MPO (myeloperoxidase) - Rat Genome Database

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Gene: MPO (myeloperoxidase) Chlorocebus sabaeus
Analyze
Symbol: MPO
Name: myeloperoxidase
RGD ID: 18540969
Description: ENCODES a protein that exhibits peroxidase activity (ortholog); INVOLVED IN defense response to fungus (ortholog); defense response to Gram-positive bacterium (ortholog); hydrogen peroxide catabolic process (ortholog); PARTICIPATES IN etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; interleukin-23 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); alcoholic liver cirrhosis (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11635,120,194 - 35,130,851 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1635,120,581 - 35,130,671 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660775,935,107 - 5,946,375 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
bacterial pneumonia  (ISO)
brain disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cardiovascular system disease  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
Contrast-Induced Nephropathy  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
Drug Eruptions  (ISO)
end stage renal disease  (ISO)
Enteritis  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
extrahepatic cholestasis  (ISO)
glomerulonephritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
interstitial lung disease  (ISO)
Joubert syndrome 1  (ISO)
keratosis  (ISO)
Kidney Calculi  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
major depressive disorder  (ISO)
Myeloperoxidase Deficiency  (ISO)
Myocardial Ischemia  (ISO)
Occupational Diseases  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
pleurisy  (ISO)
pre-malignant neoplasm  (ISO)
Prostatic Neoplasms  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
status asthmaticus  (ISO)
Systemic Candidiasis  (ISO)
traumatic brain injury  (ISO)
trichuriasis  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
vasculitis  (ISO)
Viral Bronchiolitis  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11635,120,194 - 35,130,851 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1635,120,581 - 35,130,671 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660775,935,107 - 5,946,375 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381758,269,855 - 58,280,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,269,855 - 58,280,935 (-)EnsemblGRCh38hg38GRCh38
GRCh371756,347,216 - 56,358,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,702,216 - 53,713,295 (-)NCBINCBI36Build 36hg18NCBI36
Build 341753,702,215 - 53,713,295NCBI
Celera1752,808,995 - 52,820,066 (-)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1751,708,013 - 51,718,966 (-)NCBIHuRef
CHM1_11756,412,238 - 56,423,315 (-)NCBICHM1_1
T2T-CHM13v2.01759,137,736 - 59,148,814 (-)NCBIT2T-CHM13v2.0
Mpo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,684,610 - 87,695,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,684,407 - 87,695,239 (+)EnsemblGRCm39 Ensembl
GRCm381187,793,784 - 87,804,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,793,581 - 87,804,413 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,607,286 - 87,617,914 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,609,776 - 87,620,592 (+)NCBIMGSCv36mm8
Celera1197,389,547 - 97,400,150 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.22NCBI
Mpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81073,092,124 - 73,102,057 (+)NCBIGRCr8
mRatBN7.21072,594,883 - 72,608,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,594,661 - 72,604,819 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1077,205,622 - 77,215,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,710,570 - 76,720,225 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,175,076 - 72,184,731 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01075,087,892 - 75,098,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1075,087,892 - 75,098,260 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,004,128 - 75,014,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,085,872 - 76,097,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1071,507,771 - 71,517,382 (+)NCBICelera
Cytogenetic Map10q26NCBI
Mpo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554514,743,744 - 4,753,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554514,743,744 - 4,753,358 (+)NCBIChiLan1.0ChiLan1.0
MPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21974,441,104 - 74,453,615 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11779,252,255 - 79,263,874 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01752,333,882 - 52,357,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11757,189,654 - 57,212,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1757,201,073 - 57,212,111 (-)Ensemblpanpan1.1panPan2
MPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1932,927,483 - 32,938,007 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl932,927,483 - 32,937,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha932,164,643 - 32,175,070 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0933,734,267 - 33,744,696 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl933,734,273 - 33,744,637 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1932,520,407 - 32,530,846 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0932,803,860 - 32,814,324 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0932,897,366 - 32,907,792 (-)NCBIUU_Cfam_GSD_1.0
Mpo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,254,998 - 32,265,476 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364904,809,631 - 4,819,070 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364904,809,773 - 4,819,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,556,408 - 34,567,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11234,557,031 - 34,570,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21236,245,391 - 36,256,372 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Mpo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624871121,026 - 131,323 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624871121,026 - 131,433 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
68 28 18 26 26 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000003712   ⟹   ENSCSAP00000001986
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1635,120,581 - 35,130,671 (+)Ensembl
RefSeq Acc Id: XM_037993752   ⟹   XP_037849680
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660775,935,107 - 5,946,375 (+)NCBI
RefSeq Acc Id: XM_037993754   ⟹   XP_037849682
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660775,935,107 - 5,946,375 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037849680 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849682 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001986.1
Ensembl Acc Id: ENSCSAP00000001986   ⟸   ENSCSAT00000003712
RefSeq Acc Id: XP_037849680   ⟸   XM_037993752
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R047 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037849682   ⟸   XM_037993754
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R047 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005701 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003712.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/TrEMBL
InterPro Haem_peroxidase_animal UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/TrEMBL
  Peroxidase/ROS_Generation UniProtKB/TrEMBL
NCBI Gene MPO ENTREZGENE
PANTHER OXIDASE/PEROXIDASE UniProtKB/TrEMBL
  PTHR11475:SF108 UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/TrEMBL
PRINTS ANPEROXIDASE UniProtKB/TrEMBL
PROSITE PEROXIDASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48113 UniProtKB/TrEMBL
UniProt A0A0D9R047 ENTREZGENE, UniProtKB/TrEMBL