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
2. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Kiser PD, etal., Biochim Biophys Acta. 2012 Jan;1821(1):137-51. Epub 2011 Apr 5.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy. Thompson DA, etal., Nat Genet. 2001 Jun;28(2):123-4.
17. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Wright AF, etal., Nat Rev Genet. 2010 Apr;11(4):273-84. doi: 10.1038/nrg2717.
18. Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. Wu L and Ross AC, J Lipid Res. 2010 Feb;51(2):378-87. Epub 2009 Aug 20.
19. Lecithin:retinol acyltransferase from mouse and rat liver. CDNA cloning and liver-specific regulation by dietary vitamin a and retinoic acid. Zolfaghari R and Ross AC, J Lipid Res 2000 Dec;41(12):2024-34.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14681479   PMID:14684738   PMID:16115871   PMID:16141072   PMID:16141073   PMID:16174770   PMID:16216874  
PMID:16250670   PMID:16566595   PMID:16707424   PMID:16788071   PMID:16934000   PMID:17114808   PMID:17270348   PMID:17504753   PMID:18055784   PMID:18093970   PMID:18195010   PMID:18296659  
PMID:18348983   PMID:18400900   PMID:18455147   PMID:18606814   PMID:18713813   PMID:19304658   PMID:19339306   PMID:19471114   PMID:19549509   PMID:19665987   PMID:19812372   PMID:19901021  
PMID:20040693   PMID:20061533   PMID:20356843   PMID:20404157   PMID:20439489   PMID:20628054   PMID:20881313   PMID:21076393   PMID:21224384   PMID:21285397   PMID:21555576   PMID:21677750  
PMID:21873635   PMID:21925467   PMID:22116467   PMID:22531707   PMID:22637576   PMID:22739378   PMID:22918645   PMID:23012479   PMID:23105095   PMID:23221340   PMID:23249702   PMID:23349206  
PMID:23583843   PMID:23839944   PMID:23871845   PMID:23988655   PMID:24005908   PMID:24106281   PMID:24129572   PMID:24186946   PMID:24194600   PMID:24401276   PMID:24664772   PMID:24706832  
PMID:25317684   PMID:25416279   PMID:25602705   PMID:25721651   PMID:25974161   PMID:26062936   PMID:26139608   PMID:26387748   PMID:26405179   PMID:26876013   PMID:27084391   PMID:27462111  
PMID:27815220   PMID:28758396   PMID:29453250   PMID:30115683   PMID:31562240   PMID:32290105   PMID:32492112   PMID:32768676   PMID:35921818   PMID:35959865   PMID:36152631   PMID:36891060  
PMID:38355793  


Genomics

Comparative Map Data
Lrat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,799,889 - 82,811,281 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,799,886 - 82,811,280 (-)EnsemblGRCm39 Ensembl
GRCm38382,892,582 - 82,903,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,892,579 - 82,903,973 (-)EnsemblGRCm38mm10GRCm38
MGSCv37382,696,504 - 82,707,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36382,978,509 - 82,989,901 (-)NCBIMGSCv36mm8
Celera382,903,193 - 82,914,568 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.81NCBI
LRAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384154,740,838 - 154,753,120 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4154,626,945 - 154,753,120 (+)EnsemblGRCh38hg38GRCh38
GRCh374155,661,990 - 155,674,272 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,884,613 - 155,893,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 344156,022,767 - 156,031,875NCBI
Celera4152,996,143 - 153,005,248 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4151,405,746 - 151,414,958 (+)NCBIHuRef
CHM1_14155,643,059 - 155,652,147 (+)NCBICHM1_1
T2T-CHM13v2.04158,072,645 - 158,084,927 (+)NCBIT2T-CHM13v2.0
Lrat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82170,562,148 - 170,571,212 (-)NCBIGRCr8
mRatBN7.22168,264,093 - 168,273,155 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,266,877 - 168,273,619 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2175,454,144 - 175,463,229 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,475,076 - 173,484,161 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,076,492 - 168,085,579 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,896,304 - 181,905,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,896,305 - 181,905,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02201,310,924 - 201,319,986 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,636,382 - 174,645,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12174,586,488 - 174,595,550 (-)NCBI
Celera2162,290,825 - 162,299,887 (-)NCBICelera
Cytogenetic Map2q34NCBI
Lrat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554712,603,678 - 2,609,079 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554712,603,395 - 2,610,988 (+)NCBIChiLan1.0ChiLan1.0
LRAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23152,653,378 - 152,665,654 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14153,008,750 - 153,021,026 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04147,110,568 - 147,119,706 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14158,928,607 - 158,937,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4158,928,607 - 158,937,747 (+)Ensemblpanpan1.1panPan2
LRAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,399,773 - 52,409,590 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,399,544 - 52,406,176 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,744,532 - 52,752,466 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01553,086,516 - 53,094,290 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1553,087,735 - 53,096,027 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11552,341,249 - 52,349,017 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01552,447,030 - 52,454,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01552,762,096 - 52,769,963 (+)NCBIUU_Cfam_GSD_1.0
Lrat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,044,997 - 38,054,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365761,492,297 - 1,501,917 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365761,491,480 - 1,498,568 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,409,461 - 74,419,681 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1874,412,226 - 74,428,713 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,710,192 - 78,726,673 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,297,114 - 101,304,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,297,691 - 101,302,520 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603780,952,291 - 80,959,916 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248532,936,109 - 2,945,101 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248532,936,426 - 2,941,993 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1373
Count of miRNA genes:657
Interacting mature miRNAs:835
Transcripts:ENSMUST00000029632
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34949500583495118Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34949500583495118Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4935758183357581Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse

