LRAT (lecithin retinol acyltransferase) - Rat Genome Database

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Gene: LRAT (lecithin retinol acyltransferase) Chlorocebus sabaeus
Analyze
Symbol: LRAT
Name: lecithin retinol acyltransferase
RGD ID: 18574285
Description: ENCODES a protein that exhibits phosphatidylcholine-retinol O-acyltransferase activity (ortholog); retinoic acid binding (ortholog); retinol binding (ortholog); INVOLVED IN response to retinoic acid (ortholog); response to vitamin A (ortholog); retinol metabolic process (ortholog); PARTICIPATES IN altered retinoid cycle metabolic pathway; retinitis pigmentosa pathway; retinoic acid metabolic pathway; ASSOCIATED WITH breast ductal carcinoma (ortholog); celiac disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN multivesicular body (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,297,114 - 101,304,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,297,691 - 101,302,520 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603780,952,291 - 80,959,916 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LRATGreen Monkeybreast ductal carcinoma  ISORGD:685158554872ClinVar Annotator: match by term: Ductal breast carcinomaClinVar 
LRATGreen Monkeycone-rod dystrophy  ISORGD:685158554872ClinVar Annotator: match by term: Rod-cone dystrophyClinVarPMID:25741868
LRATGreen MonkeyEye Abnormalities  ISORGD:685158554872ClinVar Annotator: match by term: Abnormality of the eyeClinVarPMID:25741868
LRATGreen Monkeyfundus dystrophy  ISORGD:685158554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:21217109|PMID:22559933|PMID:24265693|PMID:25741868|PMID:28492532|PMID:3144818
LRATGreen Monkeygenetic disease  ISORGD:685158554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868|PMID:28492532
LRATGreen Monkeyinvasive ductal carcinoma  ISORGD:685158554872ClinVar Annotator: match by term: Breast cancer, invasive ductalClinVar 
LRATGreen MonkeyLeber congenital amaurosis  ISORGD:685158554872ClinVar Annotator: match by term: Leber congenital amaurosisClinVarPMID:24033266|PMID:25741868|PMID:28492532|PMID:37510321
LRATGreen MonkeyLeber congenital amaurosis 1  ISORGD:685158554872ClinVar Annotator: match by term: Leber congenital amaurosis 1ClinVarPMID:25324289|PMID:25472526|PMID:25741868|PMID:28492532|PMID:29186038|PMID:29844330|PMID:30190494|PMID:32865313
LRATGreen MonkeyLeber congenital amaurosis 14  ISORGD:685158554872ClinVar Annotator: match by term: LRAT-related condition | ClinVar Annotator: match by term: Leber congenital more ...ClinVarPMID:11381255|PMID:17011878|PMID:18055821|PMID:22025579|PMID:22559933|PMID:22570351|PMID:24265693|PMID:25741868|PMID:26656277|PMID:27854360|PMID:28492532|PMID:29186038|PMID:30054919|PMID:32865313|PMID:34828430
LRATGreen Monkeyretinitis pigmentosa  ISORGD:685158554872ClinVar Annotator: match by term: Autosomal recessive retinitis pigmentosa | ClinVar Annotator: match by term: more ...ClinVarPMID:22025579|PMID:25324289|PMID:25741868|PMID:26355662|PMID:28492532|PMID:29844330|PMID:30054919|PMID:30190494|PMID:30718709
1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LRATGreen Monkeyceliac disease  ISORGD:685159068941CTD Direct Evidence: marker/mechanismCTDPMID:30097691
LRATGreen MonkeyChemical and Drug Induced Liver Injury  ISORGD:685159068941CTD Direct Evidence: marker/mechanismCTDPMID:25226513
LRATGreen MonkeyExperimental Liver Cirrhosis  ISORGD:685159068941CTD Direct Evidence: marker/mechanismCTDPMID:25380136
LRATGreen Monkeyhepatocellular carcinoma  ISORGD:685159068941CTD Direct Evidence: marker/mechanismCTDPMID:28284560
LRATGreen MonkeyHereditary Eye Diseases  ISORGD:685159068941CTD Direct Evidence: marker/mechanismCTDPMID:16968212
LRATGreen MonkeyLeber hereditary optic neuropathy  ISORGD:685159068941CTD Direct Evidence: marker/mechanismCTDPMID:16250670|PMID:17011878
LRATGreen MonkeyVitamin A Deficiency  ISORGD:685159068941CTD Direct Evidence: marker/mechanismCTDPMID:16174770
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LRATGreen MonkeyLeber congenital amaurosis 14  ISORGD:685157240710 OMIM 


Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LRATGreen Monkeycellular response to leukemia inhibitory factor acts_upstream_of_or_withinIEAUniProtKB:Q9JI60|ensembl:ENSMUSP00000029632150520179 EnsemblGO_REF:0000107
LRATGreen Monkeylipid storage involved_inIEAUniProtKB:Q9JI60|ensembl:ENSMUSP00000029632150520179 EnsemblGO_REF:0000107
LRATGreen Monkeypositive regulation of lipid transport acts_upstream_of_or_withinIEAUniProtKB:Q9JI60|ensembl:ENSMUSP00000029632150520179 EnsemblGO_REF:0000107
LRATGreen Monkeyresponse to bacterium acts_upstream_of_or_withinIEAUniProtKB:Q9JI60|ensembl:ENSMUSP00000029632150520179 EnsemblGO_REF:0000107
LRATGreen Monkeyresponse to retinoic acid  ISORGD:683629068941 RGDPMID:19700416|REF_RGD_ID:6484694
LRATGreen Monkeyresponse to vitamin A  ISORGD:683629068941 RGDPMID:19700416|REF_RGD_ID:6484694
LRATGreen Monkeyretinoid metabolic process involved_inIEAUniProtKB:Q9JI60|ensembl:ENSMUSP00000029632150520179 EnsemblGO_REF:0000107
LRATGreen Monkeyretinol metabolic process involved_inIEAPANTHER:PTN000358774150520179 TreeGrafterGO_REF:0000118
LRATGreen Monkeyretinol metabolic process involved_inIEAUniProtKB:O95237|ensembl:ENSP00000337224150520179 EnsemblGO_REF:0000107
LRATGreen Monkeyretinol metabolic process involved_inIEAInterPro:IPR042288150520179 InterProGO_REF:0000002
LRATGreen Monkeyretinol metabolic process acts_upstream_of_or_withinIEAUniProtKB:Q9JI60|ensembl:ENSMUSP00000029632150520179 EnsemblGO_REF:0000107
LRATGreen Monkeyretinol metabolic process  ISORGD:683629068941 RGDPMID:14642897|PMID:2253789|PMID:8460936|PMID:9244401|REF_RGD_ID:1599829|REF_RGD_ID:1599831|REF_RGD_ID:1599832|REF_RGD_ID:6484737
LRATGreen Monkeyvitamin A metabolic process involved_inIEAPANTHER:PTN000358774150520179 TreeGrafterGO_REF:0000118
LRATGreen Monkeyvitamin A metabolic process acts_upstream_of_or_withinIEAUniProtKB:Q9JI60|ensembl:ENSMUSP00000029632150520179 EnsemblGO_REF:0000107
1 to 14 of 14 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LRATGreen Monkeyendoplasmic reticulum located_inIEAUniProtKB:Q9JI60|ensembl:ENSMUSP00000029632150520179 EnsemblGO_REF:0000107
LRATGreen Monkeymembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
LRATGreen Monkeymultivesicular body located_inISORGD:683629068941PMID:18544127UniProtPMID:18544127|REF_RGD_ID:6893660
LRATGreen Monkeymultivesicular body  ISORGD:683629068941 RGDPMID:18544127|REF_RGD_ID:6893660
LRATGreen Monkeyperinuclear region of cytoplasm  ISORGD:683629068941 RGDPMID:18544127|REF_RGD_ID:6893660
LRATGreen Monkeyperinuclear region of cytoplasm located_inISORGD:683629068941PMID:18544127UniProtPMID:18544127|REF_RGD_ID:6893660
LRATGreen Monkeyrough endoplasmic reticulum located_inIEAPANTHER:PTN000358774150520179 TreeGrafterGO_REF:0000118

