RETINOID CYCLE METABOLIC PATHWAY (PW:0001005)

View Ontology Report

Description

The retinoid cycle metabolic pathway, also known as the visual cycle, represents the set of enzymatic reactions underlying the regeneration of vitamin A derived chromophore 11-cis retinal which assures the continued visual phototransduction response to light. The chromophore is covalently bound to the G-protein coupled (GPCR) photoreceptors; the linkage is supplied by a protonated Schiff base to a lysine residue. In the absence of light 11-cis retinal acts as an inverse agonist by constraining t

Pathway Diagram:

Ariadne Genomics Inc. 11-cis-retinal --+> visual phototransduction pathway 11-cis-retinal ---> all-trans-retinal light 11-cis-retinal NADH NAD+ 11-cis-retinol retinyl ester phosphatidylcholine all-trans-retinol all-trans-retinal NADP+ NADPH ATP ADP Rho cone opsins visual phototransduction pathway Rlbp1 11-cis-retinal ---- Rlbp1 Rbp1 Lrat Rpe65 NAD+ ---> NADH 11-cis-retinol ---> 11-cis-retinal NADPH ---> NADP+ all-trans-retinal ---> all-trans-retinol Abca4 ATP ---> ADP light --+> 11-cis-retinal all-trans-retinol ---> retinyl ester Rdh8 Rdh12 Abca4 ---> all-trans-retinal Abca4 ---- all-trans-retinal retinyl ester ---> 11-cis-retinol all-trans-retinol ---- Rbp1 11-cis-retinal ---- Rho 11-cis-retinal ---- cone opsins Rdh10 Rdh11 Rdh5 all-trans-retinol ---- Rbp3 Rbp3 phosphatidylcholine ---> retinyl ester
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
retinoid cycle metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca4 ATP binding cassette subfamily A member 4 JBrowse link 2 225,645,539 225,783,288 RGD:6893650
G Lrat lecithin retinol acyltransferase JBrowse link 2 181,896,304 181,905,366 RGD:6893650
G Opn1mw opsin 1, medium wave sensitive JBrowse link X 156,569,683 156,589,907 RGD:6893536
G Opn1sw opsin 1, short wave sensitive JBrowse link 4 56,653,840 56,656,980 RGD:6893536
G Rbp1 retinol binding protein 1 JBrowse link 8 106,449,321 106,470,842 RGD:6893650
G Rbp3 retinol binding protein 3 JBrowse link 16 10,277,775 10,286,243 RGD:6893650
G Rdh10 retinol dehydrogenase 10 JBrowse link 5 2,605,265 2,631,905 RGD:6893650
G Rdh11 retinol dehydrogenase 11 JBrowse link 6 102,356,498 102,372,618 RGD:6893650
G Rdh12 retinol dehydrogenase 12 JBrowse link 6 102,392,828 102,405,750 RGD:6893650
G Rdh5 retinol dehydrogenase 5 JBrowse link 7 3,335,681 3,342,573 RGD:6893650
G Rdh8 retinol dehydrogenase 8 JBrowse link 8 21,835,065 21,842,374 RGD:6893650
G Rho rhodopsin JBrowse link 4 147,832,136 147,837,298 RGD:6893536
G Rlbp1 retinaldehyde binding protein 1 JBrowse link 1 141,097,789 141,111,375 RGD:6903223
G Rpe65 RPE65, retinoid isomerohydrolase JBrowse link 2 266,141,581 266,169,197 RGD:6893650
RGD:6893661
altered retinoid cycle metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca4 ATP binding cassette subfamily A member 4 JBrowse link 2 225,645,539 225,783,288 RGD:8547536
G Lrat lecithin retinol acyltransferase JBrowse link 2 181,896,304 181,905,366 RGD:8547536
G Rbp3 retinol binding protein 3 JBrowse link 16 10,277,775 10,286,243 RGD:8547536
G Rdh12 retinol dehydrogenase 12 JBrowse link 6 102,392,828 102,405,750 RGD:8547536
G Rlbp1 retinaldehyde binding protein 1 JBrowse link 1 141,097,789 141,111,375 RGD:8547536
G Rpe65 RPE65, retinoid isomerohydrolase JBrowse link 2 266,141,581 266,169,197 RGD:8547536

Pathway Gene Annotations

Disease Annotations Associated with Genes in the retinoid cycle metabolic pathway
Disease TermsGene Symbols
age related macular degeneration 2Abca4
Autoimmune DiseasesRbp3
basal cell carcinomaRpe65
blindnessAbca4 , Rpe65
blue color blindnessOpn1sw
blue cone monochromacyOpn1mw
Bothnia retinal dystrophyRlbp1
breast ductal carcinomaLrat
carcinomaRbp1
Chemical and Drug Induced Liver InjuryLrat , Rbp1
cleft lipAbca4
Coats diseaseRho
Colorectal NeoplasmsAbca4
cone dystrophyAbca4
cone-rod dystrophyAbca4
cone-rod dystrophy 3Abca4
Congenital AbnormalitiesRdh5
congenital stationary night blindnessAbca4 , Rbp3 , Rho
congenital stationary night blindness autosomal dominant 1Rho
Craniofacial AbnormalitiesRdh10
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsOpn1mw
Experimental Autoimmune UveitisRpe65
Experimental Diabetes MellitusRpe65
Experimental Liver CirrhosisLrat , Rdh10
eye diseaseRdh12
Fetal DeathRdh10
Fetal Growth RetardationRbp1
fundus albipunctatusRdh5 , Rho , Rlbp1
fundus dystrophyAbca4 , Lrat , Rbp3 , Rdh12 , Rdh5 , Rlbp1 , Rpe65
genetic diseaseAbca4
Hereditary Eye DiseasesLrat , Rlbp1 , Rpe65
Leber congenital amaurosisAbca4 , Lrat , Rbp1 , Rdh12 , Rpe65
Leber congenital amaurosis 13Rdh12
Leber congenital amaurosis 14Lrat
Leber congenital amaurosis 2Rpe65
Leber congenital amaurosis 3Rdh12
Leber hereditary optic neuropathyLrat , Rdh12 , Rpe65
macular degenerationAbca4
Macular Dystrophy, Concentric AnnularAbca4
Mammary Neoplasms, AnimalRbp1
Mammary Neoplasms, ExperimentalRbp1
Mandibulofacial Dysostosis with Mental DeficiencyAbca4
myopiaRdh5
neuritisAbca4
Newfoundland cone-rod dystrophyRlbp1
night blindnessRdh5 , Rho , Rlbp1
peripheral nervous system diseaseAbca4
pleomorphic xanthoastrocytomaOpn1sw
red-green color blindnessOpn1mw
retinal degenerationAbca4 , Rdh12 , Rho , Rpe65
retinal diseaseAbca4
Retinal Dystrophy, Early Onset SevereAbca4
Retinal Dystrophy, Juvenile Cataracts, and Short Stature SyndromeRdh11
retinitis pigmentosaAbca4 , Lrat , Rbp3 , Rdh12 , Rho , Rlbp1 , Rpe65
retinitis pigmentosa 19Abca4
retinitis pigmentosa 20Rpe65
retinitis pigmentosa 4Rho
retinitis pigmentosa 66Rbp3
squamous cell carcinomaRpe65
Stargardt diseaseAbca4
Stargardt Disease 1Abca4
Stomach NeoplasmsRbp1
uveitisRbp3
Vision DisordersAbca4
Vitamin A DeficiencyLrat
Pathway Annotations Associated with Genes in the retinoid cycle metabolic pathway

References Associated with the retinoid cycle metabolic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: