RETINOID CYCLE METABOLIC PATHWAY (PW:0001005)

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Description

The retinoid cycle metabolic pathway, also known as the visual cycle, represents the set of enzymatic reactions underlying the regeneration of vitamin A derived chromophore 11-cis retinal which assures the continued visual phototransduction response to light. The chromophore is covalently bound to the G-protein coupled (GPCR) photoreceptors; the linkage is supplied by a protonated Schiff base to a lysine residue. In the absence of light 11-cis retinal acts as an inverse agonist by constraining t

Pathway Diagram:

Ariadne Genomics Inc. 11-cis-retinal --+> visual phototransduction pathway 11-cis-retinal ---> all-trans-retinal light 11-cis-retinal NADH NAD+ 11-cis-retinol retinyl ester phosphatidylcholine all-trans-retinol all-trans-retinal NADP+ NADPH ATP ADP Rho cone opsins visual phototransduction pathway Rlbp1 11-cis-retinal ---- Rlbp1 Rbp1 Lrat Rpe65 NAD+ ---> NADH 11-cis-retinol ---> 11-cis-retinal NADPH ---> NADP+ all-trans-retinal ---> all-trans-retinol Abca4 ATP ---> ADP light --+> 11-cis-retinal all-trans-retinol ---> retinyl ester Rdh8 Rdh12 Abca4 ---> all-trans-retinal Abca4 ---- all-trans-retinal retinyl ester ---> 11-cis-retinol all-trans-retinol ---- Rbp1 11-cis-retinal ---- Rho 11-cis-retinal ---- cone opsins Rdh10 Rdh11 Rdh5 all-trans-retinol ---- Rbp3 Rbp3 phosphatidylcholine ---> retinyl ester
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Genes in Pathway:

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retinoid cycle metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca4 ATP binding cassette subfamily A member 4 JBrowse link 2 225,645,539 225,783,288 RGD:6893650
G Lrat lecithin retinol acyltransferase JBrowse link 2 181,896,304 181,905,366 RGD:6893650
G Opn1mw opsin 1, medium wave sensitive JBrowse link X 156,569,683 156,589,907 RGD:6893536
G Opn1sw opsin 1, short wave sensitive JBrowse link 4 56,653,840 56,656,980 RGD:6893536
G Rbp1 retinol binding protein 1 JBrowse link 8 106,449,321 106,470,842 RGD:6893650
G Rbp3 retinol binding protein 3 JBrowse link 16 10,277,775 10,286,243 RGD:6893650
G Rdh10 retinol dehydrogenase 10 JBrowse link 5 2,605,265 2,631,905 RGD:6893650
G Rdh11 retinol dehydrogenase 11 JBrowse link 6 102,356,498 102,372,618 RGD:6893650
G Rdh12 retinol dehydrogenase 12 JBrowse link 6 102,392,828 102,405,750 RGD:6893650
G Rdh5 retinol dehydrogenase 5 JBrowse link 7 3,335,681 3,342,573 RGD:6893650
G Rdh8 retinol dehydrogenase 8 JBrowse link 8 21,835,065 21,842,374 RGD:6893650
G Rho rhodopsin JBrowse link 4 147,832,136 147,837,298 RGD:6893536
G Rlbp1 retinaldehyde binding protein 1 JBrowse link 1 141,097,789 141,111,375 RGD:6903223
G Rpe65 RPE65, retinoid isomerohydrolase JBrowse link 2 266,141,581 266,169,197 RGD:6893650
RGD:6893661
altered retinoid cycle metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca4 ATP binding cassette subfamily A member 4 JBrowse link 2 225,645,539 225,783,288 RGD:8547536
G Lrat lecithin retinol acyltransferase JBrowse link 2 181,896,304 181,905,366 RGD:8547536
G Rbp3 retinol binding protein 3 JBrowse link 16 10,277,775 10,286,243 RGD:8547536
G Rdh12 retinol dehydrogenase 12 JBrowse link 6 102,392,828 102,405,750 RGD:8547536
G Rlbp1 retinaldehyde binding protein 1 JBrowse link 1 141,097,789 141,111,375 RGD:8547536
G Rpe65 RPE65, retinoid isomerohydrolase JBrowse link 2 266,141,581 266,169,197 RGD:8547536

Pathway Gene Annotations

Disease Annotations Associated with Genes in the retinoid cycle metabolic pathway
Disease TermsGene Symbols
age related macular degenerationAbca4
age related macular degeneration 2Abca4
Animal Mammary NeoplasmsRbp1
atrial fibrillationOpn1sw
Autoimmune DiseasesRbp3
basal cell carcinomaRpe65
blindnessAbca4 , Rpe65
blue color blindnessOpn1sw
blue cone monochromacyOpn1mw
Bothnia retinal dystrophyRlbp1
breast ductal carcinomaLrat
carcinomaRbp1
Chemical and Drug Induced Liver InjuryLrat , Rbp1
cleft lipAbca4
Coats diseaseRho
Colorectal NeoplasmsAbca4
cone dystrophyAbca4
cone-rod dystrophyAbca4 , Rpe65
cone-rod dystrophy 3Abca4
Congenital AbnormalitiesRdh5
congenital stationary night blindnessAbca4 , Rbp3 , Rho
congenital stationary night blindness autosomal dominant 1Rho
Craniofacial AbnormalitiesRdh10
Diabetes Mellitus, Experimental Rpe65
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsOpn1mw
Experimental Autoimmune UveitisRpe65
Experimental Liver CirrhosisLrat , Rdh10
eye diseaseRdh12
Fetal DeathRdh10
Fetal Growth RetardationRbp1
fundus albipunctatusRdh5 , Rho , Rlbp1
fundus dystrophyAbca4 , Lrat , Rbp3 , Rdh12 , Rdh5 , Rlbp1 , Rpe65
genetic diseaseAbca4
Hereditary Eye DiseasesLrat , Rlbp1 , Rpe65
Leber congenital amaurosisAbca4 , Lrat , Rbp1 , Rdh12 , Rpe65
Leber congenital amaurosis 13Rdh12
Leber congenital amaurosis 14Lrat
Leber congenital amaurosis 2Rpe65
Leber congenital amaurosis 3Rdh12
Leber hereditary optic neuropathyLrat , Rdh12 , Rpe65
macular degenerationAbca4
Macular Dystrophy, Concentric AnnularAbca4
Mammary Neoplasms, ExperimentalRbp1
Mandibulofacial Dysostosis with Mental DeficiencyAbca4
myopiaRdh5
neuritisAbca4
neuropathyAbca4
Newfoundland cone-rod dystrophyRlbp1
night blindnessRdh5 , Rho , Rlbp1
peripheral nervous system diseaseAbca4
pleomorphic xanthoastrocytomaOpn1sw
red-green color blindnessOpn1mw
retinal degenerationAbca4 , Rdh12 , Rho , Rpe65
retinal diseaseAbca4
Retinal Dystrophy, Early Onset SevereAbca4
Retinal Dystrophy, Juvenile Cataracts, and Short Stature SyndromeRdh11
retinitis pigmentosaAbca4 , Lrat , Rbp3 , Rdh12 , Rho , Rlbp1 , Rpe65
retinitis pigmentosa 19Abca4
retinitis pigmentosa 20Rpe65
retinitis pigmentosa 4Rho
retinitis pigmentosa 66Rbp3
squamous cell carcinomaRpe65
Stargardt diseaseAbca4
Stargardt Disease 1Abca4
Stomach NeoplasmsRbp1
uveitisRbp3
Vision DisordersAbca4
Vitamin A DeficiencyLrat
Pathway Annotations Associated with Genes in the retinoid cycle metabolic pathway

References Associated with the retinoid cycle metabolic pathway:

Ontology Path Diagram:

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