Molecular Function
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LRATGreen MonkeyO-acyltransferase activity enablesIEAUniProtKB:Q9JI60|ensembl:ENSMUSP00000029632150520179 EnsemblGO_REF:0000107
LRATGreen MonkeyO-palmitoyltransferase activity enablesIEAUniProtKB:Q9JI60|ensembl:ENSMUSP00000029632150520179 EnsemblGO_REF:0000107
LRATGreen Monkeyphosphatidylcholine-retinol O-acyltransferase activity  ISORGD:683629068941 RGDPMID:14642897|PMID:2253789|PMID:8460936|PMID:9244401|REF_RGD_ID:1599829|REF_RGD_ID:1599831|REF_RGD_ID:1599832|REF_RGD_ID:6484737
LRATGreen Monkeyphosphatidylcholine-retinol O-acyltransferase activity enablesIEAUniProtKB:O95237|UniProtKB:Q9JI60|ensembl:ENSMUSP00000029632|ensembl:ENSP00000337224150520179 EnsemblGO_REF:0000107
LRATGreen Monkeyphosphatidylcholine-retinol O-acyltransferase activity enablesIEAInterPro:IPR042288150520179 InterProGO_REF:0000002
LRATGreen Monkeyphosphatidylcholine-retinol O-acyltransferase activity enablesIEAPANTHER:PTN000358774150520179 TreeGrafterGO_REF:0000118
LRATGreen Monkeyprotein binding enablesISOUniProtKB:O603619068941 PMID:28514442, PMID:33961781IntActPMID:28514442|PMID:33961781
LRATGreen Monkeyprotein binding enablesISOUniProtKB:P62952|UniProtKB:Q7Z5P4|UniProtKB:Q9Y3209068941 PMID:32296183IntActPMID:32296183
LRATGreen Monkeyretinoic acid binding  ISORGD:683629068941 RGDPMID:8460936|PMID:9244401|REF_RGD_ID:1599831|REF_RGD_ID:1599832
LRATGreen Monkeyretinol binding  ISORGD:683629068941 RGDPMID:2253789|PMID:8460936|PMID:9244401|REF_RGD_ID:1599829|REF_RGD_ID:1599831|REF_RGD_ID:1599832
1 to 10 of 10 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LRATGreen Monkeyaltered retinoid cycle metabolic pathway   ISORGD:685159068941 RGDPMID:20212494|REF_RGD_ID:8547536
LRATGreen Monkeyretinitis pigmentosa pathway   ISORGD:685159068941 RGDPMID:23701314|REF_RGD_ID:8547535
LRATGreen Monkeyretinoic acid metabolic pathway   ISORGD:685159068941 RGDPMID:21621639|REF_RGD_ID:6484672
LRATGreen Monkeyretinoid cycle metabolic pathway   ISORGD:685159068941 RGDPMID:21447403|REF_RGD_ID:6893650
LRATGreen Monkeyretinol metabolic pathway   ISORGD:685159068941 RGDPMID:21718801|REF_RGD_ID:6484679
LRATGreen Monkeyretinol metabolic pathway   ISORGD:683629068941 RGDPMID:21718801|REF_RGD_ID:6484679

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LRATGreen Monkeyretinol metabolic pathway   ISORGD:685159068941 SMPDBSMP:00074
LRATGreen Monkeyvitamin A deficiency pathway  ISORGD:685159068941 SMPDBSMP:00336
PMID:30032202  



LRAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,297,114 - 101,304,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,297,691 - 101,302,520 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603780,952,291 - 80,959,916 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LRAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384154,740,838 - 154,753,120 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4154,626,945 - 154,753,120 (+)EnsemblGRCh38hg38GRCh38
GRCh374155,661,990 - 155,674,272 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,884,613 - 155,893,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 344156,022,767 - 156,031,875NCBI
Celera4152,996,143 - 153,005,248 (+)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4151,405,746 - 151,414,958 (+)NCBIHuRef
CHM1_14155,643,059 - 155,652,147 (+)NCBICHM1_1
T2T-CHM13v2.04158,072,645 - 158,084,927 (+)NCBIT2T-CHM13v2.0
Lrat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,799,889 - 82,811,281 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,799,886 - 82,811,280 (-)EnsemblGRCm39 Ensembl
GRCm38382,892,582 - 82,903,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl382,892,579 - 82,903,973 (-)EnsemblGRCm38mm10GRCm38
MGSCv37382,696,504 - 82,707,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36382,978,509 - 82,989,901 (-)NCBIMGSCv36mm8
Celera382,903,193 - 82,914,568 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.81NCBI
Lrat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82170,562,148 - 170,571,212 (-)NCBIGRCr8
mRatBN7.22168,264,093 - 168,273,155 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,266,877 - 168,273,619 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2175,454,144 - 175,463,229 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,475,076 - 173,484,161 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,076,492 - 168,085,579 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,896,304 - 181,905,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2181,896,305 - 181,905,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02201,310,924 - 201,319,986 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,636,382 - 174,645,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12174,586,488 - 174,595,550 (-)NCBI
Celera2162,290,825 - 162,299,887 (-)NCBICelera
Cytogenetic Map2q34NCBI
Lrat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554712,603,678 - 2,609,079 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554712,603,395 - 2,610,988 (+)NCBIChiLan1.0ChiLan1.0
LRAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23152,653,378 - 152,665,654 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14153,008,750 - 153,021,026 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04147,110,568 - 147,119,706 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14158,928,607 - 158,937,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4158,928,607 - 158,937,747 (+)Ensemblpanpan1.1panPan2
LRAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,399,773 - 52,409,590 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,399,544 - 52,406,176 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,744,532 - 52,752,466 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01553,086,516 - 53,094,290 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1553,087,735 - 53,096,027 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11552,341,249 - 52,349,017 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01552,447,030 - 52,454,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01552,762,096 - 52,769,963 (+)NCBIUU_Cfam_GSD_1.0
Lrat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,044,997 - 38,054,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365761,492,297 - 1,501,917 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365761,491,480 - 1,498,568 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,409,461 - 74,419,681 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1874,412,226 - 74,428,713 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,710,192 - 78,726,673 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Lrat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248532,936,109 - 2,945,101 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248532,936,426 - 2,941,993 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in LRAT
123 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
68 28 17 25 25 60 20


RefSeq Transcripts XM_008000058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037993123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JBLKOC010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000001290   ⟹   ENSCSAP00000014784
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl7101,297,691 - 101,302,520 (+)Ensembl
RefSeq Acc Id: XM_037993123   ⟹   XP_037849051
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603780,952,291 - 80,959,916 (+)NCBI
Protein RefSeqs XP_037849051 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000014784.1
Ensembl Acc Id: ENSCSAP00000014784   ⟸   ENSCSAT00000001290
RefSeq Acc Id: XP_037849051   ⟸   XM_037993123



1 to 12 of 12 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000003265 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001290.1 UniProtKB/TrEMBL
Gene3D-CATH endopeptidase domain like (from Nostoc punctiforme) UniProtKB/TrEMBL
InterPro LRAT UniProtKB/TrEMBL
  LRAT_dom UniProtKB/TrEMBL
KEGG Report csab:103236423 UniProtKB/TrEMBL
NCBI Gene LRAT ENTREZGENE
PANTHER LECITHIN RETINOL ACYLTRANSFERASE UniProtKB/TrEMBL
  PTHR46678 UniProtKB/TrEMBL
Pfam LRAT UniProtKB/TrEMBL
PROSITE LRAT UniProtKB/TrEMBL
UniProt A0A0D9S1P5_CHLSB UniProtKB/TrEMBL
1 to 12 of 12 rows