Markers in Region
BE197763  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38382,892,870 - 82,892,955UniSTSGRCm38
MGSCv37382,696,792 - 82,696,877UniSTSGRCm37
Celera382,903,481 - 82,903,566UniSTS
Cytogenetic Map3E3UniSTS
Whitehead/MRC_RH3824.37UniSTS
AI449251  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38382,896,612 - 82,896,717UniSTSGRCm38
MGSCv37382,700,534 - 82,700,639UniSTSGRCm37
Celera382,907,223 - 82,907,328UniSTS
Cytogenetic Map3E3UniSTS
Whitehead/MRC_RH3810.08UniSTS
Lrat  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3E3UniSTS
cM Map3 UniSTS
Lrat  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3E3UniSTS
Lrat  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3E3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000029632   ⟹   ENSMUSP00000029632
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl382,799,886 - 82,811,280 (-)Ensembl
GRCm38.p6 Ensembl382,892,579 - 82,903,973 (-)Ensembl
RefSeq Acc Id: NM_023624   ⟹   NP_076113
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39382,799,889 - 82,811,281 (-)NCBI
GRCm38382,892,582 - 82,903,974 (-)ENTREZGENE
MGSCv37382,696,504 - 82,707,896 (-)RGD
Celera382,903,193 - 82,914,568 (-)RGD
cM Map3 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_076113 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF97787 (Get FASTA)   NCBI Sequence Viewer  
  AAI41376 (Get FASTA)   NCBI Sequence Viewer  
  AAI41379 (Get FASTA)   NCBI Sequence Viewer  
  BAB23696 (Get FASTA)   NCBI Sequence Viewer  
  EDL15427 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000029632
  ENSMUSP00000029632.7
GenBank Protein Q9JI60 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_076113   ⟸   NM_023624
- UniProtKB: Q9JI60 (UniProtKB/Swiss-Prot),   B2RUR5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000029632   ⟸   ENSMUST00000029632
Protein Domains
LRAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JI60-F1-model_v2 AlphaFold Q9JI60 1-231 view protein structure

Promoters
RGD ID:6834041
Promoter ID:MM_KWN:34679
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000072001,   UC008PPB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36382,707,591 - 82,708,091 (-)MPROMDB
RGD ID:6880966
Promoter ID:EPDNEW_M3934
Type:multiple initiation site
Name:Lrat_1
Description:Mus musculus lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase), mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38382,903,972 - 82,904,032EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891259 AgrOrtholog
Ensembl Genes ENSMUSG00000028003 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029632 ENTREZGENE
  ENSMUST00000029632.7 UniProtKB/Swiss-Prot
Gene3D-CATH endopeptidase domain like (from Nostoc punctiforme) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LRAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRAT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:79235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1891259 ENTREZGENE
NCBI Gene Lrat ENTREZGENE
PANTHER LECITHIN RETINOL ACYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46678 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrat PhenoGen
PROSITE LRAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RUR5 ENTREZGENE, UniProtKB/TrEMBL
  LRAT_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Lrat  lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)  1300010A18Rik  RIKEN cDNA 1300010A18 gene  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 1300010A18Rik  RIKEN cDNA 1300010A18 gene  Lrat  lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)  Symbol and/or name change 5135510 APPROVED